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arXiv 2022年

作者： Abdollahi, S. Acero, F. Baldini, L. Ballet, Jean Bastieri, D. Bellazzini, R. Berenji, B. Berretta, A. Bissaldi, E. Blandford, R.D. Bloom, E. Bonino, R. Brill, A. Britto, R.J. Bruel, P. Burnett, T.H. Buson, S. Cameron, R.A. Caputo, R. Caraveo, P.A. Castro, D. Chaty, S. Cheung, C.C. Chiaro, G. Cibrario, N. Ciprini, S. Coronado-Blázquez, J. Crnogorcevic, M. Cutini, S. D'Ammando, F. De Gaetano, S. Digel, S.W. Di Lalla, N. Dirirsa, F. Di Venere, L. Domínguez, A. Fallah Ramazani, V. Fegan, S.J. Ferrara, E.C. Fiori, A. Fleischhack, H. Franckowiak, A. Fukazawa, Y. Funk, S. Fusco, P. Galanti, G. Gammaldi, V. Gargano, F. Garrappa, S. Gasparrini, D. Giacchino, F. Giglietto, N. Giordano, F. Giroletti, M. Glanzman, T. Green, D. Grenier, I.A. Grondin, M.-H. Guillemot, L. Guiriec, S. Gustafsson, M. Harding, A.K. Hays, E. Hewitt, J.W. Horan, D. Hou, X. Jóhannesson, G. Karwin, C. Kayanoki, T. Kerr, M. Kuss, M. Landriu, D. Larsson, S. Latronico, L. Lemoine-Goumard, M. Li, J. Liodakis, I. Longo, F. Loparco, F. Lott, B. Lubrano, P. Maldera, S. Malyshev, D. Manfreda, A. Martí-Devesa, G. Mazziotta, M.N. Mereu, I. Meyer, M. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Moiseev, A.A. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Omodei, N. Orienti, M. Orlando, E. Paneque, D. Pei, Z. Perkins, J.S. Persic, M. Pesce-Rollins, M. Petrosian, V. Pillera, R. Poon, H. Porter, T.A. Principe, G. Rainò, S. Rando, R. Rani, B. Razzano, M. Razzaque, S. Reimer, A. Reimer, O. Reposeur, T. Sánchez-Conde, M. Saz Parkinson, P.M. Scotton, L. Serini, D. Sgrò, C. Siskind, E.J. Smith, D.A. Spandre, G. Spinelli, P. Sueoka, K. Suson, D.J. Tajima, H. Tak, D. Thayer, J.B. Thompson, D.J. Torres, D.F. Troja, E. Valverde, J. Wood, K. Zaharijas, G. IRAP Université de Toulouse CNRS UPS CNES ToulouseF-31028 France Université Paris Saclay Université Paris Cité CEA CNRS AIM Gif-sur-Yvette F-91191 France Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Center for Space Studies and Activities "G. Colombo" University of Padova Via Venezia 15 PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy California State University Los Angeles Department of Physics and Astronomy Los AngelesCA90032 United States Dipartimento di Fisica Università degli Studi di Perugia PerugiaI-06123 Italy Dipartimento di Fisica "M. Merlin" Università e del Politecnico di Bari via Amendola 173 BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Postdoctoral Program NASA Goddard Space Flight Center GreenbeltMD20771 United States Department of Physics University of the Free State P.O. Box 339 Bloemfontein9300 South Africa Laboratoire Leprince-Ringuet École Polytechnique CNRS IN2P3 PalaiseauF-91128 France Department of Physics University of Washington SeattleWA98195-1560 United States Institut für Theoretische Physik and Astrophysik Universität Würzburg WürzburgD-97074 Germany NASA Goddard Space Flight Center GreenbeltMD20771 United States INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Harvard-Smithsoni

We present an incremental version (4FGL-DR3, for Data Release 3) of the fourth Fermi-LAT catalog of γ-ray sources. Based on the first twelve years of science data in the energy range from 50 MeV to 1 TeV, it contains 6658 sources. The analysis improves on that used for the 4FGL catalog over eight years of data: more sources are fit with curved spectra, we introduce a more robust spectral parameterization for pulsars, and we extend the spectral points to 1 TeV. The spectral parameters, spectral energy distributions, and associations are updated for all sources. Light curves are rebuilt for all sources with 1 yr intervals (not 2 month intervals). Among the 5064 original 4FGL sources, 16 were deleted, 112 are formally below the detection threshold over 12 yr (but are kept in the list), while 74 are newly associated, 10 have an improved association, and seven associations were withdrawn. Pulsars are split explicitly between young and millisecond pulsars. Pulsars and binaries newly detected in LAT sources, as well as more than 100 newly classified blazars, are reported. We add three extended sources and 1607 new point sources, mostly just above the detection threshold, among which eight are considered identified, and 699 have a plausible counterpart at other wavelengths. We discuss the degree-scale residuals to the global sky model and clusters of soft unassociated point sources close to the Galactic plane, which are possibly related to limitations of the interstellar emission model and missing extended sources. © 2022, CC BY.

关键词： Pulsars

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

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Nature communications 2023年第1期14卷 3043页

作者： Jianxin Shi Kouya Shiraishi Jiyeon Choi Keitaro Matsuo Tzu-Yu Chen Juncheng Dai Rayjean J Hung Kexin Chen Xiao-Ou Shu Young Tae Kim Maria Teresa Landi Dongxin Lin Wei Zheng Zhihua Yin Baosen Zhou Bao Song Jiucun Wang Wei Jie Seow Lei Song I-Shou Chang Wei Hu Li-Hsin Chien Qiuyin Cai Yun-Chul Hong Hee Nam Kim Yi-Long Wu Maria Pik Wong Brian Douglas Richardson Karen M Funderburk Shilan Li Tongwu Zhang Charles Breeze Zhaoming Wang Batel Blechter Bryan A Bassig Jin Hee Kim Demetrius Albanes Jason Y Y Wong Min-Ho Shin Lap Ping Chung Yang Yang She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young-Chul Kim Neil E Caporaso Jiang Chang James Chung Man Ho Michiaki Kubo Yataro Daigo Minsun Song Yukihide Momozawa Yoichiro Kamatani Masashi Kobayashi Kenichi Okubo Takayuki Honda Dean H Hosgood Hideo Kunitoh Harsh Patel Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Hidehito Horinouchi Masahiro Tsuboi Ryuji Hamamoto Koichi Goto Yuichiro Ohe Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Megumi Hara Yuichiro Nishida Kenji Takeuchi Kenji Wakai Koichi Matsuda Yoshinori Murakami Kimihiro Shimizu Hiroyuki Suzuki Motonobu Saito Yoichi Ohtaki Kazumi Tanaka Tangchun Wu Fusheng Wei Hongji Dai Mitchell J Machiela Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Gee-Chen Chang Ying-Huang Tsai Kuan-Yu Chen Ming-Shyan Huang Wu-Chou Su Yuh-Min Chen Adeline Seow Jae Yong Park Sun-Seog Kweon Kun-Chieh Chen Yu-Tang Gao Biyun Qian Chen Wu Daru Lu Jianjun Liu Ann G Schwartz Richard Houlston Margaret R Spitz Ivan P Gorlov Xifeng Wu Ping Yang Stephen Lam Adonina Tardon Chu Chen Stig E Bojesen Mattias Johansson Angela Risch Heike Bickeböller Bu-Tian Ji H-Erich Wichmann David C Christiani Gadi Rennert Susanne Arnold Paul Brennan James McKay John K Field Sanjay S Shete Loic Le Marchand Geoffrey Liu Angeline Andrew Lambertus A Kiemeney Shan Zienolddiny-Narui Kjell Grankvist Mikael Johansson Angela Cox Fiona Taylor Jian-Min Yuan Philip Lazarus Matthew B Schabath Melinda C Aldrich Hyo-Sung Jeon Shih Sheng Jiang Jae Sook Sung C Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. jianxin.shi@nih.gov. Division of Genome Biology National Cancer Research Institute Tokyo Japan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China. Prosserman Centre for Population Health Research Lunenfeld-Tanenbaum Research Institute Sinai Health Toronto ON Canada. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Tianjin China. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Epidemiology School of Public Health China Medical University Shenyang China. Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang China. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China. S

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

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Corrigendum re "Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma" [Eur Urol 2017;72:747-54]

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European urology 2018年第3期74卷 e85-e86页

作者： Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H B As Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department Health and Human Services Bethesda MS USA. International Agency for Research on Cancer (IARC) Lyon France. St. Jude Children's Research Hospital Memphis TN USA. Department of Epidemiology Division of Cancer Prevention and Population Sciences The University of Texas MD Anderson Cancer Center Houston TX USA. Icahn School of Medicine New York NY USA. Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne Australia. QIMR Berghofer Medical Research Institute Herston Queensland Australia School of Public Health The University of Queensland Brisbane Australia. Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne Australia Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Carlton Australia Human Genetics Foundation (HuGeF) Torino Italy Centre de Recherche en Épidémiologie et Santé des Populations Université Paris-Saclay UPS USQ Gustave Roussy Villejuif France. HUNT Research Centre Department of Public Health and General Practice Norwegian University of Science and Technology Levanger Sweden. Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology Trondheim Norway. London School of Hygiene and Tropical Medicine University of London London UK. Regional Authority of Public Health in Banska Bystrica Banska Bystrica Slovakia. Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden. Leeds Institute of Cancer and Pathology University of Leeds Cancer Research Building St James's University Hospital Leeds UK. Department of Oncology and Department of Public Health and Primary Care University of Cambridge Cambridge UK. National Institute for Health and Welfare Helsinki Finland. Vanderbilt-Ingram Cancer Center Nashville TN USA. American Cancer Society At

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Community-developed checklists for publishing images and image analyses

arXiv

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arXiv 2023年

作者： Schmied, Christopher Nelson, Michael S. Avilov, Sergiy Bakker, Gert-Jan Bertocchi, Cristina Bischof, Johanna Boehm, Ulrike Brocher, Jan Carvalho, Mariana Chiritescu, Catalin Christopher, Jana Cimini, Beth A. Conde-Sousa, Eduardo Ebner, Michael Ecker, Rupert Eliceiri, Kevin Fernandez-Rodriguez, Julia Gaudreault, Nathalie Gelman, Laurent Grunwald, David Gu, Tingting Halidi, Nadia Hammer, Mathias Hartley, Matthew Held, Marie Jug, Florian Kapoor, Varun Koksoy, Ayse Aslihan Lacoste, Judith Le Dévédec, Sylvia Le Guyader, Sylvie Liu, Penghuan Martins, Gabriel G. Mathur, Aastha Miura, Kota Llopis, Paula Montero Nitschke, Roland North, Alison Parslow, Adam C. Payne-Dwyer, Alex Plantard, Laure Ali, Rizwan Schroth-Diez, Britta Schütz, Lucas Scott, Ryan T. Seitz, Arne Selchow, Olaf Sharma, Ved P. Spitaler, Martin Srinivasan, Sathya Strambio-De-Castillia, Caterina Taatjes, Douglas Tischer, Christian Jambor, HelenaKlara Fondazione Human Technopole Viale Rita Levi-Montalcini 1 Milano20157 Italy Department of Biomedical Engineering University of Wisconsin-Madison MadisonWI53706 United States Max Planck Institute of Immunobiology and Epigenetics Freiburg79108 Germany Medical BioSciences department Radboud University Medical Centre Nijmegen Netherlands Laboratory for Molecular mechanics of cell adhesions Pontificia Universidad Católica de Chile Santiago Chile Osaka University Graduate School of Engineering Science Japan Euro-BioImaging ERIC Bio-Hub Meyerhofstr. 1 Heidelberg69117 Germany Carl Zeiss AG Carl-Zeiss-Straße 22 Oberkochen73447 Germany BioVoxxel Scientific Image Processing and Analysis Eugen-Roth-Strasse 8 Ludwigshafen67071 Germany Nanophotonics and BioImaging Facility at INL International Iberian Nanotechnology Laboratory 4715-330 Portugal Phi Optics Inc. 1800 S. Oak St Ste 106 ChampaignIL61820 United States Biochemistry Center Heidelberg Heidelberg University Germany Imaging Platform Broad Institute CambridgeMA02142 United States i3S Instituto de Investigação e Inovação Em Saúde and INEB Instituto de Engenharia Biomédica Universidade do Porto Porto Portugal Translational Research Institute Queensland University of Technology 37 Kent Street WoolloongabbaQLD4102 Australia School of Biomedical Sciences Faculty of Health Queensland University of Technology BrisbaneQLD4059 Australia TissueGnostics GmbH Vienna1020 Austria Department of Medical Physics and Biomedical Engineering University of Wisconsin-Madison MadisonWI53706 United States Centre for Cellular Imaging Core Facility Sahlgrenska Academy University of Gothenburg Sweden Allen Institute for Cell Science SeattleWA United States Friedrich Miescher Institute for Biomedical Research Basel Switzerland RNA Therapeutics Institute University of Massachusetts Chan Medical School WorcesterMA01605 United States University of Oklahoma NormanOK United States Advanced Light Microscopy Unit Ce

Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained images and image analyses results, there are to date no unified guidelines. Consequently, microscopy images and image data in publications may be unclear or difficult to interpret. Here we present community-developed checklists for preparing light microscopy images and image analysis for publications. These checklists offer authors, readers, and publishers key recommendations for image formatting and annotation, color selection, data availability, and for reporting image analysis workflows. The goal of our guidelines is to increase the clarity and reproducibility of image figures and thereby heighten the quality and explanatory power of microscopy data is in publications. © 2023, CC BY-SA.

关键词： Image analysis

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Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation

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Nature biotechnology 2023年第11期41卷 1656页

作者： Julia M Gauglitz Kiana A West Wout Bittremieux Candace L Williams Kelly C Weldon Morgan Panitchpakdi Francesca Di Ottavio Christine M Aceves Elizabeth Brown Nicole C Sikora Alan K Jarmusch Cameron Martino Anupriya Tripathi Michael J Meehan Kathleen Dorrestein Justin P Shaffer Roxana Coras Fernando Vargas Lindsay DeRight Goldasich Tara Schwartz MacKenzie Bryant Gregory Humphrey Abigail J Johnson Katharina Spengler Pedro Belda-Ferre Edgar Diaz Daniel McDonald Qiyun Zhu Emmanuel O Elijah Mingxun Wang Clarisse Marotz Kate E Sprecher Daniela Vargas-Robles Dana Withrow Gail Ackermann Lourdes Herrera Barry J Bradford Lucas Maciel Mauriz Marques Juliano Geraldo Amaral Rodrigo Moreira Silva Flavio Protasio Veras Thiago Mattar Cunha Rene Donizeti Ribeiro Oliveira Paulo Louzada-Junior Robert H Mills Paulina K Piotrowski Stephanie L Servetas Sandra M Da Silva Christina M Jones Nancy J Lin Katrice A Lippa Scott A Jackson Rima Kaddurah Daouk Douglas Galasko Parambir S Dulai Tatyana I Kalashnikova Curt Wittenberg Robert Terkeltaub Megan M Doty Jae H Kim Kyung E Rhee Julia Beauchamp-Walters Kenneth P Wright Maria Gloria Dominguez-Bello Mark Manary Michelli F Oliveira Brigid S Boland Norberto Peporine Lopes Monica Guma Austin D Swafford Rachel J Dutton Rob Knight Pieter C Dorrestein Collaborative Mass Spectrometry Innovation Center University of California San Diego La Jolla CA USA. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA USA. Beckman Center for Conservation Research San Diego Zoo Wildlife Alliance Escondido CA USA. Center for Microbiome Innovation Joan and Irwin Jacobs School of Engineering University of California San Diego La Jolla CA USA. Division of Biological Sciences University of California San Diego La Jolla CA USA. Department of Pediatrics School of Medicine University of California San Diego La Jolla CA USA. Bioinformatics and Systems Biology Program University of California San Diego La Jolla CA USA. Division of Rheumatology Allergy & Immunology Department of Medicine University of California San Diego La Jolla CA USA. Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN USA. Department of Integrative Physiology University of Colorado Boulder Boulder CO USA. Department of Population Health Sciences University of Wisconsin-Madison Madison WI USA. Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales Simón Bolívar Puerto Ayacucho Amazonas Venezuela. Department of Pediatrics Billings Clinic Billings MT USA. Department of Animal Science Michigan State University East Lansing MI USA. Department of Pharmacology Ribeirão Preto Medicinal School Center of Research in Inflammatory Diseases University of São Paulo Ribeirão Preto Sao Paolo Brazil. Multidisciplinary Health Institute Federal University of Bahia Vitória da Conquista Bahia Brazil. NPPNS Department of Biomolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo Ribeirão Preto Sao Paolo Brazil. Department of Internal Medicine Ribeirão Preto Medical School Center of Research in Inflammatory Diseases University of São Paulo Ribeirão Preto Sao Paolo Brazil. Department

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Author Correction: Widening global variability in grassland biomass since the 1980s

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Nature ecology & evolution 2024年第10期8卷 2003页

作者： Andrew S MacDougall Ellen Esch Qingqing Chen Oliver Carroll Colin Bonner Timothy Ohlert Matthias Siewert John Sulik Anna K Schweiger Elizabeth T Borer Dilip Naidu Sumanta Bagchi Yann Hautier Peter Wilfahrt Keith Larson Johan Olofsson Elsa Cleland Ranjan Muthukrishnan Lydia O'Halloran Juan Alberti T Michael Anderson Carlos A Arnillas Jonathan D Bakker Isabel C Barrio Lori Biederman Elizabeth H Boughton Lars A Brudvig Martin Bruschetti Yvonne Buckley Miguel N Bugalho Marc W Cadotte Maria C Caldeira Jane A Catford Carla D'Antonio Kendi Davies Pedro Daleo Christopher R Dickman Ian Donohue Mary Ellyn DuPre Kenneth Elgersma Nico Eisenhauer Anu Eskelinen Catalina Estrada Philip A Fay Yanhao Feng Daniel S Gruner Nicole Hagenah Sylvia Haider W Stanley Harpole Erika Hersch-Green Anke Jentsch Kevin Kirkman Johannes M H Knops Lauri Laanisto Lucíola S Lannes Ramesh Laungani Ariuntsetseg Lkhagva Petr Macek Jason P Martina Rebecca L McCulley Brett Melbourne Rachel Mitchell Joslin L Moore John W Morgan Taofeek O Muraina Yujie Niu Meelis Pärtel Pablo L Peri Sally A Power Jodi N Price Suzanne M Prober Zhengwei Ren Anita C Risch Nicholas G Smith Grégory Sonnier Rachel J Standish Carly J Stevens Michelle Tedder Pedro Tognetti G F Ciska Veen Risto Virtanen Glenda M Wardle Elizabeth Waring Amelia A Wolf Laura Yahdjian Eric W Seabloom Department of Integrative Biology University of Guelph Guelph Ontario Canada. asm@uoguelph.ca. Department of Ecology and Environmental Sciences Umeå University Umeå Sweden. asm@uoguelph.ca. Department of Integrative Biology University of Guelph Guelph Ontario Canada. Institute of Ecology College of Urban and Environmental Science Peking University Beijing China. Department of Biology University of New Mexico Albuquerque NM USA. Department of Ecology and Environmental Sciences Umeå University Umeå Sweden. Department of Plant Agriculture University of Guelph Guelph Ontario Canada. Department of Land Resources and Environmental Sciences Montana State University Bozeman MT USA. Department of Ecology Evolution and Behavior University of Minnesota Saint Paul MN USA. Centre for Ecological Sciences Indian Institute of Science Bangalore India. Ecology and Biodiversity Group Department of Biology Utrecht University Utrecht The Netherlands. Division of Biological Sciences University of California San Diego San Diego CA USA. Department of Biology Boston University Boston MA USA. Baruch Institute of Coastal Ecology and Forest Science Clemson University Clemson SC USA. Instituto de Investigaciones Marinas y Costeras (IIMyC) FCEyN UNMdP-CONICET Mar del Plata Argentina. Department of Biology Wake Forest University Winston-Salem NC USA. Department of Physical and Environmental Sciences University of Toronto-Scarborough Toronto Ontario Canada. School of Environmental and Forest Sciences University of Washington Seattle WA USA. Faculty of Environmental and Forest Sciences Agricultural University of Iceland Reykjavik Iceland. Department of Ecology Evolution and Organismal Biology Iowa State University Ames IA USA. Archbold Biological Station Venus FL USA. Department of Plant Biology and Program in Ecology Evolution and Behavior Michigan State University East Lansing MI USA. Department of Zoology School of Natural Sciences Trinity College Dubli

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Analysis of the BraTS 2023 Intracranial Meningioma Segmentation Challenge

arXiv

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arXiv 2024年

作者： LaBella, Dominic Baid, Ujjwal Khanna, Omaditya McBurney-Lin, Shan McLean, Ryan Nedelec, Pierre Rashid, Arif Tahon, Nourel Hoda Altes, Talissa Bhalerao, Radhika Dhemesh, Yaseen Godfrey, Devon Hilal, Fathi Floyd, Scott Janas, Anastasia Kazerooni, Anahita Fathi Kirkpatrick, John Kent, Collin Kofler, Florian Leu, Kevin Maleki, Nazanin Menze, Bjoern Pajot, Maxence Reitman, Zachary J. Rudie, Jeffrey D. Saluja, Rachit Velichko, Yury Wang, Chunhao Warman, Pranav Adewole, Maruf Albrecht, Jake Anazodo, Udunna Anwar, Syed Muhammad Bergquist, Timothy Chen, Sully Francis Chung, Verena Conte, Gian-Marco Dako, Farouk Eddy, James Ezhov, Ivan Khalili, Nastaran Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Liu, Xinyang Mahtabfar, Aria Meier, Zeke Moawad, Ahmed W. Mongan, John Piraud, Marie Shinohara, Russell Takeshi Wiggins, Walter F. Abayazeed, Aly H. Akinola, Rachel Jakab, András Bilello, Michel de Verdier, Maria Correia Crivellaro, Priscila Davatzikos, Christos Farahani, Keyvan Freymann, John Hess, Christopher Huang, Raymond Lohmann, Philipp Moassefi, Mana Pease, Matthew W. Vollmuth, Phillipp Sollmann, Nico Diffley, David Nandolia, Khanak K. Warren, Daniel I. Hussain, Ali Fehringer, Pascal Bronstein, Yulia Deptula, Lisa Stein, Evan G. Taherzadeh, Mahsa de Oliveira, Eduardo Portela Haughey, Aoife Kontzialis, Marinos Saba, Luca Turner, Benjamin Brüßeler, Melanie M.T. Ansari, Shehbaz Gkampenis, Athanasios Weiss, David Maximilian Mansour, Aya Shawali, Islam H. Yordanov, Nikolay Stein, Joel M. Hourani, Roula Moshebah, Mohammed Yahya Abouelatta, Ahmed Magdy Rizvi, Tanvir Willms, Klara Martin, Dann C. Okar, Abdullah D'Anna, Gennaro Taha, Ahmed Sharifi, Yasaman Faghani, Shahriar Kite, Dominic Pinho, Marco Haider, Muhammad Ammar Aristizabal, Alejandro Karargyris, Alexandros Kassem, Hasan Pati, Sarthak Sheller, Micah Alonso-Basanta, Michelle Villanueva-Meyer, Javier Rauschecker, Andreas M. Nada, Ayman Aboian, Mariam Flanders, Adam E. Wiestler, Benedikt Bakas, Spyridon Ca Duke University Medical Center Department of Radiation Oncology DurhamNC United States Division of Computational Pathology Department of Pathology Laboratory Medicine Indiana University School of Medicine IndianapolisIN United States Center for Federated Learning in Medicine Indiana University IndianapolisIN United States Department of Neurosurgery Thomas Jefferson University PhiladelphiaPA United States University of California San FranciscoCA United States Yale University New HavenCT United States Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States University of Missouri ColumbiaMO United States Department of Biostatistics and Health Data Science Indiana University School of Medicine IndianapolisIN United States Children's Hospital of Philadelphia University of Pennsylvania PhiladelphiaPA United States University of Pennsylvania PhiladelphiaPA United States Helmholtz AI Helmholtz Munich Germany Department of Informatics Technical University Munich Germany TranslaTUM - Central Institute for Translational Cancer Research Technical University of Munich Germany Department of Diagnostic and Interventional Neuroradiology School of Medicine Klinikum rechts der Isar Technical University of Munich Germany San FranciscoCA United States Biomedical Image Analysis and Machine Learning Department of Quantitative Biomedicine University of Zurich Switzerland Department of Neuroradiology Technical University of Munich Munich Germany University of San Diego CA United States Cornell University IthacaNY United States Department of Radiology Northwestern University EvanstonIL United States Duke University Medical Center School of Medicine DurhamNC United States Lab Crestview Radiology Lagos Nigeria Sage Bionetworks United States McGill University MontrealQC Canada Children's National Hospital WashingtonDC United States George Washington University WashingtonDC United State

We describe the design and results from the BraTS 2023 Intracranial Meningioma Segmentation Challenge. The BraTS Meningioma Challenge differed from prior BraTS Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic and anatomical presentation and a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data from the largest multi-institutional systematically expert annotated multilabel multi-sequence meningioma MRI dataset to date, which included 1000 training set cases, 141 validation set cases, and 283 hidden test set cases. Each case included T2, T2/FLAIR, T1, and T1Gd brain MRI sequences with associated tumor compartment labels delineating enhancing tumor, non-enhancing tumor, and surrounding non-enhancing T2/FLAIR hyperintensity. Participant automated segmentation models were evaluated and ranked based on a scoring system evaluating lesion-wise metrics including dice similarity coefficient (DSC) and 95% Hausdorff Distance. The top ranked team had a lesion-wise median dice similarity coefficient (DSC) of 0.976, 0.976, and 0.964 for enhancing tumor, tumor core, and whole tumor, respectively and a corresponding average DSC of 0.899, 0.904, and 0.871, respectively. These results serve as state-of-the-art benchmarks for future pre-operative meningioma automated segmentation algorithms. Additionally, we found that 1286 of 1424 cases (90.3%) had at least 1 compartment voxel abutting the edge of the skull-stripped image edge, which requires further investigation into optimal pre-processing face anonymization steps. © 2024, CC BY.

关键词： Tumors

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Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Nature communications 2017年第1期8卷 1414页

作者： M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Department of Internal Medicine Erasmus MC Rotterdam 3000 The Netherlands. Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) Leiden 2593 The Netherlands. Department of Biostatistics Boston University School of Public Health Boston MA 02118 USA. Hebrew SeniorLife Institute for Aging Research Roslindale MA 02131 USA. Harvard Medical School Boston MA 02115 USA. Molecular and Integrative Physiological Sciences Program Harvard School of Public Health Boston MA 02115 USA. Program in Personalized and Genomic Medicine and Department of Medicine Division of Endocrinology Diabetes and Nutrition University of Maryland School of Medicine Baltimore MD 21201 USA. Broad Institute Cambridge MA 02142 USA. Sackler Faculty of Medicine Department of Anatomy and Anthropology Tel Aviv University Tel Aviv 6997801 Israel. Department of Twin Research and Genetic Epidemiology King's College London St Thomas' Campus London WC2R 2LS UK. Department of Epidemiology Erasmus MC Rotterdam 3000 The Netherlands. Department of Medical Genetics University of Lausanne Lausanne 1011 Switzerland. Swiss Institute of Bioinformatics Lausanne 1015 Switzerland. Centre Hospitalier Universitaire (CHUV) University Institute for Social and Preventive Medicine Lausanne 1010 Switzerland. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN 46202 USA. MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge Biomedical Campus Cambridge CB2 OQQ UK. Institute of Epidemiology II Helmholtz Zentrum München - German Research Center for Environmental Health Neuherberg 85764 Germany. Icelandic Heart Association Kopavogur 201 Iceland. Faculty of Medicine University of Iceland Reykjavik 101 Iceland. deCODE Genetics Reykjavik 101 Iceland. Department of Internal Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg SE-405 30 Sweden. Dep

A correction to this article has been published and is linked from the HTML version of this article.

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Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

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Nature nanotechnology 2019年第8期14卷 811页

作者： Hon S Leong Kimberly S Butler C Jeffrey Brinker May Azzawi Steve Conlan Christine Dufès Andrew Owen Steve Rannard Chris Scott Chunying Chen Marina A Dobrovolskaia Serguei V Kozlov Adriele Prina-Mello Ruth Schmid Peter Wick Fanny Caputo Patrick Boisseau Rachael M Crist Scott E McNeil Bengt Fadeel Lang Tran Steffen Foss Hansen Nanna B Hartmann Lauge P W Clausen Lars M Skjolding Anders Baun Marlene Ågerstrand Zhen Gu Dimitrios A Lamprou Clare Hoskins Leaf Huang Wantong Song Huiliang Cao Xuanyong Liu Klaus D Jandt Wen Jiang Betty Y S Kim Korin E Wheeler Andrew J Chetwynd Iseult Lynch Sayed Moein Moghimi André Nel Tian Xia Paul S Weiss Bruno Sarmento José das Neves Hélder A Santos Luis Santos Samir Mitragotri Steve Little Dan Peer Mansoor M Amiji Maria José Alonso Alke Petri-Fink Sandor Balog Aaron Lee Barbara Drasler Barbara Rothen-Rutishauser Stefan Wilhelm Handan Acar Roger G Harrison Chuanbin Mao Priyabrata Mukherjee Rajagopal Ramesh Lacey R McNally Sara Busatto Joy Wolfram Paolo Bergese Mauro Ferrari Ronnie H Fang Liangfang Zhang Jie Zheng Chuanqi Peng Bujie Du Mengxiao Yu Danielle M Charron Gang Zheng Chiara Pastore Department of Urology Mayo Clinic Rochester MN USA. Department of Physiology and Biomedical Engineering Mayo Clinic Rochester MN USA. Department of Nanobiology Sandia National Laboratories Albuquerque NM USA. Center for Micro-Engineered Materials University of New Mexico Albuquerque Albuquerque NM USA. Departments of Chemical and Biological Engineering University of New Mexico Albuquerque NM USA. Department of Molecular Genetics and Microbiology University of New Mexico Albuquerque NM USA. UNM Comprehensive Cancer Center University of New Mexico Albuquerque NM USA. Cardiovascular Research Group School of Healthcare Science Manchester Metropolitan University Manchester UK. British Society for Nanomedicine Liverpool UK. Institute of Life Science Swansea University Medical School Swansea University Swansea UK. Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK. Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK. Department of Chemistry School of Physical Sciences University of Liverpool Liverpool UK. Centre for Cancer Research and Cell Biology Queen's University of Belfast Belfast UK. National Center for Nanoscience and Technology of China Beijing China. Cancer Research Technology Program Nanotechnology Characterization Laboratory Frederick National Laboratory for Cancer Research Frederick MD USA. Laboratory of Animal Sciences Program Center for Advanced Preclinical Research Frederick National Laboratory for Cancer Research Frederick National Laboratory for Cancer Research Frederick MD USA. Trinity Translational Medicine Institute Department of Clinical Medicine Trinity College Dublin Dublin Ireland. Laboratory for Biological Characterisation of Advanced Materials Trinity Translational Medicine Institute Trinity College Dublin Dublin Ireland. Nanomedicine Group Advanced Materials and Bioengineering Research (AMBER) centre Centre

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

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Nature communications 2019年第1期10卷 382页

作者： Marco Matejcic Edward J Saunders Tokhir Dadaev Mark N Brook Kan Wang Xin Sheng Ali Amin Al Olama Fredrick R Schumacher Sue A Ingles Koveela Govindasami Sara Benlloch Sonja I Berndt Demetrius Albanes Stella Koutros Kenneth Muir Victoria L Stevens Susan M Gapstur Catherine M Tangen Jyotsna Batra Judith Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Alicja Wolk Catharine West Lorelei Mucci Peter Kraft Géraldine Cancel-Tassin Karina D Sorensen Lovise Maehle Eli M Grindedal Sara S Strom David E Neal Freddie C Hamdy Jenny L Donovan Ruth C Travis Robert J Hamilton Barry Rosenstein Yong-Jie Lu Graham G Giles Adam S Kibel Ana Vega Jeanette T Bensen Manolis Kogevinas Kathryn L Penney Jong Y Park Janet L Stanford Cezary Cybulski Børge G Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Manuel R Teixeira Susan L Neuhausen Kim De Ruyck Azad Razack Lisa F Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A Townsend Manuela Gago-Dominguez Monique J Roobol Florence Menegaux Kay-Tee Khaw Lisa A Cannon-Albright Hardev Pandha Stephen N Thibodeau Daniel J Schaid Fredrik Wiklund Stephen J Chanock Douglas F Easton Rosalind A Eeles Zsofia Kote-Jarai David V Conti Christopher A Haiman Department of Preventive Medicine Keck School of Medicine University of Southern California/Norris Comprehensive Cancer Center Los Angeles CA 90033 USA. The Institute of Cancer Research London SW7 3RP UK. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care Strangeways Research Laboratory University of Cambridge Cambridge CB1 8RN UK. Department of Clinical Neurosciences University of Cambridge Cambridge CB2 0QQ UK. Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland OH 44106-7219 USA. Seidman Cancer Center University Hospitals Cleveland OH 44106 USA. Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Bethesda MD 20892 USA. Institute of Population Health University of Manchester Manchester M13 9PL UK. Warwick Medical School University of Warwick Coventry CV4 7AL UK. Epidemiology Research Program American Cancer Society 250 Williams Street Atlanta GA 30303 USA. SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Australian Prostate Cancer Research Centre-Qld Institute of Health and Biomedical Innovation and School of Biomedical Science Queensland University of Technology Brisbane QLD 4059 Australia. Translational Research Institute Brisbane QLD 4102 Australia. Department of Medical Epidemiology and Biostatistics Karolinska Institute SE-171 77 Stockholm Sweden. Centre for Cancer Genetic Epidemiology Department of Oncology Strangeways Laboratory University of Cambridge Cambridge CB1 8RN UK. Department of Applied Health Research University College London London WC1E 7HB UK. Department of Medical Biochemistry and Genetics Institute of Biomedicine University of Turku FI-20014 Turku Finland. Tyks Microbiology and Genetics Department of Medical Genetics Turku University Hospital 20521 Turku Finland. BioMediTech University of Tampere 33520 Tampere Finland. Division of Nutritional Epidemiology Insti

The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML v...

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