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Glucose-Responsive Charge-Switchable Lipid Nanoparticles for Insulin Delivery

Angewandte Chemie 2023年第20期135卷

作者： Yun Liu Yanfang Wang Yuejun Yao Juan Zhang Wei Liu Kangfan Ji Xinwei Wei Yuanwu Wang Prof. Xiangsheng Liu Prof. Shiming Zhang Prof. Jinqiang Wang Prof. Zhen Gu Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical Sciences Zhejiang University 310058 Hangzhou China Jinhua Institute of Zhejiang University 321299 Jinhua China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Methodology (lead) Software (lead) Validation (lead) Visualization (lead) Writing - original draft (lead) Writing - review & editing (lead) Contribution: Data curation (supporting) Investigation (supporting) Visualization (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) Investigation (supporting) Contribution: Formal analysis (supporting) Investigation (supporting) Methodology (supporting) Contribution: Formal analysis (supporting) Investigation (supporting) Contribution: Writing - review & editing (supporting) Contribution: Investigation (supporting) Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences 310022 Hangzhou China Department of Electrical and Electronic Engineering The University of Hong Kong 999077 Hong Kong SAR China Second Affiliated Hospital Zhejiang University School of Medicine 310009 Hangzhou China Contribution: Conceptualization (lead) Data curation (equal) Formal analysis (equal) Funding acquisition (lead) Investigation (lead) Methodology (equal) Project administration (lead) Resources (lead) Software (lead) Supervision (lead) Validation (supporting) Visualization (supporting) Writing - review & editing (lead) Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University 310009 Hangzhou China Zhejiang Laboratory of Systems & Precision Medicine Zhejiang University Medical Center 310009 Hangzhou China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University 310009 Hangzhou China Contribution: Funding acquisition (lead) Project administration (lead) Resources (lead) Softwar

Lipid nanoparticle-based drug delivery systems have a profound clinical impact on nucleic acid-based therapy and vaccination. Recombinant human insulin, a negatively-charged biomolecule like mRNA, may also be delivered by rationally-designed positively-charged lipid nanoparticles with glucose-sensing elements and be released in a glucose-responsive manner. Herein, we have designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles in an aqueous solution. Upon mixing insulin and the lipid nanoparticles, a heterostructured insulin complex is formed immediately arising from the electrostatic attraction. In a hyperglycemia-relevant glucose solution, lipid nanoparticles become less positively charged over time, leading to reduced attraction and subsequent insulin release. Compared with native insulin, this lipid nanoparticle-based glucose-responsive insulin shows prolonged blood glucose regulation ability and blood glucose-triggered insulin release in a type 1 diabetic mouse model.

关键词： Diabetes Drug Delivery Glucose-Responsive Insulin Delivery Lipid Nanoparticles

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Corrigendum to: Multi-Swarm Cuckoo Search Algorithm withQ-Learning Model

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The Computer Journal 2022年第7期65卷 1938-1938页

作者： Li, Juan Xiao, Dan-dan Zhang, Ting Liu, Chun Li, Yuan-xiang Wang, Gai-ge School of Artificial Intelligence Wuhan Technology and Business University Wuhan 430065 China School of Artificial Intelligence Wuchang University of Technology Wuhan 430223 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University No. 2699 Qianjin Street Gaoxin District Changchun Jilin China 130012 School of Computer Wuhan University No. 299 Bayi Street Wuchang District Wuhan Hubei China 430072 Department of Computer Science and Technology Ocean University of China No. 238 Songling Street Laoshan District Qingdao Shandong China 266100 Institute of Algorithm and Big Data Analysis Northeast Normal University No. 5268 Renmin Street Nanguan District Changchun Jilin China 130117

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NaCdSb: An Orthorhombic Zintl Phase with Exceptional Intrinsic Thermoelectric Performance

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Angewandte Chemie 2022年第3期135卷

作者： Kai Guo Yuting Zhang Song Yuan Qinghang Tang Chen Lin Pengfei Luo Jiong Yang Shusheng Pan Li-Dong Zhao Guofeng Cheng Jiye Zhang Jun Luo School of Physics and Materials Science Guangzhou University Guangzhou 510006 China Research Center for Advanced Information Materials (CAIM) Huangpu Research & Graduate School of Guangzhou University Sino-Singapore Guangzhou Knowledge City Huangpu District Guangzhou 510555 China Contribution: Conceptualization (lead) Formal analysis (equal) Writing - original draft (lead) School of Materials Science and Engineering Shanghai University 99 Shangda Road Shanghai 200444 China Contribution: Data curation (equal) Investigation (equal) Validation (lead) Contribution: Data curation (lead) Formal analysis (equal) Materials Genome Institute Shanghai University 99 Shangda Road Shanghai 200444 China Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education and School of Physics and Technology Wuhan University Wuhan 430072 China Contribution: Investigation (equal) Contribution: Investigation (equal) Methodology (supporting) Contribution: Investigation (equal) Writing - review & editing (supporting) School of Materials Science and Engineering Beihang University Beijing 100191 China Contribution: Methodology (equal) Writing - review & editing (equal) Analysis & Testing Center for Inorganic Materials Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Contribution: Formal analysis (equal) Investigation (supporting) Contribution: Data curation (equal) Writing - review & editing (supporting) Contribution: Supervision (lead) Writing - review & editing (equal)

Many Zintl phases are promising thermoelectric materials owning to their features like narrow band gaps, multiband behaviors, ideal charge transport tunnels, and loosely bound cations. Herein we show a new Zintl phase NaCdSb with exceptional intrinsic thermoelectric performance. Pristine NaCdSb exhibits semiconductor behaviors with an experimental hole concentration of 2.9×10 18 cm −3 and a calculated band gap of 0.5 eV. As the temperature increases, the hole concentration rises gradually and approaches its optimal one, leading to a high power factor of 11.56 μW cm −1 K −2 at 673 K. The ultralow thermal conductivity is derived from the small phonon group velocity and short phonon lifetime, ascribed to the structural anharmonicity of Cd−Sb bonds. As a consequence, a maximum zT of 1.3 at 673 K has been achieved without any doping optimization or structural modification, demonstrating that NaCdSb is a remarkable thermoelectric compound with great potential for performance improvement.

关键词： Electron-Crystal NaCdSb Phonon-Glass Thermoelectric Properties Zintl Phase

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scTenifoldXct: A semi-supervised method for predicting cell-cell interactions and mapping cellular communication graphs

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Cell systems 2023年第4期14卷 302-311.e4页

作者： Yongjian Yang Guanxun Li Yan Zhong Qian Xu Yu-Te Lin Cristhian Roman-Vicharra Robert S Chapkin James J Cai Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA. Department of Statistics Texas A&M University College Station TX 77843 USA. Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University 3663 North Zhongshan Road Shanghai 200062 China. Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan. Department of Nutrition and the Program in Integrative Nutrition & Complex Diseases Texas A&M University College Station TX 77843 USA. Electronic address: r-chapkin@tamu.edu. Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA Interdisciplinary Program of Genetics Texas A&M University College Station TX 77843 USA. Electronic address: jcai@tamu.edu.

We present scTenifoldXct, a semi-supervised computational tool for detecting ligand-receptor (LR)-mediated cell-cell interactions and mapping cellular communication graphs. Our method is based on manifold alignment, using LR pairs as inter-data correspondences to embed ligand and receptor genes expressed in interacting cells into a unified latent space. Neural networks are employed to minimize the distance between corresponding genes while preserving the structure of gene regression networks. We apply scTenifoldXct to real datasets for testing and demonstrate that our method detects interactions with high consistency compared with other methods. More importantly, scTenifoldXct uncovers weak but biologically relevant interactions overlooked by other methods. We also demonstrate how scTenifoldXct can be used to compare different samples, such as healthy vs. diseased and wild type vs. knockout, to identify differential interactions, thereby revealing functional implications associated with changes in cellular communication status.

关键词： cell-cell interaction cellular communication gene regression network machine learning manifold alignment neural networks scRNA-seq single-cell RNA sequencing

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Corrigendum to: The TianQin project: current progress on science and technology

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Progress of Theoretical and Experimental Physics 2021年第5期2021卷

作者： Mei, Jianwei Bai, Yan-Zheng Bao, Jiahui Barausse, Enrico Cai, Lin Canuto, Enrico Cao, Bin Chen, Wei-Ming Chen, Yu Ding, Yan-Wei Duan, Hui-Zong Fan, Huimin Feng, Wen-Fan Fu, Honglin Gao, Qing Gao, TianQuan Gong, Yungui Gou, Xingyu Gu, Chao-Zheng Gu, De-Feng He, Zi-Qi Hendry, Martin Hong, Wei Hu, Xin-Chun Hu, Yi-Ming Hu, Yuexin Huang, Shun-Jia Huang, Xiang-Qing Jiang, Qinghua Jiang, Yuan-Ze Jiang, Yun Jiang, Zhen Jin, Hong-Ming Korol, Valeriya Li, Hong-Yin Li, Ming Li, Pengcheng Li, Rongwang Li, Yuqiang Li, Zhu Li, Zhulian Li, Zhu-Xi Liang, Yu-Rong Liang, Zheng-Cheng Liao, Fang-Jie Liu, Qi Liu, Shuai Liu, Yan-Chong Liu, Li Liu, Pei-Bo Liu, Xuhui Liu, Yuan Lu, Xiong-Fei Lu, Yang Lu, Ze-Huang Luo, Yan Luo, Zhi-Cai Milyukov, Vadim Ming, Min Pi, Xiaoyu Qin, Chenggang Qu, Shao-Bo Sesana, Alberto Shao, Chenggang Shi, Changfu Su, Wei Tan, Ding-Yin Tan, Yujie Tan, Zhuangbin Tu, Liang-Cheng Wang, Bin Wang, Cheng-Rui Wang, Fengbin Wang, Guan-Fang Wang, Haitian Wang, Jian Wang, Lijiao Wang, Panpan Wang, Xudong Wang, Yan Wang, Yi-Fan Wei, Ran Wu, Shu-Chao Xiao, Chun-Yu Xu, Xiao-Shi Xue, Chao Yang, Fang-Chao Yang, Liang Yang, Ming-Lin Yang, Shan-Qing Ye, Bobing Yeh, Hsien-Chi Yu, Shenghua Zhai, Dongsheng Zhang, Caishi Zhang, Haitao Zhang, Jian-dong Zhang, Jie Zhang, Lihua Zhang, Xin Zhang, Xuefeng Zhou, Hao Zhou, Ming-Yue Zhou, Ze-Bing Zhu, Dong-Dong Zi, Tie-Guang Luo, Jun TianQin Research Center for Gravitational Physics & School of Physics and Astronomy Sun Yat-sen University (Zhuhai Campus) Zhuhai 519082 P.R. China Centre for Gravitational Experiments School of Physics MOE Key Laboratory of Fundamental Physical Quantities Measurement & Hubei Key Laboratory of Gravitation and Quantum Physics PGMF Huazhong University of Science and Technology Wuhan 430074 P.R. China SISSA Via Bonomea 265 34136 Trieste Italy and INFN Sezione di Trieste & IFPU – Institute for Fundamental Physics of the Universe Via Beirut 2 34014 Trieste Italy Former Faculty Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy Yunnan Observatories Chinese Academy of Sciences Kunming 650011 China School of Physical Science and Technology Southwest University Chongqing 400715 China Beijing Institute of Control Engineering Beijing 100094 P.R. China SUPA School of Physics and Astronomy University of Glasgow Glasgow G12 8QQ UK DFH Satellite Co. Ltd. Beijing 100094 P.R. China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing 100049 China School of Physics and Astronomy University of Birmingham Birmingham B15 2TT United Kingdom Center for High Energy Physics & Department of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University No. 5 Yiheyuan Rd Beijing 100871 P.R. China Lomonosov Moscow State University Sternberg Astronomical Institute Moscow 119992 Russia Dipartimento di Fisica “G. Occhialini” Universitá degli Studi Milano Bicocca Piazza della Scienza 3 I-20126 Milano Italy School of Aeronautics and Astronautics Shanghai Jiao Tong University Shanghai 200240 China Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 & School of Astronomy and Space Science University of Science and Technology of China Hefei Anhui 230026 P.R. China Max-Planck-Institut für Gravitationsphysik (Al

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Dense sampling of bird diversity increases power of comparative genomics (vol 587, pg 252, 2020)

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NATURE 2021年第7856期592卷 E24-E24页

作者： Feng, Shaohong Stiller, Josefin Deng, Yuan Armstrong, Joel Fang, Qi Reeve, Andrew Hart Xie, Duo Chen, Guangji Guo, Chunxue Faircloth, Brant C. Petersen, Bent Wang, Zongji Zhou, Qi Diekhans, Mark Chen, Wanjun Andreu-Sanchez, Sergio Margaryan, Ashot Howard, Jason Travis Parent, Carole Pacheco, George Sinding, Mikkel-Holger S. Puetz, Lara Cavill, Emily Ribeiro, Angela M. Eckhart, Leopold Fjeldsa, Jon Hosner, Peter A. Brumfield, Robb T. Christidis, Les Bertelsen, Mads F. Sicheritz-Ponten, Thomas Tietze, Dieter Thomas Robertson, Bruce C. Song, Gang Borgia, Gerald Claramunt, Santiago Lovette, Irby J. Cowen, Saul J. Njoroge, Peter Dumbacher, John Philip Ryder, Oliver A. Fuchs, Jerome Bunce, Michael Burt, David W. Cracraft, Joel Meng, Guanliang Hackett, Shannon J. Ryan, Peter G. Jonsson, Knud Andreas Jamieson, Ian G. da Fonseca, Rute R. Braun, Edward L. Houde, Peter Mirarab, Siavash Suh, Alexander Hansson, Bengt Ponnikas, Suvi Sigeman, Hanna Stervander, Martin Frandsen, Paul B. van der Zwan, Henriette van der Sluis, Rencia Visser, Carina Balakrishnan, Christopher N. Clark, Andrew G. Fitzpatrick, John W. Bowman, Reed Chen, Nancy Cloutier, Alison Sackton, Timothy B. Edwards, Scott V. Foote, Dustin J. Shakya, Subir B. Sheldon, Frederick H. Vignal, Alain Soares, Andre E. R. Shapiro, Beth Gonzalez-Solis, Jacob Ferrer-Obiol, Joan Rozas, Julio Riutort, Marta Tigano, Anna Friesen, Vicki Dalen, Love Urrutia, Araxi O. Szekely, Tamas Liu, Yang Campana, Michael G. Corvelo, Andre Fleischer, Robert C. Rutherford, Kim M. Gemmell, Neil J. Dussex, Nicolas Mouritsen, Henrik Thiele, Nadine Delmore, Kira Liedvogel, Miriam Franke, Andre Hoeppner, Marc P. Krone, Oliver Fudickar, Adam M. Mila, Borja Ketterson, Ellen D. Fidler, Andrew Eric Friis, Guillermo Parody-Merino, Angela M. Battley, Phil F. Cox, Murray P. Lima, Nicholas Costa Barroso Prosdocimi, Francisco Parchman, Thomas Lee Schlinger, Barney A. Loiselle, Bette A. Blake, John G. Lim, Haw Chuan Day, Lainy B. Fuxjager, Matthew J. Baldwin, Maude W. Braun, Michael J. Wirthlin, Morgan Dikow, China National GeneBank BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China BGI-Shenzhen Shenzhen China Villum Centre for Biodiversity Genomics Section for Ecology and Evolution Department of Biology University of Copenhagen Copenhagen Denmark BGI Education Center University of Chinese Academy of Sciences Shenzhen China MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute Zhejiang University Hangzhou China Department of Neuroscience and Developmental Biology University of Vienna Vienna Austria Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China James D. Watson Institute of Genome Sciences Hangzhou China UC Santa Cruz Genomics Institute UC Santa Cruz Santa Cruz CA USA Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark Center for Macroecology Evolution and Climate GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Biological Sciences Louisiana State University Baton Rouge LA USA Museum of Natural Science Louisiana State University Baton Rouge LA USA Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) Faculty of Applied Sciences AIMST University Kedah Malaysia Section for Evolutionary Genomics The GLOBE Institute Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Institute of Molecular Biology National Academy of Sciences Yerevan Armenia University Museum Norwegian University of Science and Technology Trondheim Norway Center for Reproductive Medicine The 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Novogene Durham NC USA Duke University Medical Center Durham NC USA The Rockefeller University New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA Department of Dermatology Medical University of Vienna Vienna Austria

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. Ehrlich Leon B. Ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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