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Association of long-term ozone exposure with the incidence and progression of hypertension, diabetes, and chronic kidney disease: A national retrospective cohort study

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Science of the Total Environment 2025年 975卷 179209页

作者： Li, Yu-Ling Chang, Po-Ya Chuang, Ting-Wu Hsieh, Yi-Chen Wang, Bo-Sian Chen, Szu-Ying Chiou, Hung-Yi Institute of Population Health Sciences National Health Research Institutes Miaoli County Zhunan Taiwan Department of Leisure Industry and Health Promotion National Taipei University of Nursing and Health Sciences Taipei Taiwan Department of Molecular Parasitology and Tropical Diseases School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan Master Program in Applied Epidemiology College of Public Health Taipei Medical University Taipei Taiwan

Evidence suggests that ozone is associated with an increased risk of hypertension, diabetes, or chronic kidney disease (CKD). However, the associations of ozone exposure with the dynamic progression of these diseases among Asian population remain unknown. This study included 9,256,945 participants from Taiwan's National Health Insurance Research Database between 2006 and 2021. Multimorbidity was defined as the coexistence of CKD and either hypertension or diabetes. The ordinary kriging method was used to estimate daily concentrations of ozone, sulfur dioxide, carbon monoxide, nitrogen dioxide, suspended fine particles, and suspended particles. Then, five-year average concentrations of pollutants were calculated. We performed multi-state survival models to analyze the association between ozone and dynamic progression of these diseases. During follow-up, 3,555,498 participants experienced hypertension, diabetes, or CKD;656,515 experienced multimorbidity;and 792,555 died. Ozone exposure was significantly associated with incidence of the results in all transitions. The hazard ratios of each IQR (3.57 ppb) increment in ozone for the transition to incident disease were 1.016 [95 % confidence interval (CI): 1.014, 1.017], for the transition to death were 1.04 [95 % CI: 1.036, 1.043], for the transition to multimorbidity were 1.015 [95 % CI: 1.012, 1.017]. Furthermore, with each IQR increase of ozone, the hazard ratios for transition from the disease incidence to death and from multimorbidity to death were 1.03 [95 % CI: 1.026, 1.033] and 1.007 [95 % CI: 1.002, 1.013], respectively. Our results suggest long-term exposure to ozone might be an important determinant for the incidence and dynamic progression of hypertension, diabetes, and CKD in Taiwan. © 2025 Elsevier B.V.

关键词： Health insurance

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Association of Long-Term Ozone Exposure with the Incidence and Progression of Hypertension, Diabetes, and Chronic Kidney Disease: A National Retrospective Cohort Study

SSRN

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SSRN 2024年

作者： Li, Yu-Ling Chang, Po-Ya Chuang, Ting-Wu Hsieh, Yi-Chen Wang, Bo-Sian Chen, Szu-Ying Chiou, Hung-Yi Institute of Population Health Sciences National Health Research Institutes Miaoli County Zhunan Taiwan Department of Leisure Industry and Health Promotion National Taipei University of Nursing and Health Sciences Taipei Taiwan Department of Molecular Parasitology and Tropical Diseases School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Ph.D Program of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Master Program in Applied Epidemiology College of Public Health Taipei Medical University Taipei Taiwan

Emerging evidence indicates particulate matter and nitrogen oxides are associated with increased risk of transition from healthy state to incident hypertension, diabetes, or chronic kidney disease (CKD) in the dynamic progression of these three chronic diseases. However, across different dynamic disease trajectories the associations of gaseous pollutants such as ozone remain unknown. This study aimed to investigate the long-term effects of exposure to ambient ozone on dynamic progression to multimorbidity, and consequent death from these diseases, with consideration of other air pollutants. This study included 9,256,945 participants from Taiwan’s National Health Insurance Research Database between 2006 and 2021. Multimorbidity was defined as the coexistence of CKD and either hypertension or diabetes. The ordinary kriging method was used to estimate daily concentrations of ozone, sulfur dioxide, carbon monoxide, nitrogen dioxide, suspended fine particles, and suspended particles. We performed multi-state models to analyze the association between ambient air pollutants and dynamic progression of hypertension, diabetes, and CKD. During follow-up, 3,555,498 participants experienced hypertension, diabetes, or CKD;656,515 experienced multimorbidity;and 792,555 died. Ozone exposure was significantly associated with incidence of the results in all transitions. The hazard ratios of each IQR (3.57 ppb) increment in ozone for the transition to incident disease were 1.016 [95% confidence interval (CI): 1.014, 1.017], for the transition to death were 1.04 [95% CI: 1.036, 1.043], for the transition to multimorbidity were 1.015 [95% CI: 1.012, 1.017] after adjusting other risk factors. Furthermore, with each IQR increase of ozone, the hazard ratios for transition from the incidence disease to death and from multimorbidity to death were 1.03 [95% CI: 1.026, 1.033] and 1.007 [95% CI: 1.002, 1.013], respectively. Our results suggest that long-term exposure to ozone might be an import

关键词： Health insurance

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Interactive Effects of a Combination of the HDAC3 and HDAC9 Genes with Diabetes Mellitus on the Risk of Ischemic Stroke

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Thrombosis and Haemostasis 2020年第3期121卷 396-404页

作者： Hung-Yi Chiou Chyi-Huey Bai Li-Ming Lien Chaur-Jong Hu Jiann-Shing Jeng Sung-Chun Tang Huey-Juan Lin Yi-Chen Hsieh School of Public Health College of Public Health Taipei Medical University Taipei Taiwan Master Program in Applied Molecular Epidemiology College of Public Health Taipei Medical University Taipei Taiwan School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Neurology Shin Kong Wu Ho-Su Memorial Hospital Taipei Taiwan Stroke Center Department of Neurology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Stroke Center and Department of Neurology National Taiwan University Hospital Taipei Taiwan Department of Emergency Medicine Chi-Mei Medical Center Tainan Taiwan Department of Biotechnology Southern Taiwan University of Science and Technology Tainan Taiwan PhD Program of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan PhD Program in Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei Taiwan

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Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma

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Journal of Biological Chemistry 2023年第6期299卷 104814页

作者： Hong, Xuan Hsieh, Min-Tsang Tseng, Tzu-Yu Lin, Hui-Yi Chang, Hung-Chih Yau, Sir-Theng Cheng, Wei-Chung Ke, Baozhen Liao, Hsiao-Hui Wu, Chih-Ying Liu, An-An Wu, Meei-Maan Huang, Kuo-Yen Yang, Pan-Chyr Kuo, Sheng-Chu Hung, Mien-Chie Lee, Pei-Chih Department of Medical Oncology Harbin Medical University Cancer Hospital Harbin China School of Pharmacy China Medical University Taichung Taiwan Research Center for Chinese Herbal Medicine China Medical University Taichung Taiwan Chinese Medicinal Research and Development Center China Medical University Hospital Taichung Taiwan Research Center for Cancer Biology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery China Medical University Taichung Taiwan Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center HoustonTX United States Department of Pathology and Laboratory Medicine Taichung Veterans General Hospital Taichung Taiwan Department of Public Health School of Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Public Health College of Public Health Taipei Medical University Taipei Taiwan Master Program in Applied Epidemiology College of Public Health Taipei Medical University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Genomics Research Center Academia Sinica Taipei Taiwan

Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) patients often respond to EGFR tyrosine kinase inhibitors (TKIs) initially but eventually develop resistance to TKIs. The switch of EGFR downstream signaling from TKI-sensitive to TKI-insensitive is a critical mechanism-driving resistance to TKIs. Identification of potential therapies to target EGFR effectively is a potential strategy to treat TKI-resistant LUADs. In this study, we developed a small molecule diarylheptanoid 35d, a curcumin derivative, that effectively suppressed EGFR protein expression, killed multiple TKI-resistant LUAD cells in vitro, and suppressed tumor growth of EGFR-mutant LUAD xenografts with variant TKI-resistant mechanisms including EGFR C797S mutations in vivo. Mechanically, 35d triggers heat shock protein 70–mediated lysosomal pathway through transcriptional activation of several components in the pathway, such as HSPA1B, to induce EGFR protein degradation. Interestingly, higher HSPA1B expression in LUAD tumors associated with longer survival of EGFR-mutant, TKI-treated patients, suggesting the role of HSPA1B on retarding TKI resistance and providing a rationale for combining 35d with EGFR TKIs. Our data showed that combination of 35d significantly inhibits tumor reprogression on osimertinib and prolongs mice survival. Overall, our results suggest 35d as a promising lead compound to suppress EGFR expression and provide important insights into the development of combination therapies for TKI-resistant LUADs, which could have translational potential for the treatment of this deadly disease. © 2023 The Authors

关键词： Tumors

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5th National Congress of the Italian Society of Physiotherapy

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Archives of Physiotherapy 2016年第1期6卷 1-42页

作者： Alessandro Aina Elisabetta Sarasso Marco Barbero Barbara Cagnie Elena Castelli Chad Cook Silvano Ferrari Andrea Foglia Paolo Bizzarri Donatella Giraudo Chris Littlewood Paolo Pillastrini Daniele Piscitelli Michele Romano Andrea Tettamanti Carla Vanti Stefano Vercelli Lennard Voogt Aceto Maria Spina Emanuele Silvestre Francesco Carotenuto Antonio Cerillo Ilaria Orefice Giuseppe Paone Paolo Bassi Raffaele Fiorito Serena Aina Alessandro M. Bonfanti M. Pasquetti Bortolami Arianna Pillastrini Paolo Vanti Carla D. Brioschi A. Pedretti M. Vitali G. Fraschini A. Tettamanti G. Castellini S. Gianola L. Moja S. Bonovas G. Banfi Greta Castellini Monica Gasparini Silvia Gianola Valentina Pecoraro Lorenzo Moja A. Andreano Pamela Frigerio Michela Agostini Andrea Turolla Rosa Bolotta Davide Corbetta Valeria Sirtori Paolo Gozzer Erica Guariento Linda Li G Castellini L Moja S Gianola S Bonovas Alessandro Chiarotto Caroline B. Terwee Maarten Boers Raymond W. Ostelo Lara J. Maxwell George A. Wells Peter Tugwell Ron Clijsen Cesar Fernandez-de-las-Penas Ciceri Matteo Rossetti Sara Vercelli Stefano M. Cislaghi G. Penone G. Marinelli G. Rezzan G. Melegati R. Gatti Colombo Claudio Tolosa Francesca Andrea Moriondo Stefano Doronzio Matteo Paci Marco Monticone Garzonio Fabiola Zanetta Anna Bargeri Serena Cerone Giorgia Sartorio Francesco Filippo Ghirlanda Alessandro Schneebeli Corrado Cescon G. Gioia S. Faccendini A. Aina G. Granzotto F. Gattinoni L. Coppola I. Gava M. Frassinelli Lorenzo Guidotti Marco Postiglione Bruna Lombardi Diego Leoni Michele Egloff Davide Storer Roberto Gatti Magno Tiziano Tettamanti Andrea Daniele Maremmani Giuseppe Plebani Sebastiano Cencini Federica Moresi Matteo Isnardi Alberto Gallace N. Moretti Maselli M. Testa Stefano Negrini Sabrina Donzelli Francesco Saveri Alessandra Negrini Silvana Parzini Fabio Zaina Leonardo Nesi Francesco Ferrarello Valeria Anna Maria Bianchi Luca Nannetti Giuditta Mini Mariangela Marchettini Fabio Piccolo Federica Agosta Massimo Filippi Andrea Falini Paola Adamo Federico Temporiti Rob Physiotherapist Dip. MDT private practice Milan Italy Laboratory of Movement Analysis Division of Neuroscience San Raffaele Scientific Institute and Vita-Salute San Raffaele University Milan Italy Neuroimaging Research Unit San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy Rehabilitation Research Laboratory Department of Business Economics Health and Social Care University of Applied Sciences and Arts of Southern Switzerland SUPSI Manno Switzerland Department of Business Health and Social Care University of Applied Sciences and Arts of Southern Switzerland (SUPSI) Manno Switzerland Department of Business Economics Health and Social Care University of Applied Sciences and Arts of Southern Switzerland SUPSI Manno Switzerland Department of Rehabilitation Sciences and Physiotherapy Ghent University Ghent Belgium San Raffaele Scientific Institute and Vita Salute University Milan Italy Division of Physical Therapy Duke University Durham NC USA Master of Manual Therapy and Musculoskeletal Rehabilitation Molecular Medicine Department of Human Anatomy University of Padova Padova Italy Master of Manual Therapy and Musculoskeletal Rehabilitation University of Padova Padova Italy Physiotherapists Orthopaedic Manual Therapists (OMT) Private practitioners Civitanova Marche Italy San Raffaele Turro Hospital Milan Italy University of Sheffield Sheffield UK Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy Ph.D. Candidate in Neuroscience Department of Translational Medicine and Surgery University of Milano-Bicocca Milano Italy Department of Translational medicine and Surgery Program in Physical Therapy University of Bicocca Milan Italy Rehabilitation Department S. Anna Hospital Como Italy ISICO Istituto Scientifico Italiano Colonna Vertebrale Milan Italy Laboratory of Analysis and Rehabilitation of Motor Function Neuroscience Division San Raffaele Hospital Milan Italy School of Physiotherapy

S1 Criteria for exercises selection in subjects with low back painAlessandro AinaS2 Recent advances in pathophysiology and treatment of myofascial trigger pointsMarco BarberoS3 Rehabilitation of scapular dyskinesiaBar... 详细信息

S1 Criteria for exercises selection in subjects with low back pain

Alessandro Aina

S2 Recent advances in pathophysiology and treatment of myofascial trigger points

Marco Barbero

S3 Rehabilitation of scapular dyskinesia

Barbara Cagnie

S4 Musculoskeletal rehabilitation in subjects affected by neurological disorders

Elena Castelli

S5 Which examination tests suggest the best candidates for manual therapy

Chad Cook

S6 Case study: the role of the measurements for the identification of targets and guidance of the treatment

Silvano Ferrari

S7 Assessment of joint mobility: state of the art

Andrea Foglia, Paolo Bizzarri

S8 Core stabilization exercises in the treatment of urinary incontinence

Donatella Giraudo

S9 Preventing surgical subacromial decompression through rotator cuff rehabilitation

Chris Littlewood

S10 Methodological aspects of Clinical Prediction Rules in the rehabilitation of Low Back Pain

Paolo Pillastrini

S11 Interpretability of outcome measures in musculoskeletal rehabilitation

Daniele Piscitelli

S12 Conservative treatment of the misalignment of the spine: state of the art and perspectives

Michele Romano

S13 Balance training in subjects with musculoskeletal disorders

Andrea Tettamanti

S14 Dosage of manual therapy: principles for clinical practice

Carla Vanti

S15 Are there speed limits in post-surgery lower limb rehabilitation?

Stefano Vercelli

S16 Classification of predominant neuropathic, nociceptive or central sensation pain

Lennard Voogt

P1 A wearable proprioceptive stabilizer (Equistasi®) for rehabilitation of balance disorders in multiple sclerosis patients: preliminary results of a randomized, double-blind, versus placebo controlled study

Aceto Maria, Spina Emanuele, Paone Paolo, Silvestre Francesco, Carotenuto Antonio, Ceri

关键词： Motor Imagery Oswestry Disability Index Manual Therapy Myofascial Pain Syndrome Clinical Prediction Rule

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