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The Binding of Fluorophores to Proteins Depends on the Cellular Environment†

Angewandte Chemie 2011年第12期123卷

作者： Yun Kyung Kim Jun‐Seok Lee Xuezhi Bi Hyung‐Ho Ha Shin Hui Ng Young‐hoon Ahn Jae‐Jung Lee Bridget K. Wagner Paul A. Clemons Young‐Tae Chang Department of Chemistry National University of Singapore Singapore 11754 (Singapore) Fax: (+65) 6779‐6591 http://ytchang.science.nus.edu.sg Korea Institute of Science and Technology (KIST) Life/Health Division Integrated Omics Center Seoul (Korea) Laboratory of Bioimaging Probe Development Singapore Bioimaging Consortium A*STAR Biopolis Singapore NUS MedChem Program of the Office of Life Sciences National University of Singapore Singapore Department of Pharmacology Johns Hopkins University Baltimore MD (USA) Chemical Biology Program Broad Institute of Harvard and MIT Cambridge MA (USA)

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Titelbild: The Binding of Fluorophores to Proteins Depends on the Cellular Environment (Angew. Chem. 12/2011)

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Angewandte Chemie 2011年第12期123卷

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Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): Explanation and elaboration

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Journal of Clinical Epidemiology 2011年第8期64卷 e1-e22页

作者： Janssens, A. Cecile J.W. Ioannidis, John P.A. Bedrosian, Sara Boffetta, Paolo Dolan, Siobhan M. Dowling, Nicole Fortier, Isabel Freedman, Andrew N. Grimshaw, Jeremy M. Gulcher, Jeffrey Gwinn, Marta Hlatky, Mark A. Janes, Holly Kraft, Peter Melillo, Stephanie Pencina, Michael J. Ransohoff, David Schully, Sheri D. Seminara, Daniela Winn, Deborah M. Wright, Caroline F. Van Duijn, Cornelia M. Little, Julian Khoury, Muin J. Department of Epidemiology Erasmus University Medical Center 3000 CA Rotterdam PO Box 2040 Netherlands Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece Biomedical Research Institute Foundation for Research and Technology Ioannina Greece Department of Medicine Tufts University School of Medicine Boston MA United States Center for Genetic Epidemiology and Modeling and Tufts CTSI Institute for Clinical Research and Health Policy Studies Tufts Medical Center Boston MA United States Stanford Prevention Research Center Stanford University School of Medicine Stanford CA United States Office of Public Health Genomics Centers for Disease Control and Prevention Atlanta GA United States Tisch Cancer Institute Mount Sinai School of Medicine New York NY United States International Prevention Research Institute Lyon France Department of Obstetrics and Gynecology and Women's Health Albert Einstein College of Medicine Montefiore Medical Center Bronx NY United States Public Population Project in Genomics (P3G) Montreal QC Canada Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Bethesda MD United States Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa ON Canada Department of Medicine University of Ottawa Ottawa ON Canada DeCODE Genetics Reykjavik Iceland Department of Health Research and Policy Stanford University Palo Alto CA United States Fred Hutchinson Cancer Research Center Vaccine and Infectious Disease Institute Division of Public Health Sciences Seattle WA United States Department of Epidemiology Harvard School of Public Health Boston MA United States National Heart Lung and Blood Institute (NHLBI) NHLBI's Framingham Heart Study Framingham MA United States Cardiology Division Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Biostatistics Boston University Boston MA United S

The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality. Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines. These recommendations aim to enhance the transparency, quality and completeness of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis.

关键词： AUC Area Under the receiver operating characteristic Curve CONSORT Consolidated Standard of Reporting Trials dbGaP Database of Genotype and Phenotype EQUATOR Enhancing the QUAlity and Transparency Of health Research GAIN Genetic Association Information Network GRIPS Genetic RIsk Prediction Studies HuGENet Human Genome Epidemiology Network IDI Integrated Discrimination Improvement MeSH Medical Subject Headings REMARK Guidelines for Reporting of tumor MARKer studies SNP single nucleotide polymorphism STARD STAndards for Reporting Diagnostic accuracy STREGA STrenghtening the REporting of Genetic Association studies STROBE Strengthening the Reporting of OBservational studies in Epidemiology

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Evaluation Strategies for Midwifery Education Linked to Digital Media and Distance Delivery technology

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Journal of Midwifery & Women's health 2010年第6期48卷

作者： Judith T. Fullerton CNM, phd Henry T. Ingle phd Judith T. Fullerton CNM PhD FACNM is professor in the College of Health Sciences School of Nursing University of Texas at El Paso. Dr. Fullerton has special expertise in the field of measurement and evaluation and teaches this topic online via the UT Telecampus. Henry T. Ingle PhD is Professor and Associate Academic Affairs Vice President for Technology Planning and Distance Learning at the University of Texas at El Paso where he is responsible for program policy development and implementation of technology-based alternative instructional delivery systems.

The goal of the teaching and learning process for health professionals is the acquisition of a fundamental core of knowledge, the demonstration of critical thinking ability, and the demonstration of competency in the performance of clinical skills. Teaching and learning in distance education programs require that the administration, teachers, and students be creative in developing evaluation strategies that can be adapted to the challenges of the cyberspace on-line educational environment. Evaluation standards for distance education programs recently have been delineated by federal agencies, private organizations, and academic accreditation associations. These standards are linked to principles of sound education practice that promote program quality, high levels of student-faculty interaction, and support effective teaching and learning in the distance education context. A growing body of evidence supports the conclusion that technology-enhanced teaching is equivalent in effectiveness compared with traditional methods when student-learning outcomes are the focus of measurement. An allied body of literature offers model approaches that can be useful to educators who must also conduct the evaluation of clinical skills, provide feedback, and promote socialization to the nurse-midwifery/midwifery role for students being educated in whole or in part through instruction delivered at a distance.

关键词： distance education midwifery education evaluation assessment clinical competencies

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CEU: Prevention and Treatment of Postpartum Hemorrhage: New Advances for Low-Resource Settings

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Journal of Midwifery & Women's health 2010年第4期49卷

作者： Suellen Miller CNM, phd Felicia Lester MPH, MS Paul Hensleigh md, phd Suellen Miller RN CNM MHA PhD is Director of Safe Motherhood Programs the Women's Global Health Imperative University of California San Francisco Department of Obstetrics Gynecology and Reproductive Sciences and Adjunct Assistant Professor University of California Berkeley School of Public Health Maternal and Child Health Program. Dr. Miller is researching postpartum hemorrhage prevention and treatment in Egypt Nigeria Mexico and Tibet. Felicia Lester is a student in the UCB/UCSF Joint Medical Program through which she received an MPH in Maternal and Child Health and an MS in Health and Medical Sciences. She is currently doing clinical rotations at UCSF and will receive her MD in 2005. Paul Hensleigh MD PhD served on the faculty of the Stanford University Medical School Department of Gynecology and Obstetrics from 1977 to 2000. During this time he also was Chief of Obstetrics at the Santa Clara Valley Medical Center San Jose California. Since his early retirement he has worked in Pakistan Macedonia Albania Mexico Nigeria and South Korea.

Postpartum hemorrhage due to uterine atony is the primary direct cause of maternal mortality globally. Management strategies in developed countries involve crystalloid fluid replacement, blood transfusions, and surgery. These definitive therapies are often not accessible in developing countries. Long transports from home or primary health care facilities, a dearth of skilled providers, and lack of intravenous fluids and/or a safe blood supply often create long delays in instituting appropriate treatment. We review the evidence for active management of third-stage labor and for the use of specific uterotonics. New strategies to prevent and manage postpartum hemorrhage in developing countries, such as community-based use of misoprostol, oxytocin in the Uniject delivery system, the non-inflatable antishock garment to stabilize and resuscitate hypovolemic shock, and the balloon condom catheter to treat intractable uterine bleeding are reviewed. New directions for clinical and operations research are suggested.

关键词： mortality maternal postpartum hemorrhage oxytocics hypovolemia misoprostol

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Physical Therapy 2009年第4期89卷 394-395页

作者： George, Steven Z Beneciuk, Jason M Bishop, Mark D SZ George PT PhD is Assistant Professor Department of Physical Therapy Brooks Center for Rehabilitation Studies Center for Pain Research and Behavioral Health University of Florida Gainesville FL 32610-0154 (USA). JM Beneciuk PT DPT FAAOMPT is currently enrolled in the Rehabilitation Sciences Doctoral Program Department of Physical Therapy University of Florida. MD Bishop PT PhD is Assistant Professor Department of Physical Therapy University of Florida.

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Reprint-Comprehensive Foot Examination and Risk Assessment: A Report of the Task Force of the Foot Care Interest Group of the American Diabetes Association, With Endorsement by the American Association of Clinical Endocrinologists

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PHYSICAL THERAPY 2008年第11期88卷 1436-1436页

作者： Boulton, Andrew J. M. Armstrong, David G. Albert, Stephen F. Frykberg, Robert G. Hellman, Richard Kirkman, M. Sue Lavery, Lawrence A. LeMaster, Joseph W. Mills, Joseph L. Mueller, Michael J. Sheehan, Peter Wukich, Dane K. MD FRCP Manchester Diabetes Centre Manchester U.K. Division of Endocrinology Diabetes & Metabolism University of Miami School of Medicine Miami Florida DPM PHD William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science North Chicago Illinois DPM CPED Denver Department of Veterans Affairs Medical Center Denver Colorado DPM MPH Carl T. Hayden VA Medical Center Phoenix Arizona MD FACP American Association of Clinical Endocrinologists Jacksonville Florida Department of Medicine University of Missouri-Kansas City School of Medicine Kansas City Missouri MD American Diabetes Association Alexandria Virginia DPM MPH Department of Surgery Texas A&M Health Science Center Temple Texas MD MPH Department of Family & Community Medicine University of Missouri-Columbia School of Medicine Columbia Missouri MD Department of Surgery University of Arizona Health Sciences Center Tucson Arizona PT PHD Program in Physical Therapy and Department of Radiology Washington University School of Medicine St. Louis Missouri MD Department of Medicine Mount Sinai School of Medicine New York New York MD Department of Orthopedic Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania

The following article is the report of an American Diabetes Association task force that summarizes the recent literature on tests and measures to identify people at risk for foot ulceration and to recommend what should be included in the comprehensive foot exam for adult patients with diabetes. Although this information would be timely and pertinent for physical therapists at any time, its content is particularly complementary to the content of PTJ's Special Issue on Diabetes. This article has been reprinted with permission of the American Diabetes Association from Boulton AJM, Armstrong DG, Albert SF, et al. Comprehensive foot examination and risk assessment: a report of the Task Force of the Foot Care Interest Group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists [ABSTRACT FROM AUTHOR]

关键词： REPRINTS (Publications) health risk assessment SCIENTIFIC literature TASK forces ENDOCRINOLOGISTS ASSOCIATIONS, institutions, etc. FOOT -- Care & hygiene ABSTRACTS

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改进实效型试验的报告质量：CONSORT声明的扩充（2）

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英国医学杂志中文版 2009年第3期12卷 174-179页

作者： Merrick Zwarenstein Shaun Treweek Joel J Gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) Health Services Sciences Surmybrook Hospital Toronto Ontario Canada Insdtute for Clinical Evaluative Sciences Toronto Department of Health Policy Management and Evaluation University of Tomato Toronto Division of International Health (IHCAR) Karolinska Institute Stockholm Sweden Clinical and Population Sciences and Education University of Dundee Dundee Norwegian Centre for Services Oslo Norway Faculty of Medicine University of Tomato Centre for Statistics in Medicine University of Oxford Oxford Center for Medical Technology Policy Baltimore MD USA Division of General Internal Medicine Johns Hopkins School of Medicine Baltimore MD Center for Healthcare Policy Stanford University School of Medicine Palo Alto CA USA Department of Medicine McMastor University Faculty of Health Sciences Hamilton ON Canada Clinical Epidemiology Program Ottawa Health Research institute Ottawa Canada Department of Epidemiology and Community Medicine Faculty of Medicine University of Ottawa Ottawa 中华医学杂志英文版编辑部

实效型试验旨在为临床实践决策提供依据，但报告得不好会降低其实用性。CONSORT和Practihc小组描述了对CONSORT指南的修改，帮助读者评估研究结果的适用性。

关键词： CONSORT声明报告质量试验临床实践适用性

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改进实效型试验的报告质量：CONSORT声明的扩充（1）

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英国医学杂志中文版 2009年第2期12卷 108-111页

作者： Merrick Zwarenstein Shaun Treweek Joel J Gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) Health Services Sciences Sunnybrook Hospital Toronto Ontario Canada Institute for Clinical Evaluative Sciences Toronto Depamnent of Health Policy Management and Evaluation University of Toronto Toronto Division of International Health (IHCAR) Karolinska Institute Stockholm Sweden Clinical and Population Sciences and Education University of Dundee Dundee Norwegian Knowledge Centre for the Health Services Oslo Norway Faculty of Medicine University of Toronto Centre for Statistics in Medicine University of Oxford Oxford Center for Medical Technology Policy Baltimore MD USA Division of General Internal Medicine Johns Hopkins School of Medicine Baltimore MD Center for Heahhcare Policy Stanford University School of Medicine Palo Alto CA USA Department of Clinical Epidemiology and Biostatistics and Department of Medicine McMaster University Faculty of Health Sciences Hamilton ON Canada Clinical Epidemiology Program Ottawa Health Research Institute Ottawa Canada Department of Epidemiology and Community Medicine Faculty of Medicine University of Ottawa Ottawa 中华医学杂志英文版编辑部

关键词： CONSORT声明报告质量试验临床实践适用性

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Corrigendum to “Complete inactivation of venezuelan equine encephalitis virus by 1,5-iodonaphthylazide” [Biochem. Biophys. Res. Commun. 358 (2007) 392–398]

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Biochemical and Biophysical Research Communications 2008年第2期368卷 453-453页

作者： Anuj Sharma Yossef Raviv Anu Puri Mathias Viard Robert Blumenthal Radha K. Maheshwari Centre for Combat Casualty and Life Sustainment Research Department of Pathology Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda MD 20814 USA Birla Institute of Technology and Science Pilani India CCR Nanobiology Program Centre for Cancer Research National Cancer Research Institute Frederick MD USA Basic Research Program SAIC-Frederick Inc. Frederick MD USA

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