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arXiv 2024年

作者： Mittmann, Gesa Laiouar-Pedari, Sara Mehrtens, Hendrik A. Haggenmüller, Sarah Bucher, Tabea-Clara Chanda, Tirtha Gaisa, Nadine T. Wagner, Mathias Klamminger, Gilbert Georg Rau, Tilman T. Neppl, Christina Compérat, Eva Maria Gocht, Andreas Hämmerle, Monika Rupp, Niels J. Westhoff, Jula Krücken, Irene Seidl, Maximillian Schürch, Christian M. Bauer, Marcus Solass, Wiebke Tam, Yu Chun Weber, Florian Grobholz, Rainer Augustyniak, Jaroslaw Kalinski, Thomas Hörner, Christian Mertz, Kirsten D. Döring, Constanze Erbersdobler, Andreas Deubler, Gabriele Bremmer, Felix Sommer, Ulrich Brodhun, Michael Griffin, Jon Lenon, Maria Sarah L. Trpkov, Kiril Cheng, Liang Chen, Fei Levi, Angelique Cai, Guoping Nguyen, Tri Q. Amin, Ali Cimadamore, Alessia Shabaik, Ahmed Manucha, Varsha Ahmad, Nazeel Messias, Nidia Sanguedolce, Francesca Taheri, Diana Baraban, Ezra Jia, Liwei Shah, Rajal B. Siadat, Farshid Swarbrick, Nicole Park, Kyung Hassan, Oudai Sakhaie, Siamak Downes, Michelle R. Miyamoto, Hiroshi Williamson, Sean R. Holland-Letz, Tim Schneider, Carolin V. Kather, Jakob Nikolas Tolkach, Yuri Brinker, Titus J. Heidelberg Germany Medical Faculty of University Heidelberg Heidelberg Germany Institute of Pathology RWTH Aachen University Aachen Germany Institute of Pathology University Hospital University of Ulm Germany Department of Pathology University of Saarland Homburg Saar Campus Saar Homburg Germany Institute of Pathology University Hospital Düsseldorf Düsseldorf Germany Department of Pathology Medical University of Vienna Vienna Austria Institute of Pathology University Hospital Schleswig-Holstein Lübeck Germany Germany Department of Pathology and Molecular Pathology University Hospital Zurich Zurich Switzerland Institute of Pathology Städtisches Klinikum Karlsruhe Karlsruhe Germany Institute of Pathology University of Leipzig Leipzig Germany Department of Pathology University Medical Center Freiburg Freiburg Germany Department of Pathology and Neuropathology University Hospital and Comprehensive Cancer Center Tübingen Tübingen Germany "Image-Guided and Functionally Instructed Tumor Therapies" University of Tübingen Germany Institute of Pathology University Bern Bern Switzerland Institute of Pathology Georgius Agricola Foundation Ruhr Ruhr University Bochum Bochum Germany Institute of Pathology University of Regensburg Regensburg Germany Institute of Pathology Cantonal Hospital Aarau Aarau Switzerland Medical Faculty University of Zurich Zurich Switzerland Institute of Pathology Kantonsspital St Gallen St Gallen Switzerland Clinic for Pathology University Hospital Brandenburg an der Havel Brandenburg an der Havel Germany Institute for Pathology University Medical Faculty Mannheim University of Heidelberg Mannheim Germany Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland Pathology of Infectious and Immunologic Diseases University of Basel Basel Switzerland Pathology Zwickau Diagnosticum Germany Institute of Pathology University Medicine Rostock Rostock Germany Institute of Pathology Kreiskliniken R

The aggressiveness of prostate cancer, the most common cancer in men worldwide, is primarily assessed based on histopathological data using the Gleason scoring system. While artificial intelligence (AI) has shown promise in accurately predicting Gleason scores, these predictions often lack inherent explainability, potentially leading to distrust in human-machine interactions. To address this issue, we introduce a novel dataset of 1,015 tissue microarray core images, annotated by an international group of 54 pathologists. The annotations provide detailed localized pattern descriptions for Gleason grading in line with international guidelines. Utilizing this dataset, we develop an inherently explainable AI system based on a U-Net architecture that provides predictions leveraging pathologists' terminology. This approach circumvents post-hoc explainability methods while maintaining or exceeding the performance of methods trained directly for Gleason pattern segmentation (Dice score: trained on explanations vs. trained on 0. 713 Gleason patterns). By ±0.003 0. 691±0.010 employing soft labels during training, we capture the intrinsic uncertainty in the data, yielding strong results in Gleason pattern segmentation even in the context of high interobserver variability. With the release of this dataset, we aim to encourage further research into segmentation in medical tasks with high levels of subjectivity and to advance the understanding of pathologists' reasoning processes. © 2024, CC0.

关键词： Urology

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Proceedings of the Frontiers of Retrovirology Conference 2016

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Retrovirology 2016年第1期13卷 1-40页

作者： Irena Zurnic Sylvia Hütter Nicole Stanke Tobias Kern Fabian Lindel Gesche Gerresheim Martin Hamann Erik Müllers Dirk Lindemann Ute Lehmann Juliane Reh Paul Lesbats Peter Cherepanov Melanie Mann Erik Serrao Alan Engelman Claire Da Silva Santos Kevin Tartour Andrea Cimarelli Rya Burdick Jianbo Chen Jaya Sastri Wei-Shau Hu Vinay Pathak Oliver T. Keppler Patrícia de Sousa-Pereira Hanna-Mari Baldauf Marcel Stern Karine Pradeau Sylvia Eiler Nicolas Levy Marc Ruff Sarah Lennon Sarah Cianferani Stéphane Emiliani Vincent Parissi Sylvie Rato Miguel Munoz Angela Ciuffi Antonio Rausell Amalio Telenti Alexander Zhyvoloup Ian Anderson Chen- Hsuin Lee Ariberto Fassati Anat Melamed Delphine Planas Petronela Ancuta Yuwei Zhang Huicheng Chen Annie Bernier Annie Gosselin Janos Kriston-Vizi Robin Ketteler Andy Merritt Charles Bangham Jocelyn Turpin Anthony Rodari Benoit Van Driessche Mathilde Galais Nadége Delacourt Sylvain Fauquenoy Caroline Vanhulle Anna Kula Carine Van Lint Ernst J. Wolvetang Arsène Burny Olivier Rohr Thijs van Montfort Renee van der Sluis Ben Berkhout Dave Speijer Gang Wang Na Zhao Atze T. Das Mirte Scherpenisse Bo Meng Andrzej Rutkowski Lars Dölken Andrew Lever Neil Berry Claire Ham Neil Almond Hoi Ping Mok Nicholas Norton Axel Fun Jack Hirst Mark Wills Chris Hellmund Harriet Groom Thomas Schuster Benedikt Asbach Ralf Wagner Christine Gross Martina Kalmer Andrea K. Thoma-Kress Norbert Donhauser Sebastian Millen Sandra M. Müller-Schmucker Veit Wiesmann Thomas Wittenberg Jan Gettemans Minghua Li Shan-Lu Liu Eric O. Freed Janis Müller Jan Münch Simone Joas Clement Wesley Gnanadurai Edina Lump Christina M. Stürzel Daniel Sauter Frank Kirchhoff Katharina Mack Kathrin Starz Christina Stürzel Xaver Sewald Nasim Motamedi Pradeep Uchil Ruoxi Pi Christin Herrmann Walther Mothes Mark Ladinsky Pamela Bjorkman Jagadish Beloor Priti Kumar Thomas Murooka Thorsten Mempel Michael Brehm Dale Greiner Erica Parrish Nicholas F. Parrish Beatrice H. Hahn Frederic Bibollet-Ruche Ulrike Sauermann Katharina Töpfer Tina Schultheiss Chris Molecular Virology and Gene Therapy Molecular Medicine Leuven Belgium Molecular Virology Technical University Dresden Dresden Germany Center for Regenerative Therapies Dresden Dresden Germany Potsdam University Potsdam Germany The Francis Crick Institute London Great Britain Institute of Clinical and Molecular Virology Friedrich-Alexander-Universität Erlangen-Nuremberg Erlangen Germany Dana Farber Cancer Institute Boston MA United States CIRI Lyon France National Cancer Institute Frederick MD United States Virology Max von Pettenkofer-Institut LMU Munich Munich Germany Institute of Medical Virology University of Frankfurt Frankfurt a. M. Germany German Center for Infection Research Munich Germany Institute of Medical Virology University Hospital Frankfurt Frankfurt a. M. Germany CIBIO/InBIO University of Porto Vairão Portugal Faculty of Sciences University of Porto Porto Portugal Virology Max von Pettenkofer Institute LMU Munich Germany Institute for Medical Virology Frankfurt a. M. Germany Integrative structural Biology IGBMC Illkirch France Institut Pluridisciplinaire Hubert Curien Strasbourg France Institut Cochin Paris France CNRS UMR5234 MFP Lab Bordeaux France Associated International Laboratory (LIA) Microbiology and Immunology CNRS/Université de Bordeaux/Heinrich Pette Institute-Leibniz Institute for Experimental Virology Bordeaux/Hamburg France Institute of Microbiology University Hospital Center and University of Lausanne Lausanne Switzerland Imagine Institute Paris Descartes University Paris France J. Craig Venter Institute La Jolla CA United States Infection University College London London Great Britain Medicine Imperial College London Great Britain Microbiology & Infection University of Montreal Montreal Great Britain CRCHUM Montreal Canada University College London LMCB London Great Britain MRC Technology Centre for Therapeutic Discovery London Great Britain Section of Virology Department of Medicine Imperial Co

Oral presentationsSession 1: Entry & uncoatingO1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replicationIrena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Re... 详细信息

Oral presentations

Session 1: Entry & uncoating

O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication

Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann

O2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infection

Claire Da Silva Santos, Kevin Tartour, Andrea Cimarelli

O3 Dynamics of nuclear envelope association and nuclear import of HIV-1 complexes

Rya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay Pathak

O4 Human papillomavirus protein E4 potently enhances the susceptibility to HIV infection

Oliver T. Keppler

Session 2: Reverse transcription & integration

O5 Structure and function of HIV-1 integrase post translational modifications

Karine Pradeau, Sylvia Eiler, Nicolas Levy, Sarah Lennon, Sarah Cianferani, Stéphane Emiliani, Marc Ruff

O6 Regulation of retroviral integration by RNA polymerase II associated factors and chromatin structure

Vincent Parissi

Session 3: Transcription and latency

O7 A novel single-cell analysis pipeline to identify specific biomarkers of HIV permissiveness

Sylvie Rato, Antonio Rausell, Miguel Munoz, Amalio Telenti, Angela Ciuffi

O8 A capsid-dependent integration program linking T cell activation to HIV-1 gene expression

Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Janos Kriston-Vizi, Robin Ketteler, Chen-Hsuin Lee, Andy Merritt, Petronela Ancuta, Charles Bangham, Ariberto Fassati

O9 Characterisation of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome

Anthony Rodari, Benoit Van Driessche, Mathilde Galais, Nadége Delacourt, Sylv

关键词： Human Immunodeficiency Virus Infection Simian Immunodeficiency Virus Feline Immunodeficiency Virus Bovine Leukemia Virus Prototype Foamy Virus

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Arenicolide Family Macrolides Provide a New Therapeutic Lead Combating Multidrug-Resistant Tuberculosis

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Angewandte Chemie 2024年第1期137卷

作者： Dr. Sunghoon Hwang Bo Eun Heo Thanh Quang Nguyen Young Jae Kim Dr. Sung-Gwon Lee Thanh-Hau Huynh Dr. Eunji Kim Dr. Shin-Il Jo Dr. Min-Jun Baek Eun-Kyung Shin Dr. Joonseok Oh Prof. Chungoo Park Prof. Yeo Joon Yoon Dr. Eun-Jin Park Kyung Tae Kim Sungweon Ryoo Da-Gyum Lee Connor Wood Minjeong Woo Prof. Dae-Duk Kim Prof. Seungwha Paik Prof. Eun-Kyeong Jo Prof. Jichan Jang Prof. Dong-Chan Oh Natural Products Research Institute College of Pharmacy Seoul National University 1 Gwanak-ro Gwanak-gu 08826 Seoul Republic of Korea Division of Life Science Department of Bio & Medical Big Data (BK21 Four Program) Research Institute of Life Science Gyeongsang National University 52828 Jinju Republic of Korea Department of Microbiology College of Medicine Chungnam National University 35015 Daejeon Republic of Korea Department of Medical Science College of Medicine Chungnam National University 35015 Daejeon Republic of Korea Section of Genetics and Physiology Laboratory of Molecular and Cellular Biology National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health (NIH) Bethesda 20892 MD USA Institute of Korean Insect Life 23 Banchuk-ro 83 beon-gil Dong-gu 22530 Incheon Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences 1 Gwanak-ro Gwanak-gu 08826 Seoul Republic of Korea Institute of Biomolecular Design & Discovery and Department of Chemistry Yale University West Haven 06516 CT USA School of Biological Sciences and Technology Chonnam National University 61186 Gwangju Republic of Korea MolGenBio Co. Ltd. 08826 Seoul Republic of Korea Clinical Research Centre Masan National Tuberculosis Hospital 51755 Changwon-si Gyeongsangnam-do Republic of Korea Tuberculosis Research Laboratory Institute Pasteur Korea 13488 Seongnam-si Gyeonggi-do Republic of Korea

The emergence of multidrug-resistant (mdR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb) poses a significant threat to health globally. During searching for new chemical entities regulating mdR- and XDR-Mtb, chemical investigation of the black oil beetle gut bacterium Micromonospora sp. GR10 led to the discovery of eight new members of arenicolides along with the identification of arenicolide A (Ar−A, 1 ), which was a previously reported macrolide with incomplete configuration. Genomic analysis of the bacterial strain GR10 revealed their putative biosynthetic pathway. Quantum mechanics-based computation, chemical derivatizations, and bioinformatic analysis established the absolute stereochemistry of Ar−A and arenicolides D−K (Ar−D−K, 2 – 9 ) completely for the first time. Biological studies of 1 – 9 revealed their antimicrobial activity against mdR and XDR strains of Mtb. Ar−A had the most potent in vitro antimicrobial efficacy against mdR- and XDR-Mtb. Mechanistically, Ar−A induced ATP depletion and destabilized Mtb cell wall, thereby inhibiting growth. Notably, Ar−A exerted a significant antimicrobial effect against Mtb in macrophages, was effective in the treatment of Mtb infections, and showed a synergistic effect with amikacin (AMK) in a mouse model of mdR-Mtb lung infection. Collectively, our findings indicate Ar−A to be a promising drug lead for drug-resistant tuberculosis.

关键词： tuberculosis multidrug resistance structure determination anti-tubercular mechanism natural product

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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

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Human molecular genetics 2016年第3期25卷 620-9页

作者： Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA wangzha@mail.nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Division of Genome Biology National Cancer Center Hospital Tokyo Japan. Institute of Population Health Sciences. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China. Epidemiology and Prevention Group Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shanghai Pulmonary Hospital Shanghai China. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Preventive Medicine. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Cancer Genome Biology Group Institute of Predictive and Personalized Medicine of Cancer Barcelona Spain. Department of Medical Oncology Japanese Red Cross Medical Center Tokyo Japan. Laboratory for Genotyping Development RIKEN Center for Integrative Medical Sciences Yokohama Japan. Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan. Division of Thoracic Surgery Kinki University School of Medicine

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

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Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

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Nature medicine 2024年第12期30卷 3779页

作者： Sebastian Moguilner Sandra Baez Hernan Hernandez Joaquín Migeot Agustina Legaz Raul Gonzalez-Gomez Francesca R Farina Pavel Prado Jhosmary Cuadros Enzo Tagliazucchi Florencia Altschuler Marcelo Adrián Maito María E Godoy Josephine Cruzat Pedro A Valdes-Sosa Francisco Lopera John Fredy Ochoa-Gómez Alfredis Gonzalez Hernandez Jasmin Bonilla-Santos Rodrigo A Gonzalez-Montealegre Renato Anghinah Luís E d'Almeida Manfrinati Sol Fittipaldi Vicente Medel Daniela Olivares Görsev G Yener Javier Escudero Claudio Babiloni Robert Whelan Bahar Güntekin Harun Yırıkoğulları Hernando Santamaria-Garcia Alberto Fernández Lucas David Huepe Gaetano Di Caterina Marcio Soto-Añari Agustina Birba Agustin Sainz-Ballesteros Carlos Coronel-Oliveros Amanuel Yigezu Eduar Herrera Daniel Abasolo Kerry Kilborn Nicolás Rubido Ruaridh A Clark Ruben Herzog Deniz Yerlikaya Kun Hu Mario A Parra Pablo Reyes Adolfo M García Diana L Matallana José Alberto Avila-Funes Andrea Slachevsky María I Behrens Nilton Custodio Juan F Cardona Pablo Barttfeld Ignacio L Brusco Martín A Bruno Ana L Sosa Ortiz Stefanie D Pina-Escudero Leonel T Takada Elisa Resende Katherine L Possin Maira Okada de Oliveira Alejandro Lopez-Valdes Brian Lawlor Ian H Robertson Kenneth S Kosik Claudia Duran-Aniotz Victor Valcour Jennifer S Yokoyama Bruce Miller Agustin Ibanez Latin American Brain Health Institute Universidad Adolfo Ibañez Santiago de Chile Chile. Cognitive Neuroscience Center Universidad de San Andrés Buenos Aires Argentina. Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston MA USA. Universidad de los Andes Bogota Colombia. Global Brain Health Institute (GBHI) University of California San Francisco CA USA. Global Brain Health Institute (GBHI) Trinity College Dublin Dublin Ireland. The University of California Santa Barbara (UCSB) Santa Barbara CA USA. Escuela de Fonoaudiología Universidad San Sebastián Santiago de Chile Chile. Grupo de Bioingeniería Decanato de Investigación Universidad Nacional Experimental del Táchira San Cristóbal Venezuela. Advanced Center for Electrical and Electronic Engineering Universidad Técnica Federico Santa María Valparaíso Chile. University of Buenos Aires Buenos Aires Argentina. The Clinical Hospital of Chengdu Brain Sciences Institute University of Electronic Sciences and Technology of China Chengdu China. Technology of China Chengdu China. Cuban Neuroscience Center La Habana Cuba. Grupo de Neurociencias de Antioquia (GNA) University of Antioquia Medellín Colombia. Department of Psychology Master Program of Clinical Neuropsychology Universidad Surcolombiana Neiva Neiva Colombia. Department of Psychology Universidad Cooperativa de Colombia Arauca Colombia. Neurocognition and Psychophysiology Laboratory Universidad Surcolombiana Neiva Colombia. Reference Center of Behavioural Disturbances and Dementia School of Medicine University of Sao Paulo Sao Paulo Brazil. Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center University of Sao Paulo Sao Paulo Brazil. Center for Social and Cognitive Neuroscience School of Psychology Universidad Adolfo Ibáñez Santiago Chile. Neuropsychology and Clinical Neuroscience Laboratory (LANNEC) Physiopathology Program-Institute of Biomedical Sciences (ICBM) Neuroscience and East Neuroscience Dep

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Publisher Correction: Clarifying the effect of biodiversity on productivity in natural ecosystems with longitudinal data and methods for causal inference

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Nature communications 2023年第1期14卷 4131页

作者： Laura E Dee Paul J Ferraro Christopher N Severen Kaitlin A Kimmel Elizabeth T Borer Jarrett E K Byrnes Adam Thomas Clark Yann Hautier Andrew Hector Xavier Raynaud Peter B Reich Alexandra J Wright Carlos A Arnillas Kendi F Davies Andrew MacDougall Akira S Mori Melinda D Smith Peter B Adler Jonathan D Bakker Kate A Brauman Jane Cowles Kimberly Komatsu Johannes M H Knops Rebecca L McCulley Joslin L Moore John W Morgan Timothy Ohlert Sally A Power Lauren L Sullivan Carly Stevens Michel Loreau Department of Ecology and Evolutionary Biology University of Colorado Boulder CO USA. laura.dee@colorado.edu. Department of Environmental Health and Engineering Bloomberg School of Public Health & Whiting School of Engineering Johns Hopkins University Baltimore MD USA. pferrar5@jhu.edu. Carey Business School Johns Hopkins University Baltimore MD USA. pferrar5@jhu.edu. Research Department Federal Reserve Bank of Philadelphia Philadelphia PA USA. Department of Ecology and Evolutionary Biology University of Colorado Boulder CO USA. Department of Ecology Evolution and Behavior University of Minnesota St. Paul MN 55108 USA. Department of Biology University of Massachusetts Boston 100 Morissey Blvd Boston MA 02125 USA. Institute of Biology University of Graz Holteigasse 6 8010 Graz Austria. Ecology and Biodiversity Group Department of Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands. Department of Plant Sciences University of Oxford Oxford OX1 3RB UK. Sorbonne Université Université Paris Cité UPEC IRD CNRS INRA Institute of Ecology and Environmental Sciences iEES Paris Paris France. Institute for Global Change Biology and School for Environment and Sustainability University of Michigan Ann Arbor MI USA. Department of Forest Resources University of Minnesota St. Paul MN 55108 USA. Hawkesbury Institute for the Environment Western Sydney University Penrith NSW 2751 Australia. Department of Biological Sciences California State University Los Angeles Los Angeles CA USA. Department of Physical and Environmental Sciences University of Toronto at Scarborough Toronto 1265 Military Trail ON M1C 1A4 Canada. Department of Integrative Biology University of Guelph Guelph Ontario N1G 2W1 Canada. Research Center for Advanced Science and Technology The University of Tokyo 4-6-1 Komaba Meguro Tokyo 153-8904 Japan. Department of Biology Colorado State University Fort Collins CO 80523 USA. Graduate Degree Program in Eco

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

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Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

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Nature communications 2021年第1期12卷 2463页

作者： Joris Deelen Daniel S Evans Dan E Arking Niccolò Tesi Marianne Nygaard Xiaomin Liu Mary K Wojczynski Mary L Biggs Ashley van der Spek Gil Atzmon Erin B Ware Chloé Sarnowski Albert V Smith Ilkka Seppälä Heather J Cordell Janina Dose Najaf Amin Alice M Arnold Kristin L Ayers Nir Barzilai Elizabeth J Becker Marian Beekman Hélène Blanché Kaare Christensen Lene Christiansen Joanna C Collerton Sarah Cubaynes Steven R Cummings Karen Davies Birgit Debrabant Jean-François Deleuze Rachel Duncan Jessica D Faul Claudio Franceschi Pilar Galan Vilmundur Gudnason Tamara B Harris Martijn Huisman Mikko A Hurme Carol Jagger Iris Jansen Marja Jylhä Mika Kähönen David Karasik Sharon L R Kardia Andrew Kingston Thomas B L Kirkwood Lenore J Launer Terho Lehtimäki Wolfgang Lieb Leo-Pekka Lyytikäinen Carmen Martin-Ruiz Junxia Min Almut Nebel Anne B Newman Chao Nie Ellen A Nohr Eric S Orwoll Thomas T Perls Michael A Province Bruce M Psaty Olli T Raitakari Marcel J T Reinders Jean-Marie Robine Jerome I Rotter Paola Sebastiani Jennifer Smith Thorkild I A Sørensen Kent D Taylor André G Uitterlinden Wiesje van der Flier Sven J van der Lee Cornelia M van Duijn Diana van Heemst James W Vaupel David Weir Kenny Ye Yi Zeng Wanlin Zheng Henne Holstege Douglas P Kiel Kathryn L Lunetta P Eline Slagboom Joanne M Murabito Max Planck Institute for Biology of Ageing Cologne Germany. Joris.Deelen@age.mpg.de. Molecular Epidemiology Department of Biomedical Data Sciences Leiden University Medical Center Leiden The Netherlands. Joris.Deelen@age.mpg.de. California Pacific Medical Center Research Institute San Francisco CA USA. DEvans@***. McKusick-Nathans Institute of Genetic Medicine Department of Genetic Medicine Johns Hopkins University School of Medicine Baltimore MD USA. Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam The Netherlands. Department of Clinical Genetics Amsterdam UMC Amsterdam The Netherlands. Delft Bioinformatics Lab Delft University of Technology Delft The Netherlands. The Danish Aging Research Center Department of Public Health University of Southern Denmark Odense C Denmark. BGI-Shenzhen Shenzhen China. China National Genebank BGI-Shenzhen Shenzhen China. Division of Statistical Genomics Department of Genetics Washington University School of Medicine Saint Louis MO USA. Department of Biostatistics University of Washington Seattle WA USA. Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle WA USA. Department of Epidemiology Erasmus MC Rotterdam The Netherlands. Department of Biology Faculty of Natural Science University of Haifa Haifa Israel. Departments of Medicine and Genetics Albert Einstein College of Medicine Bronx NY USA. Institute for Social Research Survey Research Center University of Michigan Ann Arbor MI USA. Department of Biostatistics Boston University School of Public Health Boston MA USA. School of Public Health Department of Biostatistics University of Michigan Ann Arbor MI USA. Icelandic Heart Association Kópavogur Iceland. Department of Clinical Chemistry Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere Faculty of Medicine and Health Technology Tampere University Tampere Finland. I

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Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer

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Nature communications 2021年第1期12卷 7354页

作者： Wei Zhou Ben Brumpton Omer Kabil Julius Gudmundsson Gudmar Thorleifsson Josh Weinstock Matthew Zawistowski Jonas B Nielsen Layal Chaker Marco Medici Alexander Teumer Silvia Naitza Serena Sanna Ulla T Schultheiss Anne Cappola Juha Karjalainen Mitja Kurki Morgan Oneka Peter Taylor Lars G Fritsche Sarah E Graham Brooke N Wolford William Overton Humaira Rasheed Eirin B Haug Maiken E Gabrielsen Anne Heidi Skogholt Ida Surakka George Davey Smith Anita Pandit Tanmoy Roychowdhury Whitney E Hornsby Jon G Jonasson Leigha Senter Sandya Liyanarachchi Matthew D Ringel Li Xu Lambertus A Kiemeney Huiling He Romana T Netea-Maier Jose I Mayordomo Theo S Plantinga Jon Hrafnkelsson Hannes Hjartarson Erich M Sturgis Aarno Palotie Mark Daly Cintia E Citterio Peter Arvan Chad M Brummett Michael Boehnke Albert de la Chapelle Kari Stefansson Kristian Hveem Cristen J Willer Bjørn Olav Åsvold Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor Michigan USA. wzhou@***. Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts USA. wzhou@***. Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA. wzhou@***. Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge Massachusetts USA. wzhou@***. K.G. Jebsen Center for Genetic Epidemiology Department of Public Health and Nursing NTNU Norwegian University of Science and Technology Trondheim Norway. Medical Research Council (MRC) Integrative Epidemiology Unit University of Bristol Bristol UK. Department of Thoracic Medicine St. Olavs Hospital Trondheim University Hospital Trondheim Norway. Department of Biological Chemistry University of Michigan Medical School Ann Arbor Michigan USA. Division of Metabolism Endocrinology and Diabetes University of Michigan Medical School Ann Arbor Michigan USA. deCODE genetics/AMGEN 101 Reykjavik Iceland. Center for Statistical Genetics and Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA. Department of Internal Medicine Division of Cardiology University of Michigan Medical School Ann Arbor Michigan USA. Department of Epidemiology Research Statens Serum Institute Copenhagen Denmark. Erasmus MC Academic Center for Thyroid Diseases Rotterdam The Netherlands. Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands. Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands. Division of Endocrinology Department of Internal Medicine Radboud University Medical Centre Radboud Institute for Molecular Life Sciences 6500HB Nijmegen The Netherlands. Institute for Community Medicine University Medicine Greifswald Greifswald Germany. DZHK (German Center for Cardiovascular Research) Partner Site Greifswald Greifswald Germany. Istit

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Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts

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Journal of Translational Medicine 2017年第1期15卷 1-14页

作者： Vera Hirsh Sandro Pignata Melissa Bersanelli Donatello Gasparro Francesco Leonardi Sebastiano Buti Letizia Gnetti Cinzia Azzoni Lorena Bottarelli Enrico Maria Silini Erik Wennerberg Sandra Demaria Claire Vanpouille-Box Karsten Pilones Nils Rudqvist Julie Diamond Silvia Formenti Aranzazu Mediero Bruce Cronstein Zachary S. Morris Emily I. Guy David M. Francis Monica M. Gressett Eric A. Armstrong Shyhmin Huang Jacquelyn A. Hank Anna Hoefges Alexander L. Rakhmilevich Paul M. Harari Paul M. Sondel Stephen D. Gilles Alan J. Korman Yared Hailemichael Willem W. Overwijk Per thor Straten Alessandro Lugli Heather Dawson Annika Blank Inti Zlobec Luigi Fattore Susan Costantini Maria Elena Pisanu Paolo Antonio Ascierto Gennaro Ciliberto Debora Malpicci Mario Acunzo Giulia Romano Giovanni Nigita Carlo Maria Croce Alessandro Laganà Ciro Francesco Ruggiero Alessia Noto Claudia De Vitis Rita Mancini Michael Postow Jason Luke David Stroncek Luciano Castiello Wenjing Chen Ping Jin Jiaqiang Ren Marianna Sabatino Soldano Ferrone Connie PM Duong Marie Vetizou Laurence Zitvogel Marcella Occelli Carolina Cauchi Cristiana Lo Nigro Chiara Varamo Daniela Vivenza Silvia Violante Laura Lattanzio Marco Carlo Merlano Grazia Sciancalepore Giuseppe Forte Michela Rovera Zelda Seia Stefania Palazzini Fabiana Errico Davide Basso Laura Quaranta Fulvio Lavagna Paolo Bosio Duane Moogk Shi Zhong Victoria Fang Janna Dougherty Arianne Perez-Garcia Iman Osman Michelle Krogsgaard Zhiya Yu Nicholas P. Restifo Ivan Liadi Navin Varadarajan William Rittase Cheng Zhu Alan Frey Timea Balatoni Gabriella Liszkay Miklós Kasler Anita Moho Timea Sebestyén Anita Varga Judit Oláh Zsuzsanna Lengyel Gabriella Emri Andrea Ladányi Beatrice Polini Stefano Fogli Sara Carpi Maria Cristina Breschi Paola Nieri Barbara Pardini Alessio Naccarati Nevio Dubbini Antonella Romanini Francesca Morgese Davide Soldato Silvia Pagliaretta Riccardo Giampieri Silvia Rinaldi Mariangela Torniai Agnese Savini Azzurra Onofri Francesca Bianchi Rossana Berardi Donatella Brancorsini Anna Campanati McGill University Health Centre Cedars Cancer Centre Montreal QC Canada Dipartimento Uro-Ginecologico S.C. Oncologia Medica Uro-Ginecologica Istituto Nazionale Tumori Fondazione “G. Pascale” Napoli Italy Medical Oncology University Hospital of Parma Via Gramsci 14 43126 Parma PR Italy Anatomic Pathology Unit University Hospital of Parma Via Gramsci 14 43126 Parma PR Italy Weill Cornell Medicine Cornell University New York NY USA Department of Radiation Oncology Weill Cornell Medical College New York NY USA New York University Langone Medical Center New York NY USA Dept. of Human Oncology School of Medicine and Public Health University of Wisconsin Madison WI USA Provenance Biopharmaceuticals Carlisle MA USA Bristol-Myers Squibb Company Redwood City CA USA Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Hematology Center for Cancer Immune Therapy (CCIT) University Hospital Herlev Copenhagen Denmark Department of Immunology and Microbiology University of Copenhagen Copenhagen Denmark Institute of Pathology University of Bern Bern Switzerland Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale” Naples Italy Dipartimento di Chirurgia “P. Valdoni” Sapienza Università di Roma Rome Italy IRCCS Pascale Naples Italy Dipartimento Melanoma Tessuti molli Muscolo-Scheletrico e Testa-Collo Oncologia Medica Melanoma Immunoterapia Oncologica e Terapie Innovative Istituto Nazionale Tumori “G. Pascale” Via M. Semmola 80131 Naples Italy Dipartimento di Medicina Sperimentale e Clinica Università degli Studi di Catanzaro “Magna Graecia” Catanzaro Italy Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Comprehensive Cancer Center Columbus OH USA Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA Dipartimento di Medicina Clinica e Molecolare Sapienza Università di Roma Rome

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