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Reconstruction of Core-Shell Dispersed Particles in Impact Polypropylene Copolymer during Extrusion

Chinese Journal of Polymer Science 2015年第4期33卷 633-645页

作者： Feng Chen Bi-wei Qiu Ya-nan Ye Yu-hua Lv 上官勇刚 Yi-hu Song 郑强 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

We reported an approach to reconstruct the complex phase morphology of impact polypropylene copolymer （IPC） with core-shell dispersed particles and to optimize its toughness in approximate shear condition. The molten-state annealing results indicate that the phase structure with core-shell dispersed particles is unstable and could be completely destroyed by static annealing, resulting in the degradation of impact strength. By using a co-rotating twin screw extruder, we found that the dispersed particle with core-shell structure could be rebuilt in appropriate condition with the recovery of excellent impact strength due to both the huge interfacial tension during solidification and the great difference in viscosity of components. Results reveal that almost all the extruded IPCs show the impact strength 60%-90% higher than that of annealed IPCs at room temperature. And the twice-extruded IPC shows the highest impact strength, 446% higher than that of IPC annealed for 30 min. As for low temperature tests, the impact strength of extruded IPCs also increases by 33%-58%. According to adjusting the processing conditions including extrusion speed, extrusion frequency and temperature, an optimization of toughness was well established.

关键词： Impact polypropylene copolymer Shear Phase morphology Core-shell dispersed particle Impact strength.

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Effects of Composition on Microstructure and Crystallization Behavior for Impact Polypropylene Copolymer Investigated by Restructuring the Complex Core-Shell Dispersed Particles in Ternary Blends

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Chinese Journal of Polymer Science 2015年第1期33卷 95-108页

作者： Bi-wei Qiu Feng Chen 上官勇刚 Yu Lin 郑强 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

A series of ternary blends of polypropylene/ethylene-propylene random copolymer/ethylene-propylene segmented copolymer（HPP/EPR/Eb P） whose microstructures are similar to those of impact polypropylene copolymer（IPC） were prepared in order to systematically investigate the effects of composition on microstructure and crystallization behavior of IPC. The observation of primary phase morphology reveals that the dispersed phase with core-shell structure could be rebuilt in certain composition and excessive EPR leads to a bicontinuous phase structure in ternary blends. After undergoing same quiescent crystallization including isothermal and non-isothermal crystallization, these blend samples exhibit special composition-dependent melting behavior, i.e., the melting point increases markedly with the increase of EPR content until it turns down at a critical content（about 30 wt%）. The crystallization behavior is mainly ascribed to the different nucleation abilities. It is suggested that although the compatibility between EPR and HPP components becomes worse with the increase of EPR content due to the increased interfacial area and the decreased concentration of Eb P, higher EPR content in the blend facilitates to heterogeneous nucleation except for the appearance of obvious bicontinuous phase structure.

关键词： Core-shell dispersed phase Microstrcture Crystallization Nucleation.

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MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFTPOLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES:IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY

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Chinese Journal of Polymer Science 2012年第5期30卷 719-726页

作者： Li-li Xie 仝维鋆 Jian-quan Xu Chang-you Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

To improve the colloidal stability of bovine serum albumin （BSA） nanoparticles （hiPs） in diverse mediums, poly（allylamine hydrochloride）（PAH）/sodium poly（4-styrene sulfonate）（PSS） multilayers and poly（allylamine hydrochloride）-graft-poly（ethylene glycol）（PAH-g-PEG） coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering （DLS）. Multilayers and PAH-g-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index （PDI）. The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-g-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9, the encapsulation efficiency of doxorubicin reaches almost 99%, and the release rate at pH 5.5 is significantly higher than that at pH 7.4.

关键词： BSA nanoparticle PEG LBL Drug delivery pH-responsive.

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synthesis AND PROPERTIES OF ORGANIC-INORGANIC HYBRID P(NIPAM-co-AM-co-TMSPMA)MICROGELS

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Chinese Journal of Polymer Science 2011年第4期29卷 439-449页

作者：杜滨阳 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science & Engineering Zhejiang University

Utilizing the hydrolysis and condensation of the methoxysilyl moieties, organic-inorganic hybrid poly（N- isopropylacrylamide-co-acrylamide-co-3-（trimethoxysilyl）propylmethacrylate） P（NIPAM-eo-AM-eo-TMSPMA） microgels were prepared via two different methods. The first method was that the microgels were post-fabricated from the cross- linkable linear P（NIPAM-co-AM-co-TMSPMA） terpolymer aqueous solutions above the lower critical solution temperature （LCST） of the terpolymer. For the second method, the mierogels were directly synthesized by conventional surfactant free emulsion copolymerization of NIPAM, AM, and TMSPMA. The hydrodynamic diameter and stability of the resultant P（NIPAM-co-AM-co-TMSPMA） microgels strongly depend on the pH and temperature of the microgel aqueous solution. The hydrodynamic diameters of the microgels decreased with increasing the measuring temperature. The phase transition temperature of the microgels was found to be around 34℃, which was independent of the initial terpolymer concentration and shifted to lower temperature with increasing the preparation temperature. Increasing the initial amount of AM will enhance the instability of the microgels at high pH values. Moreover, the P（NIPAM-co-AM-eo-TMSPMA） microgels obtained from the linear terpolymer had more homogeneous microstructures as compared with the corresponding NIPAM/AM/TMSPMA microgels prepared by one step emulsion copolymerization as revealed by light scattering measurements.

关键词： Microgel Thermo-sensitive Hybrid.

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Dual inhibition of PD-1 and LAG-3:uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity

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Science Bulletin 2025年第5期70卷 624-626页

作者： Xiaoxue Zhou Fangfang Zhou Long Zhang School of Medicine Hangzhou City UniversityHangzhou 310015China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China The First Affiliated Hospital the Institutes of Biology and Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhou 215031China MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330031China Cancer Center Zhejiang UniversityHangzhou 310058China

Recent studies published in Cell have elucidated the collaborative roles of LAG-3 and PD-1 in driving T cell exhaustion,revealing how targeting both immune checkpoints could enhance immune responses[1],[2],[3].Among these,two studies were led by Dario ***'s team at the University of Pittsburgh School of Medicine,while the third was conducted by *** Wherry's team at the University of Pennsylvania.

关键词： immunity driving exhaustion

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Erratum to “Supramolecular microgels/microgel scaffolds for tissue repair and regeneration” [Supramolecular Materials 1 (2022) 100006]

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Supramolecular Materials 2025年 4卷

作者： Kai Wang Zhaoyi Wang Haijun Hu Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

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Gold nanoparticles with surface-anchored chiral poly（acryloyI-L（D）-valine） induce differential response on mesenchymal stem cell osteogenesis

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Nano Research 2016年第12期9卷 3683-3694页

作者： Jun Deng Honghao Zheng Xiaowen Zheng Mengyun Yao Zheng Li Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering ZhejiangUniversity Hangzhou 310027 China

Chirality is one of the most distinctive biochemical signatures of life, and plays crucial roles in maintaining normal functions of living cells or organisms. Pioneering work from another group has demonstrated the dependency of cell differentiation on the chirality of nano-coated substrates, but the effect of the chiral surface of nanoparticles on stem cell fates has not been investigated. In this study, the influence of molecular chiral poly（acryloyl-L（D）-valine）（L（D）- PAV）-anchored gold nanoparticles （L（D）-PAV-AuNPs） on the differentiation of mesenchymal stem cells （MSCs） was investigated. Though osteogenic differentiation of MSCs was not affected by D-PAV-AuNPs, it was significantly promoted by L-PAV-AuNPs in terms of calcium deposition, alkaline phosphatase （ALP） activity, and expression of collagen type I and osteocalcin （OCN） at both mRNA and protein levels. L-PAV-AuNPs could activate the P38 mitogen-activated protein kinase （MAPK） pathway, and may exert mechanical stress on MSCs because of high amounts of internalization. These results provide new insights on surface chirality at the nanoscale as a direct regulator to guide the differentiation of MSCs, and the use of these nanomaterials for strategic regenerative medicine.

关键词： chiralpoly(acryloyl-L(D)-valine) gold nanoparticles mesenchymal stem cells osteogenic differentiation

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Click chemistry approach to functionalize two-dimensional macromolecules of graphene oxide nanosheets

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Nano-Micro Letters 2010年第3期2卷 177-183页

作者： Liang Kou Hongkun He Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

A facile "click chemistry" approach to functionalize 2D macromolecules of graphene oxide nanosheets with poly(ethylene glycol) of different molecular weights,polystyrene,palmitic acid and various amino acids was ***,TGA,Raman spectroscopy,XPS,XRD,TEM,AFM and SEM were utilized to characterize the *** degree of functionalization was achieved on the flat surfaces of graphene oxide,affording polymer-grafted 2D brushes and amino acids-immobilized nanosheets,which show improved solubility in organic *** click chemistry strategy reported herein provides a facile and general method for functionalization of graphene oxide with macromolecules and desired biomolecules.

关键词： Graphene Click chemistry Chemical modification PEG Amino acids

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FERROFERRIC OXIDE/CHITOSAN SCAFFOLDS WITH THREE-DIMENSIONAL ORIENTED STRUCTURE

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Chinese Journal of Polymer Science 2012年第3期30卷 436-442页

作者：胡巧玲 Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationZhejiang University

A facile approach to construct ferroferric oxide/chitosan composite scaffolds with three-dimensional oriented structure has been explored in this research. Chitosan and ferroferric oxide are co-precipitated by using an in situ precipitation method, and then lyophilized to get the composite scaffolds. XRD indicated that Fe304 was generated during the gel formation process, and increasing the content of magnetic particles could destruct the crystal structure of chitosan. When the content of magnetic particles is lower than 10%, the layer-by-layer structure and wheel spoke structure are coexisting in the scaffolds. Increasing the content of magnetic particles, just layer-by-layer structure could be observed in the scaffolds. Ferroferric oxide particles were uniformly distributed in the matrix, the size of which was about 0.48 gm in diameter, 2 gm in length. Porosity of magnetic chitosan composite scaffolds is about 90%. When the ratio of ferroferric oxide to chitosan is 5/100, the compressive strength of the material is 0.4367 MPa, which is much higher than that of pure chitosan scaffolds, indicating that the layer-by-layer and wheel spokes complex structure is beneficial for the improvement of the mechanical properties of chitosan scaffolds. However, increasing the content of ferroferric oxide, the compressive strength of scaffolds decreased, because of the decreasing of chitosan crystallization and aggregation of magnetic particles as stress centralized body. Another reason is that the layer-by-layer and wheel spokes complex structure makes bigger contributions for the compressive strength than the layer-by-layer structure does. Three-dimensional ferroferric oxide/chitosan scaffolds could be used as hyperthermia generator system, improving the local circulation of blood, promoting the aggradation of calcium salt and stimulating bone tissue regeneration.

关键词： Chitosan Ferroferric oxide Scaffold Three-dimensional oriented structure.

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Biological identity of nanomaterials:Opportunities and challenges

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Science China Chemistry 2013年第11期56卷 1533-1541页

作者： DENG Jun YU DaHai GAO ChangYou MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and *** novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or ***,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in *** efforts have been paid to studying the interactions and mechanisms of NPs and *** deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological *** this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are *** understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed.

关键词： nanoparticles carriers cellular uptake protein corona

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