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48th IEEE International Conference on Acoustics, speech and signal Processing, ICAssP 2023

作者： Chi, Tin-Han Liu, Kai-Chun Hsieh, Chia-Yeh Tsao, Yu Chan, Chia-Tai National Yang Ming Chiao Tung University Department of Biomedical Engineering Taiwan Academia Sinica Research Center for Information Technology Innovation Taiwan Fu Jen Catholic University Bachelor's Program in Medical Informatics and Innovative Applications Taiwan

ISBN: (纸本)9781728163277

Fall accidents are critical issues in an aging and aged society. Recently, many researchers developed "pre-impact fall detection systems"using deep learning to support wearable-based fall protection systems for preventing severe injuries. However, most works only employed simple neural network models instead of complex models considering the usability in resource-constrained mobile devices and strict latency requirements. In this work, we propose a novel pre-impact fall detection via CNN-ViT knowledge distillation, namely PreFallKD, to strike a balance between detection performance and computational complexity. The proposed PreFallKD transfers the detection knowledge from the pre-trained teacher model (vision transformer) to the student model (lightweight convolutional neural networks). Additionally, we apply data augmentation techniques to tackle issues of data imbalance. We conduct the experiment on the KFall public dataset and compare PreFallKD with other state-of-the-art models. The experiment results show that PreFallKD could boost the student model during the testing phase and achieves reliable F1-score (92.66%) and lead time (551.3 ms). © 2023 IEEE.

关键词： Inertial measurement units Knowledge distillation Pre-impact fall detection Vision transformer Wearable sensors

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A Computationally Efficient Algorithm for Estimating Respiratory Rate from seismocardiogram

SSRN

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ssRN 2024年

作者： Ku, Tienhsiung Lin, Yue-Der Department of Anesthesiology Changhua Christian Hospital Changhua50051 Taiwan Artificial Intelligence Development Center Changhua Christian Hospital Changhua50051 Taiwan Department of Automatic Control Engineering Feng Chia University Taichung40724 Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung40724 Taiwan

Respiratory rate (RR) monitoring is crucial in clinical and healthcare settings. With the advancements in microelectromechanical system (MEMs) technology, monitoring respiration using seismocardiogram (sCG) is emerging as a promising approach. This study presents a computationally efficient algorithm for estimating RR from sCG signal. The proposed algorithm consists of two primary steps: firstly applying Gaussian averaging filter for pre-processing and next computing the averaged spectrum from the scalogram based on complex Morlet wavelet within the specified frequency range. RR is then estimated from the dominant frequency appeared in the averaged spectrum. This study also establishes the analytical relationship between the parameters of Gaussian averaging filter and the sampling frequency of sCG signal, which serves as the design criterion for pre-processing filter. The proposed algorithm undergoes testing on two sCG datasets and has demonstrated its feasibility for estimating RR from sCG signal. Furthermore, the algorithm is also tested on both finger and wrist PPG datasets for RR estimation. The test results present high agreement between the RR estimations from sCG (or PPG) signal and those from respiration signal. Based on these testing results, the proposed algorithm shows significant potential in clinical and healthcare applications. © 2024, The Authors. All rights reserved.

关键词： Computational efficiency

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Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains

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Computational and structural Biotechnology Journal 2024年 23卷 1864-1876页

作者： Do, Duyen Thi Yang, Ming-Ren Vo, Tran Nam son Le, Nguyen Quoc Khanh Wu, Yu-Wei Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Business Administration College of Management Lunghwa University of Science and Technology Taoyuan City Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan

In current genomic research, the widely used methods for predicting antimicrobial resistance (AMR) often rely on prior knowledge of known AMR genes or reference genomes. However, these methods have limitations, potentially resulting in imprecise predictions owing to incomplete coverage of AMR mechanisms and genetic variations. To overcome these limitations, we propose a pan-genome-based machine learning approach to advance our understanding of AMR gene repertoires and uncover possible feature sets for precise AMR classification. By building compacted de Brujin graphs (cDBGs) from thousands of genomes and collecting the presence/absence patterns of unique sequences (unitigs) for Pseudomonas aeruginosa, we determined that using machine learning models on unitig-centered pan-genomes showed significant promise for accurately predicting the antibiotic resistance or susceptibility of microbial strains. Applying a feature-selection-based machine learning algorithm led to satisfactory predictive performance for the training dataset (with an area under the receiver operating characteristic curve (AUC) of > 0.929) and an independent validation dataset (AUC, approximately 0.77). Furthermore, the selected unitigs revealed previously unidentified resistance genes, allowing for the expansion of the resistance gene repertoire to those that have not previously been described in the literature on antibiotic resistance. These results demonstrate that our proposed unitig-based pan-genome feature set was effective in constructing machine learning predictors that could accurately identify AMR pathogens. Gene sets extracted using this approach may offer valuable insights into expanding known AMR genes and forming new hypotheses to uncover the underlying mechanisms of bacterial AMR. © 2024 The Authors

关键词： Genes

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An Analysis of Fluid Intake Assessment Approaches for Fluid Intake Monitoring system

Biosensors

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Biosensors 2024年第1期14卷 14页

作者： Hsieh, Chia-Yeh Huang, Hsiang-Yun Chan, Chia-Tai Chiu, Li-Tzu Bachelor’s Program in Medical Informatics and Innovative Applications Fu Jen Catholic University New Taipei City24205 Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei City11221 Taiwan

Monitoring fluid intake is essential to help people manage their individual fluid intake behaviors and achieve adequate hydration. Previous studies of fluid intake assessment approaches based on inertial sensors can be categorized into wrist-worn-based and smart-container-based approaches. This study aims to analyze wrist-worn-based and smart-container-based fluid intake assessment approaches using inertial sensors. The comparison of these two approaches should be analyzed according to gesture recognition and volume estimation. In addition, the influence of the fill level and sip size information on the performance is explored in this study. The accuracy of gesture recognition with postprocessing is 92.89% and 91.8% for the wrist-worn-based approach and smart-container-based approach, respectively. For volume estimation, sip-size-dependent models can achieve better performance than general sVR models for both wrist-worn-based and smart-container-based approaches. The improvement of MAPE, MAD, and RMsE can reach over 50% except MAPE for small sip sizes. The results demonstrate that the sip size information and recognition performance are important for fluid intake assessment approaches. © 2023 by the authors.

关键词： Containers

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Benefits and drawbacks of radiofrequency ablation via percutaneous or minimally invasive surgery for treating hepatocellular carcinoma

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World Journal of Gastrointestinal surgery 2024年第11期16卷 3400-3407页

作者： Ching-Lung Hsieh Cheng-Ming Peng Chun-Wen Chen Chang-Hsien Liu Chih-Tao Teng Yi-Jui Liu Department of Computer Science and Information Engineering Feng Chia UniversityTaichung 40724Taiwan Department of Surgery Chung Shan Medical University HospitalTaichung 40201Taiwan School of Medicine Chung Shan Medical UniversityTaichung 40201Taiwan Department of Radiology Taichung Armed Forces General HospitalTaichung 406Taiwan Department of Medical Imaging and Radiological Sciences Central Taiwan University of Science and TechnologyTaichung 406Taiwan Department of Radiology School of MedicineNational Defense Medical CenterTaipei 11490Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital and China Medical UniversityHsinchu 302Taiwan Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsinchu 300Taiwan Department of Radiology Nantou Hospital of the Ministry of Health and WelfareNantou 540Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia UniversityTaichung 407Taiwan Department of Automatic Control Engineering Feng Chia UniversityTaichung 407Taiwan

The management of early stage hepatocellular carcinoma(HCC)presents significant *** radiofrequency ablation(RFA)has shown safety and effectiveness in treating HCC,with lower mortality rates and shorter hospital stays,its high recurrence rate remains a significant ***,achieving improved survival solely through RFA is challenging,particularly in retrospective studies with inherent *** is commonly used for guiding percutaneous RFA,but its low contrast can lead to missed tumors and the risk of HCC *** enhance the efficiency of ultrasound-guided percutaneous RFA,various techniques such as artificial ascites and contrast-enhanced ultrasound have been developed to facilitate complete tumor *** invasive surgery(MIs)offers advantages over open surgery and has gained traction in various surgical *** studies suggest that laparoscopic intraoperative RFA(IORFA)may be more effective than percutaneous RFA in terms of survival for HCC patients unsuitable for surgery,highlighting its ***,combining MIs-IORFA with these enhanced percutaneous RFA techniques may hold greater significance for HCC treatment using the MIs-IORFA *** article reviews liver resection and RFA in HCC treatment,comparing their merits and proposing a trajectory involving their combination in future therapy.

关键词： Percutaneous radiofrequency ablation Minimally invasive surgery Hepatocellular carcinoma Intraoperative radiofrequency ablation Contrast-enhanced ultrasound

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Deep Learning-based Fall Detection Algorithm Using Ensemble Model of Coarse-fine CNN and GRU Networks

Deep Learning-based Fall Detection Algorithm Using Ensemble ...

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2023 IEEE International symposium on Medical Measurements and Applications, MeMeA 2023

作者： Liu, Chien-Pin Li, Ju-Hsuan Chu, En-Ping Hsieh, Chia-Yeh Liu, Kai-Chun Chan, Chia-Tai Tsao, Yu National Yang Ming Chiao Tung University Department of Biomedical Engineering Taipei City112 Taiwan Fu Jen Catholic University Bachelor's Program in Medical Informatics and Innovative Applications New Taipei City242062 Taiwan Research Center for Information Technology Innovation Academia Sinica Taipei City115 Taiwan

ISBN: (纸本)9781665493840

Falls are the public health issue for the elderly all over the world since the fall-induced injuries are associated with a large amount of healthcare cost. Falls can cause serious injuries, even leading to death if the elderly suffers a 'long-lie.' Hence, a reliable fall detection (FD) system is required to provide an emergency alarm for first aid. Due to the advances in wearable device technology and artificial intelligence, some fall detection systems have been developed using machine learning and deep learning methods to analyze the signal collected from accelerometer and gyroscopes. In order to achieve better fall detection performance, an ensemble model that combines a coarse-fine convolutional neural network and gated recurrent unit is proposed in this study. The parallel structure design used in this model restores the different grains of spatial characteristics and capture temporal dependencies for feature representation. This study applies the FallAllD public dataset to validate the reliability of the proposed model, which achieves a recall, precision, and F-score of 92.54%, 96.13%, and 94.26%, respectively. The results demonstrate the reliability of the proposed ensemble model in discriminating falls from daily living activities and its superior performance compared to the state-of-the-art convolutional neural network long short-term memory (CNN-LsTM) for FD. © 2023 IEEE.

关键词： Fall detection

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The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net

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European Radiology 2023年第9期33卷 6157-6167页

作者： Li, Ya-Hui Lin, shao-Chieh Chung, Hsiao-Wen Chang, Chia-Ching Peng, Hsu-Hsia Huang, Teng-Yi shen, Wu-Chung Tsai, Chon-Haw Lo, Yu-Chien Lee, Tung-Yang Juan, Cheng-Hsuan Juan, Cheng-En Chang, Hing-Chiu Liu, Yi-Jui Juan, Chun-Jung Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital No. 199 Sec. 1 Xinglong Rd. Zhubei City Hsinchu County 302 Hsinchu Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Department of Management Science National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Department of Medical Imaging Medical University Hospital Taichung Taiwan Department of Neurology China Medical University Hospital Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Automatic Control Engineering Feng Chia University No. 100 Wenhwa Rd. Seatwen Taichung 40724 Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong ERB1112 11/F William M.W. Mong Engineering Building N.T Shatin Hong Kong Multi-Scale Medical Robotics Center The Chinese University of Hong Kong N.T Shatin Hong Kong Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

Background: To evaluate the effect of the weighting of input imaging combo and ADC threshold on the performance of the U-Net and to find an optimized input imaging combo and ADC threshold in segmenting acute ischemic stroke (AIs) lesion. Methods: This study retrospectively enrolled a total of 212 patients having AIs. Four combos, including ADC-ADC-ADC (AAA), DWI-ADC-ADC (DAA), DWI-DWI-ADC (DDA), and DWI-DWI-DWI (DDD), were used as input images, respectively. Three ADC thresholds including 0.6, 0.8 and 1.8 × 10–3sup> mm2sup>/s were applied. Dice similarity coefficient (DsC) was used to evaluate the segmentation performance of U-Nets. Nonparametric Kruskal–Wallis test with Tukey–Kramer post-hoc tests were used for comparison. A p <.05 was considered statistically significant. Results: The DsC significantly varied among different combos of images and different ADC thresholds. Hybrid U-Nets outperformed uniform U-Nets at ADC thresholds of 0.6 × 10–3sup> mm2sup>/s and 0.8 × 10–3sup> mm2sup>/s (p <.001). The U-Net with imaging combo of DDD had segmentation performance similar to hybrid U-Nets at an ADC threshold of 1.8 × 10–3sup> mm2sup>/s (p =.062 to 1). The U-Net using the imaging combo of DAA at the ADC threshold of 0.6 × 10–3sup> mm2sup>/s achieved the highest DsC in the segmentation of AIs lesion. Conclusions: The segmentation performance of U-Net for AIs varies among the input imaging combos and ADC thresholds. The U-Net is optimized by choosing the imaging combo of DAA at an ADC threshold of 0.6 × 10–3sup> mm2sup>/s in segmentating AIs lesion with highest DsC. Key Points: • segmentation performance of U-Net for AIs differs among input imaging combos. • segmentation performance of U-Net for AIs differs among ADC thresholds. • U-Net is optimized using DAA with ADC = 0.6 × 10–3sup>mm2sup>/s. © 2023, The Author(s), under exclusive licence to European society of Radiology.

关键词： Deep Learning Diffusion Magnetic Resonance Imaging Ischemic stroke Neural Networks, Computer Retrospective study

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A VAE-Based Data Augmentation Method for Fall Detection system using Wearable sensor

A VAE-Based Data Augmentation Method for Fall Detection Syst...

引用

International Conference on Applied system Innovation (ICAsI)

作者： Yu-Chen Tu Hsuan-Chih Wang Chien-Pin Liu Chia-Yeh Hsieh Chia-Tai Chan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei City Taiwan Bachelor's Program in Medical Informatics and Innovative Applications Fu Jen Catholic University New Taipei City Taiwan

ISBN: (数字)9798350394924

ISBN: (纸本)9798350394931

Fall incidents among the elderly represent a significant global concern, often resulting in physical injuries and psychological distress. It is crucial to develop reliable fall detection systems which are capable of identifying fall events immediately and triggering alerts for assistance. However, real-world fall occurrences are infrequent, leading to a highly imbalanced class situation. Training a model with imbalanced datasets may result in biased models with poor performance in fall detection. To address this challenge, various techniques such as data transformation and synthetic Minority Oversampling Technique (sMOTE) have been proposed. However, these methods are constrained by issues such as limitations in input data size or sensitivity to outliers. Compared to other methods, variational autoencoder (VAE) can generate data with a similar probability distribution to the original input data while constraining the latent representation in a Gaussian distribution. This study proposes a VAE-based data augmentation method for wearable-based fall detection system. The proposed method is validated on the FallAllD public dataset, achieving a F-score of 99.46%. The performance has been increased by 2.21%. The results demonstrate the effectiveness of VAE-based data augmentation technique in enhancing fall detection systems and its superior performance compared with other traditional data augmentation methods.

关键词： Training Technological innovation sensitivity Psychology Data augmentation Probability distribution Reliability

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A potential imaging biomarker distinguishing neurodegenerative parkinsonism using brainstem MRI shape analysis

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European radiology 2023年第7期33卷 4537-4539页

作者： Ming-Ting Tsai Cheng-En Juan Yi-Jui Liu Chun-Jung Juan Department of Medical Imaging China Medical University Hsinchu Hospital Hsinchu Taiwan Republic of China. Master's Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Republic of China. Master's Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Republic of China. erliu@fcu.edu.tw. Department of Automatic Control Engineering Feng Chia University Taichung Taiwan Republic of China. erliu@fcu.edu.tw. Department of Medical Imaging China Medical University Hsinchu Hospital Hsinchu Taiwan Republic of China. peterjuancj@yahoo.com.tw. Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Republic of China. peterjuancj@yahoo.com.tw. Department of Medical Imaging China Medical University Hospital Taichung Taiwan. peterjuancj@yahoo.com.tw. Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Republic of China. peterjuancj@yahoo.com.tw. Department of Radiology School of Medicine National Defense Medical Center Taipei Taiwan Republic of China. peterjuancj@yahoo.com.tw.

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Convolutional neural network-based fast seizure detection from video electroencephalograms

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biomedical signal Processing and Control 2023年 80卷

作者： Chou, Chi-Hsiang shen, Tsu-Wang Tung, Hsin Hsieh, Peiyuan F. Kuo, Chih-En Chen, Ting-Mao Yang, Chao-Wei Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan The Department of Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Neurology National Yang Ming Chiao Tung University School of Medicine Taipei Taiwan Department of Automatic Control Engineering Feng Chia University Taichung Taiwan Master's Program in Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Applied Mathematics National Chung Hsing University Taichung Taiwan

Objective: Ictal stage detection in electroencephalography (EEG) is important for epilepsy diagnosis. However, it's a laborious and time-consuming task for neurologists, especially with lengthy EEG recordings (such as video-EEG). Here we applied the current deep learning techniques to improve ictal stage detection efficiency. Methods: We enrolled epileptic patients at video-EEG examination beds of our neurology department between Jan 2016 and Apr 2020. Four stages of EEG (interictal, preictal, ictal and postictal) were labeled and confirmed by neurologists. Labeled EEG signals were transformed into second-order Poincaré difference plots. The whole dataset was divided into ‘Training’, ‘Validation’ and ‘Testing’ datasets with the proportions of 45%, 5% and 50% respectively. We applied 4 Convolutional Neural Networks (CNNs), namely, AlexNet, GoogLeNet, ResNet50 and DenseNet201, to learn classifying. The top three CNNs were put into an ensemble model for datasets classification. Results: 30 epileptic patients were included: Male/Female 16/14, mean age 42.8 ± 15.0 (range 22 ∼ 81) years old. Total recorded ictal duration was 47,444 s. Overall accuracies for each of the 4 CNN models (AlexNet, GoogLeNet, ResNet50 and DenseNet201) were 78.0%, 78.3%, 81.7% and 80.8%. We omitted the AlexNet, the other 3 CNNs were put into the ensemble model. The best performance was under test with 1% of the Testing dataset yielded the overall accuracies of 85.9%. The ictal stage accuracy was 97.7%. Conclusion: Our method is a promising computer-aid deep learning approach to detect seizures on video EEG. significance: For testing phase, selected proportion of testing dataset may influence the performances of deep learning models. © 2022 The Author(s)

关键词： Electroencephalography

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