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Lab on a Chip 2013年第10期13卷 1842-1845页

作者： João Ribas Mark W. Tibbitt Mehmet R. Dokmeci Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA PhD Program in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell Biology and Institute for Interdisciplinary Research (IIIUC) University of Coimbra 3004-517 Coimbra Portugal Biocant–Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal Department of Chemical and Biological Engineering University of Colorado Boulder Colorado 80303 USA Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International–Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Research highlights

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Lab on a Chip 2013年第4期13卷 599-601页

作者： Francesco Piraino João Ribas Mehmet R. Dokmeci Ali Khademhosseini Bioengineering Department Politecnico di Milano Piazza Leonardo da Vinci 32 20133 Milano Italy Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Biocant-Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal PhD Program in Experimental Biology and Biomedicine CNC-Centre for Neuroscience and Cell Biology 3004-517 Coimbra Portugal Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International – Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Corrigendum: Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy

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Nanotechnology 2013年第39期24卷

作者： Hsing-Yuan Li Shing-Hua Tseng Tsai-Mu Cheng Hsueh-Liang Chu Yu-Ning Lu Fang-Yu Wang Li-Yun Tsai Juo-Yu Shieh Jyh-Yuan Yang Chien-Chang Juan Lung-Chen Tu Chia-Ching Chang Department of Biological Science and Technology National Chiao Tung University Hsinchu Taiwan Department of Pediatrics National Taiwan University Hospital Hsinchu Branch Hsinchu Taiwan The PhD Program for Translational Medicine Taipei Medical University and Academia Sinica Taiwan Institute of Biomedical Sciences Academia Sinica Taiwan Department of Health Research and Diagnostic Center Centers for Disease Control Taipei Taiwan Department of Pediatrics National Yang-Ming University School of Medicine Ilan branch Taiwan Department of Plastic Surgery Mackay Memorial Hospital Taipei Taiwan Institute of Physics Academia Sinica Taiwan

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Drug Delivery: Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination (Adv. Funct. Mater. 2/2013)

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Advanced Functional Materials 2013年第2期23卷

作者： Peter C. DeMuth Wilfredo F. Garcia‐Beltran Michelle Lim Ai‐Ling Paula T. Hammond Darrell J. Irvine Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Program in Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Department of Materials Oxford University Oxford UK Department of Chemical Engineering Koch Institute for Integrative Cancer Research Institute for Soldier Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Department of Materials Science and Engineering Department of Biological Engineering Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Ragon Institute of MIT MGH and Harvard Boston MA 02139 USA Howard Hughes Medical Institute 4000 Jones Bridge Rd. Chevy Chase MD 20815 USA

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Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)

Efficient targeted gene disruption in Xenopus embryos using ...

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2012全国发育生物学大会

作者： Yong Lei Hui Zhao Xiaogang Guo Yun Liu Yang Cao Yi Deng Xiongfeng Chen Hon Ki Christopher Cheng Igor B.Dawid Yonglong Chen Shenzhen Research Institute The Chinese University of Hong Kong Shenzhen 518057 P.R.China Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Guangzhou 510530 P.R.China Department of Biology South University of Science and Technology of China Shenzhen 518055 P.R.China Advanced Biomedical Computing Center National Cancer Institute National Institutes of Health Frederick MD 21702 USA Program in Genomics of Differentiation The Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892 USA School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin New TerritoriesHong Kong P.R.China School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin New TerritoriesHong Kong P.R.China

Transcription activator-like effector nucleases (TALENs) are a novel approach for directed gene disruption and have been proved to be effective in various animal *** we report that TALENs can induce somatic mutations in Xenopus embryos with reliably high efficiency and that such mutations are heritable through germline *** modified the Golden Gate method for TALEN assembly to make the product suitable for RNA transcription and microinjection into Xenopus embryos.

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Development of multiplex serological assays to detect oncoviral infections

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Infectious Agents and Cancer 2012年第1期7卷 1-1页

作者： William E Burgan Katie Beam Matthew Bess Allison Meade Rachel K Bagni Katie Wakeham Robert Newton Denise Whitby Protein Expression Laboratory Advanced Technology Program SAIC-Frederick Frederick MD USA Medical Research Council/Uganda Virus Research Institute Uganda Research Unit on AIDS Entebbe Uganda Africa Epidemiology and Genetics Unit Department of Health Sciences University of York York UK Viral Oncology Section AIDS and Cancer Virus Program SAIC-Frederick Frederick MD USA

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The ABCs of Experimental Evolution

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International Scholarly Research Notices 2013年第1期2013卷

作者： Zaid Abdo Mathew Stein Andrzej Wojtowicz Kim M. Pepin Departments of Statistics University of Idaho Moscow ID 83844 USAuidaho.edu Department of Mathematics University of Idaho Moscow ID 83844 USAuidaho.edu Program of Bioinformatics and Computational Biology (BCB) University of Idaho Moscow ID 83844 USAuidaho.edu USDA-ARS South Atlantic Area 950 College Station Road Athens GA 30605-2720 USA Department of Computer Engineering University of Idaho Moscow ID 83844 USAuidaho.edu Micron Technology Inc. Boise ID 83716 *** Department of Animal Sciences Washington State University Pullman WA 99164 USAwsu.edu Fogarty International Center National Institutes of Health 31 Center Drive MSC 2220 Bethesda MD 20892-2220 USAfic.nih.gov Department of Biology Colorado State University Campus Delivery 1878 Fort Collins CO 80523 USAcolostate.edu

Microbial evolution is complex and is influenced by many sources of variation. Experimental evolution is no exception, although it is more controlled, easily replicated, and typically devoid of interactions between species. Mathematical modeling of the evolutionary process can help in understanding the underlying mechanisms that drive outcome of such experiments. These models can be complex and parameter rich, limiting their feasibility for statistical inference. In this paper, we introduce the use of Approximate Bayesian Computation (ABC) as a tool for statistical inference in the study of experimental evolution. ABC is a fast and simple method for fitting complex models to data. We utilize this method, coupled with a mechanistic model of experimental evolution, to study the evolution process of bacteriophage ϕ X174 under benign selection pressure. Our results highlight three mutation-selection scenarios that could explain this process: high mutation/low selection pressure, low mutation/high selection pressure, and low mutation/low selection pressure, with posterior support of 19%, 9.5%, and 71.5% for each of these scenarios, respectively. Sequence data support the first candidate. Though surprising, this scenario was not improbable based on our analysis.

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Cover Picture: The Binding of Fluorophores to Proteins Depends on the Cellular Environment (Angew. Chem. Int. Ed. 12/2011)

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Angewandte Chemie International Edition 2011年第12期50卷

作者： Dr. Yun Kyung Kim Dr. Jun-Seok Lee Dr. Xuezhi Bi Dr. Hyung-Ho Ha Shin Hui Ng Dr. Young-hoon Ahn Dr. Jae-Jung Lee Dr. Bridget K. Wagner Dr. Paul A. Clemons Prof. Dr. Young-Tae Chang Korea Institute of Science and Technology (KIST) Life/Health Division Integrated Omics Center Seoul (Korea) Laboratory of Bioimaging Probe Development Singapore Bioimaging Consortium A*STAR Biopolis Singapore NUS MedChem Program of the Office of Life Sciences National University of Singapore Singapore Department of Pharmacology Johns Hopkins University Baltimore MD (USA) Chemical Biology Program Broad Institute of Harvard and MIT Cambridge MA (USA)

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A boost for the emerging field of RNA nanotechnology report on the First International Conference on RNA nanotechnology

A boost for the emerging field of RNA nanotechnology report ...

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作者： Shukla, Girish C. Haque, Farzin Tor, Yitzhak Wilhelmsson, L. Marcus Toulmé, Jean-Jacques Isambert, Hervé Guo, Peixuan Rossi, John J. Tenenbaum, Scott A. Shapiro, Bruce A. Center for Gene Regulation in Health and Disease Department of Biological Sciences Cleveland State University Cleveland OH 44115 United States Nanobiomedical Center College of Engineering and Applied Science University of Cincinnati Cincinnati OH 45267 United States Department of Chemistry and Biochemistry University of California San Diego San Diego CA 92093 United States Department of Chemical and Biological Engineering/Physical Chemistry Chalmers University of Technology Kemivägen 10 SE-412 96 Göteborg Sweden Universite Bordeaux Segalen INSERM U869 Bâtiment 3A 1er étage 33076 Bordeaux Cedex France Institut Curie Research Division CNRS UMR168 11 rue P. and M. Curie 75005 Paris France Department of Molecular and Cellular Biology Beckman Research Institute of City of Hope Duarte CA 91010 United States College of Nanoscale Science and Engineering University at Albany-SUNY Albany NY 12203 United States Center for Cancer Research Nanobiology Program National Cancer Institute at Frederick Frederick MD 21702 United States

This Nano Focus article highlights recent advances in RNA nanotechnology as presented at the First International Conference of RNA Nanotechnology and Therapeutics, which took place in Cleveland, OH, USA (October 23-25, 2010) (http://***/nanomedicine/RNA2010/), chaired by Peixuan Guo and co-chaired by David Rueda and Scott Tenenbaum. The conference was the first of its kind to bring together more than 30 invited speakers in the frontier of RNA nanotechnology from France, Sweden, South Korea, China, and throughout the United States to discuss RNA nanotechnology and its applications. It provided a platform for researchers from academia, government, and the pharmaceutical industry to share existing knowledge, vision, technology, and challenges in the field and promoted collaborations among researchers interested in advancing this emerging scientific discipline. The meeting covered a range of topics, including biophysical and single-molecule approaches for characterization of RNA nanostructures;structure studies on RNA nanoparticles by chemical or biochemical approaches, computation, prediction, and modeling of RNA nanoparticle structures;methods for the assembly of RNA nanoparticles;chemistry for RNA synthesis, conjugation, and labeling;and application of RNA nanoparticles in therapeutics. A special invited talk on the well-established principles of DNA nanotechnology was arranged to provide models for RNA nanotechnology. An Administrator from National Institutes of health (NIH) National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer discussed the current nanocancer research directions and future funding opportunities at NCI. As indicated by the feedback received from the invited speakers and the meeting participants, this meeting was extremely successful, exciting, and informative, covering many groundbreaking findings, pioneering ideas, and novel discoveries. © 2011 American Chemical Society.

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Telehealth tools for public health, emergency, or disaster preparedness and response: A summary report

Telehealth tools for public health, emergency, or disaster p...

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作者： Alverson, Dale C. Edison, Karen Flournoy, Larry Korte, Brenda Magruder, Charles Miller, Craig Center for Telehealth and Cybermedicine Research University of New Mexico Health Sciences Center 1005 Columbia NE Albuquerque NM 87106 United States Department of Dermatology University of Missouri Columbia MI United States Texas AandM University College Station TX United States National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD United States Centers for Disease Control and Prevention Atlanta GA United States Federal Health Architecture Program Office of the National Coordinator for Health Information Technology U.S. Department of Health and Human Services Bethesda MD United States

Rapid advances in telehealth development and adoption are increasing the spectrum of information and communication technologies that can be applied not only to individual patient care but more broadly to population health as well. Participants in this breakout session were asked to address, from their diverse perspectives, a series of questions relating to the current and potential uses of telehealth applications and networks for public health and emergency/disaster preparedness and response systems. Participants identified several gaps in current understanding and research emphasis. There is a clear need for more and larger outcome studies to assess the impact and cost benefit of telehealth applications in terms of improving public health at the population and community levels. In addition, more research is needed to demonstrate the ability of telehealth tools and technologies to facilitate and extend the reach of major national clinical and public health research initiatives. Perhaps most importantly, the National Institutes of health should develop and/or strengthen strategic partnerships with other funding agencies with overlapping or complementary interests to accelerate interdisciplinary research in this rapidly evolving but relatively understudied and complex field. © 2010 Mary Ann Liebert, Inc.

关键词： Telemedicine

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