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Development of a Universal RNA Dual-Terminal Labeling Method for Sensing RNA-Ligand Interactions

CCS Chemistry 2023年第1期5卷 221-233页

作者： Longhuai Cheng Dejun Ma Jie Zhang Xueying Kang Yang Wu Yi Zhao Long Yi Zhen Xi State Key Laboratory of Elemento-Organic Chemistry Department of Chemical BiologyCollege of ChemistryNational Pesticide Engineering Research CenterCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071 State Key Laboratory of Organic-Inorganic Composites and Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology(BUCT)Beijing 100029 Key Laboratory of Intelligent Information Processing Research Center for Ubiquitous Computing SystemsInstitute of Computing TechnologyChinese Academy of SciencesBeijing 100190

Dual labeling of an RNA can provide Förster resonance energy transfer(FRET)sensors for studying RNA folding,miRNA maturation,and RNA-protein ***,we report the development of a highly efficient strategy for direct dual-terminal labeling of any RNA of *** explored new Michael cycloaddition for facile labeling of 5′-terminal RNA with improved *** chemical tetrazinylation of RNA at the 3′-terminus was achieved with the highly efficient and catalysis-free tetrazine-cycloalkyne *** single-terminal labeling methods were combined for dual-terminal labeling of an RNA including short hairpin RNA,pre-miRNA,riboswitch,and noncoding ***,these dual-labeled RNA-based FRET sensors were used to monitor RNA-ligand interactions in vitro and in live *** is anticipated that these universal RNA labeling strategies will be useful to study RNA structures and functions.

关键词： dual labeling Förster resonance energy transfer sensor Michael cycloaddition tetrazinecycloalkyne ligation RNA-ligand interaction

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A New Method for Predefined-Time Synchronization Control of Memristive Cohen-Grossberg Neural Networks

A New Method for Predefined-Time Synchronization Control of ...

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2023 IEEE International Conference on Memristive computing and Applications, ICMCA 2023

作者： Liu, Aidi Yu, Wenyue Huang, Lili Guo, Jian Lei, Tengfei Zhao, Hui School of Computer and Information Engineering Qilu Institute of Technology Jinan China School of Computer and Information Engineering Qilu Institute of Technology China Collaborative Innovation Center of Memristive Computing Application School of Computer and Information Engineering Qilu Institute of Technology China School of Information Science and Engineering University of Jinan Shandong Provincial Key Laboratory of Network Based Intelligent Computing Jinan China

ISBN: (纸本)9798350316230

This article mainly conducts a series of research on the synchronization control of Cohen-Grossberg neural networks. Firstly, a memristive Cohen-Grossberg neural network model with time-varying delay was constructed, and an equivalent system was obtained by combining inverse function theory, differential inclusion, and set-valued mapping. Secondly, a new predefined-time stability theorem was proposed, and sufficient conditions were obtained to ensure that the drive-response system achieves predefined-time synchronization by designing appropriate control strategy. The simulation results show that the stability time of the error system can be adjusted by the user, verifying the correctness and of the theory. © 2023 IEEE.

关键词： Neural network models

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CAMG: Context-Aware Moment Graph Network for Multimodal Temporal Activity Localization via Language 12th

CAMG: Context-Aware Moment Graph Network for Multimodal Tem...

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12th National CCF Conference on Natural Language processing and Chinese computing, NLPCC 2023

作者： Hu, Yuelin Xu, Yuanwu Zhang, Yuejie Feng, Rui Zhang, Tao Lu, Xuequan Gao, Shang School of Computer Science Shanghai Key Laboratory of Intelligent Information Processing Shanghai Collaborative Innovation Center of Intelligent Visual Computing Fudan University Shanghai200433 China School of Information Management and Engineering Shanghai Key Laboratory of Financial Information Technology Shanghai University of Finance and Economics Shanghai200433 China School of Information Technology Deakin University Waurn PondsVIC3216 Australia

ISBN: (纸本)9783031446924

Temporal Activity Localization via Language (TALL) is a challenging task for language based video understanding, especially when a video contains multiple moments of interest and the language query has words describing complex context dependencies between the moments. Latest studies have proposed various ways to exploit the temporal context of adjacent moments, but two apparent limitations remained. First, only limited context information was encoded based on RNNs or 2-D convolutions, which highly depended on the pre-sorting of proposals and lacked flexibility. Second, semantically correlated content in different moments was ignored, i.e., semantic context. To address these limitations, we propose a novel GCN-based framework, i.e., Context-Aware Moment Graph (CAMG) network, to jointly model the temporal context and semantic context. Also, we design a multi-step fusion scheme to aggregate object, motion and textual features. A Query-Gated Integration Module is further designed to select queried objects and filter out noisy ones. Our model achieves superior performance to state-of-the-art methods on two widely-used benchmark datasets. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Semantics

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End-to-End Paired Ambisonic-Binaural Audio Rendering

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 502-513页

作者： Yin Zhu Qiuqiang Kong Junjie Shi Shilei Liu Xuzhou Ye Ju-Chiang Wang Hongming Shan Junping Zhang Shanghai Key Laboratory of Intelligent Information Processing School of Computer ScienceFudan UniversityShanghai 200433China Beijing ByteDance Technology Co.Ltd. Shanghai 201102China. Chinese University of Hong Kong Hong KongChina IEEE Institute of Science and Technology for Brain-Inspired Intelligence and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433 Shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 200031China

Binaural rendering is of great interest to virtual reality and immersive media. Although humans can naturally use their two ears to perceive the spatial information contained in sounds, it is a challenging task for machines to achieve binaural rendering since the description of a sound field often requires multiple channels and even the metadata of the sound sources. In addition, the perceived sound varies from person to person even in the same sound field. Previous methods generally rely on individual-dependent head-related transferred function(HRTF)datasets and optimization algorithms that act on HRTFs. In practical applications, there are two major drawbacks to existing methods. The first is a high personalization cost, as traditional methods achieve personalized needs by measuring HRTFs. The second is insufficient accuracy because the optimization goal of traditional methods is to retain another part of information that is more important in perception at the cost of discarding a part of the information. Therefore, it is desirable to develop novel techniques to achieve personalization and accuracy at a low cost. To this end, we focus on the binaural rendering of ambisonic and propose 1) channel-shared encoder and channel-compared attention integrated into neural networks and 2) a loss function quantifying interaural level differences to deal with spatial information. To verify the proposed method, we collect and release the first paired ambisonic-binaural dataset and introduce three metrics to evaluate the content information and spatial information accuracy of the end-to-end methods. Extensive experimental results on the collected dataset demonstrate the superior performance of the proposed method and the shortcomings of previous methods.

关键词： Ambisonic attention binaural rendering neural network

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Scale‐wise interaction fusion and knowledge distillation network for aerial scene recognition

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CAAI Transactions on Intelligence technology 2023年第4期8卷 1178-1190页

作者： Hailong Ning Tao Lei Mengyuan An Hao Sun Zhanxuan Hu Asoke K.Nandi School of Computer Science and Technology Xi'an University of Posts and TelecommunicationsShaanxi Key Laboratory of Network Data Analysis and Intelligent ProcessingXi'anChina Xi'an Key Laboratory of Big Data and Intelligent Computing Xi'anChina School of Electronic Information and Artificial Intelligence Shaanxi University of Science and TechnologyXi'anChina School of Computer Central China Normal UniversityWuhanChina Department of Electronic and Electrical Engineering Brunel University LondonLondonUK Xi'an Jiaotong University Xi'anChina

Aerial scene recognition(ASR)has attracted great attention due to its increasingly essential *** of the ASR methods adopt the multi‐scale architecture because both global and local features play great roles in ***,the existing multi‐scale methods neglect the effective interactions among different scales and various spatial locations when fusing global and local features,leading to a limited ability to deal with challenges of large‐scale variation and complex background in aerial scene *** addition,existing methods may suffer from poor generalisations due to millions of to‐belearnt parameters and inconsistent predictions between global and local *** tackle these problems,this study proposes a scale‐wise interaction fusion and knowledge distillation(SIF‐KD)network for learning robust and discriminative features with scaleinvariance and background‐independent *** main highlights of this study include two *** the one hand,a global‐local features collaborative learning scheme is devised for extracting scale‐invariance features so as to tackle the large‐scale variation problem in aerial scene ***,a plug‐and‐play multi‐scale context attention fusion module is proposed for collaboratively fusing the context information between global and local *** the other hand,a scale‐wise knowledge distillation scheme is proposed to produce more consistent predictions by distilling the predictive distribution between different scales during *** experimental results show the proposed SIF‐KD network achieves the best overall accuracy with 99.68%,98.74%and 95.47%on the UCM,AID and NWPU‐RESISC45 datasets,respectively,compared with state of the arts.

关键词： deep learning image analysis image classification information fusion

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A Novel Effectiveness Assessment Framework for Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer Based on Multi-modal Intelligence

A Novel Effectiveness Assessment Framework for Neoadjuvant C...

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2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

作者： Tian, Xiao Sui, Dong Liu, Weifeng Guo, Maozu Luo, Gongning Wang, Kuanquan Beijing Key Laboratory for Intelligent Processing Methods of Architectural Big Data Beijing China School of Electrical and Information Engineering Beijing University of Civil Engineering and Architecture Beijing China Perceptual Computing Research Center Harbin Institute of Technology Harbin China

ISBN: (纸本)9798350337488

Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC). With the development of artificial intelligence, an increasing number of studies have begun to explore its application in cancer treatment prediction. However, the prior methods exhibit considerable variability even with slight modifications to the input data, which could potentially undermine the reliability of the results. In this paper, we proposed RP-Net, a novel multi-modal fusion-based framework that combines feature information from magnetic resonance imaging (MRI) and whole slide images (WSI), establishing a relationship to map the therapeutic effectiveness of nCRT for LARC. We investigated the relationship of the tumour region and its periphery tissues, and demonstrated the validity of the proposed framework that involving 11 different combinations of modalities. The experimental results revealed that it has achieved higher prediction accuracy compared to the four intra-categories single-modal combinations and outperformed the two intra-categories multi-modal combinations. When compared to the other four inter-categories multi-modal combinations, the fusion features get accuracy of 2% ∼ 6% improvement respectively. © 2023 IEEE.

关键词： Magnetic resonance imaging

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Context-Driven Index Trimming: A Data Quality Perspective to Enhancing Precision of RALMs

Context-Driven Index Trimming: A Data Quality Perspective to...

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2024 Conference on Empirical Methods in Natural Language processing, EMNLP 2024

作者： Ma, Kexin Jin, Ruochun Wang, Haotian Wang, Xi Chen, Huan Tang, Yuhua Wang, Qian Institute for Quantum Information State Key Laboratory of High Performance Computing China College of Computer Science and Technology National University of Defense Technology Changsha China Intelligent Game and Decision Lab Academy of Military Science Beijing China

ISBN: (纸本)9798891761681

Retrieval-Augmented Large Language Models (RALMs) have made significant strides in enhancing the accuracy of generated responses. However, existing research often overlooks the data quality issues within retrieval results, often caused by inaccurate existing vector-distance-based retrieval methods. We propose to boost the precision of RALMs' answers from a data quality perspective through the Context-Driven Index Trimming (CDIT) framework, where Context Matching Dependencies (CMDs) are employed as logical data quality rules to capture and regulate the consistency between retrieved contexts. Based on the semantic comprehension capabilities of Large Language Models (LLMs), CDIT can effectively identify and discard retrieval results that are inconsistent with the query context and further modify indexes in the database, thereby improving answer quality. Experiments demonstrate average improvement of 3.75% in accuracy on challenging question-answering tasks. Also, the flexibility of CDIT is verified through its compatibility with various language models and indexing methods, which offers a promising approach to bolster RALMs' data quality and retrieval precision jointly. © 2024 Association for Computational Linguistics.

关键词： Data accuracy

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Collaborative Pushing and Grasping in Complex Scenarios via a Generator-Evaluator Network with Multiple Action Primitives 17th

Collaborative Pushing and Grasping in Complex Scenarios vi...

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17th International Conference on intelligent Robotics and Applications, ICIRA 2024

作者： Zuo, Guoyu Wang, Zihao Luo, Yongkang Yu, Shuangyue Zhao, Min School of Information Science and Technology Beijing University of Technology Beijing100124 China Beijing Key Laboratory of Computing Intelligence and Intelligent Systems Beijing100124 China The State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China

ISBN: (纸本)9789819607761

As robotic technologies advance, robotic arm manipulation tasks in complex environments become increasingly important. This paper presents a new collaborative pushing and grasping strategy to address two major challenges robotic arms encounter in complex environments: invisibility and tight enclosure of target objects. We propose a generator-evaluator network architecture based on multiple action primitives, incorporating hierarchical reinforcement learning and Double DQN techniques to optimize the operational efficiency of the robotic arm. By introducing a new action primitive to prioritize pushing operations around the topmost objects in space, our approach effectively reveals and locates obscured target objects. Additionally, utilizing the Spatial Correlation Test (SCT), our method explores all possible collision-free operational positions in the action space, selecting the optimal position from among them. Experimental results demonstrate that our approach achieves high efficiency and success rates in scenarios with randomly distributed objects, objects tightly enclosed by others, and invisible objects. This strategy enhances the speed and accuracy of tasks and improves the robot’s adaptability to complex environments. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Robotic arms

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An End-to-End Autoencoder-based Probabilistic Shaping Method for Optical Communication 7

An End-to-End Autoencoder-based Probabilistic Shaping Method...

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7th Optics Young Scientist Summit, OYSS 2024

作者： Teng, Ziqiang Guo, Dong Gao, Ran Kong, Leyi Han, Wentao Chang, Huan Li, Zhipei Xin, Xiangjun School of Information and Electronics Beijing Institute of Technology 5 Zhongguancun South Street Haidian District Beijing100081 China National Key Laboratory of Science and Technology on Space-Born Intelligent Information Processing Beijing Institute of Technology 5 Zhongguancun South Street Haidian District Beijing100081 China Institute of Science and Technology Research Beijing Institute of Technology 5 Zhongguancun South Street Haidian District Beijing100081 China

ISBN: (数字)9781510688377

ISBN: (纸本)9781510688360

The advent of services such as big data and cloud computing has driven a continuous increase in the required transmission rate and capacity of optical fiber communication systems, which now support over 90% of global data traffic. Probability shaping (PS), which adjusts the probability distribution of constellation points, enhances both data transmission rates and the resilience of signals to channel nonlinearity. However, traditional PS methods, such as those using constant composition distribution matching (CCDM), cannot dynamically adjust the probability distribution of constellation points based on channel conditions. To address this limitation, we propose an end-to-end Autoencoder (AE)-based PS technique for optical communication. Simulation results show that compared to traditional 16/64/256QAM, this scheme achieves a maximum improvement of 0.356 bit/symbol in mutual information over the AWGN channel. In the optical fiber channel, under varying signal power and fiber length conditions, the mutual information is improved in different degrees and the influence of channel nonlinearity on the signal is reduced. Innovatively, residual connections are added to the decoder to enhance the model's generalization performance, enabling a deeper network structure and improving its ability to handle complex optical fiber channels. © 2025 SPIE.

关键词： Optical fiber communication

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A Sparsity Knowledge Transfer-Based Evolutionary Algorithm for Large-Scale Multitasking Multi-Objective Optimization

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IEEE Transactions on Evolutionary Computation 2024年

作者： Wu, Chengming Tian, Ye Zhang, Limiao Xiang, Xiaoshu Zhang, Xingyi Anhui University Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Artificial Intelligence Hefei230601 China Anhui University Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Hefei230039 China Anhui University Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui Hefei230601 China Anhui University Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education Institutes of Physical Science and Information Technology Hefei230601 China

Multitasking multi-objective evolutionary algorithms (MMEAs) have been extensively studied in the past decade, which mainly concentrate on multitasking multi-objective optimization problems (MMOPs) with dozens of decision variables. Nevertheless, many real-world MMOPs have thousands of decision variables and are of sparse nature, which are regarded as large-scale MMOPs (LSMMOPs) in this study. To address LSMMOPs, a sparsity knowledge transfer-based evolutionary multi-objective algorithm, termed EMO-SKT, is proposed for efficiently finding high-quality sparse solutions of LSMMOPs. For each target optimization task, a sparsity knowledge transfer strategy extracts sparse distribution information from a source task and incorporates the information into the target task for two types of sparsity knowledge: variable importance and sparse degree. The variable importance is utilized to produce high-quality sparse solutions during the evolutionary search for EMO-SKT, while the sparse degree facilitates the reduction of search space and thus speeds up the convergence of the evolutionary search. Experimental results on eight benchmark problems and six practical LSMMOPs demonstrate the effectiveness of the sparsity knowledge transfer strategy. Furthermore, the proposed EMO-SKT is capable of efficiently finding high-quality sparse solutions on an LSMMOP with over 1000 decision variables. In comparison with five state-of-the-art multitasking or sparse optimization algorithms, the proposed EMO-SKT exhibits superior performance in terms of both solution quality and search efficiency. © 1997-2012 IEEE.

关键词： Optimization algorithms

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