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Dysfunction and recovery of the cortical connectome gradient and its association with gene expression profiles in methamphetamine and heroin use disorders

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Progress in Neuro-Psychopharmacology and Biological Psychiatry 2025年 139卷 111391页

作者： Du, Zhe Yang, Wenhan Wen, Xinwen Cai, Suping Liu, Jun Yuan, Kai School of Life Science and Technology Xidian University Shaanxi Xi'an 710126 China Department of Radiology Second Xiangya Hospital Central South University Changsha 410011 China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing School of Information Engineering Inner Mongolia University of Science and Technology Inner Mongolia Baotou 014010 China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Shaanxi Xi'an China Ganzhou City Key Laboratory of Mental Health The Third People's Hospital of Ganzhou City Jiangxi Ganzhou 341000 China Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information School of Life Science and Technology Xidian University Shaanxi Xi'an 710126 China

Background: The hierarchy and segregation of community-based brain networks can be characterized by functional connectome gradient (FCG). Whether the cortical FCG was disrupted and could even be reversed after prolonged abstinence in substance use disorders (SUDs) remained unclear. Less is known about the underlying genetic basis. Methods: We utilized three independent datasets (n = 247) to investigate cortical FCG dysfunction and recovery after prolonged abstinence in methamphetamine use disorder (MUD) (n = 131), and validated in heroin use disorder (HUD) (n = 36). Furthermore, magnetic resonance spectroscopy (MRS) was employed to test the relationship between the glutamate in the ventral tegmental area (VTA) and cortical FCG. Postmortem gene expression was utilized to assess the transcriptional profiles related to cortical FCG alterations. Support vector regression (SVR) model based on the baseline cortical FCG was built to predict craving changes after long-term abstinence. Results: MUD and HUD individuals exhibited similar cortical FCG dysfunction and recovery at global and network levels, mainly in dorsal and ventral attentions network (DAN and VAN), frontoparietal network (FPN) and default mode network (DMN). The glutamate levels in VTA were correlated with the gradient distance between FPN and limbic network (LIM). The transcriptional profiles explained variance of the altered gradient pattern, with the most related genes enriched in synaptic signaling. Baseline cortical FCG significantly predicted craving changes after long-term abstinence. Conclusions: We provided novel insights into the understanding of SUD as treatable health conditions from cortical FCG changes, which could be considered as the potential biomarkers of craving changes after prolonged abstinence for SUDs. © 2025 Elsevier Inc.

关键词： Cortical functional connectome gradient Gene expression Glutamate Heroin use disorder Methamphetamine use disorder Support vector regression

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Optical focusing feature of single element in 128×128 elements electrically controllable cylindrical liquid crystal lens array

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Chinese Optics Letters 2010年第3期8卷 329-331页

作者：李晖刘侃张新宇张天序沈绪榜 Institute for Pattern Recognition and Artificial IntelligenceHuazhong University of Science and Technology National Laboratory for Multi-Spectral Information Processing Technology Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics

A 128× 128 elements cylindrical liquid crystal （LC） lens array with electrically controllable focal length is proposed. The cylindrical LC lens array uses transparent indium tin oxide （ITO） films as electrode, avoiding to affect the optical path operating in the voltage-off status. As the top electrode of the cylindrical LC lens array contacts with LC, the operation voltage root-mean-square （RMS） amplitude can be as low as 1.4 V and the response time is about 20-30 ms. The special optical focusing feature of the cylindrical LC lens array is got. And the focal length of this array is about 60-450 μm.

关键词： Focusing ITO glass Liquid crystals Oxide films Tin Titanium compounds

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Mem Brain: An Easy-to-Use Online Webserver for Transmembrane Protein Structure Prediction

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Nano-Micro Letters 2018年第1期10卷 12-19页

作者： Xi Yin Jing Yang Feng Xiao Yang Yang Hong-Bin Shen Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Key Laboratory of System Control and Information Processing Ministry of Education of China Department of Computer Science Shanghai Jiao Tong University Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering

Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate the membrane protein's structure by wet-lab experiments,accurate and fast amino acid sequence-based computational methods are highly desired. In this paper, we report an online prediction tool called Mem Brain, whose input is the amino acid sequence. Mem Brain consists of specialized modules for predicting transmembrane helices, residue–residue contacts and relative accessible surface area of a-helical membrane proteins. Mem Brain achieves aprediction accuracy of 97.9% of ATMH, 87.1% of AP,3.2 ± 3.0 of N-score, 3.1 ± 2.8 of C-score. Mem BrainContact obtains 62%/64.1% prediction accuracy on training and independent dataset on top L/5 contact prediction,respectively. And Mem Brain-Rasa achieves Pearson correlation coefficient of 0.733 and its mean absolute error of13.593. These prediction results provide valuable hints for revealing the structure and function of membrane *** Brain web server is free for academic use and available at ***/bioinf/Mem Brain/.

关键词： Transmembrane a-helices Structure prediction Machine learning Contact map prediction Relative accessible surface area

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An Adaptive Regulation Problem and Its Application

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International Journal of Automation and computing 2017年第2期14卷 221-228页

作者： Yuan Jiang Ji-Yang Dai Key Laboratory of Image Processing and Pattern Recognition Nanchang Hangkong University Nanchang 330063 China School of Information Engineering Nanchang Hangkong University Nanchang 330063 China

This paper studies an adaptive regulation problem for the modified FitzHugh-Nagumo neuron model under external electrical stimulation. We first present the solution of the global robust output regulation problem for output feedback system with an uncertain exosystem which models the external electrical stimulation with unknown frequency and amplitude. Then, we show that the robust control problem for the modified FitzHugh-Nagumo neuron model can be formulated as the global robust output regulation problem and the solvability conditions for the output regulation problem for the modified FitzHugh-Nagumo neuron model are all satisfied. Then, we apply the obtained output regulation result to constructing an output feedback control law for the modified FitzHugh-Nagumo neuron model to achieve global stability of the closed-loop system in the presence of uncertain parameters and external stimulus. An example is given to show that the proposed algorithm can completely reject the external electrical stimulation.

关键词： Control theory Lyapunov methods internal model principle modified FitzHugh-Nagumo model.

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Object classification via PCANet and color constancy model 4

Object classification via PCANet and color constancy model

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4th International Conference on Advanced Design and Manufacturing Engineering, ADME 2014

作者： Hu, De Kun Zhang, L. Zhao, Wei Dong Yan, Tao Key Laboratory of Pattern Recognition and Intelligent Information Processing Institutions of Higher Education of Sichuan Province Chengdu University Chengdu China

ISBN: (纸本)9783038352570

In order to classify the objects in nature images, a model with color constancy and principle component analysis network (PCANet) is proposed. The new color constancy model imitates the functional properties of the HVS from the retina to the double-opponent cells in V1. PCANet can be designed and learned extremely, which comprises only the very basic data processing components: cascaded principal component analysis (PCA), binary hashing, and block-wise histograms. At last, a SVM is trained to classify the object in the image. The results of experiments demonstrate the potential of the model for object classification in wild color images. © (2014) Trans Tech Publications, Switzerland.

关键词： Object recognition

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recognition of facial expression via kernel PCA network 3

Recognition of facial expression via kernel PCA network

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3rd International Conference on information Technology and Management Innovation, ICITMI 2014

作者： Hu, De Kun Ye, An Sheng Li, Li Zhang, Li Key Laboratory of Pattern Recognition and Intelligent Information Processing Institutions of Higher Education of Sichuan Province Chengdu University Chengdu China

ISBN: (纸本)9783038352396

In this work, a kernel principle component analysis network (KPCANet) is proposed for classification of the facial expression in unconstrained images, which comprises only the very basic data processing components: cascaded kernel principal component analysis (KPCA), binary hashing, and block-wise histograms. In the proposed model, KPCA is employed to learn multistage filter banks. It is followed by simple binary hashing and block histograms for indexing and pooling. For comparison and better understanding, We have tested these basic networks extensively on many benchmark visual datasets(such as the JAFFE [13] database, the CMU AMP face expression database, a part of the Extended Cohn-Kanade (CK+) database), The results demonstrate the potential of the KPCANet serving as a simple but highly competitive baseline for facial expression recognition. © 2014 Trans Tech Publications, Switzerland.

关键词： Database systems

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SOUND CLASSIFICATION BASED ON SPECTROGRAM FOR SURVEILLANCE APPLICATIONS 5

SOUND CLASSIFICATION BASED ON SPECTROGRAM FOR SURVEILLANCE A...

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2016 5th IEEE International Conference on Network Infrastructure and Digital Content(IC-NIDC 2016)

作者： Yingjie Li Gang Liu Pattern Recognition and Intelligent System Laboratory School of Information and Communication EngineeringBeijing University of Posts and Telecommunications

ISBN: (纸本)9781509012473

This paper presents an audio event classification algorithm which automatically classifies an audio event as footstep,glass breaking,gunshot or scream mainly for surveillance ***,the Gabor feature of the audio spectrogram is extracted,there are two kinds of Gabor features,namely global Gabor feature and local Gabor *** we use Principal Components Analysis(PCA) and Linear Discriminant Analysis(LDA) to compress the feature dimension,finally the K nearest neighbor classifier(KNN) is used to recognize audio *** carried out extensive experiments on the clean and noisy audio *** results demonstrate that the algorithm is able to guarantee a recall of 96.1%on clean sets and is proved to be more effective than traditional methods.

关键词： Spectrogram Global Gabor feature Local Gabor feature PCA LDA

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Pulsar/CNS integrated navigation based on federated UKF

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Journal of Systems Engineering and Electronics 2010年第4期21卷 675-681页

作者： Jin Liu Jie Ma Jinwen Tian State Key Laboratory for Multi-spectral Information Processing Technologies Institue for Pattern Recognition and artifical Intelligence Huazhong University of Science and Technology Wuhan 430074 P. R. China

In order to improve the autonomous navigation capability of satellite,a pulsar/CNS（celestial navigation system） integrated navigation method based on federated unscented Kalman filter（UKF） is *** celestial navigation is a mature and stable navigation ***,its position determination performance is not satisfied due to the low accuracy of horizon *** pulsar navigation is a new navigation method,which can provide highly accurate range *** major drawback of single pulsar navigation is that the system is completely *** two methods are complementary to each other,the federated UKF is used here for fusing the navigation data from single pulsar navigation and *** to the traditional celestial navigation method and single pulsar navigation,the integrated navigation method can provide better navigation *** simulation results demonstrate the feasibility and effectiveness of the navigation method.

关键词： autonomous navigation celestial navigation system（CNS） pulsar federated unscented Kalman filter（UKF）.

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HUMMING FEATURE EXTRACTION BASED ON LOCALITY STATISTICAL ANALYSIS 5

HUMMING FEATURE EXTRACTION BASED ON LOCALITY STATISTICAL ANA...

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2016 5th IEEE International Conference on Network Infrastructure and Digital Content(IC-NIDC 2016)

作者： Gang Liu Yanyao Bian Yanqiu Wang Pattern Recognition and Intelligent System Laboratory School of Information and Communication EngineeringBeijing University of Posts and Telecommunications

ISBN: (纸本)9781509012473

This paper presents a novel humming feature extraction algorithm based on locality statistical analysis to tackle the problem of the instability of humming features in the query by humming（QBH） *** carrying out statistics to humming notes sequences in both longitudinal vocal range distribution and horizontal temporal variation distribution,we can obtain the locality statistical humming *** we concatenate several features using the idea of N-gram to improve feature *** the framework of QBH based on Locality Sensitive Hashing（LSH）,the proposed method has achieves 86%top-1 rate and 92%top-5 rate in the experiment,indicating the effectiveness of the method.

关键词： query by humming feature extraction locality statistics note distribution temporal distribution

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Research on a novel restoration algorithm of turbulence-degraded images with alternant iterations

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Journal of Systems Engineering and Electronics 2006年第3期17卷 477-482页

作者： Liu Chunsheng Hong Hanyu Zhang Tianxu Inst. for Pattern Recognition and AI State Key Laboratory of Image Processing and Intelligent Control Huazhong Univ. of Science and Technology Wuhan 430074 P. R. China

A new restoration algorithm based on double loops and alternant iterations is proposed to restore the object image effectively from a few frames of turbulence-degraded images, Based on the double loops, the iterative relations for estimating the turbulent point spread function PSF and object image alternately are derived. The restoration experiments have been made on computers, showing that the proposed algorithm can obtain the optimal estimations of the object and the point spread function, with the feasibility and practicality of the proposed algorithm being convincing.

关键词： turbulence-degraded image image restoration double loops alternant iterations.

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