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arXiv 2023年

作者： Wu, Yong Liu, Mingzhou Yan, Jing Fu, Yanwei Wang, Shouyan Wang, Yizhou Sun, Xinwei Institute of Science and Technology for Brain-Inspired Intelligence Fudan University China Computer Science Department Peking University China School of Data Science Fudan University China Key Laboratory of Computational Neuroscience Brain-Inspired Intelligence China MOE Frontiers Center for Brain Science Fudan University China Zhangjiang Fudan International Innovation Center China Engineering Research Center of AI & Robotics Ministry of Education Fudan University China

Assessing causal effects in the presence of unobserved confounding is a challenging problem. Existing studies leveraged proxy variables or multiple treatments to adjust for the confounding bias. In particular, the latter approach attributes the impact on a single outcome to multiple treatments, allowing estimating latent variables for confounding control. Nevertheless, these methods primarily focus on a single outcome, whereas in many real-world scenarios, there is greater interest in studying the effects on multiple outcomes. Besides, these outcomes are often coupled with multiple treatments. Examples include the intensive care unit (ICU), where health providers evaluate the effectiveness of therapies on multiple health indicators. To accommodate these scenarios, we consider a new setting dubbed as multiple treatments and multiple outcomes. We then show that parallel studies of multiple outcomes involved in this setting can assist each other in causal identification, in the sense that we can exploit other treatments and outcomes as proxies for each treatment effect under study. We proceed with a causal discovery method that can effectively identify such proxies for causal estimation. The utility of our method is demonstrated in synthetic data and sepsis disease. Copyright © 2023, The Authors. All rights reserved.

关键词： Intensive care units

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Ontology Revision based on Pre-trained Language Models

arXiv

引用

arXiv 2023年

作者： Ji, Qiu Zhang, Xiaoping Ye, Yuxin Qi, Guilin Li, Jiaye Li, Site Ren, Jianjie Lu, Songtao School of Modern Posts Institute of Modern Posts Nanjing University of Posts and Telecommunications Nanjing China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China National Data Center ofTraditional Chinese MedicineChina Academy of ChineseMedical Sciences Beijing100700 China College of Computer Science and Technology Jilin University Changchun130012 China School of Computer Science and Engineering Southeast University Nanjing China Key Laboratory of Computer Network and Information Integration Southeast University Ministry of Education Nanjing China School of Mathematics Southeast University Nanjing China Chien-Shiung Wu College Southeast University Nanjing China

Ontology revision aims to seamlessly incorporate a new ontology into an existing ontology and plays a crucial role in tasks such as ontology evolution, ontology maintenance, and ontology alignment. Similar to repair single ontologies, resolving logical incoherence in the task of ontology revision is also important and meaningful, because incoherence is a main potential factor to cause inconsistency and reasoning with an inconsistent ontology will obtain meaningless answers. To deal with this problem, various ontology revision approaches have been proposed to define revision operators and design ranking strategies for axioms in an ontology. However, they rarely consider axiom semantics which provides important information to differentiate axioms. In addition, pre-trained models can be utilized to encode axiom semantics, and have been widely applied in many natural language processing tasks and ontology-related ones in recent years. Therefore, in this paper, we study how to apply pre-trained models to revise ontologies. We first define four scoring functions to rank axioms based on a pre-trained model by considering various information from an ontology. Based on the functions, an ontology revision algorithm is then proposed to deal with unsatisfiable concepts at once. To improve efficiency, an adapted revision algorithm is designed to deal with unsatisfiable concepts group by group. We conduct experiments over 19 ontology pairs and compare our algorithms and scoring functions with existing ones. According to the experiments, our algorithms could achieve promising performance. The adapted revision algorithm could improve the efficiency largely, and at most about 90% of the time could be saved for some ontology pairs. Some of our scoring functions like reliableOnt cos could help a revision algorithm obtain better results in many cases, especially for those challenging ontology pairs like OM8. We also provide discussion about the overall experimental results and guidelin

关键词： Ontology

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Static and Dynamic Connectivity Structure of White-Matter Functional Network across the Adult Lifespan

Research Square

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Research Square 2024年

作者： LinLi, Zeqiang Hu, Kang Guo, Qingdong Guo, Shuixia School of Mathematics and Statistics Guangdong University of Foreign Studies Guangzhou510004 China MOE-LCSM School of Mathematics and Statistics Hunan Normal University Changsha410006 China School of Information Engineering Wuhan Business University Wuhan430056 China School of Mathematical Sciences Xiamen University Xiamen361005 China Key Laboratory of Applied Statistics and Data Science Hunan Normal University College of Hunan Province Changsha410006 China

Background. The maturation and ageing of the human brain involve intricate biological processes that result in complex changes in brain structure and function. Although the effects of aging on functional connectivity within gray matter (GM) regions have been extensively studied, the investigation of white matter (WM) functional changes remains limited. Methods. In this study, our aim was to investigate age-related trajectory in WM functional dynamics using resting-state functional magnetic resonance imaging (rs-fMRI) data from a large lifespan sample of 494 individuals. First, GM and WM functional networks (FNs) were identified by k-means clustering. Next, we performed static and dynamic analysis of WM functional network connectivity (FNC) to explore age effect on WM-FNs. Furthermore, we investigated recurrent patterns of dynamic FNC. Finally, we conducted several validation analyses to ensure replicability. Results. We identified 9 reliable WM and 12 GM FNs. The findings revealed age-related effects on WM FNC strength and WM-GM FNC dynamics, primarily including linear positive and U-shaped age trajectories in static FNC strength, as well as linear negative and inverted U-shaped age trajectories in FNC temporal variability. Additionally, we identified three distinct brain states with significant age-related differences. The aforementioned findings were largely replicated in the validation analysis. Conclusion. High integration and low temporal variability in WN-GM FNC may reflect a less efficient network system in older adults. These findings enhance our understanding of brain aging processes and provide insights into the trajectory of WM functional dynamics during normal ageing. © 2024, CC BY.

关键词： Trajectories

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A Relation-Constraint Link Prediction Model for Dynamic knowledge Graphs with Entity Drift

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ACM Transactions on knowledge Discovery from data 1000年

作者： Xiulin Zheng Peipei Li Zan Zhang Jia Wu Xindong Wu Key Laboratory of Knowledge Engineering with Big Data (the Ministry of Education of China) Hefei University of Technology China and School of Computer Science and Information Engineering Hefei University of Technology China School of Computing Faculty of Science and Engineering Macquarie University Australia

knowledge Graphs (KGs) often suffer from incompleteness and this issue motivates the task of knowledge Graph Completion (KGC). Traditional KGC models mainly concentrate on static KGs with a fixed set of entities and relations, or dynamic KGs with temporal characteristics, faltering in their generalization to constantly evolving KGs with possible irregular entity drift. Thus, in this paper, we propose a novel link prediction model based on the embedding representation to handle the incompleteness of KGs with entity drift, termed as DCEL. Unlike traditional link prediction, DCEL could generate precise embeddings for drifted entity without imposing any regular temporal characteristic. The drifted entity is added into the KG with its links to the existing entity predicted in an incremental fashion with no requirement to retrain the whole KG for computational efficiency. In terms of DCEL model, it fully takes advantages of unstructured textual description, and is composed of four modules, namely MRC (Machine Reading Comprehension), RCAA (Relation Constraint Attentive Aggregator), RSA (Relation Specific Alignment) and RCEO (Relation Constraint Embedding Optimization). Specifically, the MRC module is first employed to extract short texts from long and redundant descriptions. Then, RCAA is used to aggregate the embeddings of textual description of drifted entity and the pre-trained word embeddings learned from corpus to a single text-based entity embedding while shielding the impact of noise and irrelevant information. After that, RSA is applied to align the text-based entity embedding to graph-based space to obtain the corresponding graph-based entity embedding, and then the learned embeddings are fed into the gate structure to be optimized based on the RCEO to improve the accuracy of representation learning. Finally, the graph-based model TransE is used to perform link prediction for drifted entity. Extensive experiments conducted on benchmark datasets in terms of evaluat

关键词： dynamic knowledge graph entity drift link prediction relation constraint

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Exploring linguistic features and user engagement in Chinese online mental health counseling

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Heliyon 2024年第19期10卷 e38042页

作者： Zhang, Liyuan Liu, Dexi Li, Jing Wan, Changxuan Liu, Xiping School of Computer and Artificial Intelligence Jiangxi University of Finance and Economics JiangXi Nanchang 330013 China School of Mathematics and Computer YuZhang Normal College Jiangxi Nanchang 330013 China Jiangxi Key Laboratory of Data and Knowledge Engineering Jiangxi University of Finance and Economics Jiangxi Nanchang 330013 China School of Electronic Management Science Fujian Jiangxia University Fujian Fuzhou 350108 China

With the popularity of online mental health platforms, more individuals are seeking help and receiving social support by openly discussing their problems. Therefore, it's crucial to gain a deeper understanding of which problem disclosures and social support on these platforms can attract more user attention and engagement. Previous research has primarily focused on social media forums. Our work concentrates on the professional mental health platform, intending to understand the linguistic features present in posts that promote user engagement and interaction. We employ text mining and deep learning techniques to analyze posts consisting of 22,250 questions from help-seekers and 78,328 answers providing social support extracted from the Chinese online mental health counseling platform. Initially, we analyze the high-frequency words and topics of the questions and answers to gain insights into the primary focal points and the range of topics covered in these posts. The results indicate that work-related issues are the most concerning and troublesome for help-seekers, and the topics that users follow are approximately 8 types, including growth, family, in-love, marriage, emotions, human-relations, behavioral-therapy and career. Subsequently, we analyze the language usage in question-and-answer posts with different engagement from three aspects: vocabulary categories, linguistic style matching, and language modeling, aiming to identify which linguistic features can attract more user attention and engagement. The results reveal that high-engagement answer posts exhibit a higher degree of linguistic style matching with the corresponding questions, and the use of vocabulary categories also influences the attention and engagement of the posts. By exploring the linguistic features and patterns displayed in posts with different levels of engagement on the professional online mental health platform, this study offers deep insights into user behavior and the factors that impact

关键词： Language modeling Linguistic style matching Online mental health counseling The topics of questions and answers Vocabulary categories

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PR-PL: A Novel Transfer Learning Framework with Prototypical Representation based Pairwise Learning for EEG-Based Emotion Recognition

arXiv

引用

arXiv 2022年

作者： Zhou, Rushuang Zhang, Zhiguo Fu, Hong Zhang, Li Li, Linling Huang, Gan Dong, Yining Li, Fali Yang, Xin Jane, Zhen Liang School of Biomedical Engineering Health Science Center Shenzhen University Shenzhen China Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging Shenzhen China School of Computer Science and Technology Harbin Insti- tute of Technology Shenzhen China Marshall Laboratory of Biomedical Engineering Shenzhen China Peng Cheng Laboratory Shenzhen China Department of Mathematics and Information Technology The Education University of Hong Kong Hong Kong School of Data Science City University of Hong Kong Hong Kong The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China China School of Life Science and Technology Center for Information in Medicine University of Electronic Science and Technology of China China

Affective brain-computer interfaces based on electroencephalography (EEG) is an important branch in the field of affective computing. However, individual differences and noisy labels seriously limit the effectiveness and generalizability of EEG-based emotion recognition models. In this paper, we propose a novel transfer learning framework with Prototypical Representation based Pairwise Learning (PR-PL) to learn discriminative and generalized prototypical representations for emotion revealing across individuals and formulate emotion recognition as pairwise learning for alleviating the reliance on precise label information. More specifically, a prototypical learning-based adversarial discriminative domain adaptation method is developed to encode the inherent emotion-related semantic structure of EEG data, while pairwise learning with an adaptive pseudo-labeling method is developed to achieve a reliable and stable model learning with noisy labels. Through domain adaptation, feature representations of source and target domains are aligned on a shared feature space, while the feature separability of both source and target domains is also considered. The characterized prototypical representations are evident with a high feature concentration within one single emotion category and a high feature separability across different emotion categories. Extensive experiments are conducted on two benchmark databases under four cross-validation evaluation protocols (cross-subject cross-session, cross-subject within-session, within-subject cross-session, and within-subject within-session). The experimental results demonstrate the superiority of the proposed PR-PL against the state-of-the-arts under all four evaluation protocols, which shows the effectiveness and generalizability of PR-PL in dealing with the ambiguity of EEG responses in affective studies. The source code is available at https://***/KAZABANA/PR-PL. Copyright © 2022, The Authors. All rights reserved.

关键词： Electrophysiology

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DPHL:A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.M.Ijzermans John W.M.Martens Renske D.M.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta Mantoo Sze S.Lee Serene J.Y.Yeow Syed M.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang Man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan Meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding Ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of Medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by *** data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

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Micro-Expression Recognition based on 2D Gabor Filter and Sparse Representation

引用

Journal of Physics: Conference Series 2017年第1期787卷

作者： Hao Zheng Key Laboratory of Trusted Cloud Computing and Big Data Analysis School of Information Engineering Nanjing XiaoZhuang University Nanjing China MOE Key Laboratory of Computer Network and Information Integration School of Computer Science and Engineering Southeast University Nanjing China State Key Laboratory for Novel Software Technology Nanjing University Nanjing China

Micro-expression recognition is always a challenging problem for its quick facial expression. This paper proposed a novel method named 2D Gabor filter and Sparse Representation (2DGSR) to deal with the recognition of micro-expression. In our method, 2D Gabor filter is used for enhancing the robustness of the variations due to increasing the discrimination power. While the sparse representation is applied to deal with the subtlety, and cast recognition as a sparse approximation problem. We compare our method to other popular methods in three spontaneous micro-expression recognition databases. The results show that our method has more excellent performance than other methods.

关键词：

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Poisoning attack against estimating from pairwise comparisons

arXiv

引用

arXiv 2021年

作者： Ma, Ke Xu, Qianqian Zeng, Jinshan Cao, Xiaochun Huang, Qingming The School of Computer Science and Technology University of Chinese Academy of Sciences Beijing100049 China The Artificial Intelligence Research Center Peng Cheng Laboratory Shenzhen518055 China The Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China The School of Computer and Information Engineering Jiangxi Normal University Jiangxi Nanchang330022 China Institute of Information Engineering Chinese Academy of Sciences Beijing100093 China The School of Cyber Security University of Chinese Academy of Sciences Beijing100049 China The Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China The School of Computer Science and Technology University of Chinese Academy of Sciences Beijing100049 China The Key Laboratory of Big Data Mining and Knowledge Management The School of Economics and Management University of Chinese Academy of Sciences Beijing100049 China

As pairwise ranking becomes broadly employed for elections, sports competitions, recommendation, information retrieval and so on, attackers have strong motivation and incentives to manipulate or disrupt the ranking list. They could inject malicious comparisons into the training data to fool the target ranking algorithm. Such a technique is called "poisoning attack" in regression and classification tasks. In this paper, to the best of our knowledge, we initiate the first systematic investigation of data poisoning attack on the pairwise ranking algorithms, which can be generally formalized as the dynamic and static games between the ranker and the attacker, and can be modeled as certain kinds of integer programming problems mathematically. To break the computational hurdle of the underlying integer programming problems, we reformulate them into the distributionally robust optimization (DRO) problems, which are computational tractable. Based on such DRO formulations, we propose two efficient poisoning attack algorithms and establish the associated theoretical guarantees including the existence of Nash equilibrium and the generalization ability bounds. The effectiveness of the suggested poisoning attack strategies is demonstrated by a series of toy simulations and several real data experiments. These experimental results show that the proposed methods can significantly reduce the performance of the ranker in the sense that the correlation between the true ranking list and the aggregated results with toxic data can be decreased dramatically. © 2021, CC BY-NC-ND.

关键词： Toys

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Culture versus Policy: More Global Collaboration to Effectively Combat COVID-19

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The Innovation 2020年第2期1卷 15-16页

作者： Jianping Li Kun Guo Enrique Herrera Viedma Heesoek Lee Jiming Liu Ning Zhong Luiz Flavio Autran Monteiro Gomes Florin Gheorghe Filip Shu-Cherng Fang Mujgan SagirÖzdemir Xiaohui Liu Guoqing Lu Yong Shi School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of SciencesBeijing 100190China Research Center on Fictitious Economy&Data Science Chinese Academy of SciencesBeijing 100190China Department of Computer Science and Artificial Intelligence E.T.S.de Ingenieria Informatica y de TelecomunicacionesUniversity of Granada18071 GranadaSpain Department of Information Management Korea Advanced Institute of Science and TechnologySeoul 207-43 Korea Department of Computer Science and HKBU-CSD&NIPD Joint Research Laboratory for Intelligent Disease Surveillance and Control Hong Kong Baptist UniversityHong KongChina Department of Life Science and Informatics Maebashi Institute of TechnologyMaebashi 371-0816Japan Ibmec University Center Av.Presidente Wilson118Office#111020030-020 Rio de JaneiroBrazil The Romanian Academy Bucharest010071Romania Industrial and Systems Engineering Department North Carolina State UniversityRaleighNC 27695USA Department of Industrial Engineering Eskisehir Osmangazi University26480 EskisehirTurkey Department of Computer Science Brunel University LondonLondonUB83PHUK Department of Biology and School of Interdisciplinary Informatics University of Nebraska at OmahaOmahaNE 68182USA College of Information Science and Technology University of Nebraska at OmahaOmahaNE 68182USA

The outbreak of COVID-19 seriously challenges every government with regard to capacity and management of public health systems facing the catastrophic *** and anti-epidemic policy do not necessarily conflict with each *** countries and governments should be more tolerant to each other in seeking cultural and political consensus to overcome this historically tragic pandemic together.

关键词： seeking overcome policy

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