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检索条件"机构=Leukemia Service and Human Oncology and Pathogenesis Program"
91 条 记 录,以下是1-10 订阅
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Management of patients with advanced-stage HER2-positive breast cancer: current evidence and future perspectives (vol 21, pg 185, 2024)
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NATURE REVIEWS CLINICAL oncology 2024年 第9期21卷 701-701页
作者: Marra, Antonio Chandarlapaty, Sarat Modi, Shanu Division of New Drugs and Early Drug Development European Institute of Oncology IRCCS Milan Italy Human Oncology and Pathogenesis Program (HOPP) Memorial Sloan Kettering Cancer Center New York NY USA Breast Medicine Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA
Amplification and/or overexpression of ERBB2, the gene encoding HER2, can be found in 15–20% of invasive breast cancers and is associated with an aggressive phenotype and poor clinical outcomes. Relentless research e... 详细信息
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Defining 2 biologically and clinically distinct groups in acute leukemia with a mixed phenotype
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Blood 2025年 第18期145卷 2056-2069页
作者: Galera, Pallavi Dilip, Deepika Derkach, Andriy Chan, Alexander Zhang, Yanming Persaud, Sonali Mishra, Tanmay Kramer, Kyle Kathpalia, Mahak Liu, Ying Famulare, Christopher Gao, Qi Mata, Douglas A. Arcila, Maria Geyer, Mark B. Stein, Eytan Dogan, Ahmet Roshal, Mikhail Levine, Ross L. Glass, Jacob Xiao, Wenbin Hematopathology Service Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York NY United States Center for Epigenetics Research Memorial Sloan Kettering Cancer Center New York NY United States Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY United States Department of Pathology and Laboratory Medicine Cytogenetics Laboratory Memorial Sloan Kettering Cancer Center New York NY United States Molecular Cancer Medicine Service Human Oncogenesis and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY United States Department of Pathology and Laboratory Medicine Diagnostic Molecular Laboratory Memorial Sloan Kettering Cancer Center New York NY United States Center for Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York NY United States Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY United States Cell Therapy Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY United States
A mixed phenotype (MP) is a characteristic of de novo MP acute leukemia (MPAL), but it can also be found in other leukemias. It poses substantial classification and management dilemmas. Herein, we report a large cohor...
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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation
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Signal Transduction and Targeted Therapy 2024年 第8期9卷 3519-3532页
作者: Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.Chan Charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility Memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland
Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by t... 详细信息
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LSD1 Inhibitor CPI-482 Shows Efficacy and Prolongs Survival in Mouse Models of AML and Post-MPN AML in the Context of Constitutive JAK-STAT Pathway Activation
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BLOOD 2020年 136卷 50-51页
作者: Rampal, Raajit K. McGrath, John P. Krishnan, Aishwarya Li, Bing Xiao, Wenbin Nikom, David Wang, Jing Levine, Ross L. Trojer, Patrick Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY Translational Sciences Constellation Pharmaceuticals Cambridge MA Center for Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York NY Department of Pathology Memorial Sloan Kettering Cancer Center New York NY Constellation Pharmaceuticals Cambridge MA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY Department of Medicine Leukemia Service Memorial Sloan Kettering Cancer Center New York NY
Several novel mechanism-based therapeutic modalities are currently being clinically investigated for the treatment of patients with acute myelogenous leukemia (AML), including agents that exploit genomic vulnerabiliti...
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Venetoclax Therapy for Relapsed and Treatment Refractory AML: Clinical Outcomes and Molecular Predictors
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BLOOD 2020年 136卷 47-48页
作者: Stahl, Maximilian Menghrajani, Kamal Derkach, Andriy Chan, Alexander Xiao, Wenbin Glass, Jacob L. King, Amber C. Daniyan, Anthony Famulare, Christopher Cuello, Bernadette M. Abdel-Wahab, Omar Levine, Ross L. Viny, Aaron D. Stein, Eytan M. Roshal, Mikhail Tallman, Martin S. Goldberg, Aaron D. Department of Medicine Leukemia Service Memorial Sloan Kettering Cancer Center New York NY Weill Cornell Medical College New York NY Department of Biostatistics and Epidemiology Memorial Sloan Kettering Cancer Center New York NY Department of Pathology Memorial Sloan Kettering Cancer Center New York NY Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York Center for Epigenetics Research Memorial Sloan Kettering Cancer Center New York NY Department of Pharmacy Memorial Sloan Kettering Cancer Center New York NY Department of Medicine Leukemia Service Memorial Sloan Kettering Cancer Center NY NY Center for Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York NY Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY Memorial Sloan-Kettering Cancer Center New York NY Department of Medicine Leukemia Service Memorial Sloan-Kettering Cancer Center New York NY
Background: Venetoclax combined with azacitidine (aza/ven), decitabine (dec/ven), and low-dose cytarabine (LDAC/ven) is commonly used off-label in relapsed/refractory (RR)-AML patients; however, predictors of response...
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ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR1
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BLOOD 2020年 136卷 10-11页
作者: Inoue, Daichi Polaski, Jacob T. Taylor, Justin Castel, Pau Chen, Sisi Kobayashi, Susumu Hogg, Simon J. Hayashi, Yasutaka Pineda, Jose Mario Bello Penson, Alexander V. El Marabti, Ettaib Erickson, Caroline Fukumoto, Miki Yamazaki, Hiromi Fukui, Chie Lu, Sydney X. Durham, Benjamin H. Liu, Bo Mehta, Sanjoy Zakheim, Daniel Garippa, Ralph Chew, Guo-Liang McCormick, Frank Bradley, Robert K. Abdel-Wahab, Omar Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY Department of Hematology-Oncology Institute of Biomedical Research and Innovation Foundation for Biomedical Research and Innovation at Kobe Kobe Japan Public Health Sciences and Basic Sciences Divisions Fred Hutchinson Cancer Research Center Seattle Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Miami FL Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco Foundation for Biomedical Research and Innovation at Kobe Kobe Japan Department of Genome Sciences University of Washington Seattle Memorial Sloan Kettering Cancer Center New York Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York Myeloma Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY Gene Editing & Screening Facility Memorial Sloan Kettering Cancer Center New York
Mutations in RNA splicing factors are amongst the most common genetic alterations in myeloid malignancies. Mutations in the splicing factors SF3B1 , SRSF2 , and U2AF1 occur as heterozygous, missense mutations and have...
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Fundamental immuneoncogenicity trade-offs define driver mutation fitness (vol 606, pg 172, 2022)
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NATURE 2022年 第7914期606卷 E5-E5页
作者: Hoyos, David Zappasodi, Roberta Schulze, Isabell Sethna, Zachary de Andrade, Kelvin Cesar Bajorin, Dean F. Bandlamudi, Chaitanya Callahan, Margaret K. Funt, Samuel A. Hadrup, Sine R. Holm, Jeppe S. Rosenberg, Jonathan E. Shah, Sohrab P. Vazquez-Garcia, Ignacio Weigelt, Britta Wu, Michelle Zamarin, Dmitriy Campitelli, Laura F. Osborne, Edward J. Klinger, Mark Robins, Harlan S. Khincha, Payal P. Savage, Sharon A. Balachandran, Vinod P. Wolchok, Jedd D. Hellmann, Matthew D. Merghoub, Taha Levine, Arnold J. Luksza, Marta Greenbaum, Benjamin D. Computational Oncology Department of Epidemiology & Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Swim Across America Laboratory and Ludwig Collaborative Immunology Program Parker Institute for Cancer Immunotherapy Memorial Sloan Kettering Cancer Center New York NY USA Department of Medicine Weill Cornell Medical College New York NY USA Parker Institute for Cancer Immunotherapy Memorial Sloan Kettering Cancer Center New York NY USA Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical Sciences New York NY USA Hepatopancreatobiliary Service Department of Surgery Memorial Sloan Kettering Cancer Center New York NY USA Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA Division of Cancer Epidemiology and Genetics Clinical Genetics Branch National Cancer Institute National Institutes of Health Rockville MD USA Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York NY USA Kravis Center for Molecular Oncology Memorial Sloan Kettering Cancer Center New York NY USA Experimental and Translational Immunology Health Technology Technical University of Denmark Lyngby Denmark Physiology Biophysics & Systems Biology Weill Cornell Medicine Weill Cornell Medical College New York NY USA Department of Surgery Memorial Sloan Kettering Cancer Center New York NY USA Adaptive Biotechnologies Seattle WA USA David M. Rubenstein Center for Pancreatic Cancer Research Memorial Sloan Kettering Cancer Center New York NY USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY USA Thoracic Oncology Service Memorial Sloan Kettering Cancer Center New York NY USA Simons Center for Systems Biology Institute for Advanced Study Princeton NJ USA Department of Oncological Sciences Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY USA
Missense driver mutations in cancer are concentrated in a few hotspots1. Various mechanisms have been proposed to explain this skew, including biased mutational processes2, phenotypic differences3,4,5,6 and immunoedit... 详细信息
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Redifferentiation therapy in unresectable or metastatic radioactive iodine refractory thyroid cancer: an International Thyroid oncology Group statement
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The Lancet Diabetes and Endocrinology 2025年 第6期13卷 516-527页
作者: Leboulleux, Sophie Boucai, Laura Busaidy, Naifa Durante, Cosimo Fagin, James A Fazeli, Sasan Gianoukakis, Andrew G Haugen, Bryan R Kang, Hyunseok Konda, Bhavana Laetsch, Theodore W Locati, Laura Ryder, Mabel Spitzweg, Christine Worden, Francis P Wirth, Lori Ho, Alan Department of Medicine Endocrinology and Diabetology Service Geneva University Hospitals and Univerisity of Geneva Geneva Switzerland Department of Medicine Endocrinology Service Memorial Sloan Kettering Cancer Center New York NY United States Department of Endocrine Neoplasia and Hormonal Disorders The University of Texas MD Anderson Cancer Center Houston TX United States Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy Department of Medicine Memorial Sloan Kettering Cancer Center New York NY United States Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY United States Department of Clinical Diabetes Endocrinology & Metabolism City of Hope Comprehensive Cancer Center Duarte CA United States Division of Endocrinology Diabetes and Metabolism David Geffen School of Medicine at UCLA Harbor-UCLA Medical Center Los Angeles CA United States Division of Endocrinology Metabolism and Diabetes University of Colorado School of Medicine Aurora CO United States Department of Medicine University of California at San Francisco San Francisco CA United States Division of Medical Oncology Department of Internal Medicine The Ohio State University Comprehensive Cancer Center Columbus OH United States Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia PA United States Medical Oncology Unit Istituti Clinici Scientifici Maugeri IRCCS Pavia Italy Division of Endocrinology Diabetes Metabolism and Nutrition Mayo Clinic Rochester MN United States Department of Internal Medicine IV LMU Munich Germany Division of Endocrinology Diabetes Metabolism and Nutrition Mayo Clinic Rochester Minnesota United States Department of Internal Medicine Division of Hematology and Oncology University of Michigan Rogel Cancer Center Ann Arbor MI United States Harvard Medical School Boston MA United States Center for Head and Neck Cancers Massachusetts General Hospital
In patients with follicular cell-derived thyroid cancer that have distant metastases and no iodine uptake, redifferentiation—ie, the restoration of tumoural 131I uptake with systemic therapy—is now possible. The use...
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Regional and intratumoral adoptive T-cell therapy
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Immuno-oncology and Technology 2024年 24卷 100715-100715页
作者: Olivera, I. Etxeberria, I. Luri-Rey, C. Molero-Glez, P. Melero, I. Program of Immunology and Immunotherapy Cima Universidad de Navarra Pamplona Navarra Institute for Health Research (IDISNA) Pamplona Spain Human Oncology and Pathogenesis Program (HOPP) Immuno-Oncology Service Memorial Sloan Kettering Cancer Center New York Parker Institute for Cancer Immunotherapy New York United States Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid Department of Immunology and Immunotherapy Clínica Universidad de Navarra Pamplona Department of Oncology Clínica Universidad de Navarra Madrid Centro del Cancer de la Universidad de Navarra (CCUN) Pamplona Spain Nuffield Department of Medicine (NDM) University of Oxford Oxford United Kingdom
Adoptive T-cell therapies (ACTs) including tumor-infiltrating lymphocytes and engineered T cells (transgenic T-cell receptor and chimeric antigen receptor T cells), have made an important impact in the field of cancer... 详细信息
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Lineage plasticity in cancer: a shared pathway of therapeutic resistance (Mar, 10.1038/s41571-020-0340-z, 2020)
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NATURE REVIEWS CLINICAL oncology 2020年 第6期17卷 382-382页
作者: Quintanal-Villalonga, Alvaro Chan, Joseph M. Yu, Helena A. Pe'er, Dana Sawyers, Charles L. Sen, Triparna Rudin, Charles M. Department of Medicine Thoracic Oncology Service Memorial Sloan Kettering Cancer Center New York NY USA Program for Computational and Systems Biology Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA Parker Institute for Cancer Immunotherapy Memorial Sloan Kettering Cancer Center New York NY USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA
Lineage plasticity, the ability of cells to transition from one committed developmental pathway to another, has been proposed as a source of intratumoural heterogeneity and of tumour adaptation to an adverse tumour mi... 详细信息
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