The existence of imbalanced data between one class and another class is an important issue to be considered in a classification problem. One of the well-known data balancing technique is the artificial oversampling, w...
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Lipid nanoparticles(LNPs)are nanocarriers composed of four lipid components and can be used for gene therapy,protein replacement,and vaccine ***,LNPs also face several challenges,such as toxicity,immune activation,and...
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Lipid nanoparticles(LNPs)are nanocarriers composed of four lipid components and can be used for gene therapy,protein replacement,and vaccine ***,LNPs also face several challenges,such as toxicity,immune activation,and low delivery *** overcome these challenges,artificial intelligence can be used to optimize the design and formulation of LNPs,as well as to predict their properties and ***,antibody-targeted conjugation can be used to enhance the specificity and selectivity of LNPs by attaching an antibody that recognizes a specific antigen on the cell surface to LNPs.
Real-time object detection has been a critical component of onboard instrumentation for next-generation autonomous driving. To enable safety and reliability in autonomous driving systems, we must continue advancing it...
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Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate t...
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Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate the membrane protein's structure by wet-lab experiments,accurate and fast amino acid sequence-based computational methods are highly desired. In this paper, we report an online prediction tool called Mem Brain, whose input is the amino acid sequence. Mem Brain consists of specialized modules for predicting transmembrane helices, residue–residue contacts and relative accessible surface area of a-helical membrane proteins. Mem Brain achieves aprediction accuracy of 97.9% of ATMH, 87.1% of AP,3.2 ± 3.0 of N-score, 3.1 ± 2.8 of C-score. Mem BrainContact obtains 62%/64.1% prediction accuracy on training and independent dataset on top L/5 contact prediction,respectively. And Mem Brain-Rasa achieves Pearson correlation coefficient of 0.733 and its mean absolute error of13.593. These prediction results provide valuable hints for revealing the structure and function of membrane *** Brain web server is free for academic use and available at ***/bioinf/Mem Brain/.
Effectively extracting image subject contours holds significant importance for subsequent imageprocessing tasks. Recognizing the pivotal role of contrast features in contour characterization, this paper proposes a no...
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In this paper, we take the advantages of color contrast and color distribution to get high quality saliency maps. The overall procedure flow of our unified framework contains superpixel pre-segmentation, color contras...
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Constructing the pyramidal architecture for the feature is currently a very effective way to obtain feature information of objects at different scales. Although the feature pyramid can realize the recognition and dete...
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The PnP problem is a widely used technique for pose determination in computer vision community,and finding out geometric conditions of multiple solutions is the ultimate and most desirable goal of the multi-solution a...
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The PnP problem is a widely used technique for pose determination in computer vision community,and finding out geometric conditions of multiple solutions is the ultimate and most desirable goal of the multi-solution analysis,which is also a key research issue of the *** this paper,we prove that given 3 control points,if the camera's optical center lies on the so-called“danger cylinder”and is enough far from the supporting plane of control points,the corresponding P3P problem must have 3 positive *** result can bring some new insights into a better understanding of the multi-solution *** example,it is shown in the literature that the solution of the P3P problem is instable if the optical center lies on this danger cylinder,we think such occurrence of triple-solution is the primary source of this instability.
Recently, deep convolutional learning has been applied to image deblurring, which greatly improves the performance of single-image blind deblurring algorithms. However, most deep image deblurring models based on convo...
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Sparse representation classification (SRC) is a new framework for classification and has been successfully applied to face recognition. However, SRC can not well classify the data when they are in the overlap feature ...
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