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Ginkgolide B facilitates muscle regeneration via rejuvenating osteocalcin-mediated bone-to-muscle modulation in aged mice

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Journal of cachexia, sarcopenia and muscle 2023年第3期14卷 1349-1364页

作者： Belle Yu-Hsuan Wang Yi-Fan Chen Allen Wei-Ting Hsiao Wan-Jing Chen Chien-Wei Lee Oscar Kuang-Sheng Lee Musculoskeletal Research Laboratory SH Ho Scoliosis Research Laboratory Department of Orthopaedics and Traumatology Faculty of Medicine The Chinese University of Hong Kong Hong Kong. Center for Neuromusculoskeletal Restorative Medicine CUHK InnoHK Centres Hong Kong Science Park Hong Kong. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Graduate Institute of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan. International Ph.D. Program for Translational Science College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Master Program in Clinical Genomics and Proteomics School of Pharmacy Taipei Medical University Taipei Taiwan. Department of Orthopaedics and Traumatology Faculty of Medicine Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong. Center for Translational Genomics & Regenerative Medicine Research China Medical University Hospital China Medical University Taichung Taiwan. Department of Biomedical Engineering China Medical University Taichung Taiwan. Department of Orthopedics China Medical University Hospital Taichung Taiwan. Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan.

BACKGROUND:The progressive deterioration of tissue-tissue crosstalk with aging causes a striking impairment of tissue homeostasis and functionality, particularly in the musculoskeletal system. Rejuvenation of the systemic and local milieu via interventions such as heterochronic parabiosis and exercise has been reported to improve musculoskeletal homeostasis in aged organisms. We have shown that Ginkgolide B (GB), a small molecule from Ginkgo biloba, improves bone homeostasis in aged mice by restoring local and systemic communication, implying a potential for maintaining skeletal muscle homeostasis and enhancing regeneration. In this study, we investigated the therapeutic efficacy of GB on skeletal muscle regeneration in aged mice. METHODS:Muscle injury models were established by barium chloride induction into the hind limb of 20-month-old mice (aged mice) and into C2C12-derived myotubes. Therapeutic efficacy of daily administrated GB (12 mg/kg body weight) and osteocalcin (50 μg/kg body weight) on muscle regeneration was assessed by histochemical staining, gene expression, flow cytometry, ex vivo muscle function test and rotarod test. RNA sequencing was used to explore the mechanism of GB on muscle regeneration, with subsequent in vitro and in vivo experiments validating these findings. RESULTS:GB administration in aged mice improved muscle regeneration (muscle mass, P = 0.0374; myofiber number/field, P = 0.0001; centre nucleus, embryonic myosin heavy chain-positive myofiber area, P = 0.0144), facilitated the recovery of muscle contractile properties (tetanic force, P = 0.0002; twitch force, P = 0.0005) and exercise performance (rotarod performance, P = 0.002), and reduced muscular fibrosis (collagen deposition, P < 0.0001) and inflammation (macrophage infiltration, P = 0.03). GB reversed the aging-related decrease in the expression of osteocalcin (P < 0.0001), an osteoblast-specific hormone, to promote muscle regeneration. Exogenous osteocalcin supplementation was

关键词： Ginkgolide B aging osteocalcin rejuvenation skeletal muscle regeneration

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Corrigendum to “Room-temperature cured hydrophobic epoxy/graphene composites as corrosion inhibitor for cold-rolled steel” [Carbon 66 (2014) 144–153]

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Carbon 2015年 82卷 611-611页

作者： Kung-Chin Chang Min-Hsiang Hsu Hsin-I Lu Mei-Chun Lai Pei-Ju Liu Chien-Hua Hsu Wei-Fu Ji Tsao-Li Chuang Yen Wei Jui-Ming Yeh Wei-Ren Liu Department of Chemistry Center for Nanotechnology and Institute of Biomedical Technology at Chung at Yuan Christian University (CYCU) Chung Li 32023 Taiwan ROC Master Program in Nanotechnology and Center for Nanotechnology at CYCU Chung Li 32023 Taiwan ROC Department of Chemistry and Key Lab of Organic Optoelectronic & Molecular Engineering of Ministry of Education Tsinghua University Beijing 100084 China Department of Chemical Engineering CYCU Chung Li 32023 Taiwan ROC

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Correction: Synergistic effects of hydrophobicity and gas barrier properties on the anticorrosion property of PMMA nanocomposite coatings embedded with graphene nanosheets

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Polymer Chemistry 2014年第23期5卷 6865-6865页

作者： Kung-Chin Chang Wei-Fu Ji Mei-Chun Lai You-Rong Hsiao Chien-Hua Hsu Tsao-Li Chuang Yen Wei Jui-Ming Yeh Wei-Ren Liu Department of Chemistry Center for Nanotechnology and Institute of Biomedical Technology at Chung-Yuan Christian University (CYCU) Chung Li Taiwan 32023 Republic of China Master Program in Nanotechnology and Center for Nanotechnology at CYCU Chung Li Taiwan 32023 Republic of China Department of Chemistry and Key Lab of Organic Optoelectronic & Molecular Engineering of Ministry of Education Tsinghua University Beijing 100084 China Department of Chemical Engineering CYCU Chung Li Taiwan 32023 Republic of China

Correction for ‘Synergistic effects of hydrophobicity and gas barrier properties on the anticorrosion property of PMMA nanocomposite coatings embedded with graphene nanosheets’ by Kung-Chin Chang et al., Polym. Chem...

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P1563THE ANALYSIS OF RISK FACTORS FOR THE PATIENTS EXPERIENCED VENOUS NEEDLE DISLODGEMENT OR BLEEDING DURING DIALYSIS

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Nephrology Dialysis Transplantation 2020年第SUPPLEMENT_3期35卷

作者： Wu, Hsiu Wen Lin, HsuanMing Chen, KuanYu Lin, YuChih Hu, HsiangWei I-Shou University Executive Master Program Department of Healthcare Administration Kaohsiung City Taiwan R.O.C An Nan Hospital China Medical University Tainan Taiwan Nephrologist division Internal medicine Tainan City Taiwan R.O.C AcuSense BioMedical Technology Corp. Tainan City Taiwan R.O.C National Cheng Kung University Department of Biomedical Engineering National Tainan city Taiwan R.O.C

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Agar-altered foaming bacterial cellulose with carvacrol for active food packaging applications

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Food Packaging and Shelf Life 2024年 42卷

作者： Kusuma, Anita Chandra Chou, Yu-Chieh Hsieh, Chen-Che Santoso, Shella Permatasari Go, Alchris Woo Lin, Hong-Ting Victor Hsiao, I.-Lun Lin, Shin-Ping Master Program in Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Section 4 Taipei 10617 Taiwan Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya 60114 Indonesia Department of Chemical Engineering National Taiwan University of Science and Technology 43 Keelung Road Section 4 Taipei 10607 Taiwan Department of Food Science National Taiwan Ocean University No. 2 Pei-Ning Road Keelung 20224 Taiwan School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan

Bacterial cellulose (BC) is a biodegradable nanoscale film produced by microorganisms, which possesses great mechanical properties and biocompatibility. In this study, we produced foaming BC (FBC) utilizing foam medium with different concentrations of agar. In addition, carvacrol was loaded into the agar/FBC to establish active packaging material. Evaluation by characterization tests indicated that agar/FBC provided lower crystallinity (59.8%∼71.4%) and a high swelling ability (94.7%∼97.9%) compared to BC (92.2% and 96.1%). The 1.5% agar/FBC with carvacrol group exhibited the significantly highest antimicrobial properties against Escherichia coli and Staphylococcus aureus. Moreover, release measurements showed that greater agar addition contributed to higher protein and carvacrol release extents out of the film. Finally, a sea bass packaging test indicated that carvacrol with 1.5% agar/FBC presented a higher antimicrobial ability against Shewanella putrefaciens, great inhibition of lipid oxidation (67.5%), and a slower spoilage degree (49.8%) which suggested that agar/FBC with carvacrol has potential for active food packaging. © 2024 Elsevier Ltd

关键词： Agar Bacterial cellulose Carvacrol Foaming bacterial cellulose Food packaging Sea bass

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Identification of gene expression signatures for psoriasis classification using machine learning techniques

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Medicine in Omics 2021年 1卷

作者： Nguyen Quoc Khanh Le Duyen Thi Do Trinh-Trung-Duong Nguyen Ngan Thi Kim Nguyen Truong Nguyen Khanh Hung Nguyen Thi Thu Trang Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei City 106 Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei City 106 Taiwan Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City 106 Taiwan Department of Computer Science and Engineering Yuan Ze University Chung-Li 32003 Taiwan School of Nutrition and Health Sciences Taipei Medical University Taipei City 110 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Orthopedic and Trauma Department Cho Ray Hospital Ho Chi Minh City Viet Nam International PhD Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan

Psoriasis classification requires the accurate identification of the lesional types for the early and effective diagnosis and it is worth interesting that the normal and psoriasis cell tissues exhibit different gene expression. Therefore, gene expression data is an effective source for psoriasis classification and there is a challenge regarding the selection of suitable gene signatures for its purpose. In this present study, the gene expression-based microarray data were used and 35 expression features linked with psoriasis were utilized to feed into our machine learning model. Overall, the performance of our model based on 35 mentioned-above features surpassed that of other state-of-the-art classifiers with an average accuracy of 98.3%, recall of 98.6%, and precision of 98% in 5-fold cross-validation tests. We also validate our model on two different sets of psoriasis and the performance results are significant. These results have suggested that our 35 expression signatures have been identified as key features for classifying samples between lesion and non-lesion. More specifically, the expression levels of few genes i.e., FABP5 , TGM1 , or BCAR3 are discovered as newly potential biomarkers for psoriasis classification and treatment with high confidence. This study, therefore, could shed light on developing the prediction models for psoriasis classification and treatment using gene expression profiles.

关键词： Psoriasis classification Random forest Gene expression Feature selection Machine learning FABP5 Dermatology

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Improvement of extracellular polysaccharides production from Cordyceps militaris immobilized alginate beads in repeated-batch fermentation

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LWT 2024年 193卷

作者： Hou, Shi-Jing Cheng, Kuan-Chen Lin, Shyh-Hsiang Hsiao, I-Lun Santoso, Shella Permatasari Singajaya, Stephanie Chou, Yu-Chieh Lin, Shin-Ping Master Program in Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei10617 Taiwan Graduate Institute of Food Science and Technology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei10617 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Rd. Taichung40402 Taiwan Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung41354 Taiwan School of Nutrition and Health Sciences Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 East Java Surabaya60114 Indonesia Collaborative Research Center for Sustainable and Zero Waste Industries Kalijudan 37 East Java Surabaya60114 Indonesia Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan

Cordyceps militaris (C. militaris) is a unique medicinal fungus of the genus Cordyceps. It has high economic value due to various biological functions from the extracellular polysaccharides (EPSs) it produces. The aim of this study was to establish a mycelium-immobilization system for EPS production in a bubble column system. First, EPS production was optimized by 90.2% (from 0.72 to 1.37 g/L) using response surface methodology under an alginate-immobilized mycelium system with 6 days of cultivation. The highest EPS production was obtained (5.3 g/L) in a flask system through elongation to 15 days of cultivation. EPS production subsequently further increased to 10.42 g/L utilizing a bubble column reactor. Furthermore, the system can be reused for at least three rounds. In the EPS characteristics analysis, the produced EPSs were mainly composed of glucose and galactose. They presented strong antibacterial activity against Staphylococcus aureus. In terms of antioxidant activity, respective the EPS concentration that caused 50% scavenging of DPPH and ABTS free radicals values (IC50) were 4.65 and 7.92 mg/mL. In summary, these findings should be helpful for establishing a suitable industrial fermentation system for C. militaris and can be studied in the food and medical industries in future work. © 2024 The Authors

关键词： Mycelium

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Magnesium-enriched deep-sea water inhibits NLRP3 inflammasome activation and dampens inflammation

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Heliyon 2024年第15期10卷 e35136页

作者： Wang, Hsueh-Hsiao Huang, Chi-Ruei Lin, Hsin-Chung Lin, Hsin-An Chen, Yu-Jen Tsai, Kuen-Jou Shih, Chieh-Tien Huang, Kuo-Yang Ojcius, David M. Tsai, Ming-Hang Tseng, Kuang-Wen Chen, Lih-Chyang Department of Medicine MacKay Medical College Master Program in Biomedicine College of Science and Engineering National Taitung University Biomedicine Agriculture and Food Sciences Research Center College of Science and Engineering National Taitung University Graduate Institute of Pathology and Parasitology National Defense Medical Center Division of Clinical Pathology Department of Pathology Tri-Service General Hospital National Defense Medical Center Division of Infection Department of Medicine Tri-Service General Hospital SongShan Branch National Defense Medical Center Department of Health Promotion and Health Education National Taiwan Normal University Department of Medical Research MacKay Memorial Hospital Department of Radiation Oncology MacKay Memorial Hospital Department of Artificial Intelligence and Medical Application MacKay Junior College of Medicine Nursing and Management Department of Medical Research China Medical University Hospital Department of Laboratory Medicine MacKay Memorial Hospital Department of Nursing MacKay Medical College Department of Biomedical Sciences University of the Pacific Arthur Dugoni School of Dentistry Department of Medicine Tri-Service General Hospital SongShan Branch National Defense Medical Center

The NLRP3 inflammasome is an essential component of the innate immune system, but excessive activation can lead to inflammatory diseases. Ion fluxes across the plasma membrane or from intracellular stores are known to regulate NLRP3 inflammasome activation. Deep-sea water (DSW) contains high concentrations of many mineral ions, which could potentially influence NLRP3 inflammasome activation. However, the impact of DSW on NLRP3 inflammasome activation has not been investigated. Here, we demonstrated that DSW with water hardness levels up to 500 mg/L did not affect cell viability or the expression of NLRP3 inflammasome components in macrophages derived from THP-1 cells. However, the DSW significantly inhibited IL-1β secretion and caspase-1 activation in response to NLRP3 activators such as nigericin, ATP, or monosodium urate (MSU) crystals. Mechanically, it was discovered that the presence of 5 mM magnesium ions (Mg2⁺), equivalent to the Mg2⁺ concentration found in the DSW with a water hardness of 500 mg/L, inhibits NLRP3 inflammasome activation. This indicates that Mg2⁺ contributes to the mechanism by which DSW mitigates NLRP3 inflammasome activation. Moreover, DSW administration effectively lessens MSU-triggered peritonitis in mice, a commonly used model for examining the impacts of NLRP3 inflammasome activation. These results show that DSW enriched with Mg²⁺ could potentially be beneficial in modulating NLRP3 inflammasome-associated diseases. © 2024 The Authors

关键词： Deep-sea water Macrophages Magnesium NLRP3 inflammasome

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MetaMOPE: a web service for mobile phase determination and fast chromatography peaks evaluation for metabolomics

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Bioinformatics Advances 2023年第1期3卷

作者： Tsai, Dong-Ming Chang, Ching-Yao Lin, Shih-Ming Kuo, Tien-Chueh Wang, San-Yuan Chen, Guan-Yuan Kuo, Ching-Hua Tseng, Yufeng Jane Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 106216 Taiwan The Metabolomics Core Laboratory Centers of Genomic and Precision Medicine National Taiwan University Taipei 100225 Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei 106216 Taiwan Master Program for Clinical Pharmacogenomics and Pharmacoproteomics School of Pharmacy Taipei Medical University Taipei 110301 Taiwan Forensic Medicine College of Medicine National Taiwan University Taipei 100225 Taiwan School of Pharmacy College of Medicine National Taiwan University Taipei 100225 Taiwan

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Optimization of hybrid PVA/hFDM scaffold preparation

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AIP Conference Proceedings 2021年第1期2344卷

作者： Rizqa Inayati Muhammad Suhaeri Nuzli Fahdia Melinda Remelia Radiana Dhewayani Antarianto 1Master Program in Biomedical Science Faculty of Medicine Universitas Indonesia Jl. Salemba Raya No. 6 Central Jakarta DKI Jakarta 10430 Indonesia 2Rumah Sakit Universitas Indonesia Kampus Universitas Indonesia Depok West Java 16424 Indonesia 3Stem cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI) Universitas Indonesia Salemba Raya Jakarta West Java 10430 Indonesia 4Doctoral Program in Biomedical Science Faculty of Medicine Universitas Indonesia Jl. Salemba Raya No. 6 Central Jakarta DKI Jakarta 10430 Indonesia 5Department of Basic Biomedicine Faculty of Medicine Universitas Kristen Indonesia Jl Mayjen Sutoyo No 2 DKI Jakarta 13630 Indonesia 6Department of Histology Faculty of Medicine Universitas Indonesia Jl. Salemba Raya No. 6 Central Jakarta DKI Jakarta 10430 Indonesia

Osteogenic differentiation from Mesenchymal Stem Cell (MSC) to osteoblast has a clinical significance which is very important for treating bone injuries, in the form of femoral fractures with the most cases in Indonesia. Various studies have been conducted to find the best scaffold that can improve osteogenic differentiation, one of which is the development of a hybrid scaffold made from natural biomaterials in the form of the extracellular matrix, and from synthetic biomaterials. The discovery of the best scaffold is not only focused on the source of the scaffold but also requires optimization of the method in making the scaffold. Therefore, the aim of this study is to find out the optimum method for making hybrid scaffolds that support osteogenic differentiation from MSC. Materials and methods: human Fibroblast-derived Matrix (hFDM) as a hybrid scaffold material collected from decellularized fibroblasts cultures from post-cleft-surgery reconstruction palatal skin. Fibroblast cell cultures were divided into two groups of cultures, cultures without Platelet Rich Plasma (PRP), and cultures with the addition of PRP. For decellularization, we performed optimization at the preparation stage of the decellularization solution, and the time of culture for decellularization. In the preparation of the decellularization solution, we divided it into two groups, NH4OH as material from the decellularization solution was diluted with PBS before mixing with 0.25% Triton X-100, and NH4OH was diluted directly in 0.25% Triton X-100. In optimizing the culture time for decellularization, we divided it into three groups, decellularization on the day when cell growth reached 100% confluent, decellularization on the 3rd day after 100% confluent (H + 3) cells, and decellularization on the 4th day after 100% confluent (H + 4) cells. Next, the hFDM matrix is collected and added Polyvinyl Alcohol (PVA) solutions to form a hybrid PVA / hFDM scaffold in the form of a hydrogel. Observations on h

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