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Effect of graphene quantum dot concentration on p-toluenesulfonic acid-doped polyaniline–graphene quantum dot nanocomposites: chemical, optical, and electrical characterization for benzo[def]phenanthrene detection

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Optical and Quantum Electronics 2025年第4期57卷 1-33页

作者： Beygisangchin, Mahnoush Jakmunee, Jaroon Rashid, Suraya Abdul Shafie, Suhaidi Saetang, Songpon Research Laboratory for Analytical Instrument and Electrochemistry Innovation Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai50200 Thailand Research Laboratory On Advanced Materials for Sensor and Biosensor Innovation Materials Science Research Center and Center of Excellence for Innovation in Chemistry Faculty of Science Chiang Mai University Chiang Mai50200 Thailand Nanomaterials Processing and Technology Laboratory Institute of Nanoscience and Nanotechnology Universiti Putra Malaysia Serdang43400 Malaysia Faculty of Engineering Universiti Putra Malaysia Serdang43400 Malaysia

Monitoring of benzo[def]phenanthrene as a toxic component is essential for environmental assessment because of its adverse impact on human health and ecological systems. P-Toluenesulfonic acid-doped polyaniline (PANI) and PANI-graphene quantum dot (PANI-GQD) nanocomposites were fabricated by incorporating graphene quantum dot (GQD) concentrations between 100 and 500 ppm through oxidative chemical polymerization of aniline under acidic conditions at ambient temperature. The materials were analysed using Fourier transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), thermogravimetry analysis (TGA), UV–visible and photoluminescence (PL) spectroscopy, and electrical conductivity measurements. Key findings included significant shifts in FT-IR peaks (C=N stretching from 1651 to 1694 cm⁻1) and an increase in the AB/AP ratio from 0.27 to 0.333, indicating enhanced sp2 hybridization and improved electrical conductivity. XRD analysis showed improved molecular ordering in PANI-GQD nanocomposites. FE-SEM revealed changes in morphology from flat layers to spherical and flaky mixtures with increasing GQD concentrations. Film thickness increased from 13.52 μm (PANI-GQD-1) to 30.07 μm (PANI-GQD-5). The PANI-GQD-3 nanocomposite exhibited the lowest bandgap (2.39 eV) and the highest PL intensity because of enhanced energy transfer between PANI and GQD. Electrical conductivity decreased with increasing GQD concentration, with PANI-GQD-5 showing 2.17 (Ω cm)–1. PANI-GQD-3 successfully detected benzo[def]phenanthrene at concentrations ranging from 0.001 mol L⁻1 to 10 × 10⁻⁹ mol L⁻1 with a limit of detection of 1.5 × 10⁻⁹ mol L⁻1 through gas chromatography. Results demonstrated the potential of PANI-GQD nanocomposites for sensor and biosensor applications. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

关键词： Thermogravimetric analysis

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Evaluating the efficacy and cardiotoxicity of EGFR-TKI AC0010 with a novel multifunctional biosensor

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Microsystems & Nanoengineering 2023年第3期9卷 259-271页

作者： Deming Jiang Xinwei Wei Yuxuan Zhu Yong Qiu Xin Liu Liubing Kong Fengheng Li Jingwen Liu Liujing Zhuang Hao Wan Kejing Ying Ping Wang Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education MinistryDepartment of Biomedical EngineeringZhejiang UniversityHangzhouZhejiang 310027China Innovation Center for Smart Medical Technologies&Devices Binjiang Institute of Zhejiang UniversityZhejiang 310053China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058China College of Pharmaceutical Sciences Zhejiang UniversityHangzhouZhejiang 310058China Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiang 310009China Department of Respiratory and Critical Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory for Sensor Technology Chinese Academy of SciencesShanghai 200050China

Non-small cell lung cancer(NSCLC)is a leading cause of cancer mortality *** epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)have dramatically improved the life expectancy of patients with NSCLC,concerns about TKI-induced cardiotoxicities have ***0010,a novel third-generation TKI,was developed to overcome drug resistance induced by EGFR-T790M ***,the cardiotoxicity of AC0010 remains *** evaluate the efficacy and cardiotoxicity of AC0010,we designed a novel multifunctional biosensor by integrating microelectrodes(MEs)and interdigital electrodes(IDEs)to comprehensively evaluate cell viability,electrophysiological activity,and morphological changes(beating of cardiomyocytes).The multifunctional biosensor can monitor AC0010-induced NSCLC inhibition and cardiotoxicity in a quantitative,label-free,noninvasive,and real-time ***0010 was found to significantly inhibit NCI-H1975(EGFR-L858R/T790M mutation),while weak inhibition was found for A549(wild-type EGFR).Negligible inhibition was found in the viabilities of HFF-1(normal fibroblasts)and *** the multifunctional biosensor,we found that 10μM AC0010 significantly affected the extracellular field potential(EFP)and mechanical beating of *** amplitude of EFP continuously decreased after AC0010 treatment,while the interval decreased first and then *** analyzed the change in the systole time(ST)and diastole time(DT)within a beating interval and found that the DT and DT/beating interval rate decreased within 1 h after AC0010 *** result probably indicated that the relaxation of cardiomyocytes was insufficient,which may further aggravate the ***,we found that AC0010 significantly inhibited EGFR-mutant NSCLC cells and impaired cardiomyocyte function at low concentrations(10μM).This is the first study in which the risk of AC0010-induced cardiotoxicity was *** addition,novel multifunctional bi

关键词： cardio TKI impaired

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High-Performance Mesoporous Carbon@Dopamine nanocomposite sensor for simultaneous detection of heavy metal ions in environmental monitoring

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Electrochimica Acta 2025年 535卷

作者： Akram, Raheel Iqbal, Javed Reddy, S. Lokeswara Arshad, Anila Jakmunee, Jaroon Research Laboratory for Analytical Instrument and Electrochemistry Innovation Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Research Laboratory on Advanced Materials for Sensor and Biosensor Innovation Materials Science Research Center Center of Excellence for Innovation in Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Department of Chemistry College of Science University of Bahrain 32038 Kingdom of Bahrain Sakhir Bahrain School of Agriculture Engineering Jiangsu University Zhenjiang 212013 China

Heavy metal ion (HMI) sensors are critical tools for environmental monitoring, given the severe health risks associated with HMI overdosage. In this study, a high-performance mesoporous carbon@dopamine (MC@PDA) nanocomposite was developed as an efficient material for constructing a smart sensor capable of the simultaneous electrochemical detection of Cd²⁺, Cu²⁺ and Hg²⁺ ions. To investigate the role of template material, different electrocatalysts, such as CNT@PDA, CNH@PDA, and MC@PDA were compared. While all C@PDA materials exhibited electroactivity for HMI detection, mesoporous carbon (MC) demonstrated superior electrochemical activity due to its hierarchical micro-/mesoporous nanoarchitecture, optimized pore volume, and high surface area, which support enhanced electron transport, superior adsorption, catalytic activity, and functionalization. The MC@PDA exhibited improved peak currents over a wide large linear range of 100 nM-1.4 mM for the simultaneous detection of Cd²⁺, Cu²⁺ and Hg²⁺, with limit of detections (LODs) of 63, 122, and 82 nM, respectively. For individual ion detection, the sensor achieved even lower LODs of 8.34, 4.36, 6.17 nΜ for Cd²⁺, Cu²⁺ and Hg²⁺, respectively. Density functional theory (DFT) calculations were performed to unravel the distinct interaction mechanisms and energy variations between PDA and HMI. Moreover, the sensor was deployed for real-world water analysis from an industrial mining site with multiple contaminants, effectively detecting Cd²⁺ and Cu²⁺ ions. Results were validated using atomic absorption spectroscopy (AAS), confirming the method's reliability and practical applicability. The suggested technique will enable simultaneous detection of multiple analytes and uses interactive forces to efficiently distinguish analogue analytes. © 2025 Elsevier Ltd

关键词： DFT studies Electrochemical sensing Heavy metal ions MC@PDA SPCE

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Critical review of metal-organic framework (MOF) in direct methanol fuel cells: Membrane and electrocatalyst performance enhancement

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Inorganic Chemistry Communications 2025年 180卷

作者： Muhammad Zikri Aiman Zulkifli Norazuwana Shaari Siti Kartom Kamarudin Wai Yin Wong Ajaz Ahmad Wani Siti Hasanah Osman Mohamed Ansari Mohamed Nainar Mahnoush Beygisangchin Fuel Cell Institute Universiti Kebangsaan Malaysia 43600 Bangi Selangor Malaysia Department of Chemistry Aligarh Muslim University Aligarh Uttar Pradesh 202002 India Institute of Power Engineering Universiti Tenaga Nasional Selangor 43000 Malaysia Research Laboratory for Analytical Instrument and Electrochemistry Innovation Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Research Laboratory on Advanced Materials for Sensor and Biosensor Innovation Materials Science Research Center and Center of Excellence for Innovation in Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand

Direct methanol fuel cells (DMFCs) have attracted increasing attention as a clean and portable energy solution for electronic devices, vehicles, and off-grid applications. However, their commercial viability remains limited due to key technical challenges, including methanol crossover through the polymer electrolyte membrane (PEM) and sluggish kinetics of the methanol oxidation reaction (MOR) at the anode. Recent advances in metal–organic frameworks (MOFs) offer promising pathways to overcome these limitations. MOFs possess exceptional surface area, tunable porosity, and the ability to incorporate functional sites, making them attractive as both membrane fillers and electrocatalyst precursors. Despite a growing body of literature on MOFs in fuel cells, there remains a lack of focused reviews analyzing their dual role in DMFCs. This review critically examines the integration of MOFs into PEMs to reduce methanol permeability while enhancing proton conductivity, as well as their application as electrocatalysts to improve MOR activity and CO tolerance. A comparative analysis of recent MOF–polymer composite membranes and MOF-derived catalysts is presented, highlighting key performance indicators such as conductivity, selectivity, and power density. Finally, the paper outlines current research gaps and future directions for the rational design of multifunctional MOFs tailored for next-generation DMFCs. The insights from this review provide valuable guidance for researchers and industry stakeholders aiming to accelerate the development of commercially viable DMFC technologies.

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Adsorption of Zinc(II) onto Zn(II)-Ionic Imprinted Polymer

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IOP Conference Series: Materials Science and Engineering 2019年第2期546卷

作者： Teguh Wirawan Ganden Supriyanto Agoes Soegianto Department of Chemistry Faculty of Mathematic and Natural Sciences University of Mulawarman Samarinda Indonesia Department of Chemistry Faculty of Science and Technology University of Airlangga Surabaya Indonesia Laboratory of Sensor and Biosensor Institute of Tropical Deseases University of Airlangga Surabaya Indonesia Study Program of Environmental Science and Technology University of Airlangga Surabaya Indonesia

A new Zn(II)-ionic imprinted polymer via precipitation polymerization using 8-hydroxyquinoline (8HQ) as a ligand, methacrylic acid (MAA) as functional monomer, and ethylene glycol dimethacrylate (EGDMA) as a cross-linker has been prepared. The benzoyl peroxide and ethanol/acetonitrile (2:1) mixture were used as initiator and porogen, respectively. The template Zn(II) ion was removed from the polymer by leaching with a solution of 1 M HNO3. The experimental parameters for adsorption, such as pH of a solution, contact time, and initial zinc concentration, have been optimized. The optimum conditions of zinc adsorption onto the ionic imprinted polymer (IIP) was at pH 5.5 and contact time 15 min. The equilibrium data could be better described by the Langmuir isotherm model. The maximum adsorption capacity of IIP was 20.833 mg/g.

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GO-Fe3O4 Nanocomposite from coconut shell: Synthesis and characterization

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IOP Conference Series: Earth and Environmental Science 2019年第1期217卷

作者： N K Rukman M Jannatin G Supriyanto M Z Fahmi W A W Ibrahim Department of Chemistry Faculty of Science and Technology Airlangga University Jl. Mulyorejo Kampus C UNAIR Surabaya 60115 Indonesia Laboratory of Sensor and Biosensor Institute of Tropical Disease Airlangga University Jl. Mulyorejo Kampus C UNAIR Surabaya 60115 Indonesia Departement of Chemistry Faculty of Science Universiti Teknologi Malaysia 81310 UTM Johor Bahru Johor Malaysia

Synthesis and characterization of graphene oxide nanocomposite from coconut shell GO-Fe3O4 has been done. Graphene oxide can be prepared using Hummer's method and Subsequently, the synthesis of GO-Fe3O4 nanocomposite was carried out by ultrasound assisted co-precipitation of iron (II) and (III) chlorides in the presence of GO. The formation of GO and graphene-Fe3O4 nanocomposite was confirmed by x-ray diffraction (XRD), Fourier transform-infrared (FTIR), SEM and Raman spectroscopy. The characteristics of GO-Fe3O4 as a result of synthesis from coconut shell analyzed using XRD showed that GO characteristics peak in accordance with the characteristics of GO-Fe3O4 in (JCPDS No. 88-0315). Analysis using FTIR was seen in 3421 cm−1 (O-H stretching), 1631 cm−1 (C = C aromatic), and 565 cm−1 (Fe-O). Analysis using SEM seen in the presence of Fe, O and C in the EDX analysis confirmed the formation of GO-Fe3O4 nanocomposite. Analysis using Raman spectroscopy showed that peaks of Fe3O4 were at wavelengths of 396 cm−1 because sp3 carbon was bound to Fe3O4 so that the peak band D was not present in GO-Fe3O4 spectroscopy.

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Development and characterization of an innovative Flavobacterium oreochromis antigen-encapsulated hydrogel bead for enhancing oral vaccine delivery in hybrid red tilapia (Oreochromis spp.)

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Fish & shellfish immunology 2025年 165卷 110483页

作者： Patcharapong Thangsunan Pattanapong Thangsunan Thanisorn Mahatnirunkul Wararut Buncharoen Kanokporn Saenphet Supap Saenphet Jitraporn Phaksopa Kim D Thompson Prapansak Srisapoome Benchawan Kumwan Pakapon Meachasompop Nuttee Suree Anurak Uchuwittayakul Office of Research Administration Chiang Mai University Chiang Mai 50200 Thailand Division of Biochemistry and Biochemical Innovation Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Electronic address: tbscience@***. Division of Biochemistry and Biochemical Innovation Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Center of Excellence for Innovation in Chemistry And Research Laboratory on Advanced Materials for Sensor and Biosensor Innovation Material Science Research Center Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Electronic address: Pattanapong.t@cmu.ac.th. National Nanotechnology Center National Science and Technology Development Agency 111 Thailand Science Park Phahonyothin Road Khlong Luang Pathum Thani 12120 Thailand. Electronic address: thanisorn.mah@nanotec.or.th. Department of Biology Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Electronic address: wararut.bun@cmu.ac.th. Department of Biology Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Electronic address: kanokporn.saenphet@cmu.ac.th. Department of Biology Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Electronic address: supap.saenphet@cmu.ac.th. Department of Marine Science Faculty of Fisheries Kasetsart University Bangkok 10900 Thailand. Electronic address: jitraporn.p@ku.th. Moredun Research Institute Pentlands Science Park Penicuik EH26 0PZ United Kingdom. Electronic address: kim.thompson@moredun.ac.uk. Special Research Incubator Unit for Development and Application of Vaccine Delivery Systems for Aquatic Animals Department of Aquaculture Faculty of Fisheries Kasetsart University Bangkok 10900 Thailand Laboratory of Aquatic Animal Health Management Department of Aquaculture Faculty of Fisheries Kasetsart University Bangkok 10900 Thailand Center of Excellence in Aquatic Animal Health Management Faculty of

Traditional oral vaccines often face several challenges, such as antigen degradation and poor immune activation due to harsh gastrointestinal conditions. To address this, an effective oral vaccine was developed using hydrogel beads made of sodium alginate (SA), calcium bentonite (BN), and chitosan (CS) to generate microspheres that can encapsulate F. oreochromis (Fo) cells as an oral vaccine (SA/BN/CS hydrogel Fo-OV) for hybrid red tilapia. This study demonstrates that oral administration of a Fo-encapsulated hydrogel bead vaccine (Fo-OV hydrogel) can effectively protect the antigen from gastric degradation and release it to fish intestine, as indicated by in vitro studies showing color and structural changes under different pH conditions, allowing the controlled antigen release. This led to significant enhancements in both systemically and predominantly mucosal immune responses in hybrid red tilapia (Oreochromis spp.) after 14 and 28 days post consecutive 7-day vaccination. The vaccine increased the specific IgM antibody to F. oreochromis in serum and mucosal tissues, and increased the expression of immunoglobulin repertoire genes, IgM, IgT, and IgD in mucosal tissues, indicating activation of the fish immune system. Histological examinations revealed the beneficial changes in the intestinal mucosa by increasing the thickness of lamina propria and causing an increasing number of Goblet cells without any pathological abnormalities in the liver or intestines. Moreover, the Fo-OV hydrogel group showed significantly higher survival rates after the challenge with F. oreochromis than control groups and traditional formalin-killed Fo vaccine. These findings suggest that the hydrogel formulation can protect the antigen from degradation and enhance their uptake by mucosal-associated lymphoid tissues (MALTs), leading to stronger and more specific immune responses. The outcome of this research could be an invaluable tool as the potential application of hydrogel-based vaccines

关键词： F. oreochromis Hybrid red tilapia Hydrogel vaccine Mucosal immune responses Oral vaccines

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Graphene Oxide from Bagasse/Magnetite Composite: Preparation and Characterization

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IOP Conference Series: Earth and Environmental Science 2019年第1期217卷

作者： M Jannatin G Supriyanto Abdulloh W A W Ibrahim N K Rukman Department of Chemistry Faculty of Science and Technology Universitas Airlangga Jl. Mulyorejo Kampus C UNAIR Surabaya 60115 Indonesia Department of Chemical Engineering Institut Teknologi dan Sains Nahdlatul Ulama Pasuruan Jl. Raya Warung Dowo Pohjentrek Pasuruan 60115 Indonesia Laboratory of Sensor and Biosensor Institute of Tropical Disease Universitas Airlangga Jl. Mulyorejo Kampus C UNAIR Surabaya 60115 Indonesia Department of Chemistry Faculty of Science Universiti Teknologi Malaysia 81310 UTM Johor Bahru Johor Malaysia

The objective of this research is to synthesis and characterization of graphene oxide (GO)-nano Fe3O4 composite from bagasse. The analysis graphite, GO, and Fe3O4 using XRD result peak at position 2θ 24.56°; 26.61° and 35.4°. GO-nano Fe3O4 composite shows mixture peak of GO and Fe3O4. When GO was characterized by FTIR, it comes the distinctive vibration bands of -COOH, C = C, C-O, and -CH. While on the composite there are additional bands belonging to Fe-O and Fe-C. The ratio of D band and G band on composite is higher than that of GO, ie 1.45 and 0.79 when characterized used Raman spectroscopy. The morphology structure of the composite when analyzed using FE-SEM-EDX appears to have a large surface area filled with Fe particles on the surface with the largest composition of elements C, O, and Fe. Pore characteristics when determined using SAA belong to mesoporus with surface area total 35.911 m2/g and a specific surface area of 42.523 m2/g.

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Synthesis, characterization, and application of novel Zn(II)-ionic imprinted polymer for preconcentration of Zn(II) ions from aqueous solution

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IOP Conference Series: Materials Science and Engineering 2018年第1期349卷

作者： T Wirawan G Supriyanto A Soegianto Department of Chemistry Faculty of Mathematics and Natural Sciences University of Mulawarman Samarinda Indonesia Department of Chemistry Faculty of Science and Technology University of Airlangga Surabaya Indonesia Laboratory of Sensor and Biosensor Institute of Tropical Deseases University of Airlangga Surabaya Indonesia Department of Biologyy Faculty of Science and Technology University of Airlangga Surabaya Indonesia

Preparation of a new Zn2+ ion-imprinted polymer (Zn-IIP) is presented in this report. The Zn-IIP are prepared by precipitation polymerization using 8-hydroxyquinoline (8HQ) as a ligand, methacrylic acid (MAA) as functional monomer, and ethylene glycol dimethacrylate (EGDMA) as a cross-linker has been prepared. The benzoyl peroxide and ethanol/acetonitrile (2:1) mixture were used as initiator and porogen, respectively. Precipitation polymerization was carried out by heating in a water bath at 60°C for 8 hours. After polymerization, cavities in the polymer particles corresponding to the Zn2+ ions were created by leaching the polymer with 2 mol L-1 HNO3. The polymer was washed with aquabidest and dried in an oven at the temperature of 60°C for 24 hours. The Zn-IIP was characterized by Fourier Transform Infrared Spectrophotometry (FT-IR) and Scanning Electron Microscopy (SEM). The synthesized Zn-IIP was used as a new adsorbent for solid phase extraction (SPE) of Zn(II) prior to Flame Atomic Absorption Spectrometry (FAAS) determination. The experimental parameters for SPE, such as pH of the sample, loading rate, and elution volume, have been optimized. The effect of pH of the sample on the extraction of analyte was studied in batch mode. The effects of loading rate and elution volume on the extraction of analyte were studied in dynamic mode by loading of the sample through IIP-SPE cartridge containing 100 mg of the synthesized Zn-IIP. The imprinted polymer (Zn-IIP) have bands at 3433.06 cm-1 (O-H), 1508.23 cm-1 (C=N aromatics), 1284.5 cm-1 (C-N aromatics), 1056.9 cm-1 (C-O phenol), 1724.24 cm-1 (C=O), and 1639.38 cm-1 (conjugated C=O with C=C). The Scanning Electron Microscopy (SEM) images of IIP and IIP show that the IIP is seen to have more cavities than NIP. The optimum pH for quantitative Zn(II) retention was 5.5, and the elution was completed with 2 mL of 1.0 mol L-1 nitric acid. The optimum loading rate was 0.5 mL min-1. The recovery of Zn(II) from solution samples

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