检索结果-内蒙古大学图书馆

SSRN 2020年

作者： Tomaszewski, Claire E. DiLillo, Katarina M. Baker, Brendon M. Arnold, Kelly B. Shikanov, Ariella Department of Biomedical Engineering University of Michigan University of Michigan 1101 Beal Ave Ann ArborMI48109 United States Department of Obstetrics and Gynecology University of Michigan 1101 Beal Ave Ann ArborMI48109 United States Cellular and Molecular Biology Program University of Michigan 1101 Beal Ave Ann ArborMI48109 United States Macromolecular Science and Engineering University of Michigan 1101 Beal Ave Ann ArborMI48109 United States

Synthetic matrices offer a high degree of control and tunability for mimicking extracellular matrix functions of native tissue, allowing the study of disease and development in vitro. In this study, we functionalized degradable poly(ethylene glycol) hydrogels with extracellular matrix (ECM)-sequestering peptides aiming to recapitulate the native ECM composition for culture and maturation of ovarian follicular organoids. We hypothesized that ECM-sequestering peptides would facilitate deposition and retention of cell-secreted ECM molecules, thereby recreating cell-matrix interactions in otherwise bioinert PEG hydrogels. Specifically, heparin-binding peptide from antithrombin III (HBP), heparan sulfate binding peptide derived from laminin (AG73), basement membrane binder peptide (BMB), and heparan sulfate binding region of placental growth factor 2 (RRR) tethered to a PEG hydrogel significantly improved follicle survival, growth and maturation compared to PEG-Cys, a mechanically similar but biologically inert control. Immunohistochemical analysis of the hydrogel surrounding cultured follicles confirmed sequestration and retention of laminin, collagen I, perlecan and fibronectin in ECM-sequestering hydrogels but not in bioinert PEG-Cys hydrogels. The media from follicles cultured in PEG-AG73, PEG-BMB, and PEG-RRR also had significantly higher concentrations of factors known to regulate follicle development compared to PEG-Cys. PEG-AG73 and PEG-BMB were the most beneficial for promoting follicle maturation, likely because AG73 and BMB mimic basement membrane interactions which are crucial for follicle development. Here we have shown that functionalizing PEG with ECM-sequestering peptides allows cell-secreted ECM to be retained within the hydrogels, restoring critical cell-matrix interactions and promoting healthy organoid development in a fully synthetic culture system. © 2020, The Authors. All rights reserved.

关键词： Polyethylene glycols

来源：评论

学校读者我要写书评

暂无评论

Origin of broad polydispersion in functionalized dendrimers and its effects on cancer-cell binding affinity

引用

Physical Review E 2010年第3期82卷 036108-036108页

作者： Jack N. Waddell Douglas G. Mullen Bradford G. Orr Mark M. Banaszak Holl Leonard M. Sander Department of Mathematics University of Michigan Ann Arbor Michigan 48109 USA Program in Macromolecular Science and Engineering Ann Arbor Michigan 48109 USA Michigan Nanotechnology Institute for Medicine and Biological Sciences Ann Arbor Michigan 48109 USA Michigan Nanotechnology Institute for Medicine and Biological Sciences University of Michigan Ann Arbor Michigan 48109 USA Program in Applied Physics University of Michigan Ann Arbor Michigan 48109 USA Department of Physics University of Michigan Ann Arbor Michigan 48109 USA Department of Chemistry University of Michigan Ann Arbor Michigan 48109 USA Michigan Center for Theoretical Physics University of Michigan Ann Arbor Michigan 48109 USA

Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake. Experiments show that the distribution of conjugated ligands is unexpectedly broad, and the desorption rate appears to depend exponentially upon the mean number of attached ligands. These two findings are explained with a model in which ligands conjugate to the nanoparticle with a positive cooperativity of ≈4 kT, and that nanoparticles bound to a surface by multiple bonds are permanently affixed. This drives new analysis of the data, which confirms that there is only one time constant for desorption, that of a nanoparticle bound to the surface by a single bond.

关键词： Nanoparticles

来源：评论

学校读者我要写书评

暂无评论

Chemically Controlled Bending of Compositionally Anisotropic Microcylinders†

引用

Angewandte Chemie 2011年第3期124卷

作者： Sampa Saha Davor Copic Srijanani Bhaskar Nicholas Clay Alessandro Donini A. John Hart Joerg Lahann Department of Chemical Engineering University of Michigan Ann Arbor MI 48109 (USA) Department of Mechanical Engineering University of Michigan (USA) Macromolecular Science and Engineering Program University of Michigan Ann Arbor MI 48109 (USA)

来源：评论

学校读者我要写书评

暂无评论

Inside Cover: Multicompartmental Microcylinders (Angew. Chem. Int. Ed. 25/2009)

引用

Angewandte Chemie International Edition 2009年第25期48卷

作者： Srijanani Bhaskar Jonathon Hitt Sei-Won Laura Chang Joerg Lahann Prof. Macromolecular Science and Engineering Program University of Michigan Ann Arbor MI 48109 (USA) Fax: (+1) 734-764-7453 Department of Chemical Engineering University of Michigan Ann Arbor MI 48109 (USA)

Multicompartmental microcylinders can be produced by a combination of electrohydrodynamic co-spinning and microsectioning, as described by J. Lahann et al. in their Communication on page 4589 ff. The number of individual compartments, relative compartment orientation, chemical composition and functionality, and aspect ratio can be precisely tuned. Each color in the longitudinal and cross-sectional micrograph images depicts an individual compartment.

关键词： anisotropy biodegradable polymers electrohydrodynamic co-spinning microparticles protein immobilization

来源：评论

学校读者我要写书评

暂无评论

Multicompartmental Microcylinders†

引用

Angewandte Chemie 2009年第25期121卷

作者： Srijanani Bhaskar Jonathon Hitt Sei‐Won Laura Chang Joerg Lahann Macromolecular Science and Engineering Program University of Michigan Ann Arbor MI 48109 (USA) Fax: (+1) 734‐764‐7453 Department of Chemical Engineering University of Michigan Ann Arbor MI 48109 (USA)

Farbenprächtige Säulen : Eine einfache und dabei skalierbare Methode zur Herstellung multikompartimentalisierter Mikrozylinder, bei denen innerer Aufbau, Seitenverhältnis und Oberfläche gezielt eingestellt werden können, nutzt elektrohydrodynamisches Spinnen und Mikroabtrennen. Die Kompartimente werden mithilfe verschiedenfarbiger Farbstoffe unterschieden (siehe CLSM‐Bilder; Maßstab: 10 μm).

关键词： Anisotropie Bioabbaubare Polymere Elektrohydrodynamisches Spinnen Mikropartikel Proteinimmobilisierung

来源：评论

学校读者我要写书评

暂无评论

Innentitelbild: Multicompartmental Microcylinders (Angew. Chem. 25/2009)

引用

Angewandte Chemie 2009年第25期121卷

Mikrozylinder mit mehreren Kompartimenten lassen sich mit einer Kombination aus elektrohydrodynamischem Spinnen und Mikroabtrennen herstellen, wie J. Lahann et al. in der Zuschrift auf S. 4659 ff. beschreiben. Die Zahl der einzelnen Kompartimente, ihre relative Orientierung, chemische Zusammensetzung und Funktionalität sowie das Seitenverhältnis können maßgeschneidert eingestellt werden. Jede Farbe in den Längs‐ und Querschnitt‐Mikrographen entspricht einem individuellen Kompartiment.

关键词： Anisotropie Bioabbaubare Polymere Elektrohydrodynamisches Spinnen Mikropartikel Proteinimmobilisierung

来源：评论

学校读者我要写书评

暂无评论

A Crystalline Mesoporous Coordination Copolymer with High Microporosity†

引用

Angewandte Chemie 2008年第4期120卷

作者： Kyoungmoo Koh Antek G. Wong‐Foy Adam J. Matzger Department of Chemistry and the Macromolecular Science and Engineering Program University of Michigan 930 North University Ave Ann Arbor MI 48109‐1055 USA Fax: (+1) 734‐6715‐8853

来源：评论

学校读者我要写书评

暂无评论

Evidence of Positronium Bloch States in Porous Crystals of Zn4O-Coordination Polymers

引用

Physical Review Letters 2013年第19期110卷 197403-197403页

作者： Dhanadeep Dutta Jeremy I. Feldblyum David W. Gidley James Imirzian Ming Liu Adam J. Matzger Richard S. Vallery Antek G. Wong-Foy Department of Physics University of Michigan 450 Church Street Ann Arbor Michigan 48109 USA Department of Chemistry University of Michigan 930 North University Street Ann Arbor Michigan 48109 USA Macromolecular Science and Engineering University of Michigan 2300 Hayward Avenue Ann Arbor Michigan 48109-2136 USA NIST Polymers Division 100 Bureau Dr. M/S 8541 Gaithersburg Maryland 20899-8541 USA Nuclear Reactor Program Department of Nuclear Engineering North Carolina State University P.O. Box 7909 Raleigh North Carolina 27695 USA Department of Physics Grand Valley State University 151 Padnos Hall Allendale Michigan 49401 USA

Positronium (Ps) is shown to exist in a delocalized state in self-assembled metalorganic crystals that have large 1.3–1.5 nm cell sizes. Belonging to a class of materials with record high accessible specific surface areas, these highly porous crystals are the first to allow direct probing with simple annihilation lifetime techniques of the transport properties of long-lived triplet Ps in what is hypothesized to be a Bloch state. Delocalized Ps has unprecedented (high) Ps mobility driven primarily by weak phonon scattering with unusual and profound consequences on how Ps probes the lattice.

关键词： POSITRONIUM COORDINATION polymers ORGANOMETALLIC compounds ANNIHILATION reactions PHONONS -- Scattering

来源：评论

学校读者我要写书评

暂无评论

Chiral Phonons in Biocrystals

Research Square

引用

Research Square 2021年

作者： Choi, Won Jin Yano, Keiichi Cha, Minjeong Colombari, Felippe M. Wang, Yichun Lee, Sang Hyun Kruger, John M. de Moura, André F. Kotov, Nicholas A. Department of Materials Science and Engineering University of Michigan Ann ArborMI48109 United States Biointerfaces Institute University of Michigan Ann ArborMI48109 United States Department of Chemical Engineering University of Michigan Ann ArborMI48109 United States SP Campinas13.083-100 Brazil Department of Biomedical Engineering University of Michigan Ann ArborMI48109 United States Department of Chemical and Biochemical Engineering University of Notre Dame South BendIN46556 United States Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109 United States Department of Small Animal Clinical Sciences Michigan State University East LansingMI48824 United States Department of Chemistry Federal University of São Carlos SP São Carlos13565-905 Brazil Program in Macromolecular Science and Engineering University of Michigan Ann ArborMI48109 United States

Chiral phonons are concerted mirror-symmetric movements of atomic groups connected by covalent and intermolecular bonds. Finding chiral phonons in biocrystals is fundamentally and technologically important because these lattice vibrations should be highly specific to their short- and long-range organizations. Based on theoretical and experimental data they might be expected but not identified or utilized. Here we show that terahertz chiroptical spectroscopy enables registration and attribution of chiral phonons in microcrystals of numerous amino acids and dipeptides. Theoretical analysis and computer simulations confirm that sharp mirror-symmetric bands observed for left and right enantiomers originate from collective vibrations of biomolecules interconnected by hydrogen bonds into helical chains. Structure-property relationships for strong phonons with rotatory components in biocrystals were also identified. Bladder stones and health supplements display strong spectral signatures of chiral phonons indicating their immediate importance for biomedicine. © 2021, CC BY.

关键词： Phonons

来源：评论

学校读者我要写书评

暂无评论

Self-Assembly: Liquid Crystal Order in Colloidal Suspensions of Spheroidal Particles by Direct Current Electric Field Assembly (Small 10/2012)

引用

Small 2012年第10期8卷

作者： Aayush A. Shah Heekyoung Kang Kevin L. Kohlstedt Kyung Hyun Ahn Sharon C. Glotzer Charles W. Monroe Michael J. Solomon Program of Macromolecular Science and Engineering University of Michigan Ann Arbor MI USA Department of Materials Science and Engineering University of Michigan Ann Arbor MI USA School of Chemical and Biological Engineering Seoul National University Seoul Korea Department of Chemical Engineering University of Michigan 3410 G.G. Brown 2300 Hayward Street Ann Arbor MI 48109-2136

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：