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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Chen Zhao Tian Bai Tongjia Chu Feng Wei Fa Zhang College of Computer Science and Technology Jilin University Changchun China Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Jilin University Changchun China Hepatobiliary and Pancreas Department General Surgery Center First Hospital of Jilin University Changchun China School of Medical Technology Beijing Institute of Technology Beijing China

ISBN: (数字)9781665468190

ISBN: (纸本)9781665468206

Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is of great guiding significance for the formulating treatment strategies and accessing the prognosis before the surgery. However, in traditional medicine, the gold standard for the diagnosis of MVI is obtained by examining pathological images which can only be obtained by sampling and sectioning tumors after surgery. At this time, MVI results have lost the timeliness of guiding tumor resection surgery. In order to solve this problem, existing studies began to use deep learning-based methods for preoperative prediction of MVI using non-invasive imaging. Most of these methods adopt the fusion methods of multi-sequence images to predict MVI, but fail to make full use of the characteristics of multiply sequences as prior knowledge to combine into the model, resulting in no further improvement of prediction performance. So we propose a multi-sequence image difference and correlation deep learning model. The model can extract the difference and correlation information between sequences from different scales and combine them into the model. To validate proposed model, we collected a data set consists of 120 HCC patients, including 50 MVI-positive patients. Compared with existing studies, our method has greatly improved in all evaluation metrics.

关键词： Deep learning Pathology Correlation Biological system modeling Surgery Predictive models Data mining

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Distilling Autoregressive Models to Obtain High-Performance Non-Autoregressive Solvers for Vehicle Routing Problems with Faster Inference Speed

arXiv

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arXiv 2023年

作者： Xiao, Yubin Wang, Di Li, Boyang Wang, Mingzhao Wu, Xuan Zhou, Changliang Zhou, You Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education College of Computer Science and Technology Jilin University China Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly Nanyang Technological University Singapore WeBank-NTU Joint Research Institute on Fintech Nanyang Technological University Singapore School of Computer Science and Engineering Nanyang Technological University Singapore School of System Design and Intelligent Manufacturing Southern University of Science and Technology China

Neural construction models have shown promising performance for Vehicle Routing Problems (VRPs) by adopting either the Autoregressive (AR) or Non-Autoregressive (NAR) learning approach. While AR models produce high-quality solutions, they generally have a high inference latency due to their sequential generation nature. Conversely, NAR models generate solutions in parallel with a low inference latency but generally exhibit inferior performance. In this paper, we propose a generic Guided Non-Autoregressive knowledge Distillation (GNARKD) method to obtain high-performance NAR models having a low inference latency. GNARKD removes the constraint of sequential generation in AR models while preserving the learned pivotal components in the network architecture to obtain the corresponding NAR models through knowledge distillation. We evaluate GNARKD by applying it to three widely adopted AR models to obtain NAR VRP solvers for both synthesized and real-world instances. The experimental results demonstrate that GNARKD significantly reduces the inference time (4∼5× faster) with acceptable performance drop (2∼3%). To the best of our knowledge, this study is first-of-its-kind to obtain NAR VRP solvers from AR ones through knowledge distillation. Copyright © 2023, The Authors. All rights reserved.

关键词： Distillation

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Warburg Effects in Cancer and Normal Proliferating Cells:Two Tales of the Same Name

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Genomics, Proteomics & Bioinformatics 2019年第3期17卷 273-286页

作者： Huiyan Sun Liang Chen Sha Cao Yanchun Liang Ying Xu The China-Japan Union Hospital Jilin UniversityChangchun 130033China MOE Key Laboratory of Symbolic Computation and Knowledge Engineering College of Computer Science and TechnologyJilin UniversityChangchun 130012China Computational Systems Biology Lab Department of Biochemistry and Molecular Biology and Institute of BioinformaticsUniversity of GeorgiaAthensGA 30602USA Faculty of Health Sciences University of MacaoTaipaMacao SAR 999078China Department of Biostatistics School of MedicineIndiana UniversityIndianapolisIN 46202USA Zhuhai Laboratory of MOE Key Laboratory of Symbolic Computation and Knowledge Engineering Zhuhai College of Jilin UniversityZhuhai 519041China

It has been observed that both cancer tissue cells and normal proliferating cells(NPCs)have the Warburg *** goal here is to demonstrate that they do this for different *** accomplish this,we have analyzed the transcriptomic data of over 7000 cancer and control tissues of 14 cancer types in TCGA and data of five NPC types in *** analyses reveal that NPCs accumulate large quantities of ATPs produced by the respiration process before starting the Warburg effect,to raise the intracellular pH from 6.8 to 7.2 and to prepare for cell division *** cell cycle starts,the cells start to rely on glycolysis for ATP generation followed by ATP hydrolysis and lactic acid release,to maintain the elevated intracellular pH as needed by cell division since together the three processes are pH *** cells go back to the normal respirationbased ATP production once the cell division phase *** comparison,cancer cells have reached their intracellular pH at 7.4 from top down as multiple acid-loading transporters are up-regulated and most acid-extruding ones except for lactic acid exporters are *** cells use continuous glycolysis for ATP production as way to acidify the intracellular space since the lactic acid secretion is decoupled from glycolysis-based ATP generation and is pH balanced by increased expressions of acid-loading ***-expression analyses suggest that lactic acid secretion is regulated by external,non-pH related ***,our data strongly suggest that the two cell types have the Warburg effect for very different reasons.

关键词： Cancer Warburg effect Fenton reaction Cell proliferation pH homeostasis

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AutoSTL: Automated Spatio-Temporal Multi-Task Learning

arXiv

引用

arXiv 2023年

作者： Zhang, Zijian Zhao, Xiangyu Miao, Hao Zhang, Chunxu Zhao, Hongwei Zhang, Junbo College of Computer Science and Technology Jilin University China School of Data Science City University of Hong Kong Hong Kong Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Jilin University China Department of Computer Science Aalborg University Denmark JD Intelligent Cities Research China JD iCity JD Technology China Hong Kong Institute for Data Science City University of Hong Kong Hong Kong

Spatio-temporal prediction plays a critical role in smart city construction. Jointly modeling multiple spatio-temporal tasks can further promote an intelligent city life by integrating their inseparable relationship. However, existing studies fail to address this joint learning problem well, which generally solve tasks individually or a fixed task combination. The challenges lie in the tangled relation between different properties, the demand for supporting flexible combinations of tasks and the complex spatio-temporal dependency. To cope with the problems above, we propose an Automated Spatio-Temporal multi-task Learning (AutoSTL) method to handle multiple spatio-temporal tasks jointly. Firstly, we propose a scalable architecture consisting of advanced spatio-temporal operations to exploit the complicated dependency. Shared modules and feature fusion mechanism are incorporated to further capture the intrinsic relationship between tasks. Furthermore, our model automatically allocates the operations and fusion weight. Extensive experiments on benchmark datasets verified that our model achieves state-of-the-art performance. As we can know, AutoSTL is the first automated spatio-temporal multi-task learning method. Copyright © 2023, The Authors. All rights reserved.

关键词： Smart city

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Msa-Net: A Medical Image Segmentation Network Based on Spatial Pyramid and Attention Mechanism

SSRN

引用

SSRN 2023年

作者： Feng, Yuncong Zhu, Xiaoyan Li, Yang Zhang, Xiaoli Lu, Huimin College of Computer Science and Engineering Changchun University of Technology Jilin Changchun130012 China Artificial Intelligence Research Institute Changchun University of Technology Jilin Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Jilin Changchun130012 China Academy for Advanced Interdisciplinary Studies Northeast Normal University Jilin Changchun130024 China Jilin Provincial Smart Health Joint Innovation Laboratory for the New Generation of AI 3000 North Yuanda Avenue Gaoxin North District Changchun130102 China

Medical image segmentation is an important way to assist doctors to accurately diagnose diseases. However, semantic features are difficult to be fully extracted due to the complexity of medical image lesion tissue features (e.g., size, location, and morphology) and the high similarity between the background and the target region. To tackle these problems, we propose a novel medical image segmentation network MSA-Net based on the spatial pyramid and attention mechanism. This technique facilitates the extraction of multi-scale spatial information and the establishment of channel dependencies within images. By incorporating efficient pyramid attention and channel-spatial dual attention modules, the network autonomously focuses on lesion regions while suppressing background interference. Additionally, the SPCA (Spatial Pyramid-Coordinate Attention) module is integrated at the bottleneck layer, enabling the assimilation of larger receptive field information and prioritizing relevant features. This augmentation improves the network's ability to gather both location and channel-based insights. We proceed to evaluate our model qualitatively and quantitatively across four public datasets: ISIC2018, Lung segmentation, Kvasir-SEG, and ISLES2022. The results substantiate the superior performance of our proposed model. © 2023, The Authors. All rights reserved.

关键词： Deep learning

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A Survey of Sum-Product Networks Structural Learning

SSRN

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SSRN 2022年

作者： Xia, Riting Zhang, Yan Liu, Xueyan Yang, Bo School of Artificial Intelligence Jilin University Jilin Changchun130012 China School of Computer Science and Technology Jilin University Jilin Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineer Jilin University Ministry of Education Jilin Changchun130012 China College of Communication Engineering Jilin University Jilin Changchun130012 China

Sum-product networks (SPNs) in deep probabilistic models have made great progress in computer vision, robotics, neuro-symbolic artificial intelligence, natural language processing, probabilistic programming languages, and other fields. Compared with probabilistic graphical models and deep probabilistic models, SPNs can balance the tractability and expressive efficiency. In addition, SPNs remain more interpretable than deep neural models. The expressiveness and complexity of SPNs depend on its own structure. Thus, how to design an effective SPN structure learning algorithm that can balance expressiveness and complexity has become a hot research topic in recent years. In this paper, we review SPN structure learning comprehensively, including the motivation of SPN structure learning, a systematic review of related theories, the proper categorization of different SPN structure learning algorithms, several evaluation approaches and some helpful online resources. Moreover, we discuss some open issues and research directions for SPN structure learning. To our knowledge, this is the first survey to focus specifically on SPN structure learning, and we hope to provide useful references for researchers in related fields. © 2022, The Authors. All rights reserved.

关键词： Efficiency

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Bi-classifier with neighborhood aggregation for unsupervised domain adaptation

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Information Sciences 2025年 718卷

作者： Shuai Lü Xinyu Zhang Zongze Li Jingyao Li Meng Kang Key Laboratory of Symbolic Computation and Knowledge Engineering (Jilin University) Ministry of Education Changchun 130012 China College of Computer Science and Technology Jilin University Changchun 130012 China College of Software Jilin University Changchun 130012 China

Recently, adversarial learning with bi-classifier has been confirmed to be effective in unsupervised domain adaptation, which can effectively promote the alignment of different distributions across domains. Most previous methods with bi-classifier exploit the output disagreement of the bi-classifier to learn transferable representations. However, only considering the disagreement between two classifiers cannot guarantee that the model performs well in the target domain. The main reason is that the model does not consider the local structure of the target domain data. To address this problem, we propose a Bi-Classifier with Neighborhood Aggregation (BCNA). Specifically, we provide two pseudo-labels for a target sample based on the nearest neighbor aggregation strategy. Then, we propose a self-supervised loss with two pseudo-labels based on confidence weight. In addition, we also propose a novel consistency regularization loss for bi-classifier. Unlike previous methods with bi-classifier, we achieve the goal of minimizing the disagreement between two classifiers from the perspective of different views of the sample. Our method can increase the discriminability of the model while ensuring the feature transferability. Extensive experiments show that our method has achieved state-of-the-art performance on three datasets that are widely used in unsupervised domain adaptation.

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Spirit distillation: Precise real-time semantic segmentation of road scenes with insufficient data

arXiv

引用

arXiv 2021年

作者： Wu, Zhiyuan Jiang, Yu Cui, Chupeng Yang, Zongmin Xue, Xinhui Qi, Hong Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun China With College of Computer Science and Technology Jilin University Changchun China College of Computer Science and Technology Jilin University Changchun China

Semantic segmentation of road scenes is one of the key technologies for realizing autonomous driving scene perception, and the effectiveness of deep Convolutional Neural Networks(CNNs) for this task has been demonstrated. Stateof-art CNNs for semantic segmentation suffer from excessive computations as well as large-scale training data requirement. Inspired by the ideas of Fine-tuning-based Transfer Learning (FTT) and feature-based knowledge distillation, we propose a new knowledge distillation method for cross-domain knowledge transference and efficient data-insufficient network training, named Spirit Distillation(SD), which allow the student network to mimic the teacher network to extract general features, so that a compact and accurate student network can be trained for real-time semantic segmentation of road scenes. Then, in order to further alleviate the trouble of insufficient data and improve the robustness of the student, an Enhanced Spirit Distillation (ESD) method is proposed, which commits to exploit a more comprehensive general features extraction capability by considering images from both the target and the proximity domains as input. To our knowledge, this paper is a pioneering work on the application of knowledge distillation to few-shot learning. Persuasive experiments conducted on Cityscapes semantic segmentation with the prior knowledge transferred from COCO2017 and KITTI demonstrate that our methods can train a better student network (mIOU and high-precision accuracy boost by 1.4% and 8.2% respectively, with 78.2% segmentation variance) with only 41.8% FLOPs (see Fig. 1). Copyright © 2021, The Authors. All rights reserved.

关键词： Autonomous vehicles

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ESAE: Evolutionary Strategy-Based Architecture Evolution 14th

ESAE: Evolutionary Strategy-Based Architecture Evolution

引用

14th International Conference on Bio-inspired Computing: Theories and Applications, BIC-TA 2019

作者： Gu, Xue Meng, Ziyao Liang, Yanchun Xu, Dong Huang, Han Han, Xiaosong Wu, Chunguo Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education College of Computer Science and Technology Jilin University Changchun130012 China Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education School of Computer Zhuhai College of Jilin University Zhuhai519041 China Department of Electrical Engineering and Computer Science Informatics Institute and Christopher S. Bond Life Sciences Center University of Missouri ColumbiaMO65211 United States School of Software Engineering South China University of Technology GuangZhou510006 China

ISBN: (纸本)9789811534249

Although deep neural networks (DNNs) play important roles in many fields, the architecture design of DNNs can be challenging due to the difficulty of input data representation, the huge number of parameters and the complex layer relationships. To overcome the obstacles of architecture design, we developed a new method to generate the optimal structure of DNNs, named Evolutionary Strategy-based Architecture Evolution (ESAE), consisting of a bi-level representation and a probability distribution learning approach. The bi-level representation encodes architectures in the gene and parameter levels. The probability distribution learning approach ensures the efficient convergence of the architecture searching process. By using Fashion-MNIST and CIFAR-10, the effectiveness of the proposed ESAS is verified. The evolved DNNs, starting from a trivial initial architecture with one single convolutional layer, achieved the accuracies of 94.48% and 93.49% on Fashion-MNIST and CIFAR-10, respectively, and require remarkably less hardware costs in terms of GPUs and running time, compared with the existing state-of-the-art manual screwed architectures. © 2020, Springer Nature Singapore Pte Ltd.

关键词： Deep neural networks

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A Novel Distributed Differential Privacy Preserving Based on Random Forest in Data Centers

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Procedia Computer Science 2022年 214卷 1531-1540页

作者： Xi Wang Weibei Fan Jing He Chi-Hung Chi Suzhou Institute of Industrial Technology Suzhou 215006 China Key laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012 P.R. China College of Computer Nanjing University of Posts and Telecommunications Nanjing 210003 China Department of Neuroscience University of Oxford Oxford OX1 3QR England School of Computer Nanyang Technological University Nanyang Avenue 639798 Singapore

Traditional privacy-preserving technologies have been unable to provide adequate protection and are vulnerable to background knowledge. MapReduce is parallel distributed computing model which has the advantages of good scalability and high fault tolerance. In this paper, we design a differential privacy protection based on MapReduce for the security problems faced in the distributed environment. Firstly, we propose a random forest algorithm DPMRRF that satisfies differential privacy under the MapReduce framework. Secondly, we use the MapReduce framework in the Hadoop platform to make the classification results satisfy differential privacy by adding random noise values to the leaf nodes. Finally, through the design of the feature selection scheme combined with the index mechanism, three different privacy budget allocation methods are adopted, namely, equal distribution, equal distribution and equal distribution. Experiments show that the algorithm has better classification accuracy while ensuring data availability. The proposed algorithm effectively improves the classification accuracy and operating efficiency, and greatly reduces the amount of computation.

关键词： MapReduce Differential privacy protection Random forest Privacy budget

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