Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between comp...
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Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as ***,we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover ***,we describe the scope of artificial intelligence biology analysis for novel anticancer target ***,we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence ***,we showcase the applications of artificial intelligence approaches in cancer target identification and drug *** together,the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer,thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates.
The projector production process needs to pack manufactured projectors. The key step of projector packing is to check whether the brand and model number of the projector is correct or not, for avoiding the projector’...
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Cobalamin(B_(12)),an essential nutrient and growth cofactor for many living organisms on Earth,can be fully synthesized only by selected prokaryotes in ***,microbial communities related to B_(12) biosynthesis could se...
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Cobalamin(B_(12)),an essential nutrient and growth cofactor for many living organisms on Earth,can be fully synthesized only by selected prokaryotes in ***,microbial communities related to B_(12) biosynthesis could serve as an example subsystem to disentangle the underlying ecological mechanisms balancing the function and taxonomic make-up of complex functional *** anchoring microbial traits potentially involved in B_(12) biosynthesis,we depict the biogeographic patterns of B_(12) biosynthesis genes and the taxa harboring them in the global ocean,despite the limitations of detecting de novo B_(12) synthesizers via metagenomes *** the taxonomic and functional composition of B_(12) biosynthesis genes were strongly shaped by depth,differentiating the epipelagic zones from the mesopelagic *** genes related to B_(12) biosynthesis were relatively stably distributed across different oceans,but the taxa harboring them varied considerably,showing clear functional redundancy among microbial *** taxa carrying B_(12) biosynthesis genes in the surface water were influenced by environmental factors such as temperature,oxygen,and ***,the composition of functional genes was only weakly associated with these environmental *** model analyses demonstrated that determinism governed the variations in B_(12) biosynthesis genes,whereas a higher degree of stochasticity was associated with taxonomic *** associations were observed between the chlorophyll a concentration and B_(12) biosynthesis,confirming its importance in primary production in the global *** results of this study reveal an essential ecological mechanism governing the assembly of microbes in nature:the environment selects for function rather than taxonomy;functional redundancy underlies stochastic community assembly.
Vehicular networks, also known as Vehicular Ad Hoc Networks (VANETs), have become a crucial technology for vehicle communication, providing wireless connectivity among vehicles and between vehicles and infrastructure....
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ISBN:
(数字)9798350373974
ISBN:
(纸本)9798350373981
Vehicular networks, also known as Vehicular Ad Hoc Networks (VANETs), have become a crucial technology for vehicle communication, providing wireless connectivity among vehicles and between vehicles and infrastructure. However, the dynamic and complex nature of these networks presents unique challenges in routing and resource management. In this study, we explore the use of artificial intelligence (AI) to improve the performance of vehicular networks, focusing on two widely used routing protocols: Optimized Link State Routing (OLSR) and Destination-Sequenced Distance Vector (DSDV).We aim to evaluate the performance of these traditional routing protocols within the context of vehicular networks by integrating machine learning techniques such as neural network regression (MLRegression). Our goal is to understand how the integration of artificial intelligence can enhance the prediction and optimization of vehicular network performance. Using MLRegression, we aim to develop accurate prediction models for performance metrics such as latency, throughput, packet delivery rate, and more, based on network parameters and environmental conditions. This comparative evaluation, which involves incorporating an AI-based approach, will allow us to better understand the strengths and weaknesses of each protocol and provide recommendations for improving vehicular networks.
The sole situation of semi-crystalline structure induced single performance remarkably limits the green cryogels in the application of soft devices due to uncontrolled freezing field. Here, a facile strategy for achie...
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The videoscope (VS) images have poor quality and low contrast. Hence, in this paper, three proposed frameworks to improve the quality of VS images are presented. The first framework depends on contrast-limited adaptiv...
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Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to ***,no vaccine is available in most ...
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Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to ***,no vaccine is available in most endemic regions,and no licenced treatments for EV-A71 infection are ***,we characterize a human monoclonal antibody(Hu MAb),E1,by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection.E1 exhibits strong neutralizing activity against EV-A71 virus in *** cryo-electron microscopy(cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of *** a mouse model,E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic *** particular,E1 significantly reduces virus titers and muscle damage.E1 might represent a potential adjunct to EV-A71 treatment.
The integration of visuotactile sensor technology with endoscopy enables the provision of tactile information for minimally invasive surgeries and other operations. This paper proposes a real-time sensing framework fo...
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ISBN:
(数字)9798350372601
ISBN:
(纸本)9798350372618
The integration of visuotactile sensor technology with endoscopy enables the provision of tactile information for minimally invasive surgeries and other operations. This paper proposes a real-time sensing framework for contact deformation pattern shape, providing a foundation for precise perception in miniaturized visuotactile sensors. Specifically, we first construct a Deformation Pattern shape Descriptor (DPSD) and then track the key points in the descriptor using optical flow to obtain contact deformation shape information. Through extensive qualitative and quantitative experiments, our proposed algorithm achieves an average perception accuracy of around 83.81% for contact pattern shapes. It demonstrates consistent perception accuracy across various contact force magnitudes, directions, and scenarios, highlighting its robustness. Additionally, compared to traditional marker-level methods, it achieves a notable 46.5% improvement in displacement field perception accuracy. This research elevates tactile perception to the dimension of contact pattern shape sensing and has the potential for application in miniaturized visual tactile sensors.
In contemporary agricultural practices and pest management, the deployment of outdoor wheeled mobile robots for precise and efficient plant spraying is crucial to optimize chemical application and mitigate environment...
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ISBN:
(数字)9798331544577
ISBN:
(纸本)9798331544584
In contemporary agricultural practices and pest management, the deployment of outdoor wheeled mobile robots for precise and efficient plant spraying is crucial to optimize chemical application and mitigate environmental impact. This study introduces an integrated path planning framework designed to systematically tackle the challenges of obstacle avoidance, adherence to kinematic constraints, and optimization of spraying operations, while ensuring complete coverage of target plants. The framework comprises three key components: a local route generator utilizing principal component analysis to minimize movement required for spraying, thereby enhancing efficiency; a global path optimizer that effectively sequences and connects the generated routes to produce collision-free paths; and a path regulator that fine-tunes the resulting paths to comply with the robot's kinematic constraints. Extensive simulations across various outdoor scenarios demonstrate that the proposed framework achieves comprehensive coverage, reduces path lengths, and improves operational efficiency, presenting a viable solution for advanced robotic spraying applications.
In this paper, we propose a contact-free wheat moisture monitoring system, termed Wi-Wheat+, to address the several limitations of the existing grain moisture detection technologies, such as time-consuming process, ex...
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