检索结果-内蒙古大学图书馆

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

引用

Human molecular genetics 2016年第3期25卷 620-9页

作者： Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA wangzha@mail.nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Division of Genome Biology National Cancer Center Hospital Tokyo Japan. Institute of Population Health Sciences. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China. Epidemiology and Prevention Group Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shanghai Pulmonary Hospital Shanghai China. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Preventive Medicine. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Cancer Genome Biology Group Institute of Predictive and Personalized Medicine of Cancer Barcelona Spain. Department of Medical Oncology Japanese Red Cross Medical Center Tokyo Japan. Laboratory for Genotyping Development RIKEN Center for Integrative Medical Sciences Yokohama Japan. Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan. Division of Thoracic Surgery Kinki University School of Medicine

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

关键词：

来源：评论

学校读者我要写书评

暂无评论

ASHP guidelines on preventing medication errors with chemotherapy and biotherapy

引用

American journal of health-system pharmacy : AJHP : official journal of the American Society of health-System Pharmacists 2015年第8期72卷 e6-e35页

作者： Goldspiel, Barry Hoffman, James M. Griffith, Niesha L. Goodin, Susan DeChristoforo, Robert Montello, Capt M.ichael Chase, Judy L. Bartel, Sylvia Patel, Jharana T.ina FISOPP TN. Niesha L. Griffith MD. James M. Hoffman New Brunswick. Robert DeChristoforo NCI Cancer Trials Support Unit Bethesda. Judy L. Chase is Executive Director is Associate Branch Chief for Clinical Trials Technology and Pharmacist Consultant MA. Jharana Tina Patel Pharm.D. BCPS BCOP FASHP Chief is Clinical Pharmacy Specialist Section Clinical Center Pharmacy Department National Institutes of Health Pharm.D. BCPS is Medication Outcomes and Safety Officer Pharmaceutical Sciences St. Jude Children's Research Hospital FASHP is Director of Pharmacy and Infusion Services Arthur G. James Cancer Hospital and Richard J. Solove Research Institute The Ohio State University Pharm.D. BCOP FASHP FCCP Affairs Rutgers Cancer Institute of New Jersey and Professor of Medicine Division of Medical Oncology Robert Wood Johnson Medical School FASHP Chief is Clinical Center Pharmacy Department National Institutes of Health. CAPT Michael Montello Pharm.D. M.B.A. Clinical Investigations Branch National Cancer Institute (NCI) Cancer Therapy Evaluation Program and Project Officer Pharm.D. FASHP Director is Clinical Pharmacy Services University of Texas M. D. Anderson Cancer Center M.P.H. is Director of Pharmacy and Clinical Support Services Dana-Farber Cancer Institute Pharm.D. is Quality Assurance Officer Clinical Center National Institutes of Health Houston. Sylvia Bartel Boston M.S United States FISOPP TN. Niesha L. Griffith MD. James M. Hoffman New Brunswick. Robert DeChristoforo NCI Cancer Trials Support Unit Bethesda. Judy L. Chase is Executive Director is Associate Branch Chief for Clinical Trials Technology and Pharmacist Consultant MA. Jharana Tina Patel Pharm.D. BCPS BCOP FASHP Chief is Clinical Pharmacy Specialist Section Clinical Center Pharmacy Department National Institutes of Health Pharm.D. BCPS is Medication Outcomes and Safety Officer Pharmaceutical Sciences St. Jude Children's Research Hospital FASHP is Director of Pharmacy and Inf

来源：评论

学校读者我要写书评

暂无评论

Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

引用

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

来源：评论

学校读者我要写书评

暂无评论

Comparing cancer care, outcomes, and costs across health systems: Charting the course

引用

Journal of the National Cancer Institute - Monographs 2013年第46期2013卷 124-130页

作者： Lipscomb, Joseph Yabroff, K. Robin Hornbrook, Mark C. Gigli, Anna Francisci, Silvia Krahn, Murray Gatta, Gemma Trama, Annalisa Ritzwoller, Debra P. Durand-Zaleski, Isabelle Salloum, Ramzi Chawla, Neetu Angiolini, Catia Crocetti, Emanuele Giusti, Francesco Guzzinati, Stefano Mezzetti, Maura Miccinesi, Guido Mariotto, Angela Rollins School of Public Health and Winship Cancer Institute Emory University Atlanta GA United States Health Services and Economics Branch Applied Research Program Division of Cancer Control and Population Sciences National Cancer Institute Bethesda MD United States Data Modeling Branch Surveillance Research Program Division of Cancer Control and Population Sciences National Cancer Institute Bethesda MD United States The Center for Health Research Kaiser Permanente Northwest Portland OR United States Institute of Research on Population and Social Policies National Research Council Rome Italy National Center for Epidemiology Surveillance and Health Promotion Italian National Health Institute Rome Italy Toronto Health Economics and Technology Assessment Collaborative (THETA) Department of Medicine and Faculty of Pharmacy University of Toronto Toronto ON Canada Evaluative Epidemiology Unit Fondazione IRCSS Istituto Nazionale dei Tumori Milan Italy Department of Predictive and Preventive Medicine Fondazione IRCSS Istituto Nazionale dei Tumori Milan Italy Institute for Health Research Kaiser Permanente Colorado Denver CO United States AP-HP URCEco and Hôpital Henri Mondor Paris France Department of Health Policy and Management Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill NC United States Medical Oncology Unit Oncology Department Azienda Sanitaria Florence Italy Clinical and Descriptive Epidemiology Unit Institute for Cancer Study and Prevention Florence Italy Veneto Institute of Oncology - IOV IRCCS Padua Italy Department of Economics and Finance University of Rome Tor Vergata Rome Italy

来源：评论

学校读者我要写书评

暂无评论

High-Pressure Freezing And Freeze-Substitution Shows Enhanced Details In Niemann-Pick Type C Disease Cells

引用

Microscopy and Microanalysis 2012年第S2期18卷 216-217页

作者： Soheilian, F. Xu, M. McKew, J. Zheng, W. Baxa, U. Electron Microscopy Laboratory National Cancer Institute Advanced Technology Program SAIC-Frederick Inc./National Cancer Institute at Frederick Frederick MD 21702 United States NIH Center for Advancing Translational Sciences National Institutes of Health Bethesda MD United States

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Research highlights

引用

Lab on a Chip 2013年第10期13卷 1842-1845页

作者： João Ribas Mark W. Tibbitt Mehmet R. Dokmeci Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA PhD Program in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell Biology and Institute for Interdisciplinary Research (IIIUC) University of Coimbra 3004-517 Coimbra Portugal Biocant–Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal Department of Chemical and Biological Engineering University of Colorado Boulder Colorado 80303 USA Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International–Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

A graphical abstract is available for this content

关键词：

来源：评论

学校读者我要写书评

暂无评论

Research highlights

引用

Lab on a Chip 2013年第4期13卷 599-601页

作者： Francesco Piraino João Ribas Mehmet R. Dokmeci Ali Khademhosseini Bioengineering Department Politecnico di Milano Piazza Leonardo da Vinci 32 20133 Milano Italy Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Biocant-Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal PhD Program in Experimental Biology and Biomedicine CNC-Centre for Neuroscience and Cell Biology 3004-517 Coimbra Portugal Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International – Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

A graphical abstract is available for this content

关键词：

来源：评论

学校读者我要写书评

暂无评论

Corrigendum: Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy

引用

Nanotechnology 2013年第39期24卷

作者： Hsing-Yuan Li Shing-Hua Tseng Tsai-Mu Cheng Hsueh-Liang Chu Yu-Ning Lu Fang-Yu Wang Li-Yun Tsai Juo-Yu Shieh Jyh-Yuan Yang Chien-Chang Juan Lung-Chen Tu Chia-Ching Chang Department of Biological Science and Technology National Chiao Tung University Hsinchu Taiwan Department of Pediatrics National Taiwan University Hospital Hsinchu Branch Hsinchu Taiwan The PhD Program for Translational Medicine Taipei Medical University and Academia Sinica Taiwan Institute of Biomedical Sciences Academia Sinica Taiwan Department of Health Research and Diagnostic Center Centers for Disease Control Taipei Taiwan Department of Pediatrics National Yang-Ming University School of Medicine Ilan branch Taiwan Department of Plastic Surgery Mackay Memorial Hospital Taipei Taiwan Institute of Physics Academia Sinica Taiwan

The full text of this article is available in the PDF provided.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Drug Delivery: Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination (Adv. Funct. Mater. 2/2013)

引用

Advanced Functional Materials 2013年第2期23卷

作者： Peter C. DeMuth Wilfredo F. Garcia‐Beltran Michelle Lim Ai‐Ling Paula T. Hammond Darrell J. Irvine Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Program in Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Department of Materials Oxford University Oxford UK Department of Chemical Engineering Koch Institute for Integrative Cancer Research Institute for Soldier Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Department of Materials Science and Engineering Department of Biological Engineering Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Ragon Institute of MIT MGH and Harvard Boston MA 02139 USA Howard Hughes Medical Institute 4000 Jones Bridge Rd. Chevy Chase MD 20815 USA

来源：评论

学校读者我要写书评

暂无评论

Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)

Efficient targeted gene disruption in Xenopus embryos using ...

引用

2012全国发育生物学大会

作者： Yong Lei Hui Zhao Xiaogang Guo Yun Liu Yang Cao Yi Deng Xiongfeng Chen Hon Ki Christopher Cheng Igor B.Dawid Yonglong Chen Shenzhen Research Institute The Chinese University of Hong Kong Shenzhen 518057 P.R.China Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Guangzhou 510530 P.R.China Department of Biology South University of Science and Technology of China Shenzhen 518055 P.R.China Advanced Biomedical Computing Center National Cancer Institute National Institutes of Health Frederick MD 21702 USA Program in Genomics of Differentiation The Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892 USA School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin New TerritoriesHong Kong P.R.China School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin New TerritoriesHong Kong P.R.China

Transcription activator-like effector nucleases (TALENs) are a novel approach for directed gene disruption and have been proved to be effective in various animal *** we report that TALENs can induce somatic mutations in Xenopus embryos with reliably high efficiency and that such mutations are heritable through germline *** modified the Golden Gate method for TALEN assembly to make the product suitable for RNA transcription and microinjection into Xenopus embryos.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：