spinocerebellar ataxia is a neurological disorder characterized by impaired neural coordination, leading to unstable gait, coordination difficulties, and other motor abnormalities. This disease significantly impacts p...
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Parkinson's disease (PD) is a neurodegenerative disorder often characterized by motor symptomssuch as hypomimia, and a reduction in facial expression. We explored the significance of facial features in identifyin...
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Eye-tracking studies focused on art galleries and museums within the realm of Instagram, especially in the Indonesian context, are notably scant. This investigation elucidates the user interaction and experience of th...
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Poly(polyol sebacate) (PPs) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Po...
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Poly(polyol sebacate) (PPs) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXs-co-PEG) has been developed to fabricate PPs-based hydrogels;however, current PXs-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXs-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXs-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPs-based hydrogels for advanced biomedical applications. statement of significance: Variousstrategies have been developed to fabricate poly(polyol sebacate) (PPs)-based hydrogels. However, current PPs-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXs-co-
Nanocomposite (NC) hydrogels used for sonodynamic therapy (sDT) face challengessuch as lacking interfacial interactions between the polymers and nanomaterials as well as presenting uneven dispersion of nanomaterials ...
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spinocerebellar ataxia is a neurological disorder characterized by impaired neural coordination, leading to unstable gait, coordination difficulties, and other motor abnormalities. This disease significantly impacts p...
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ISBN:
(数字)9798350360721
ISBN:
(纸本)9798350360738
spinocerebellar ataxia is a neurological disorder characterized by impaired neural coordination, leading to unstable gait, coordination difficulties, and other motor abnormalities. This disease significantly impacts patients' daily lives, making it challenging for them to maintain balance, walk smoothly, and even perform fine motor skills. The causes of spinocerebellar ataxia are diverse, including genetic factors, brain injuries, or certain diseases. Many patients with spinocerebellar ataxia require specialized medical care and ongoing monitoring to manage its effects. Thisstudy aims to utilize Human Posture Estimation to detect the gait patterns of patients with spinocerebellar ataxia and integrate it with a deep learning model to distinguish between normal and affected individuals. The outcomes offer physicians an objective diagnostic tool and facilitate early detection and intervention for patients with impaired gait, thereby supporting the enhancement or preservation of their quality of life. The current prediction accuracy for the risk of ataxia gait is 80%, with an F1 score of 78.26%. It is necessary to conduct a detailed quantitative assessment by analyzing the gait of patients with spinocerebellar ataxia. Quantitative evaluation of the data allows for an objective assessment of the patient's gait, which helps healthcare professionals to more accurately understand and assess the gait status of patients with spinocerebellar ataxia.
Parkinson's disease (PD) is a neurodegenerative disorder often characterized by motor symptomssuch as hypomimia, and a reduction in facial expression. We explored the significance of facial features in identifyin...
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ISBN:
(数字)9798350360721
ISBN:
(纸本)9798350360738
Parkinson's disease (PD) is a neurodegenerative disorder often characterized by motor symptomssuch as hypomimia, and a reduction in facial expression. We explored the significance of facial features in identifying PD through static images, focusing on detecting hypomimia. A dataset comprised of PD patients and healthy controls' static facial images were collected and analyzed. Facial feature detection was conducted using OpenCV and Dlib libraries for the precise localization of key landmarks. In the subsequent feature extraction, parameterssuch assymmetry, eye aspect ratio, mouth corner distance, muscle tension, and mouth aperture ratio were used. Through the standardization of these features, meaningful comparisons across diverse images were made. By analyzing hypomimia-related features alongside traditional facial parameters, the results provide a comprehensive understanding of the role of facial expressions in PD diagnosis. The findingssuggested that examining facial features in static images enhances the accuracy of PD detection and understanding of the nuanced motor symptoms associated with the disease.
Fall incidents among the elderly represent a significant global concern, often resulting in physical injuries and psychological distress. It is crucial to develop reliable fall detection systems which are capable of i...
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Forest fires have been detected to occur in Indonesia since 1998. The forest fires mostly resulted from human activities in order to expand their land, especially oil palm lands. Once a land clearing is carried out, i...
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Background: A dual-function phantom designed to quantify the apparent diffusion coefficient (ADC) in different fat contents (FCs) and glass bead densities (GBDs) to simulate the human tissues has not been documented y...
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Background: A dual-function phantom designed to quantify the apparent diffusion coefficient (ADC) in different fat contents (FCs) and glass bead densities (GBDs) to simulate the human tissues has not been documented yet. We propose a dual-function phantom to quantify the FC and to measure the ADC at different FCs and different GBDs. Methods: A fat-containing diffusion phantom comprised by 30 glass-bead-containing fat-water emulsions consisting of six different FCs (0, 10, 20, 30, 40, and 50%) multiplied by five different GBDs (0, 0.1, 0.25, 0.5, and 1.0 g/50 mL). The FC and ADC were measured by the “iterative decomposition of water and fat with echo asymmetry and least squares estimation-IQ,” IDEAL-IQ, and single-shot echo-planar diffusion-weighted imaging, ss-EP-DWI, sequences, respectively. Linear regression analysis was used to evaluate the relationship among the fat fraction (FF) measured by IDEAL-IQ, GBD, and ADC. Results: The ADC wassignificantly, negatively, and linearly associated with the FF (the linear slope ranged from -0.005 to -0.017, R<sup>2sup> = 0.925 to 0.986, all p < 0.001). The slope of the linear relationship between the ADC and the FF, however, varied among different GBDs (the higher the GBD, the lower the slope). ADCs among emulsions across different GBDs and FFs were overlapped. Emulsions with low GBDs plus high FFsshared a same lower ADC range with those with median or high GBDs plus median or lower FFs. Conclusions: A novel dual-function phantom simulating the human tissues allowed to quantify the influence of FC and GBD on ADC. Relevance statement: The study developed an innovative dual-function MRI phantom to explore the impact of FC on ADC variation that can affect clinical results. The results revealed the superimposed effect on FF and GBD density on ADC measurements. Key points: • A dual-function phantom made of glass bead density (GBD) and fat fraction (FF) emulsion has been developed. • Apparent diffusion coefficient (ADC) values
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