The study of luminescence phenomena in non-conjugated systems,namely clusteroluminescence,has gained significant attention for the development of advanced luminescent *** conventional strategies to manipulate the lumi...
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The study of luminescence phenomena in non-conjugated systems,namely clusteroluminescence,has gained significant attention for the development of advanced luminescent *** conventional strategies to manipulate the luminescent performances are based on complicated chemical *** contrast,nature employs complexation to modulate luminescence,inspiring researchers to adopt an engineering approach for the construction of efficient *** this work,we explore the complexationinduced clusteroluminescence of carbonyl-based polymers with nitrogen-containing organic bases,exemplified by polyamide,polyester,polycarbonate,and poly(monothiocarbonate).
N6-Methyladenosine (mA) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, mA modifica...
N6-Methyladenosine (mA) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, mA modification of mRNAs increases in cancer cells. Deletion of methyltransferase-like 3 (METTL3) down-regulates mA, impairs the migration, invasion and EMT of cancer cells both in vitro and in vivo. mA-sequencing and functional studies confirm that Snail, a key transcription factor of EMT, is involved in mA-regulated EMT. mA in Snail CDS, but not 3'UTR, triggers polysome-mediated translation of Snail mRNA in cancer cells. Loss and gain functional studies confirm that YTHDF1 mediates mA-increased translation of Snail mRNA. Moreover, the upregulation of METTL3 and YTHDF1 act as adverse prognosis factors for overall survival (OS) rate of liver cancer patients. Our study highlights the critical roles of mA on regulation of EMT in cancer cells and translation of Snail during this process.
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