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An asymmetric Janus membrane with anti-bacteria adhesion and rapid hemostasis properties for wound healing

Journal of Materials Science & Technology 2024年第25期192卷 201-214页

作者： Zihe Hu Gaoying Hong Mumian Chen Haiyan Wu Weiying Lu Yuewei Chen Zhijian Xie Changyu Shao Jue Shi Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityEngineering Research Center of Oral Biomaterials and Devices of Zhejiang ProvinceHangzhou 310000China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

Currently,commercial intraoral dressings have limitations as they only serve a single purpose and fail to meet various needs,such as hemostasis,wound protection,and dressing ***,we success-fully fabricated a multifunctional polycaprolactone-chitosan Janus membrane(PCJM)with simultaneous hydrophobic and hydrophilic *** hydrophobic layer consists of a dense and disordered poly-caprolactone,preventing bacterial adhesion,resisting fouling,and enhancing mechanical *** hydrophilic layer is a highly porous chitosan sponge,which facilitates cell and protein adhesion,as well as rapid absorption of blood and activation of the coagulation *** results are confirmed by hemostasis experiments,which demonstrate that the PCJM had superior coagulation ability compared to commercial gelatin sponges and gauze,and by an early gingival healing model of beagle tooth extraction wounds,which exhibited excellent performance in promoting wound *** work demonstrates the multifunctional PCJM wound dressing not only protects wounds from bacterial infections but also facili-tates rapid hemostasis and early healing of beagle gingival soft tissue,which holds significant potential for clinical translation and large-scale production.

关键词： Janus membrane Anti-bacteria Rapid hemostasis Wound healing

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Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring

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Nano-Micro Letters 2024年第2期16卷 347-364页

作者： Yuewei Chen Yanyan Zhou Zihe Hu Weiying Lu Zhuang Li Ning Gao Nian Liu Yuanrong Li Jing He Qing Gao Zhijian Xie Jiachun Li Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310006People’s Republic of China

Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose ***,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for *** is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most *** study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical *** regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to *** negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological *** GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high ***,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue *** GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.

关键词： Implantable hydrogel-based bioelectronics Conformality 3D printing Metamaterial design

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FANET and MANET, a Support and Composition Relationship

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Computers, Materials & Continua 2025年第2期82卷 1699-1732页

作者： Carlos Andrés Tavera Romero Jesús Hamilton Ortiz Luis Carlos Rodríguez Timaná Fernando Vélez Varela Andrés Hernando Aristizábal Montufar Javier Gamboa-Cruzado COMBA R&D Laboratory Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Development Department Closemobile R&D Telecommunications LSMadrid28070Spain GIEIAM Research Group Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Faculty of Engineering Universidad LibreCali760031Colombia Faculty of Systems and Informatics Engineering Universidad Nacional Mayor de San MarcosLima15001Perú

This study investigates the design and implementation of Flying Ad Hoc Networks(FANETs),a network architec-ture inspired by the Mobile Ad Hoc Network(MANET)model,specifically tailored to support unmanned aerial vehicles(UAVs).As UAVs increasingly contribute to diverse fields,from surveillance to delivery,FANETs have emerged as essential in ensuring stable,dynamic communication channels among drones in *** research adopts a dual approach,combining rigorous theoretical analysis with detailed practical simulations to assess the performance,adaptability,and efficiency of FANETs in varying *** findings emphasize the ability of FANETs to manage network congestion effectively in densely populated areas,a critical feature for maintaining reliable communications in complex ***,FANETs demonstrate high potential to support critical applications,such as emergency response,disaster management,and public safety operations,where quick and coordinated action is *** study also underscores the importance of establishing a hierarchical structure among nodes within the network,which allows for more efficient data exchange and helps optimize the overall network *** this work,significant insights are offered into the design principles that can enhance UAV communication networks,providing a foundation for the development of more resilient,scalable,and efficient technological *** advancements could accelerate the deployment of UAVs across a variety of sectors,including logistics,agriculture,environmental monitoring,and *** such,this study not only contributes to the field of ad hoc networking but also holds potential for transformative impacts across industries where UAVs play an increasingly central role,promoting greater integration and operational success.

关键词： Ad hoc FANET MANET network UAV

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In situ tumor vaccine with optimized nanoadjuvants and lymph node targeting capacity to treat ovarian cancer and metastases

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4102-4117页

作者： Yuan Li Fan Tong Yufan Wang Jing Wang Manqi Wu Hanmei Li Hongyan Guo Huile Gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

Tumor vaccine,a promising modality of tumor immunotherapy,needs to go through the process of tumor antigen generation and loading,antigen drainage to lymph nodes(LNs),antigen internalization by dendritic cells(DCs),DC maturation,and antigen cross-presentation to activate ***,tumor vaccines are often unable to satisfy all the steps,leading to the limitation of their application and ***,based on a smart nanogel system,an in situ nano-vaccine(CpG@Man-P/Tra/Gel)targeting LNs was constructed to induce potent anti-tumor immune effects and inhibit the recurrence and metastasis of ovarian *** CpG@Man-P/Tra/Gel exhibited MMP-2-sensitive release of trametinib(Tra)and nano-adjuvant CPG@Man-P,which generated abundant in situ depot of whole-cell tumor antigens and formed in situ nano-vaccines with CpG@*** from mannose(Man)modification,the nano-vaccines targeted to LNs,promoted the uptake of antigens by DCs,further inducing the maturation of DCs and activation of T ***,CpG@Man-P with different particle sizes were prepared and the effective size was selected to evaluate the antitumor effect and immune response in ***,combined with PD-1 blocking,the vaccine effectively inhibited primary tumor growth and induced tumor-specific immune response against tumor recurrence and metastasis of ovarian cancer.

关键词： In situ nano-vaccine Lymph node targeting MMP-2 responsive PD-1 Combination therapy CpG Ovarian cancer Metastases

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Oxygen nanobubbles of ICG dimers achieve self-cascade photothermal and photodynamic therapy for hypoxia-reversible tumor treatment

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Nano research 2025年第4期18卷 325-336页

作者： Xiang Sun Zheng Zhang Moran Wang Yuqin Chen Xiang Meng Wenjun Zhao Juan Jin Wanghanqi Yang Chengwan Xia Yuxin Wang Shengliang Li Bin Huang Ning Gu Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 210029China Department of Oral and Maxillofacial Trauma Orthognathic Plastic Surgery Nanjing Stomatological HospitalResearch Institute of StomatologyMedical School of Nanjing UniversityNanjing 210093China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical MedicineNanjing Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008China

Simultaneous photothermal and photodynamic therapies(PTT and PDT)hold great promise for noninvasive tumor ***,effective regulation of PTT and PDT with optimal synergistic effects remains a *** date,there are only a few synergistic PTT and PDT methods with suitable collaborative effects due to the rarity of efficient nanoplatforms with good cascading *** overcome this limitation,a proof-of-concept of self-cascade PTT and PDT was developed for hypoxia-reversible tumor *** the assembly of dimeric indocyanine green(DICG)with oxygen nanobubbles(O_(2)-NBs),DICG/O_(2)-NBs typically exhibit J-aggregates for significant PTT effects,with a high photothermal conversion efficiency of 51.45% under 880 nm light ***,the PTT performance of DICG/O_(2)-NBs can switch J-aggregates of DICG into DICG monomers with efficient O_(2) gas liberation,while producing hydroxyl radicals for type Ⅰ ***,the evolved DICG monomer reacts with the released O_(2) to generate plenty of 1O_(2) for efficient type Ⅱ *** these advantages,the cascaded nanoplatform achieves good tumor targeting and biocompatibility,and thus has high tumor inhibition of 94.26%,with an obvious ability to reverse *** work demonstrates the efficiency of self-cascade PTT and PDT nanomedicine for high-performance hypoxia-reversible tumor ablation,thus providing a new approach for the development of cascading phototheranostics in vivo.

关键词： indocyanine green(ICG)dimer oxygen nanobubble J-aggregate self-cascade photothermal therapies(PTT) photodynamic therapies(PDT)

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Layered niobium carbide enabling excellent kinetics and cycling stability of Li-Mg-B-H hydrogen storage material Layered niobium carbide enabling excellent kinetics

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Rare Metals 2024年第3期43卷 1153-1166页

作者： Li-Wen Lu Hui Luo Guang-Xu Li Yun Li Xin-Hua Wang Cun-Ke Huang Zhi-QiangLan Wen-Zheng Zhou Jin Guo Mohammad Ismail Hai-Zhen Liu Guangxi Novel Battery Materials Research Center of Engineering Technology Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning530004China School of Mechanical and Electrical Engineering Quzhou College of TechnologyQuzhou324000China Department of Materials Science and Engineering Zhejiang UniversityHangzhou310027China Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

The Li-Mg-B-H composite(2LiBH_(4)+MgH_(2))has a high capacity of 11.4 wt%as a hydrogen storage ***,the slow kinetics and poor cycling stability severely restrict its practical *** this work,a layered Nb_(2)C MXene was first synthesized and then introduced to tailor the kinetics and cycling stability of the Li-Mg-B-H *** milled 2LiH+MgB_(2)composites were initially hydrogenated to obtain the 2LiBH_(4)+MgH_(2)*** 2LiBH_(4)+MgH_(2)+5wt%Nb_(2)C can release 9.0 wt%H_(2)in 30 min at 400℃,while it is only 2.7 wt%for the undoped 2LiBH_(4)+MgH_(2).The dehydrogenation activation energies of MgH_(2)and LiBH_(4)are 123 and 154 kJ·mol^(-1)respectively for the 5 wt%Nb_(2)C-doped composite,lower than the undoped composite(164 and 165 kJ·mol^(-1)).The 2LiBH_(4)+MgH_(2)+5 wt%Nb_(2)C possesses excellent cycling stability,with the reversible capacity only slightly reduced from 9.4 wt%for the 1st cycle to 9.3 wt%for the 20th ***_(2)C keeps stable in the composite and acts as an efficient catalyst for the Li-Mg-B-H *** is believed that both the layered structure and the active Nb element contribu te to the enhanced hydrogen storage performances of the Li-Mg-B-H *** work confirms that the Nb_(2)C MXene with layered stru cture has a significant enhancing impact on the Li-Mg-B-H hydrogen storage materials,which is different from the bulk NbC.

关键词： Hydrogen storage Lithium borohydride Magnesium hydride Nb_(2)C MXene

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Cooperative Chemical Coupling and Physical Lubrication Effects Construct Highly Dynamic Ionic Covalent Adaptable Network for High-Performance Wearable Electronics

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CCS Chemistry 2023年第5期5卷 1096-1107页

作者： Lijie Sun Hongfei Huang Qingbao Guan Lei Yang Luzhi Zhang Benhui Hu Rasoul Esmaeely Neisiany Zhengwei You Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua UniversityShanghai 201620 Key Laboratory of Clinical and Medical Engineering School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166 Department of Materials and Polymer Engineering Faculty of EngineeringHakim Sabzevari UniversitySabzevar ***

Covalent adaptable networks(CANs),which combine the benefits of traditional thermosets and thermoplastics,have attracted considerable *** dynamics of reversible covalent bonds and mobility of polymer chains in CANs determine the topological rearrangement of the polymeric network,which is critical to their superior features,such as self-healing and ***,we introduce an ionic liquid to dimethylglyoximeurethane(DOU)-based CANs to regulate both reversible bond dynamics and polymer chain mobility by cooperative chemical coupling and physical ***-molecule model experiments demonstrated that ionic liquids can catalyze dynamic DOU bond *** liquid also breaks the hydrogen bonds between polymeric chains,thereby increasing their *** a combined result,the activation energy of the dissociation of the dynamic network decreased from 110 to 85 kJ mol^(−1).Furthermore,as a functional moiety,the ionic liquid imparts new properties to CANs and will greatly expand their *** example,the consequent conductivity of resultant ionic CAN(iCAN)has demonstrated a great power to build high-performance multifunctional wearable electronics responsive to multiple stimulations including temperature,strain,and *** study provides a new design principle that simultaneously uses the chemical and physical effects of two structural components to regulate material properties enabling novel applications.

关键词： covalent adaptable networks polyurethane self-healing recycling ionic skin

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Drosophila Larvae-Inspired Soft Crawling Robot with Multimodal Locomotion and Versatile Applications

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research 2025年第1期7卷 35-46页

作者： Qin Fang Jingyu Zhang Yinhui He Nenggan Zheng Yue Wang Rong Xiong Zhefeng Gong Haojian Lu State Key Laboratory of Industrial Control and Technology Zhejiang UniversityHangzhou 310027China Institute of Cyber-Systems and Control Zhejiang UniversityHangzhou 310027China Medical School of Zhejiang University Hangzhou 310027China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityEngineering Research Center of Oral Biomaterials and Devices of Zhejiang ProvinceHangzhou 310000China

Soft crawling robots have been widely studied and applied because of their excellent environmental adaptability and flexible ***,most existing soft crawling robots typically exhibit a single-motion mode and lack diverse *** by Drosophila larvae,this paper proposes a compact soft crawling robot(weight,13 g;length,165 mm;diameter,35 mm)with multimodal locomotion(forward,turning,rolling,and twisting).Each robot module uses 4 sets of high-power-density shape memory alloy actuators,endowing it with 4 degrees of motion *** analyze the mechanical characteristics of the robot modules through experiments and simulation *** plug-and-play modules can be quickly assembled to meet different motion and task *** soft crawling robot can be remotely operated with an external controller,showcasing multimodal motion on various material *** a narrow maze,the robot demonstrates agile movement and effective maneuvering around *** addition,leveraging the inherent bistable characteristics of the robot modules,we used the robot modules as anchoring units and installed a microcamera on the robot's head for pipeline *** robot completed the inspection in horizontal,vertical,curved,and branched pipelines,adjusted the camera view,and twisted a valve in the pipeline for the first *** research highlights the robot's superior locomotion and application capabilities,providing an innovative strategy for the development of lightweight,compact,and multifunctional soft crawling robots.

关键词： multimodal locomotion versatile applications Drosophila larvae soft crawling robot weight soft crawling robots shape memory alloy actuators

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Reassessing Glove Embeddings in Deep Learning: A Comparative Study with Classical ML Approaches 15

Reassessing Glove Embeddings in Deep Learning: A Comparative...

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15th International Conference on Emerging Ubiquitous systems and Pervasive Networks / 14th International Conference on Current and Future Trends of Information and Communication Technologies in Healthcare, EUSPN/ICTH 2024

作者： Labd, Zakia Bahassine, Said Housni, Khalid Aadi, Fatima Zahrae Aithamou Laboratory of research in informatics LatRI Department of Computer Science Faculty of Sciences Ibn Tofail University Kenitra Morocco Laboratory of Artificial Intelligence and Complex Systems Engineering Department of Computer Science National Higher School of Arts and Crafts Hassan II University Casablanca Morocco

The importance of text classification algorithms has increased due to the growing availability of large-scale data. This has led to a greater demand for efficient classification techniques and encoding algorithms. Word embedding techniques, like Glove, have shown significant success in encoding semantic relationships between words. This research paper aims to reassess the effectiveness of Glove embeddings coupled with deep learning algorithms. The impact of Glove embedding on two widely used deep learning models: Recurrent Neural Networks (RNN) and Recurrent Convolutional Neural Networks (RCNN) is analyzed. The results highlight the impact of Glove embeddings on deep learning models, showcasing significant performance enhancements in some cases while having minimal effects in others. By examining the impact of Glove embeddings on traditional ML algorithms in a previous study, valuable context for understanding the performance differences between the two approaches is obtained. © 2024 The Authors. Published by Elsevier B.V.

关键词： Convolutional neural networks

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Movable surface acoustic wave tweezers: a versatile toolbox for micromanipulation

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Microsystems & Nanoengineering 2024年第5期10卷 367-380页

作者： Xianming Qin Xianglian Liu Shuo Liu Chuanyu Zhang Ningning Bai Xue Li Weidong Wang Dan Liu Qiqi Yang Ruiguo Yang Yajing Shen Xueyong Wei School of Mechano-Electronic Engineering Xidian UniversityXi'an 710071China State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong UniversityXi'an 710049China State Key Laboratory of Electromechanical Integrated Manufacturing of High-Performance Electronic Equipment Xidian UniversityXian 710071China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi'an 710032China Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering(IQ)Michigan State UniversityEast LansingMI 48824USA Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Surface acoustic wave(SAW)tweezers are a promising multifunctional micromanipulation method that controls microscale targets via patterned acoustic *** to their device structure and bonding process,most SAW tweezers have limitations in terms of controlling the position and motion of the acoustic traps,as they generate an acoustic field with a fixed region and adjust the manipulation effects via signal *** address this challenge,we propose movable SAW tweezers with a multilayer structure,achieving dynamic control of their wave field and acoustic trap positions;we demonstrate their precise manipulation functions,such as translation,in-plane rotation,out-of-plane rotation,and cluster formation,on a wide spectrum of samples,including particles,bubbles,droplets,cells,and *** method not only improves the degree of freedom and working range of SAW tweezers but also allows for precise and selective manipulation of microtargets via microtools and localized *** to their flexibility,versatility,and biocompatibility,the movable SAW tweezers can be a practical platform for achieving arbitrary manipulation of microscale targets and have the potential to play significant roles in biomedical microrobotics.

关键词： wave precise rotation

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