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arXiv 2025年

作者： Li, Jiang Wang, Xiaoping School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China Institute of Artificial Intelligence Huazhong University of Science and Technology Wuhan430074 China Hubei Key Laboratory of Brain-Inspired Intelligent Systems Huazhong University of Science and Technology Wuhan430074 China Key Laboratory of Image Processing and Intelligent Control Huazhong University of Science and Technology Ministry of Education Wuhan430074 China

Protein-protein interaction (PPI) prediction is an instrumental means in elucidating the mechanisms underlying cellular operations, holding significant practical implications for the realms of pharmaceutical development and clinical treatment. Presently, the majority of research methods primarily concentrate on the analysis of amino acid sequences, while investigations predicated on protein structures remain in the nascent stages of exploration. Despite the emergence of several structure-based algorithms in recent years, these are still confronted with inherent challenges: (1) the extraction of intrinsic structural information of proteins typically necessitates the expenditure of substantial computational resources;(2) these models are overly reliant on seen protein data, struggling to effectively unearth interaction cues between unknown proteins. To further propel advancements in this domain, this paper introduces a novel PPI prediction method jointing masked reconstruction and contrastive learning, termed JmcPPI. This methodology dissects the PPI prediction task into two distinct phases: during the residue structure encoding phase, JmcPPI devises two feature reconstruction tasks and employs graph attention mechanism to capture structural information between residues;during the protein interaction inference phase, JmcPPI perturbs the original PPI graph and employs a multi-graph contrastive learning strategy to thoroughly mine extrinsic interaction information of novel proteins. Extensive experiments conducted on three widely utilized PPI datasets demonstrate that JmcPPI surpasses existing optimal baseline models across various data partition schemes. The associated code can be accessed via https://***/lijfrankopen/JmcPPI. Copyright © 2025, The Authors. All rights reserved.

关键词： Graph neural networks

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Adaptively wavelet-based image denoising algorithm with edge preserving

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Chinese Optics Letters 2006年第2期4卷 80-83页

作者：谭毅华田金文柳健 State Key Laboratory of Education Ministry for Image Processing and Intelligent Control

A new wavelet-based image denoising algorithm, which exploits the edge information hidden in the corrupted image, is presented. Firstly, a canny-like edge detector identifies the edges in each subband. Secondly, multiplying the wavelet coefficients in neighboring scales is implemented to suppress the noise while magnifying the edge information, and the result is utilized to exclude the fake edges. The isolated edge pixel is also identified as noise. Unlike the thresholding method, after that we use local window filter in the wavelet domain to remove noise in which the variance estimation is elaborated to utilize the edge intbrmation. This method is adaptive to local image details, and can achieve bet, ter performance than the methods of state of the art.

关键词： Adaptive algorithms Detectors Edge detection Information technology Noise abatement Pattern recognition Wavelet transforms

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Air Pollution Monitoring By Integrating Local and Global Information in Self-Adaptive Multiscale Transform Domain

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IEEE Transactions on Multimedia 2025年

作者： Gu, Ke Liu, Yuchen Liu, Hongyan Liu, Bo Qiao, Junfei Lin, Weisi Zhang, Wenjun Beijing University of Technology School of Information Science and Technology Engineering Research Center of Intelligent Perception and Autonomous Control of Ministry of Education Beijing Laboratory of Smart Environmental Protection Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing Artificial Intelligence Institute Beijing100124 China Massey University School of Mathematical and Computational Sciences New Zealand Nanyang Technological University College of Computing and Data Science Singapore Shanghai Jiao Tong University Institute of Image Communication and Information Processing Shanghai China

As the deadliest form of pollution, air pollution had a prolonged severe damage to the human health and life safety of nearly 99% of the world's population. Facing to the problem that billions of tons of pollutants discharged into the air per year by industrial activities, this paper proposed a novel image-based air pollution monitor (IAPM) by incorporating local and global information in the self-adaptive multiscale transform domain, so as to achieve the timely and effective leakage detection of typical air pollutants from a single image. To be specific, this paper first developed a screen-shaped module according to two significant findings in visual neuroscience, which include the high sensitivity of human eyes to horizontal and vertical stimuli and the center-surround inhibition, by designing and fusing the square module, horizontal strip module and vertical strip module parallelly for simulating the behaviour of human eyes to extract local features. Second, the learnable weights and proportional mapping were applied to incorporate the screen-shaped module and lightweight vision transformer as backbone, towards more richly exploiting and fusing local and global information just as the way a brain perceives external stimuli. Third, a new self-adaptive multiscale transform domain method was devised based on two motivations from the visual characteristics of multiscale perception and the brain characteristics of self-adaptive domain transform to modify the backbone by using the operations of pooling and pointwise convolution. Extensive experiments implemented on the datasets of carbon particulate matters and ethylene leakage confirmed the superior monitoring performance of the proposed IAPM model beyond the state-of-the-art (SOTA) peers by an accuracy gain of about 4%. Furthermore, the proposed IAPM model only required 0.089 GFLOPs and 0.15 million model parameters, remarkably outperforming SOTA competitors in computational efficiency and storage resources. © 1999-2

关键词： Information leakage

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Data alignment based adversarial defense benchmark for EEG-based BCIs

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Neural Networks 2025年 188卷 107516页

作者： Chen, Xiaoqing Jia, Tianwang Wu, Dongrui Key Laboratory of the Ministry of Education for Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen518063 China Zhongguancun Academy Beijing100080 China

Machine learning has been extensively applied to signal decoding in electroencephalogram (EEG)-based brain–computer interfaces (BCIs). While most studies have focused on enhancing the accuracy of EEG-based BCIs, more attention should be given to their security. Recent findings reveal that EEG-based BCIs are vulnerable to adversarial attacks. To address this, we present the first adversarial defense benchmark based on data alignment, aiming to enhance both the accuracy and robustness of EEG-based BCIs. This study evaluates nine adversarial defense approaches (including five defense strategies) across five EEG datasets (covering three paradigms), three neural networks, and four experimental scenarios. Our results show for the first time that integrating data augmentation, data alignment, and robust training can further improve both the accuracy and robustness of BCIs compared to using only one or two of them. Furthermore, we provide insights into the characteristics of various adversarial defense approaches based on EEG data alignment, offering valuable guidance for developing more accurate and secure EEG-based BCIs. © 2025 Elsevier Ltd

关键词： Adversarial attack Adversarial defense Brain–computer interface Data alignment Electroencephalogram Security

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Surrogate-Assisted Multiobjective Gene Selection for Cell Classification from Large-Scale Single-Cell RNA Sequencing Data

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IEEE Transactions on Evolutionary Computation 2025年第3期29卷 601-615页

作者： Lin, Jianqing He, Cheng Jiang, Hanjing Huang, Yabing Jin, Yaochu Huazhong University of Science and Technology Key Laboratory of Image Information Processing and Intelligent Control of Education Ministry of China School of Artificial Intelligence and Automation Wuhan430074 China Huazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic Engineering Wuhan430074 China Renmin Hospital Department of Pathology Wuhan University Wuhan430060 China Westlake University Trustworth and General Artificial Intelligence Laboratory School of Engineering Hangzhou310030 China

Accurate cell classification is crucial but expensive for large-scale single-cell RNA sequencing (scRNA-seq) analysis. Gene selection (GS) emerges as a pivotal technique in identifying gene subsets of scRNA-seq for classification accuracy improvement and gene scale reduction. Nevertheless, the rising scale of scRNA-seq data presents challenges to existing GS methods regarding performance and computational time. Thus, we propose a surrogate-assisted evolutionary algorithm for multiobjective GS to address these deficiencies. An innovative two-phase initialization method is proposed to select sparse solutions to provide preliminary insights into gene contributions. Then, a binary competitive swarm optimizer is proposed for effective global search, where a local search method is embedded to eliminate irrelevant genes for efficiency consideration. Additionally, a surrogate model is adopted to forecast classification accuracy efficiently and substitutes part of the computationally expensive classification process. Experiments are conducted on eight large-scale scRNA-seq datasets with more than 20,000 genes. The effectiveness of the proposed GS method for scRNA-seq cell classification compared with eight state-of-the-art methods is validated. Gene expression analysis results of selected genes further validated the significance of the genes selected by the proposed method in the classification of scRNA-seq data. © 1997-2012 IEEE.

关键词： Gene expression

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Spiking neural P systems with anti-spikes and without annihilating priority as number acceptors

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Journal of Systems Engineering and Electronics 2014年第3期25卷 464-469页

作者： Gangjun Tan Tao Song Zhihua Chen Key Laboratory of Image Information Processing and Intelligent Control School of AutomationHuazhong University of Science and Technology

Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems is when a neuron contains both spikes and anti-spikes, spikes and anti-spikes wil immediately annihilate each other in a maximal way. In this paper, a restricted variant of ASN P systems, cal ed ASN P systems without anni-hilating priority, is considered, where the annihilating rule is used as the standard rule, i.e., it is not obligatory to use in the neuron associated with both spikes and anti-spikes. If the annihilating rule is used in a neuron, the annihilation wil consume one time unit. As a result, such systems using two categories of spiking rules （identified by （a, a） and （a,a^-）） can achieve Turing completeness as number accepting devices.

关键词： membrane computing spiking neural P system Turing completeness register machine anti-spike.

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A reinforcement learning-based dynamic multi-objective optimization approach for integrated timetabling and vehicle scheduling

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Knowledge-Based Systems 2025年 321卷

作者： Shen, Yindong Xie, Wenliang Institute of Artificial Intelligence Huazhong University of Science and Technology Wuhan 430074 China School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan 430074 China The MOE Key Laboratory of Image Processing and Intelligent Control Huazhong University of Science and Technology Wuhan 430074 China

Dynamic integrated timetabling and vehicle scheduling (D-ITVS) is essential for mitigating the negative impacts of service disruptions. It involves multiple rescheduling stages, with inherent optimization similarities across these stages. However, existing optimization approaches for the D-ITVS problem have not systematically exploited these similarities, overlooking the potential for decision knowledge from previous stages to inform the current stage. To address this gap, this paper proposes a reinforcement learning-based dynamic multi-objective optimization approach (RL-DMOA), which focuses on transferring decision knowledge between rescheduling stages. This approach models the optimization process of each rescheduling stage in the D-ITVS problem as a Markov decision process, incorporating a state space with vehicle information, action space for vehicle assignment, and a multi-objective reward function. A multi-objective deep reinforcement learning (M-DRL) agent is employed within the RL-DMOA to select actions based on the state at each decision point. The agent is constructed on a multi-objective deep Q-learning network (M-DQN), with a Q-value adjustment layer incorporated to prevent the selection of invalid actions. To select optimal actions while balancing the conflicts among multiple objectives, the M-DRL agent applies a non-dominated sorting selection strategy. Experimental results demonstrate that the proposed RL-DMOA is capable of generating timetables and vehicle schedules with reduced costs, enhanced robustness, and improved convergence and diversity across all rescheduling stages. By balancing operational costs and passenger service quality, these improvements benefit transit operators, and during daily operations, passengers enjoy reduced travel costs and enhanced service reliability. © 2025 Elsevier B.V.

关键词： Dynamic multi-objective optimization Reinforcement learning Timetabling Vehicle scheduling

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Exponential synchronization of coupled memristive neural networks via pinning control

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Chinese Physics B 2013年第5期22卷 203-212页

作者：王冠沈轶尹泉 Department of Control Science and Engineering Huazhong University of Science and Technology Key Laboratory of Ministry of Education for Image Processing and Intelligent Control

This paper is concerned with the exponential synchronization problem of coupled memristive neural networks. In contrast to general neural networks, memristive neural networks exhibit state-dependent switching behaviors due to the physical properties of memristors. Under a mild topology condition, it is proved that a small fraction of controlled sub- systems can efficiently synchronize the coupled systems. The pinned subsystems are identified via a search algorithm. Moreover, the information exchange network needs not to be undirected or strongly connected. Finally, two numerical simulations are performed to verify the usefulness and effectiveness of our results.

关键词： synchronization memristor coupled neural networks pinning control

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Reversible spiking neural P systems

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Frontiers of Computer Science 2013年第3期7卷 350-358页

作者： Tao SONG Xiaolong SHI Jinbang XU Key Laboratory of Image Processing and Intelligent Control Department of Control Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Spiking neural （SN） P systems are a class of distributed parallel computing devices inspired by the way neurons communicate by means of spikes. In this work, we investigate reversibility in SN P systems, as well as the computing power of reversible SN P systems. Reversible SN P systems are proved to have Turing creativity, that is, they can compute any recursively enumerable set of non-negative integers by simulating universal reversible register machine.

关键词： membrane computing spiking neural P system reversible computing model universality reversible register machine

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Deep transfer learning-based decoder calibration for intracortical brain-machine interfaces

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Computers in Biology and Medicine 2025年第Pt A期192卷 110231-110231页

作者： Li, Xiao Dong, Xianxin Wang, Jun Mao, Haodong Tu, Xikai Li, Wei He, Jiping Li, Qiang Zhang, Peng Hubei Key Laboratory of Modern Manufacturing Quantity Engineering School of Mechanical Engineering Hubei University of Technology Wuhan430068 China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Hubei Wuhan China MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical Engineering School of Engineering Sciences Huazhong University of Science and Technology Hubei Wuhan China The Key Laboratory of Ministry of Education for Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Hubei Wuhan China Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of Technology Beijing China

Intracortical brain-machine interfaces (iBMIs) aim to establish a communication path between the brain and external devices. However, in the daily use of iBMIs, the non-stationarity of recorded neural signals necessitates frequent recalibration of the iBMI decoder to maintain decoding performance, which requires collecting and labeling a large amount of new data. To address this challenge and minimize the time needed for decoder recalibration, we proposed an active learning domain adversarial neural network (AL-DANN). This model leveraged a substantial volume of historical data alongside a small amount of current data (four samples per category) to calibrate the decoder. By incorporating domain adversarial and active learning strategies, the model effectively transferred knowledge from historical data to new data, reducing the demand for new samples. We validated the proposed method using neural signals recorded from three monkeys performing different movements in a classification task or a regression task. The results showed that the AL-DANN outperformed existing state-of-the-art methods. Impressively, it required only four new samples per category for decoder recalibration, leading to a recalibration time reduction of over 80 %. To our knowledge, this is the first study to incorporate deep transfer learning into iBMI decoder calibration, highlighting the significant potential of applying deep learning technologies in iBMIs. © 2025

关键词： Adversarial machine learning

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