Cancer arises as a consequence of accumulation of substantial alterations on the genome,transcriptome,and *** mining the association between these alterations and the cancer development will provide us the understandi...
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Cancer arises as a consequence of accumulation of substantial alterations on the genome,transcriptome,and *** mining the association between these alterations and the cancer development will provide us the understanding on the molecular mechanisms about cancer development and *** the past decade, with the rapid development on the omics' technologies especially on the high-throughput technologies,more
I will present an integrative, machine-learning method, incRNA, for whole-genome identification of non-coding RNAs (ncRNAs).It combines a large amount of expression data, epigenetics data, RNA secondary-structure stab...
I will present an integrative, machine-learning method, incRNA, for whole-genome identification of non-coding RNAs (ncRNAs).It combines a large amount of expression data, epigenetics data, RNA secondary-structure stability, and evolutionary conservation at the protein and nucleic-acid *** this model, we were able to separate known ncRNAs from coding sequences and other genomic elements with high accuracy (>93% AUC on an independent validation set), and find thousands of novel ncRNA candidates in *** and Arabidopsis .
作者：
Chen, Guo-QiangMOE Key Lab of Bioinformatics and Systems Biology
Department of Biological Science and Biotechnology School of Life Sciences Tsinghua-Peking Center for Life Sciences and Center for Nano and Micro Mechanics Tsinghua University Beijing 100084 China
DNA methylation is a chemical modification of the bases in genomes. This modification, most frequently found at CpG dinucleotides in eukaryotes, has been identified as having multiple critical functions in broad and d...
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DNA methylation is a chemical modification of the bases in genomes. This modification, most frequently found at CpG dinucleotides in eukaryotes, has been identified as having multiple critical functions in broad and diverse species of animals and plants, while mysteriously appears to be lacking from several other well-studied species. DNA methylation has well known and important roles in genome stability and defense, its pattern change highly correlates with gene regulation. Much evidence has linked abnormal DNA methylation to human diseases. Most prominently, aberrant DNA methylation is a common feature of cancer genomes. Elucidating the precise functions of DNA methylation therefore has great biomedical significance. Here we provide an update on large-scale experimental technologies for detecting DNA methylation on a genomic scale. We also discuss new prospect and challenges that computational biologist will face when analyzing DNA methylation data.
Background: The liver is the largest human internal organ-it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining *** these cell types the hepatocytes,...
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Background: The liver is the largest human internal organ-it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining *** these cell types the hepatocytes,which account for three-quarters of the liver’s volume,perform its main *** discover the molecular basis of hepatocyte function,we employed Massively Parallel Signature Sequencing (MPSS) to determine the transcriptomic profile of adult human hepatocytes obtained by laser capture microdissection (LCM).
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