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A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

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Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNational Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110167China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China Shenyang Key Laboratory of Vascular Biology Science and Research CenterDepartment of PharmacologyShenyang Medical CollegeShenyang 110034China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Ischemic stroke(IS)is a prevalent neurological disorder often resulting in significant disability or ***,extracted from Polygonum cuspidatum *** Zucc.(commonly known as Japanese knotweed),has been recognized for its potent neuroprotective ***,the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl)quinoline(RV02),against ischemic stroke remains inadequately *** study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in *** research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic *** findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS)through mitophagy ***,Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in *** results suggest that RV02 shows promise as a neuroprotective agent,with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3 5-dimethoxystyryl)quinoline Resveratrol Ischemic stroke Mitophagy Parkin

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Novel Uracilphenyl Sulfonamide-Based Inhibitors of Protoporphyrinogen Oxidase: design, Synthesis, and Herbicidal Activity

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SSRN 2024年

作者： Ye, Jialin Pei, Hongyan Liu, Dongdong Wang, Feng Yu, Yukui Zhang, Jing Zhang, Lixin Institute of Functional Molecules Shenyang University of Chemical Technology Liaoning Province Key Laboratory of Green Functional Molecular Design and Development Shenyang Key Laboratory of Targeted Pesticides Shenyang110142 China School of Materials Science and Engineering Shenyang University of Technology Shenyang110870 China Metisa Biotechnology Co. Ltd. Nanning530000 China School of Chemical Engineering University of Science and Technology Liaoning Liaoning Anshan114051 China

Herein, we aimed to develop effective herbicidal compounds by synthesizing 26 novel uracil derivatives containing sulfonamide groups based on the active group splicing principle, with saflufenacil as the reference compound. The structures of the final products were confirmed through 1H NMR, 13C NMR, and HRMS analyses. According to the results, 21 and 19 compounds exhibited outstanding (80%-100%) and 60-100% control efficacies against broadleaf weeds (Zinnia elegans and Abutilon theophrasti) at concentrations of 150 g/hm2 and 37.5 g/hm2, respectively. Notably, compound 2a demonstrated 100% control efficacy against Zinnia elegans even at the lowest tested concentration of 9.375 g/hm². On the other hand, the examined compounds exhibited minimal efficacy against other grass weeds, such as Setaria glauca and Echinochloa crusgalli. Furthermore, molecular docking analysis revealed that compound 2a formed hydrogen bonds with Protoporphyrinogen Oxidase (PPO). These findings offer valuable insights and guidance for developing more effective herbicides, paving the way for future advances in weed control tactics. © 2024, The Authors. All rights reserved.

关键词： Hydrogen bonds

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Sulfated Modification, Structural Features, and Anti-Tumor Effects of Polysaccharides from Medicago Sativa L. Stems

SSRN

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SSRN 2024年

作者： Lu, Xixi Xu, Shuangshuang Liu, Xuegui Gao, Pinyi Li, Danqi College of Chemical Engineering Shenyang University of Chemical Technology Shenyang110142 China Shenyang Institute of Science and Technology Shenyang110166 China Institute of Functional Molecules Shenyang University of Chemical Technology Shenyang110142 China National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology Shenyang University of Chemical Technology Shenyang110142 China Liaoning Province Key Laboratory of Green Functional Molecular Design and Development Shenyang University of Chemical Technology Shenyang110142 China

Background: Alfalfa (Medicago sativa L.), extensively cultivated in diverse regions, holds significant industrial importance due to its high yield and nutritional value. A wide range of activities has been reported for alfalfa polysaccharides, while the biological effects are often limited due to their high molecular weight and poor water solubility. Results: The study successfully sulfated water-soluble polysaccharide (APS) isolated from alfalfa stems using the chlorosulfonic acid-pyridine (CSA-Pyr) method under three distinct reaction conditions, yielding sulfation derivatives (SAPS-1, SAPS-2 and SAPS-3). The structural characteristics of APS and SAPSs were investigated through high-performance gel permeation chromatography (HPGPC), nuclear magnetic resonance spectrum (NMR), fourier transform infrared spectrum (FT-IR), and scanning electron microscope (SEM). The spectroscopic data revealed effective sulfation of APS. The molecular weights of SAPSs decreased as the degrees of substitution (DS) increased ranging from 0.10 to 0.23. In vitro activity experiments indicated that SAPSs exhibited superior anti-tumor effects compared to APS. Notably, among the three sulfated derivatives, SAPS-3 demonstrated the most potent inhibitory capacity against Hep3B cells. Conclusion: These findings underscore the efficacy of the CSA-Pyr method in enhancing anti-tumor activity, so that SAPSs can be used as a potential anti-tumor agent, providing a theoretical basis for clinical applications. Therefore, the successful utilization of alfalfa stems resources, with improved application potential for industrial and biomedical purposes, is anticipated through the development of sulfated derivatives. © 2024, The Authors. All rights reserved.

关键词： Polysaccharides

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Optimization of scleroglucan production by Sclerotium rolfsii by lowering pH during fermentation via oxalate metabolic pathway manipulation using CRISPR/Cas9

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Fungal Biology and Biotechnology 2021年第1期8卷 1页

作者： Bai, Tianlong Wang, Teng Li, Yan Gao, Na L. Zhang, Lixin Chen, Wei-Hua Yin, Xiushan Applied Biology Laboratory Shenyang University of Chemical Technology Shenyang 110142 China Key Laboratory of Molecular Biophysics of the Ministry of Education Hubei Key Laboratory of Bioinformatics and Molecular Imaging Department of Bioinformatics and Systems Biology College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Liaoning Province Key Laboratory of Green Functional Molecule Design and Development Shenyang University of Chemical Technology Shenyang 110142 China College of Life Science HeNan Normal University Xinxiang 453007 Henan China

Background: Sclerotium rolfsii is a potent producer of many secondary metabolites, one of which like scleroglucan is an exopolysaccharide (EPS) appreciated as a multipurpose compound applicable in many industrial fields. Results: Aspartate transaminase (AAT1) catalyzes the interconversion of aspartate and α-ketoglutarate to glutamate and oxaloacetate. We selected AAT1 in the oxalate metabolic pathway as a target of CRISPR/Cas9. Disruption of AAT1 leads to the accumulation of oxalate, rather than its conversion to α-ketoglutarate (AKG). Therefore, AAT1-mutant serves to lower the pH (pH 3–4) so as to increase the production of the pH-sensitive metabolite scleroglucan to 21.03 g L⁻¹ with a productivity of up to 0.25 g L⁻¹·h⁻¹. Conclusions: We established a platform for gene editing that could rapidly generate and select mutants to provide a new beneficial strain of S. rolfsii as a scleroglucan hyper-producer, which is expected to reduce the cost of controlling the optimum pH condition in the fermentation industry. © 2021, The Author(s).

关键词： AAT1 CRISPR/Cas9 Oxalate Scleroglucan Sclerotium rolfsii

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Epigenetics in the modern era of crop improvements

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Science China Life Sciences 2025年第6期 1570-1609页

作者： Yan Xue Xiaofeng Cao Xiangsong Chen Xian Deng Xing Wang Deng Yong Ding Aiwu Dong Cheng-Guo Duan Xiaofeng Fang Lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng He Hang He Shengbo He Xin-Jian He Yan He Yuehui He Guifang Jia Danhua Jiang Jianjun Jiang Jinsheng Lai Zhaobo Lang Chenlong Li Qing Li Xingwang Li Bao Liu Bing Liu Xiao Luo Yijun Qi Weiqiang Qian Guodong Ren Qingxin Song Xianwei Song Zhixi Tian Jia-Wei Wang Yuan Wang Liang Wu Zhe Wu Rui Xia Jun Xiao Lin Xu Zheng-Yi Xu Wenhao Yan Hongchun Yang Jixian Zhai Yijing Zhang Yusheng Zhao Xuehua Zhong Dao-Xiu Zhou Ming Zhou Yue Zhou Bo Zhu Jian-Kang Zhu Qikun Liu State Key Laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key Laboratory of Hybrid Rice College of Life Sciences Wuhan University School of Life Sciences Division of Life Sciences and Medicine University of Science and Technology of China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and Development Department of Biochemistry and Biophysics Institute of Plant Biology School of Life Sciences Fudan University Key Laboratory of Plant Design National Key Laboratory of Plant Molecular Genetics Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences Center for Plant Biology School of Life Sciences Tsinghua University Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE) Northeast Normal University State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design Breeding College of Biological Sciences China Agricultural University College of Life Sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural Sciences School of Advanced Agricultural Sciences Peking University State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological Sciences Key Laboratory of Seed Innovation Institute of Genetics and Developme

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades, our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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design, Synthesis and Activity of Endogenous Hydrogen Sulfide Inhibitor of MRSA

SSRN

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SSRN 2024年

作者： He, Wenfei Gao, Pinyi Li, Danqi Jin, Hui Liu, Changfeng Liu, Xuegui Institute of Functional Molecules Shenyang University of Chemical Technology Shenyang110142 China College of Pharmaceutical and Biological Engineering Shenyang University of Chemical Technology Shenyang110142 China National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology Shenyang University of Chemical Technology Shenyang110142 China Liaoning Province Key Laboratory of Green Functional Molecular Design and Development Shenyang110142 China College of Environment and Safety Engineering Shenyang University of Chemical Technology Shenyang110142 China Mianyang Central Hospital School of Medicine University of Electronic Science and Technology of China Mianyang621000 China

Eighteen indole target compounds were designed and synthesized using molecular docking technology from 3-(6-bromo-3-indolyl) propionic acid. Bioactivity assays revealed that, among the target compounds, compound 3b exhibited the most potent inhibitory effect on methicillin-resistant Staphylococcus aureus (MRSA) endogenous H2S at a concentration of 40 μM, with an inhibitory rate of 80.2% ± 0.92%. Preliminary structure-activity relationship (SAR) analysis indicated the significance of introducing phenyl, benzyl, cyclohexyl, and furfuryl groups to the carboxyl group of the 3-(6-bromo-3-indolyl) propionic acid. Furthermore, the efficacy of aromatic rings was superior to that of aliphatic rings, and incorporating potent electron-withdrawing groups in the ortho, meta, and para positions of the aromatic ring enhanced efficacy. The results from the antibacterial experiments on drug combinations revealed that co-administering target compounds 3b, 4a, 6a, 6b, and 6i with oxacillin sodium resulted in a 50% reduction in the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of MRSA towards oxacillin sodium. It was observed that this synergistic antibacterial mechanism is closely linked to the Fenton reaction. © 2024, The Authors. All rights reserved.

关键词： Propionic acid

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Phytochemical investigation of Rosa laevigata leaves and their chemotaxonomic significance

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Biochemical Systematics and Ecology 2025年 122卷

作者： Cong Wang Lang Qiu Fang He Xuegui Liu Danqi Li Pinyi Gao College of Chemical Engineering Shenyang University of Chemical Technology Shenyang Liaoning 110142 China Institute of Functional Molecules Shenyang University of Chemical Technology Shenyang Liaoning 110142 China Liaoning Province Key Laboratory of Green Functional Molecular Design and Development Shenyang University of Chemical Technology Shenyang Liaoning 110142 China National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology Shenyang University of Chemical Technology Shenyang Liaoning 110142 China

A phytochemical study of Rosa laevigata Michx. leaves identified 26 compounds, including twenty triterpenoids ( 1 – 20 ), four phenylpropanoid derivatives ( 21–24 ), one diterpene ( 25 ) and one fatty acid derivative ( 26 ). The structures of these compounds were confirmed by using nuclear magnetic resonance (NMR) spectroscopy, and were cross-referenced with literature data, to ensure reliable identification. Compounds 3 , 5 , 6 , 11 , 15 , 18 , 22 , 25 were reported within the genus Rosa and the family Rosaceae for the first time, suggesting unique biochemical traits. In addition, distribution mapping of triterpenoids across 16 plant families (e.g., Rosaceae, Asteraceae, Rubiaceae) was conducted to explore their taxonomic relevance. Triterpenoids, known for their structural diversity, may serve as potential biomarkers for investigating evolutionary or ecological relationships.

关键词： Phenylpropanoid derivatives Rosa laevigata michx. Triterpenoids

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iTRAQ-Based Proteomics Investigation of Critical Response Proteins in Embryo and Coleoptile During Rice Anaerobic Germination

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Rice science 2021年第4期28卷 391-401页

作者： Zhang Guangchen Liu Zimeng Liu Yoxihong Kuya Noriyuki HuAYuchen Shi Hongru Zhao Weilin Han Yuqing Yamamoto Toshio Chen Wenfu Sun Jian Rice Research Institute Shenyang Agricultural UniversityShenyang 110161China Institute of Crop Cultivation and Tillage Heilongjiang Academy of Agricultural Sciences/Heilongjiang Provincial Key Laboratory of Crop Molecular Design and Germplasm InnovationHaerbin 150086China Institute of Crop Science National Agriculture and Food Research OrganizationIbaraki 305-8518Japan Center of Seed Industry Development of Liaoning Province Shenyang 110034China Institute of Plant Science and Resources Okayama UniversityOkayama 710-0046Japan

Direct-seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic condition limits seedling *** this study,weedy rice WR04-6 with high germination ability under anaerobic conditions was used as a gene donor,and we successfully improved the seedling establishment rate of rice cultivar Qishanzhan(QSZ)based on selection of a new rice line R42 from the recombinant inbred line population.R42 inherited high anaerobic germination(AG)ability,and was used for isobaric tags for relative and absolute quantitation(iTRAQ)-based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG.A total of 719 differentially abundant proteins(DAPs)were shared by R42 and QSZ responded to AG,and thus defined as common response DAPs.A total of 300 DAPs that responded to AG were only identified from R42,which were defined as tolerance-specific *** common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress,however,they involved different *** tolerance-specific DAPs were involved in amino acid metabolism,starch and sucrose metabolism,tricarboxylic acid cycle pathway,ethylene synthesis pathway,cell wall-associated proteins and activity of active oxygen scavenging *** in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response *** results of physiological indicators showed thatα-amylase and superoxide dismutase activities of R42 were significantly increased under anoxic conditions compared with aerobic *** lines of evidence from western blot,physiological analysis and quantitatDirect seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic conditions can limit seedling *** the

关键词： iTRAQ-based proteomics direct-seeding anaerobic germination weedy rice differentially abundant protein

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Front Cover Picture: Strecker Reactions of Formaldehyde with TMSCN, Catalyzed by TBAF and Formic Acid:N-Monocyanomethylation of Primary Amines (Adv. Synth. Catal. 1/2023)

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Advanced Synthesis & Catalysis 2022年第1期365卷 1-1页

作者： Yunting Liu Jing Zhang Jianyu Zhang Hongyan Pei Xuegui Liu Hui Jin Do Hyun Ryu Lixin Zhang Institute of Functional Molecules Shenyang University of Chemical Technology National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology Liaoning Province Key Laboratory of Green Functional Molecular Design and Development Shenyang 110142 People's Republic of China Department of Chemistry Sungkyunkwan University Suwon 440-746 Korea

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Genomic Prediction of Drought Tolerance during Seedling Stage in Maize using Low-Cost Markers

Research Square

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Research Square 2021年

作者： Zhang, Ao Chen, Shan Cui, Zhenhai Liu, Yubo Guan, Yuan Yang, Shuang Qu, Jingtao Nie, Juchao Dang, Dongdong Li, Cong Dong, Xiaomei Fan, Jinjuan Zhu, Yanshu Zhang, Xuecai Crossa, Jose Cao, Huiying Ruan, Yanye Zheng, Hongjian CIMMYT China Specialty Maize Research Center Crop Breeding and Cultivation Research Institute Shanghai Academy of Agricultural Sciences Shanghai China College of Bioscience and Biotechnology Shenyang Agricultural University Liaoning Shenyang China Shenyang City Key Laboratory of Maize Genomic Selection Breeding Liaoning Shenyang China Texcoco El Batan Mexico Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun China Shenyang Academy of Agricultural Sciences Liaoning China Maize Research Institute Sichuan Agricultural University Sichuan Wenjiang China Fumeng County Modern Agricultural Development Service Center Liaoning Province Fuxin China

Drought tolerance in maize is a complex and polygenic trait, especially in the seedling stage. In plant breeding, such traits can be improved by genomic selection (GS), which has become a practical and effective tool. In the present study, a natural maize population named Northeast China core population (NCCP) consisting of 379 inbred lines were genotyped with diversity arrays technology (DArT) and genotyping-by-sequencing (GBS) platforms. Target traits of seedling emergence rate (ER), seedling plant height (SPH), and grain yield (GY) were evaluated under two natural drought environments in northeast China. adequate genetic variants have been found for genomic selection, they are not stable enough between two years. Similarly, the heritability of the three traits is not stable enough, and the heritabilities in 2019 (0.88, 0.82, 0.85 for ER, SPH, GY) are higher than that in 2020 (0.65, 0.53, 0.33) and cross-two-year (0.32, 0.26, 0.33). The current research obtained two kinds of marker sets: the SilicoDArT markers were from DArT-seq, and SNPs were from the GBS and DArT-seq. In total, a number of 11,865 SilicoDArT, 7,837 DArT's SNPs, and 91,003 GBS SNPs were used for analysis after quality control. The results of phylogenetic trees showed that the population was rich in consanguinity. Genomic prediction results showed that the average prediction accuracies estimated using the DArT SNP dataset under the 2-fold cross-validation scheme were 0.27, 0.19, and 0.33, for ER, SPH, and GY, respectively. The result of SilicoDArT is close to the SNPs from DArT-seq, those were 0.26, 0.22, and 0.33. For SPH, the prediction accuracies using SilicoDArT were more than ones using DArT SNP, In some cases, alignment to the reference genome results in a loss to the prediction. The trait with lower heritability can improve the prediction accuracy using filtering of linkage disequilibrium. For the same trait, the prediction accuracy estimated with two types of DArT markers was consistently h

关键词： Genome

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