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Software for administering the National Cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events: Usability study

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JMIR Human Factors 2018年第3期5卷 e10070页

作者： Schoen, Martin W. Basch, Ethan Hudson, Lori L. Chung, Arlene E. Mendoza, Tito R. Mitchell, Sandra A. St. Germain, Diane Baumgartner, Paul Sit, Laura Rogak, Lauren J. Shouery, Marwan Shalley, Eve Reeve, Bryce B. Fawzy, Maria R. Bhavsar, Nrupen A. Cleeland, Charles Schrag, Deborah Dueck, Amylou C. Abernethy, Amy P. Division of Hematology and Medical Oncology Department of Internal Medicine Saint Louis University School of Medicine Saint Louis MO United States Division of Hematology/Oncology Department of Medicine University of North Carolina School of Medicine 170 Manning Drive Chapel Hill NC United States Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY United States Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC United States Department of Health Policy and Management Gillings School of Public Health University of North Carolina Chapel Hill NC United States Duke Clinical Research Institute Duke University Durham NC United States Division of General Medicine and Clinical Epidemiology Department of Medicine University of North Carolina School of Medicine Chapel Hill NC United States Division of General Pediatrics and Adolescent Medicine Department of Pediatrics Program on Health and Clinical Informatics University of North Carolina School of Medicine Chapel Hill NC United States Department of Symptom Research University of Texas MD Anderson Cancer Center Houston TX United States Division of Cancer Control and Population Sciences National Cancer Institute Rockville MD United States Division of Cancer Prevention National Cancer Institute Rockville MD United States SemanticBits Herndon VA United States Center for Biomedical Informatics and Information Technology National Cancer Institute Rockville MD United States Duke Cancer Institute Durham NC United States FHI 360 Durham NC United States Division of General Internal Medicine Duke University School of Medicine Durham NC United States Division of Population Sciences Dana-Farber Cancer Institute Boston MA United States Alliance Statistics and Data Center Mayo Clinic Scottsdale AZ United States Flatiron Health New York NY United States

Background: The US National Cancer Institute (NCI) developed software to gather symptomatic adverse events directly from patients participating in clinical trials. The software administers surveys to patients using items from the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) through Web-based or automated telephone interfaces and facilitates the management of survey administration and the resultant data by professionals (clinicians and research associates). Objective: The purpose of this study was to iteratively evaluate and improve the usability of the PRO-CTCAE software. Methods: Heuristic evaluation of the software functionality was followed by semiscripted, think-aloud protocols in two consecutive rounds of usability testing among patients with cancer, clinicians, and research associates at 3 cancer centers. We conducted testing with patients both in clinics and at home (remotely) for both Web-based and telephone interfaces. Furthermore, we refined the software between rounds and retested. Results: Heuristic evaluation identified deviations from the best practices across 10 standardized categories, which informed initial software improvement. Subsequently, we conducted user-based testing among 169 patients and 47 professionals. Software modifications between rounds addressed identified issues, including difficulty using radio buttons, absence of survey progress indicators, and login problems (for patients) as well as scheduling of patient surveys (for professionals). The initial System Usability Scale (SUS) score for the patient Web-based interface was 86 and 82 (P=.22) before and after modifications, respectively, whereas the task completion score was 4.47, which improved to 4.58 (P=.39) after modifications. Following modifications for professional users, the SUS scores improved from 71 to 75 (P=.47), and the mean task performance improved significantly (4.40 vs 4.02;P=.001). Conclusions: Software modificati

关键词： Adverse events Cancer clinical trials Patient-reported outcomes PRO-CTCAE Symptoms Usability

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Supporting US public health experts (vol 38, pg 1381, 2020)

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NATURE BIOtechnology 2021年第1期39卷 115-115页

作者： Cohen, Ron Francois, Cedric Crowley, John Hastings, Paul King, Rachel Love, Ted W. Maraganore, John McMurry-Heath, Michelle Levin, Jeremy President and CEO Acorda Therapeutics Ardsley NY USA President and CEO Apellis Pharmaceuticals Waltham MA USA Chairman and CEO Amicus Therapeutics Cranbury NJ USA President and CEO Nkarta Therapeutics South San Francisco CA USA CEO GlycoMimetics Rockville MD USA President and CEO Global Blood Therapeutics South San Francisco CA USA CEO Alnylam Pharmaceuticals Cambridge MA USA President and CEO Biotechnology Innovation Organization Washington DC USA Chairman and CEO Ovid Therapeutics New York NY USA Chairman Biotechnology Innovation Organization Washington DC USA Founder and CEO Cydan II Inc. Cambridge MA USA President and CEO Beacon Discovery San Diego CA USA Chairman and CEO Veracyte Inc. South San Francisco CA USA President and CEO Arrowhead Pharmaceuticals Pasadena CA USA Managing Director Health Catalysts Group Tucson AZ USA Entrepreneur in Residence Third Rock Ventures Boston MA USA President and CEO Principia Biopharma Inc. South San Francisco CA USA CEO Edison Oncology Holding Corp. Menlo Park CA USA President and CEO AVEO Oncology Cambridge MA USA Partner MPM Impact Fund Boston MA USA CEO Lasson Therapeutics San Diego CA USA Partner Atlas Venture Cambridge MA USA Cofounder and CEO Strand Therapeutics Cambridge MA USA Founder Bluebird Ventures Palo Alto CA USA President and CEO Cytokinetics Inc. South San Francisco CA USA President and CEO Wave Life Sciences Cambridge MA USA Chairman of the Board Alnylam Pharmaceuticals Boston MA USA Chairman of the Board Kaleido Biosciences Boston MA USA Chairman of the Board Magenta Boston MA USA Chairman of the Board Arrakis Therapeutics Cambridge MA USA CEO Avidity Biosciences La Jolla CA USA Head of Biotechnology and Pharma William Blair and Company Boston MA USA CEO Locanabio San Diego CA USA Partner Kleiner Perkins Caulfield Byers Menlo Park CA USA President Human BioMolecular Research Institute San Diego CA USA Cofounder and

A Correction to this paper has been published: https://***/10.1038/s41587-020-00792-5.

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Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas program

arXiv

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arXiv 2019年

作者： Snyder, Michael P. Lin, Shin Posgai, Amanda Atkinson, Mark Regev, Aviv Rood, Jennifer Rozenblatt-Rosen, Orit Gaffney, Leslie Hupalowska, Anna Satija, Rahul Gehlenborg, Nils Shendure, Jay Laskin, Julia Harbury, Pehr Nystrom, Nicholas A. Bar-Joseph, Ziv Zhang, Kun Börner, Katy Lin, Yiing Conroy, Richard Procaccini, Dena Roy, Ananda L. Pillai, Ajay Brown, Marishka Galis, Zorina S. Cai, Long Shendure, Jay Trapnell, Cole Lin, Shin Jackson, Dana Snyder, Michael P. Nolan, Garry Greenleaf, William James Lin, Yiing Plevritis, Sylvia Ahadi, Sara Lee, Hayan Nevins, Stephanie Esplin, Ed Horning, Aaron Bahmani, Amir Zhang, Kun Sun, Xin Jain, Sanjay Hagood, James Kharchenko, Peter Atkinson, Mark Bodenmiller, Bernd Brusko, Todd Clare-Salzler, Michael Nick, Harry Otto, Kevin Posgai, Amanda Wasserfall, Clive Maffioletti, Sergio Caprioli, Richard M. Spraggins, Jeffrey M. Gutierrez, Danielle Patterson, Nathan Heath Neumann, Elizabeth K. Harris, Raymond deCaestecker, Mark de Plas, Raf Van Lau, Ken Cai, Long Yuan, Guo-Cheng Zhu, Qian Dries, Ruben Yin, Peng Saka, Sinem K. Kishi, Jocelyn Y. Wang, Yu Goldaracena, Isabel Laskin, Julia Ye, DongHye Burnum-Johnson, Kristin E. Piehowski, Paul D. Ansong, Charles Zhu, Ying Harbury, Pehr Desai, Tushar Mulye, Jay Chou, Peter Nagendran, Monica Bar-Joseph, Ziv Teichmann, Sarah A. Paten, Benedict Murphy, Robert F. Ma, Jian Kiselev, Vladimir Yu Kingsford, Carl Ricarte, Allyson Ruffalo, Matthew Gehlenborg, Nils Kharchenko, Peter Vella, Margaret McCallum, Chuck Börner, Katy Cross, Leonard E. Friedman, Samuel H. Heiland, Randy Herr, Bruce Macklin, Paul Quardokus, Ellen M. Record, Lisel Sluka, James P. Weber, Griffin M. Nystrom, Nicholas A. Silverstein, Jonathan C. Blood, Philip D. Ropelewski, Alexander J. Shirey, William E. Mabee, Paula Lenhardt, W. Christopher Robasky, Kimberly Michailidis, Stavros Satija, Rahul Marioni, John Regev, Aviv Butler, Andrew Stuart, Tim Fisher, Eyal Ghazanfar, Shila Rood, Jennifer Gaffney, Leslie Ersalan, Gokcen Biancalani, Tommaso Conroy, Richard Procaccini, Dena Roy, Anan School of Medicine Stanford University 300 Pasteur Drive United States Department of Genetics Stanford School of Medicine StanfordCA94305 United States Department of Medicine University of Washington SeattleWA98195 United States Department of Pathology University of Florida Diabetes Institute GainesvilleFL32610 United States Klarman Cell Observatory Broad Institute of MIT and Harvard CambridgeMA02142 United States Howard Hughes Medical Institute Koch Institute of Integrative Cancer Research Department of Biology Massachusetts Institute of Technology CambridgeMA02140 United States New York Genome Center New York CityNY10013 United States New York University New YorkNY10012 United States Department of Biomedical Informatics Harvard Medical School BostonMA02115 United States Department of Genome Sciences University of Washington SeattleWA98105 United States Department of Chemistry Purdue University West LafayetteIN47907 United States Department of Biochemistry Stanford University School of Medicine StanfordCA94305 United States Pittsburgh Supercomputing Center Carnegie Mellon University PittsburghPA15213 United States Department of Computational Biology School of Computer Science Carnegie Mellon University PittsburghPA15213 United States Department of Bioengineering University of California San Diego La JollaCA92093 United States Department of Intelligent Systems Engineering School of Informatics Computing and Engineering Indiana University BloomingtonIN47408 United States Department of Surgery Washington University School of Medicine St LouisMO63110 United States Division of Program Coordination Planning and Strategic Initiatives National Institutes of Health BethesdaMD20892 United States National Human Genome Research Institute National Institutes of Health BethesdaMD20892 United States National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Caltech-UW TMC Departmen

Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible 3D molecular and cellular atlas of the human body, in health and various disease settings. Copyright © 2019, The Authors. All rights reserved.

关键词： Mapping

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2018年第5期50卷 766-767页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

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Publisher Correction: A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations

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Scientific reports 2018年第1期8卷 4422页

作者： Rachel B. Ger Xenia J. Fave Heng Li Jihong Wang Rebecca M. Howell Laurence E. Court James A. Bankson R. Jason Stafford John D. Hazle Clifton D. Fuller Abdallah S. R. Mohamed Hesham Elhalawani Caroline Chung Steven J. Frank Musaddiq J. Awan Yao Ding Kelsey B. Mathieu Kimberly Li Wei Huang Andrew L. Beers Jayashree Kalpathy-Cramer Brandon Driscoll Catherine Coolens David A. Hormuth II Thomas E. Yankeelov Petra J. van Houdt Uulke A. van der Heide Renjie He Shouhao Zhou Vlad C. Sandulache Stephen Y. Lai Daniel P. Barboriak Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston Texas USA Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine University of Alexandria Alexandria Egypt Techna Institute University Health Network Toronto Ontario Canada Case Western Reserve University Cleveland OH USA University Hospitals Cleveland OH USA Advanced Imaging Research Center Knight Cancer Institute Oregon Health & Science University Portland Oregon USA The International School of Beaverton Beaverton Oregon USA Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital/Division of Health Sciences & Technology Massachusetts Institute of Technology Charlestown Massachusetts USA Radiation Medicine Program Princess Margaret Cancer Centre University Health Network Toronto Ontario Canada Department of Radiation Oncology University of Toronto Toronto Ontario Canada Institute for Computational Engineering and Sciences The University of Texas Austin Texas USA Department of Radiation Oncology The Netherlands Cancer Institute Amsterdam The Netherlands United Imaging Healthcare America Houston Texas USA Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Otolaryngology Head and Neck Surgery Baylor College of Medicine Houston Texas USA Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Radiology Duke University Medical Center Durham North Carolina USA

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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Proceedings of the 14th annual conference of INEBRIA

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Addiction Science & Clinical Practice 2017年第1期12卷 1-24页

作者： Aisha S. Holloway Sarah Landale Laura Cariola Jennifer Ferguson Dorothy Newbury-Birch Amy Flynn John R. Knight Lon Sherritt Sion K. Harris Amy J. O’Donnell Eileen Kaner Barbara Hanratty Denise Howel Elaine McColl Ruth McGovern Stephanie Scott Elaine Stamp Ellen Lynch Amy M. Loree Steve Martino Amy C. Justice Kimberly A. Yonkers Kate Gilstead-Hayden Steven J. Ondersma Joy Scheidell Angeline Adam Jennifer McNeely Robert P. Schwartz Li-Tzy Wu Geetha Subramaniam Gaurav Sharma Anne H. Berman Karoline Kolaas Elisabeth Petersén Erik Hedman Kristina Sinadinovic Anna Thurang Sven Andréasson Ingvar Rosendahl Mikael Gajecki Preben Bendtsen Catharina Linderoth Ulrika Müssener Fredrik Spak Ida Gremyr Ann M. Mitchell Brayden N. Kameg Deborah Finnell Christine L. Savage Khadejah F. Mahmoud Benjamin C. Riordan Tamlin S. Conner Jayde A. M. Flett Damian Scarf Bonnie McRee Janice Vendetti Karen Steinberg Gallucci Kate Robaina Brendan J. Clark Kathryne D. Reed Rachel M. Hodapp Ivor Douglas Ellen L. Burnham Jacqueline Jones Laura Aagaard Paul F. Cook Brett R. Harris Jiang Yu Margaret Wolff Meighan Rogers Carolina Barbosa Brendan J. Wedehase Laura J. Dunlap Shannon G. Mitchell Kristi A. Dusek Jan Gryczynski Arethusa S. Kirk Marla T. Oros Colleen Hosler Kevin E. O’Grady Barry S. Brown Colin Angus Sidney Sherborne Duncan Gillespie Petra Meier Alan Brennan Divane de Vargas Janaina Soares Donna Castelblanco Ian Wittman Ryan P. McCormack Mirelis Gonzalez Kelly M. Doran Donna Shelley John Rotrosen Lillian Gelberg E. Jennifer Edelman Christopher J. Cutter Lynn E. Fiellin Patrick G. O’Connor David A. Fiellin Nathan B. Hansen Stephen A. Maisto Yanhong Deng James Dziura Roger Bedimo Cynthia Gibert Vincent C. Marconi David Rimland Maria C. Rodriguez-Barradas Michael S. Simberkoff Kendall J. Bryant Emma L. Giles Grant J. McGeechan Simon Coulton Nadine Hendrie Paolo Deluca Colin Drummond Sadie Boniface Amy Ramsey Harry Sumnall Luke Vale Viviana Alabani Amanda Atkinson Grant Stanley Jo Frankham Eilish Gilvarry Nicola Howe Justine Clephane David Gar Nursing Studies School of Health in Social Science The University of Edinburgh Edinburgh UK Health and Social Care Institute School of Health and Social Care Teesside University Middlesbrough Tees Valley UK School of Health and Social Care Teesside University Middlesbrough Tees Valley UK Alcohol and Public Health Team School of Health and Social Care Middlesbrough Teesside UK Department of Pediatrics Harvard Medical School Boston MA USA Center for Adolescent Substance Abuse Research Boston Children’s Hospital Boston MA USA Institute of Health and Society Newcastle University Baddiley-Clark Building Richardson Road Newcastle Upon Tyne Northumberland UK VA Connecticut Healthcare System Veterans Aging Cohort Study West Haven CT USA Department of Psychiatry Yale University School of Medicine New Haven CT USA Department of Psychiatry Yale School of Medicine VA Connecticut Healthcare New Haven CT USA Department of Psychiatry Yale School of Medicine VA Connecticut Healthcare System West Haven CT USA Yale University School of Medicine New Haven CT USA Merrill-Palmer Skillman Institute and Department of Psychiatry and Behavioral Neurosciences Wayne State University Detroit MI USA Department of Psychiatry and Behavioral Neurosciences Merrill-Palmer Skillman Institute Detroit MI USA Department of Psychiatry and Behavioral Neurosciences and Merrill-Palmer Skillman Institute Wayne State University Detroit MI USA Department of Population Health NYU School of Medicine New York NY USA Friends Research Institute Inc Baltimore MD USA Department of Psychiatry and Behavioral Sciences Department of Medicine and Duke Clinical Research Institute Duke University Medical Center Durham NC USA Center for the Clinical Trials Network National Institute on Drug Abuse National Institutes of Health Bethesda MD USA The EMMES Corporation Rockville MD USA Department of Clinical Neuroscience Center for Psychiatry Research Karolinska Institutet Stockholm Sweden

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Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Abstracts

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FLUIDS AND BARRIERS OF THE CNS 2017年第SUPPL 2期14卷 27-27页

作者： [Anonymous] The Jerzy Kukuczka Academy of Physical Education Katowice Poland The Institute of Animal Physiology and Food Research Polish Academy of Sciences Olsztyn Poland University of Miami Miami FL USA Institute of Pharmaceutical Science King’s College London London United Kingdom Department of Ophthalmology and Molecular and Integrative Physiology The University of Michigan Ann Arbor MI USA Department of Internal Medicine and Cardiology The University of Michigan Ann Arbor MI USA School of Medicine Department of Cellular and Molecular Medicine Koc University Istanbul Turkey Department of Cellular and Molecular Medicine Medical Faculty Koc University Istanbul Turkey Department of Neuroscience School of Medicine Koc University Istanbul Turkey Department of Neuroscience Medical Faculty Koc University Istanbul Turkey Department of Laboratory Animals Science Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey Department of Neuroscience Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey School of Medicine Koc University Istanbul Turkey Department of Forensic Science Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Histology and Embryology School of Medicine Koc University Istanbul Turkey Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Physiology School of Medicine Koc University Istanbul Turkey Theodor Kocher Institute University of Bern Bern Switzerland Institute of Veterinary Physiology Vetsuisse Faculty University of Zurich Zurich Switzerland Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Zurich Center of Integrative Human Physiology University of Zurich Zurich Switzerland Institute for Veterinary Physiology and Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Institute of Veterinary Physiology Univer

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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

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Journal of neuroinflammation 2018年第1期15卷 169页

作者： Megan F Duffy Timothy J Collier Joseph R Patterson Christopher J Kemp Kelvin C Luk Malú G Tansey Katrina L Paumier Nicholas M Kanaan D Luke Fischer Nicole K Polinski Olivia L Barth Jacob W Howe Nishant N Vaikath Nour K Majbour Omar M A El-Agnaf Caryl E Sortwell Department of Translational Science and Molecular Medicine Michigan State University 400 Monroe Avenue NW Grand Rapids MI 49503-2532 USA. Neuroscience Graduate Training Program Michigan State University Grand Rapids MI USA. Mercy Health Hauenstein Neuroscience Medical Center Grand Rapids MI USA. Center for Neurodegenerative Disease Research Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Physiology Emory University School of Medicine Atlanta GA USA. MD/PhD Program Michigan State University Grand Rapids MI USA. Neurological Disorders Research Center Qatar Biomedical Research Institute (QBRI) Hamad Bin Khalifa University (HBKU) Education City Qatar. Life Sciences Division College of Science and Engineering Hamad Bin Khalifa University (HBKU) Education City Qatar. Department of Translational Science and Molecular Medicine Michigan State University 400 Monroe Avenue NW Grand Rapids MI 49503-2532 USA. caryl.sortwell@hc.msu.edu. Mercy Health Hauenstein Neuroscience Medical Center Grand Rapids MI USA. caryl.sortwell@hc.msu.edu.

After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats of the manuscript as Luke D. Fisher.

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Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the BRATS challenge

arXiv

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arXiv 2018年

作者： Bakas, Spyridon Reyes, Mauricio Jakab, Andras Bauer, Stefan Rempfler, Markus Crimi, Alessandro Shinohara, Russell Takeshi Berger, Christoph Ha, Sung Min Rozycki, Martin Prastawa, Marcel Alberts, Esther Lipkova, Jana Freymann, John Kirby, Justin Bilello, Michel Fathallah-Shaykh, Hassan M. Wiest, Roland Kirschke, Jan Wiestler, Benedikt Colen, Rivka Kotrotsou, Aikaterini Lamontagne, Pamela Marcus, Daniel Milchenko, Mikhail Nazeri, Arash Weber, Marc-Andr Mahajan, Abhishek Baid, Ujjwal Gerstner, Elizabeth Kwon, Dongjin Acharya, Gagan Agarwal, Manu Alam, Mahbubul Albiol, Alberto Albiol, Antonio Albiol, Francisco J. Alex, Varghese Allinson, Nigel Amorim, Pedro H.A. Amrutkar, Abhijit Anand, Ganesh Andermatt, Simon Arbel, Tal Arbelaez, Pablo Avery, Aaron Azmat, Muneeza Pranjal, B. Bai, Wenjia Banerjee, Subhashis Barth, Bill Batchelder, Thomas Batmanghelich, Kayhan Battistella, Enzo Beers, Andrew Belyaev, Mikhail Bendszus, Martin Benson, Eze Bernal, Jose Bharath, Halandur Nagaraja Biros, George Bisdas, Sotirios Brown, James Cabezas, Mariano Cao, Shilei Cardoso, Jorge M. Carver, Eric N. Casamitjana, Adri Castillo, Laura Silvana Cat, Marcel Cattin, Philippe Cérigues, Albert Chagas, Vinicius S. Chandra, Siddhartha Chang, Yi-Ju Chang, Shiyu Chang, Ken Chazalon, Joseph Chen, Shengcong Chen, Wei Chen, Jefferson W. Chen, Zhaolin Cheng, Kun Choudhury, Ahana Roy Chylla, Roger Clrigues, Albert Colleman, Steven Colmeiro, Ramiro German Rodriguez Combalia, Marc Costa, Anthony Cui, Xiaomeng Dai, Zhenzhen Dai, Lutao Daza, Laura Alexandra Deutsch, Eric Ding, Changxing Dong, Chao Dong, Shidu Dudzik, Wojciech Eaton-Rosen, Zach Egan, Gary Escudero, Guilherme Estienne, Tho Everson, Richard Fabrizio, Jonathan Fan, Yong Fang, Longwei Feng, Xue Ferrante, Enzo Fidon, Lucas Fischer, Martin French, Andrew P. Fridman, Naomi Fu, Huan Fuentes, David Gao, Yaozong Gates, Evan Gering, David Gholami, Amir Gierke, Willi Glocker, Ben Gong, Mingming Gonzlez-Vill, Sandra Grosges, T. Guan, Yuanfang Guo, Sheng Gupta, Sudeep Han, Woo-Sup Han, Il Song Harmuth, Ko Center for Biomedical Image Computing and Analytics University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Institute for Surgical Technology and Biomechanics University of Bern Bern Switzerland Center for MR-Research University Children's Hospital Zurich Zurich Switzerland Support Centre for Advanced Neuroimaging Inselspital Institute for Diagnostic and Interventional Neuroradiology Bern University Hospital Bern Switzerland University Hospital of Zurich Zurich Switzerland Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia United States Image-Based Biomedical Modeling Group Technical University of Munich Munich Germany Icahn School of Medicine Mount Sinai Health System New YorkNY United States Leidos Biomedical Research Inc. Frederick National Laboratory for Cancer Research FrederickMD21701 United States Cancer Imaging Program National Cancer Institute National Institutes of Health BethesdaMD20814 United States Department of Neurology University of Alabama at Birmingham BirminghamAL United States Department of Diagnostic Radiology University of Texas MD Anderson Cancer Center HoustonTX United States Department of Psychology Washington University St. LouisMO United States Neuroimaging Informatics and Analysis Center Washington University St. LouisMO United States Department of Radiology Washington University St. LouisMO United States Institute of Diagnostic and Interventional Radiology Pediatric Radiology and Neuroradiology University Medical Center Rostock Ernst-Heydemann-Str. 6 Rostock18057 Germany Tata Memorial Centre Homi Bhabha National Institute Mumbai India Shri Guru Gobind Singhji Institute of Engineering and Technology Nanded India NVIDIA Santa Clara

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset. Copyright © 2018, The Authors. All rights reserved.

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Proceedings from the 9th annual conference on the science of dissemination and implementation: Washington, DC, USA. 14-15 December 2016

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Implement Sci 2017年第SUPPL 1期12卷 48-48页

作者： David Chambers Lisa Simpson Gila Neta Ulrica von Thiele Schwarz Antoinette Percy-Laurry Gregory A. Aarons Ross Brownson Amanda Vogel Shannon Wiltsey Stirman Kenneth Sherr Rachel Sturke Wynne E. Norton Allyson Varley Cynthia Vinson Lisa Klesges Suzanne Heurtin-Roberts M. Rashad Massoud Leighann Kimble Arne Beck Claire Neely Jennifer Boggs Carmel Nichols Wen Wan Erin Staab Neda Laiteerapong Nathalie Moise Ravi Shah Susan Essock Margaret Handley Amy Jones Jay Carruthers Karina Davidson Lauren Peccoralo Lloyd Sederer Todd Molfenter Ashley Scudder Sarah Taber-Thomas Kristen Schaffner Amy Herschell Eva Woodward Jeffery Pitcock Mona Ritchie JoAnn Kirchner Julia E. Moore Sobia Khan Shusmita Rashid Jamie Park Melissa Courvoisier Sharon Straus Daniel Blonigen Allison Rodriguez Luisa Manfredi Andrea Nevedal Joel Rosenthal David Smelson Christine Timko Nicole Stadnick Jennifer Regan Miya Barnett Anna Lau Lauren Brookman-Frazee Erick Guerrero Karissa Fenwick Yinfei Kong Gregory Aarons Rebecca Lengnick-Hall Benjamin Henwood Nina Sayer Craig Rosen Robert Orazem Brandy Smith Lindsey Zimmerman David Lounsbury Rachel Kimerling Jodie A. Trafton Steven Lindley Rahul Bhargava Hal Roberts Laura Gibson Gabriel J. Escobar Vincent Liu Benjamin Turk Arona Ragins Patricia Kipnis Ashley Ketterer Gruszkowski Michael W. Kennedy Emily Rentschler Drobek Lior Turgeman Aleksandra Sasha Milicevic Terrence L. Hubert Larissa Myaskovsky Youxu C. Tjader Robert J. Monte Kathryn G. Sapnas Edmond Ramly Diane R Lauver Christie M Bartels Shereef Elnahal Andrea Ippolito Hillary Peabody Carolyn Clancy Randall Cebul Thomas Love Douglas Einstadter Shari Bolen Brook Watts Vera Yakovchenko Angela Park William Lukesh Donald R. Miller David Thornton Mari-Lynn Drainoni Allen L. Gifford Shawna Smith Julia Kyle Mark S Bauer Daniel Eisenberg Celeste Liebrecht Michelle Barbaresso Amy Kilbourne Elyse Park Giselle Perez Jamie Ostroff Sarah Greene Michael Parchman Brian Austin Eric Larson Stefanie Ferreri Chris Shea Megan Smith Kea Turner Jennifer Bacci Kyle Bigham Geoffr Division of Cancer Control and Population Sciences National Cancer Institute Rockville MD 20850 USA AcademyHealth Washington DC 20009 USA Department of Learning Informatics Management and Ethics Karolinska Institutet Stockholm 17177 Sweden Department of Psychiatry University of California San Diego San Diego CA 92093 USA George Warren Brown School of Social Work Washington University in St. Louis St. Louis MO 63130 USA Center for Global Health National Cancer Institute Rockville MD 20850 USA Dissemination and Training Division VA National Center for PTSD Palo Alto CA 94305 USA Department of Global Health University of Washington Seattle WA 98105 USA Center for Global Health Studies Fogarty International Center National Institutes of Health Bethesda MD 20912 USA School of Public Health University of Alabama at Birmingham Birmingham AL 35243 USA School of Public Health University of Memphis Memphis TN 38152 USA USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project Bethesda Maryland 20814 USA Institute for Health Research Kaiser Permanente Denver CO 80231 USA ICSI Institute for Clinical Systems Improvement Bloomington MN 55425 USA Medicine University of Chicago Chicago IL 60637 USA Medicine Columbia University Medical Center New York NY 10032 USA Psychiatry Columbia University New York NY 10032 USA General Internal Medicine Epidemiology and Biostatistics University of California San Francisco San Francisco CA 94110 USA New York State Office of Mental Health New York NY 10001 USA Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA Center for Health Enhancement System Studies University of Wisconsin Madison WI 53706 USA Department of Psychiatry University of Pittsburgh Pittsburgh PA 15213 USA Psychology University at Buffalo Buffalo NY 14260 USA Department of Psychology West Virginia University Morgantown WV 26506 USA MIRECC VA North Little Rock AR 72114 USA QUERI for Team-Based Behavioral Health Centr

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