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Field-level simulation-based inference of galaxy clustering with convolutional neural networks

Physical Review D 2024年第8期109卷 083536-083536页

作者： Pablo Lemos Liam Parker ChangHoon Hahn Shirley Ho Michael Eickenberg Jiamin Hou Elena Massara Chirag Modi Azadeh Moradinezhad Dizgah Bruno Régaldo-Saint Blancard David Spergel Department of Physics Université de Montréal Montréal 1375 Avenue Thérèse-Lavoie-Roux Montréal QC H2V 0B3 Canada Mila—Quebec Artificial Intelligence Institute Montréal 6666 Rue Saint-Urbain Montréal QC H2S 3H1 Canada Ciela—Montreal Institute for Astrophysical Data Analysis and Machine Learning Montréal Canada Center for Computational Astrophysics Flatiron Institute 162 5th Avenue New York New York 10010 USA Department of Physics Princeton University Princeton New Jersey 08544 USA Center for Cosmology and Particle Physics Department of Physics New York University New York New York 10003 USA Department of Physics Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Center for Computational Mathematics Flatiron Institute 162 5th Avenue New York New York 10010 USA Department of Astronomy University of Florida 211 Bryant Space Science Center Gainesville Florida 32611 USA Max-Planck-Institut für Extraterrestrische Physik Postfach 1312 Giessenbachstrasse 1 85748 Garching bei München Germany Waterloo Centre for Astrophysics University of Waterloo 200 University Avenue W. Waterloo Ontario N2L 3G1 Canada Department of Physics and Astronomy University of Waterloo 200 University Avenue W. Waterloo Ontario N2L 3G1 Canada Département de Physique Théorique Université de Genève 24 quai Ernest Ansermet 1211 Genève 4 Switzerland

We present the first simulation-based inference (SBI) of cosmological parameters from field-level analysis of galaxy clustering. Standard galaxy clustering analyses rely on analyzing summary statistics, such as the power spectrum Pℓ, with analytic models based on perturbation theory. Consequently, they do not fully exploit the nonlinear and non-Gaussian features of the galaxy distribution. To address these limitations, we use the SimBIG forward modeling framework to perform SBI using normalizing flows. We apply SimBIG to a subset of the Baryon Oscillation Spectroscopic Survey CMASS galaxy sample using a convolutional neural network with stochastic weight averaging to perform massive data compression of the galaxy field. We infer constraints on Ωm=0.267−0.029+0.033 and σ8=0.762−0.035+0.036. While our constraints on Ωm are in line with standard Pℓ analyses, ours on σ8 are 2.65× tighter. Our analysis also provides constraints on the Hubble constant H0=64.5±3.8 km/s/Mpc from galaxy clustering alone. This higher constraining power comes from additional non-Gaussian cosmological information, inaccessible with Pℓ. We demonstrate the robustness of our analysis by showcasing our ability to infer unbiased cosmological constraints from a series of test simulations that are constructed using different forward models than the one used in our training dataset. This work not only presents competitive cosmological constraints but also introduces novel methods for leveraging additional cosmological information in upcoming galaxy surveys like the Dark Energy Spectroscopic Instrument, Prime Focus Spectrograph, and Euclid.

关键词： Cosmology Dark energy Dark matter Large scale structure of the Universe Astrophysical & cosmological simulations Bayesian methods Deep learning machine learning Numerical simulations in gravitation & astrophysics

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Feature extraction for hyperspectral imagery: The evolution from shallow to deep

arXiv

引用

arXiv 2020年

作者： Rasti, Behnood Hong, Danfeng Hang, Renlong Ghamisi, Pedram Kang, Xudong Chanussot, Jocelyn Benediktsson, Jon Atli Machine Learning Group Exploration Division Helmholtz Institute Freiberg for Resource Technology Helmholtz-Zentrum Dresden-Rossendorf Freiberg09599 Germany Univ. Grenoble Alpes CNRS Grenoble INP GIPSAlab Grenoble38000 France Jiangsu Key Laboratory of Big Data Analysis Technology School of Automation Nanjing University of Information Science and Technology Nanjing210044 China Machine Learning Group Exploration Division Helmholtz Institute Freiberg for Resource Technology Helmholtz-Zentrum Dresden-Rossendorf Freiberg09599 Germany College of Electrical and Information Engineering Hunan University Changsha410082 China Key Laboratory of Visual Perception and Artificial Intelligence of Hunan Province Changsha410082 China Univ. Grenoble Alpes Inria CNRS Grenoble INP LJK GrenobleF-38000 France Faculty of Electrical and Computer Engineering University of Iceland Reykjavik101 Iceland Faculty of Electrical and Computer Engineering University of Iceland Reykjavik107 Iceland

The final version of the paper can be found in IEEE Geoscience and Remote Sensing Magazine. Hyperspectral images provide detailed spectral information through hundreds of (narrow) spectral channels (also known as dimensionality or bands) with continuous spectral information that can accurately classify diverse materials of interest. The increased dimensionality of such data makes it possible to significantly improve data information content but provides a challenge to the conventional techniques (the so-called curse of dimensionality) for accurate analysis of hyperspectral images. Feature extraction, as a vibrant field of research in the hyperspectral community, evolved through decades of research to address this issue and extract informative features suitable for data representation and classification. The advances in feature extraction have been inspired by two fields of research, including the popularization of image and signal processing as well as machine (deep) learning, leading to two types of feature extraction approaches named shallow and deep techniques. This article outlines the advances in feature extraction approaches for hyperspectral imagery by providing a technical overview of the state-of-the-art techniques, providing useful entry points for researchers at different levels, including students, researchers, and senior researchers, willing to explore novel investigations on this challenging topic. In more detail, this paper provides a bird's eye view over shallow (both supervised and unsupervised) and deep feature extraction approaches specifically dedicated to the topic of hyperspectral feature extraction and its application on hyperspectral image classification. Additionally, this paper compares 15 advanced techniques with an emphasis on their methodological foundations in terms of classification accuracies. Furthermore, to push this vibrant field of research forward an impressive amount of codes and libraries is shared at: https://***/Behnoo

关键词： Feature extraction

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Strong gravitational lensing as a probe of dark matter

arXiv

引用

arXiv 2023年

作者： Vegetti, S. Birrer, S. Despali, G. Fassnacht, C.D. Gilman, D. Hezaveh, Y. Levasseur, L. Perreault McKean, J.P. Powell, D.M. O’Riordan, C.M. Vernardos, G. Max Planck Institut für Astrophysik Karl-Schwarzschild-Strasse 1 Garching MünchenD-85748 Germany Department of Physics and Astronomy Stony Brook University Stony BrookNY11794 United States Dipartimento di Fisica e Astronomia "A. Righi" Alma Mater Studiorum Università di Bologna Via Piero Gobetti 93/2 BolognaI-40129 Italy Institut für Theoretische Astrophysik Zentrum für Astronomie Heidelberg Universität Albert-Ueberle-Str. 2 Heidelberg69120 Germany Dept. of Physics and Astronomy University of California Davis 1 Shields Ave. DavisCA95616 United States Department of Astronomy and Astrophysics University of Toronto TorontoONM5S 3H4 Canada Department of Physics Université de Montréal Montréal Canada Mila - Quebec Artificial Intelligence Institute Montréal Canada Ciela - Montreal Institute for Astrophysical Data Analysis and Machine Learning Montréal Canada Center for Computational Astrophysics Flatiron Institute 162 5th Avenue New YorkNY10010 United States Perimeter Institute for Theoretical Physics WaterlooONN2L 2Y5 Canada Kapteyn Astronomical Institute University of Groningen PO Box 800 AV Groningen9700 Netherlands ASTRON Netherlands Institute for Radio Astronomy PO Box 2 AA Dwingeloo7990 Netherlands Observatoire de Sauverny Versoix1290 Switzerland

Dark matter structures within strong gravitational lens galaxies and along their line of sight leave a gravitational imprint on the multiple images of lensed sources. Strong gravitational lensing provides, therefore, a key test of different dark matter models in a way that is independent of the baryonic content of matter structures on subgalactic scales. In this chapter, we describe how galaxy-scale strong gravitational lensing observations are sensitive to the physical nature of dark matter. We provide a historical perspective of the field, and review its current status. We discuss the challenges and advances in terms of data, treatment of systematic errors and theoretical predictions, that will enable one to deliver a stringent and robust test of different dark matter models in the near future. With the advent of the next generation of sky surveys, the number of known strong gravitational lens systems is expected to increase by several orders of magnitude. Coupled with high-resolution followup observations, these data will provide a key opportunity to constrain the properties of dark matter with strong gravitational lensing. Copyright © 2023, The Authors. All rights reserved.

关键词： Galaxies

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Social stress drives the multi-wave dynamics of COVID-19 outbreaks

arXiv

引用

arXiv 2021年

作者： Kastalskiy, Innokentiy A. Pankratova, Evgeniya V. Mirkes, Evgeny M. Kazantsev, Victor B. Gorban, Alexander N. Department of Neurotechnology Lobachevsky University 23 Gagarin Ave. Nizhny Novgorod603022 Russia 46 Ulyanov St. Nizhny Novgorod603950 Russia Center for Neurotechnology and Machine Learning Immanuel Kant Baltic Federal University 14 Nevsky St. Kaliningrad236016 Russia Laboratory of Perspective Methods for Analysis of Multidimensional Data Institute of Information Technology Mathematics and Mechanics Lobachevsky University 23 Gagarin Ave. Nizhny Novgorod603022 Russia Department of Applied Mathematics Institute of Information Technology Mathematics and Mechanics Lobachevsky University 23 Gagarin Ave. Nizhny Novgorod603022 Russia Department of Mathematics University of Leicester University Rd LeicesterLE1 7RH United Kingdom Neuroscience and Cognitive Technology Laboratory Innopolis University 1 Universitetskaya St. Innopolis420500 Russia Laboratory of Neuromodeling Samara State Medical University 18 Gagarin St. Samara443079 Russia

The dynamics of epidemics depend on how people's behavior changes during an outbreak. At the beginning of the epidemic, people do not know about the virus, then, after the outbreak of epidemics and alarm, they begin to comply with the restrictions and the spreading of epidemics may decline. Over time, some people get tired/frustrated by the restrictions and stop following them (exhaustion), especially if the number of new cases drops down. After resting for a while, they can follow the restrictions again. But during this pause the second wave can come and become even stronger then the first one. Studies based on SIR models do not predict the observed quick exit from the first wave of epidemics. Social dynamics should be considered. The appearance of the second wave also depends on social factors. Many generalizations of the SIR model have been developed that take into account the weakening of immunity over time, the evolution of the virus, vaccination and other medical and biological details. However, these more sophisticated models do not explain the apparent differences in outbreak profiles between countries with different intrinsic sociocultural features. In our work, a system of models of the COVID-19 pandemic is proposed, combining the dynamics of social stress with classical epidemic models. Social stress is described by the tools of sociophysics. The combination of a dynamic SIR-type model with the classical triad of stages of the general adaptation syndrome, alarm-resistance-exhaustion, makes it possible to describe with high accuracy the available statistical data for 13 countries. The sets of kinetic constants corresponding to optimal fit of model to data were found. These constants characterize the ability of society to mobilize efforts against epidemics and maintain this concentration over time, and can further help in the development of management strategies specific to a particular society. © 2021, CC BY.

关键词： Epidemiology

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Neural networks and their application in forecasting problems

引用

Journal of Physics: Conference Series 2020年第1期1703卷

作者： V A Ivanyuk F F Pashchenko Department of Data Analysis and Machine Learning Financial University under the Government of the Russian Federation 49 Leningradsky Prospekt 125993 Moscow Russia Department of Higher Mathematics Bauman Moscow State Technical University Moscow Russia V.A. Trapeznikov Institute of Control Sciences of RAS Moscow Russia

The report describes popular machine learning methods and applications of neural networks. It reveals methods of training neural networks and offers a method of forecasting based on neural networks for modelling financial time series. Neural networks have recently gained in popularity among scholars. In particular, neural networks are widely used in the field of visualization and image recognition. But the practical significance of neural networks does not end there, they also find usage in such areas as forecasting, classification, clustering and modelling. This success can mainly be attributed to the remarkable property of models based on neural networks – they can «see» non-linear connections in contrast to many models, which for the most part have linear connections only. Currently, the use of neural networks is developing in the following directions: Stock market and macroeconomic forecasting (Neuro XL, OptimuStock, StocksNeural); Speech recognition and man-machine dialogue (Siri, Alexa, Cortana, Alice); Imitation of intellectual activity (weak AI in Siri, Alexa, Cortana, Alice); Improving low-quality and noisy information (DeepImagePrior). The advantages of using neural networks include: versatility. simplicity. Neural networks are able to model dependencies also in cases when there is a large number of variables.

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Forecasting the dynamics of financial time series based on neural networks

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Journal of Physics: Conference Series 2020年第1期1703卷

作者： V A Ivanyuk N M Abdikeev A D Tsvirkun Department of Data Analysis and Machine Learning Financial University under the Government of the Russian Federation 49 Leningradsky Prospekt 125993 Moscow Russia Department of Higher Mathematics Bauman Moscow State Technical University Moscow Russia V.A. Trapeznikov Institute of Control Sciences of RAS Moscow Russia

Forecasting is one of the high-demand data mining problems, but also a very difficult one. The difficulties of forecasting are associated with insufficient quality and quantity of input data, the changes in the environment where the process takes place, and the impact of subjective factors. A forecast always implies some margin of error, which depends on the forecast model used and the completeness of the input data. Methods based on neural networks are the most relevant and highly-demanded techniques today. Neural networks are great for finding accurate solutions in an environment characterized by complex or fragmented information. In the field of finance and economics, the values of time series parameters can be more accurately modelled using neural analysis methods. Artificial neural networks have more common and flexible functional forms than statistical methods. They can generalize information and provide a qualitative forecast under conditions of uncertainty and crisis. The article proposes a forecasting model based on a neural network that can predict the price of a financial asset in a well-defined time interval. Ten technical indicators are used as input signals, and the closing price of the next period is used as an output signal.

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Ensemble forecasting method

引用

Journal of Physics: Conference Series 2020年第1期1703卷

作者： V A Ivanyuk A D Tsvirkun Department of Data Analysis and Machine Learning Financial University under the Government of the Russian Federation 49 Leningradsky Prospekt 125993 Moscow Russia Department of Higher Mathematics Bauman Moscow State Technical University Moscow Russia V.A. Trapeznikov Institute of Control Sciences of RAS Moscow Russia

The purpose of this article is to analyze the time series based on aggregate forecasting methods. Forecasting time series comprises an important scientific and technical task which is relevant in various sectors of economy and production. The main objective of any forecasting process is to get the ability to assess trends in changes to a particular factor. To predict the behaviour of future processes, a qualitative analysis of data is required, which provides the basis for the forecast. It is also important to choose the appropriate forecasting method. The forecast obtained may not be always correct, so it is crucial to determine how accurately it is built. In the present paper, characteristics of time series are provided. The main mathematical methods of time series forecasting are analyzed and their classification is presented. Criteria for the accuracy and reliability of forecasting models are defined. The accuracy of the forecast is an important criterion for evaluating the forecasting method. The aggregate ensemble forecast has proven to be an effective method for enhancing the accuracy of forecasting. The article provides an example of constructing an aggregate ensemble forecast. The types of nonlinear models are described and several methods are selected for constructing the aggregate ensemble forecast. The practical application of exponential smoothing is considered, the MA (moving average) model and the AR (autoregressive) model are constructed.

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SimBIG: Field-level Simulation-Based Inference of Galaxy Clustering

arXiv

引用

arXiv 2023年

作者： Lemos, Pablo Parker, Liam Hahn, ChangHoon Ho, Shirley Eickenberg, Michael Hou, Jiamin Massara, Elena Modi, Chirag Dizgah, Azadeh Moradinezhad Blancard, Bruno Régaldo-Saint Spergel, David Department of Physics Université de Montréal 1375 Avenue Thérèse-Lavoie-Roux MontréalQCH2V 0B3 Canada Mila - Quebec Artificial Intelligence Institute 6666 Rue Saint-Urbain MontréalQCH2S 3H1 Canada Ciela - Montreal Institute for Astrophysical Data Analysis and Machine Learning Montréal Canada Center for Computational Astrophysics Flatiron Institute 162 5th Avenue New YorkNY10010 United States Department of Physics Princeton University PrincetonNJ08544 United States Center for Cosmology and Particle Physics Department of Physics New York University New YorkNY10003 United States Department of Physics Carnegie Mellon University PittsburghPA15213 United States Center for Computational Mathematics Flatiron Institute 162 5th Avenue New YorkNY10010 United States Department of Astronomy University of Florida 211 Bryant Space Science Center GainesvilleFL32611 United States Max-Planck-Institut für Extraterrestrische Physik Postfach 1312 Giessenbachstrasse 1 Garching bei München85748 Germany Waterloo Centre for Astrophysics University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada Department of Physics and Astronomy University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada Département de Physique Théorique Université de Genève 24 quai Ernest Ansermet Genève 41211 Switzerland

We present the first simulation-based inference (SBI) of cosmological parameters from field-level analysis of galaxy clustering. Standard galaxy clustering analyses rely on analyzing summary statistics, such as the power spectrum, P, with analytic models based on perturbation theory. Consequently, they do not fully exploit the non-linear and non-Gaussian features of the galaxy distribution. To address these limitations, we use the SimBIG forward modelling framework to perform SBI using normalizing flows. We apply SimBIG to a subset of the BOSS CMASS galaxy sample using a convolutional neural network with stochastic weight averaging to perform massive data compression of the galaxy field. We infer constraints on (Equation presented) and (Equation presented). While our constraints on Ωm are in-line with standard P analyses, those on σ8 are 2.65× tighter. Our analysis also provides constraints on the Hubble constant H0 = 64.5 ± 3.8 km/s/Mpc from galaxy clustering alone. This higher constraining power comes from additional non-Gaussian cosmological information, inaccessible with P. We demonstrate the robustness of our analysis by showcasing our ability to infer unbiased cosmological constraints from a series of test simulations that are constructed using different forward models than the one used in our training dataset. This work not only presents competitive cosmological constraints but also introduces novel methods for leveraging additional cosmological information in upcoming galaxy surveys like DESI, PFS, and Euclid. © 2023, CC0.

关键词： Galaxies

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Multi-phase black-hole feedback and a bright [CII] halo in a Lo-BAL quasar at z ∼ 6.6

arXiv

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arXiv 2024年

作者： Bischetti, Manuela Choi, Hyunseop Fiore, Fabrizio Feruglio, Chiara Carniani, Stefano D’Odorico, Valentina Bañados, Eduardo Chen, Huanqing Decarli, Roberto Gallerani, Simona Hlavacek-Larrondo, Julie Lai, Samuel Leighly, Karen M. Mazzucchelli, Chiara Perreault-Levasseur, Laurence Tripodi, Roberta Walter, Fabian Wang, Feige Yang, Jinyi Zanchettin, Maria Vittoria Zhu, Yongda Dipartimento di Fisica Universitá di Trieste Sezione di Astronomia Via G.B. Tiepolo 11 TriesteI-34131 Italy INAF - Osservatorio Astronomico di Trieste Via G. B. Tiepolo 11 TriesteI–34131 Italy Département de Physique Université de Montréal Succ. Centre-Ville MontréalQCH3C 3J7 Canada Mila - Quebec Artificial Intelligence Institute MontréalQC Canada IFPU - Institut for fundamental physics of the Universe Via Beirut 2 Trieste34014 Italy Scuola Normale Superiore Piazza dei Cavalieri 7 PisaI-56126 Italy Max Planck Institut für Astronomie Königstuhl 17 HeidelbergD-69117 Germany Canadian Institute for Theoretical Astrophysics University of Toronto 60 St George St TorontoONM5R 2M8 Canada INAF - Osservatorio di Astrofisica e Scienza dello Spazio di Bologna via Gobetti 93/3 BolognaI-40129 Italy Research School of Astronomy and Astrophysics Australian National University CanberraACT2611 Australia Homer L. Dodge Department of Physics and Astronomy The University of Oklahoma 440 W. Brooks St. NormanOK73019 United States Núcleo de Astronomía de la Facultad de Ingeniería Universidad Diego Portales Av. Ejército Libertador 441 Santiago Chile Ciela - Montreal Institute for Astrophysical Data Analysis and Machine Learning Montréal Canada Center for Computational Astrophysics Flatiron Institute 162 5th Avenue New YorkNY10010 United States University of Ljubljana FMF Jadranska 19 1000 Slovenia Steward Observatory University of Arizona 933 N Cherry Avenue TucsonAZ85721 United States SISSA Via Bonomea 265 Trieste34136 Italy Department of Physics & Astronomy University of California RiversideCA92521 United States

Although the mass growth of supermassive black holes during the Epoch of Reionisation is expected to play a role in shaping the concurrent growth of their host-galaxies, observational evidence of feedback at z6 is still sparse. We perform the first multi-scale and multi-phase characterisation of black-hole driven outflows in the z ∼ 6.6 quasar J0923+0402 and assess how these winds impact the cold gas reservoir. We employ the SimBAL spectral synthesis to fit broad absorption line (BAL) features and find a powerful ionized outflow on 210 pc scale, with a kinetic power ∼ 2 − 100% of the quasar luminosity. ALMA observations of [CII] emission allow us to study the morphology and kinematics of the cold gas. We detect high-velocity [CII] emission, likely associated with a cold neutral outflow at ∼ 0.5−2 kpc scale in the host-galaxy, and a bright extended [CII] halo with a size of ∼ 15 kpc. For the first time at such an early epoch, we accurately constrain the outflow energetics in both the ionized and the atomic neutral gas phases. We find such energetics to be consistent with expectations for an efficient feedback mechanism, and both ejective and preventative feedback modes are likely at play. The scales and energetics of the ionized and atomic outflows suggest that they might be associated with different quasar accretion episodes. The results of this work indicate that strong black hole feedback is occurring in quasars at z 6 and is likely responsible for shaping the properties of the cold gas reservoir up to circum-galactic scales. © 2024, CC BY.

关键词： Galaxies

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Generating Synthetic Computed Tomography for Radiotherapy: SynthRAD2023 Challenge Report

arXiv

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arXiv 2024年

作者： Huijben, Evi M.C. Terpstra, Maarten L. Galapon, Arthur Pai, Suraj Thummerer, Adrian Koopmans, Peter Afonso, Manya van Eijnatten, Maureen Gurney-Champion, Oliver Chen, Zeli Zhang, Yiwen Zheng, Kaiyi Li, Chuanpu Pang, Haowen Ye, Chuyang Wang, Runqi Song, Tao Fan, Fuxin Qiu, Jingna Huang, Yixing Ha, Juhyung Park, Jong Sung Alain-Beaudoin, Alexandra Bériault, Silvain Yu, Pengxin Guo, Hongbin Huang, Zhanyao Li, Gengwan Zhang, Xueru Fan, Yubo Liu, Han Xin, Bowen Nicolson, Aaron Zhong, Lujia Deng, Zhiwei Müller-Franzes, Gustav Khader, Firas Li, Xia Zhang, Ye Hémon, Cédric Boussot, Valentin Zhang, Zhihao Wang, Long Bai, Lu Wang, Shaobin Mus, Derk Kooiman, Bram Sargeant, Chelsea A.H. Henderson, Edward G.A. Kondo, Satoshi Kasai, Satoshi Karimzadeh, Reza Ibragimov, Bulat Helfer, Thomas Dafflon, Jessica Chen, Zijie Wang, Enpei Perko, Zoltan Maspero, Matteo Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands Radiotherapy Department University Medical Center Utrecht Utrecht Netherlands Computational Imaging Group for MR Diagnostics & Therapy University Medical Center Utrecht Utrecht Netherlands Department of Radiation Oncology University Medical Center Groningen University of Groningen Groningen Netherlands GROW School for Oncology Maastricht University Medical Centre Maastricht Netherlands Department of Radiation Oncology LMU University Hospital LMU Munich Munich Germany Department of Radiation Oncology Radboud University Medical Center Nijmegen Netherlands Wageningen University & Research Wageningen Plant Research Wageningen Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMC Location University of Amsterdam Amsterdam Netherlands Cancer Center Amsterdam Imaging and Biomarkers Amsterdam Netherlands School of Biomedical Engineering Southern Medical University Guangzhou China School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China School of Biomedical Engineering ShanghaiTech University Shanghai China Fudan University Shanghai China Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany Indiana University Bloomington United States Advanced Development Engineering Elekta Ltd Montreal Canada Infervision Medical Technology Co. Ltd. Beijing China Department of Biomedical Engineering Shantou University China Independent researchers Department of Computer Science Vanderbilt University Nashville United States Australian e-Health Research Centre CSIRO HerstonQLD Australia Los AngelesCA United States University Hospital Aachen Aachen Germany Center for Proton Therapy Paul Scherrer Institut Villigen Switzerland Department of Computer Science ETH Zurich Zurich Switzerland University Rennes 1 CLCC Eugène Marquis INSERM LTSI Rennes France Subtle Medical Shanghai China MedMind Technology Co.

Radiation therapy plays a crucial role in cancer treatment, necessitating precise delivery of radiation to tumors while sparing healthy tissues over multiple days. Computed tomography (CT) is integral for treatment planning, offering electron density data crucial for accurate dose calculations. However, accurately representing patient anatomy is challenging, especially in adaptive radiotherapy, where CT is not acquired daily. Magnetic resonance imaging (MRI) provides superior soft-tissue contrast. Still, it lacks electron density information, while cone beam CT (CBCT) lacks direct electron density calibration and is mainly used for patient positioning. Adopting MRI-only or CBCT-based adaptive radiotherapy eliminates the need for CT planning but presents challenges. Synthetic CT (sCT) generation techniques aim to address these challenges by using image synthesis to bridge the gap between MRI, CBCT, and CT. The SynthRAD2023 challenge was organized to compare synthetic CT generation methods using multi-center ground truth data from 1080 patients, divided into two tasks: 1) MRI-to-CT and 2) CBCT-to-CT. The evaluation included image similarity and dose-based metrics from proton and photon plans. The challenge attracted significant participation, with 617 registrations and 22/17 valid submissions for tasks 1/2. Top-performing teams achieved high structural similarity indices (≥ 0.87/0.90) and gamma pass rates for photon (≥ 98.1%/99.0%) and proton (≥ 97.3%/97.0%) plans. However, no significant correlation was found between image similarity metrics and dose accuracy, emphasizing the need for dose evaluation when assessing the clinical applicability of sCT. SynthRAD2023 facilitated the investigation and benchmarking of sCT generation techniques, providing insights for developing MRI-only and CBCT-based adaptive radiotherapy. It showcased the growing capacity of deep learning to produce high-quality sCT, reducing reliance on conventional CT for treatment planning. © 2024, CC

关键词： Radiotherapy

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