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Modulatory Effects of Ophiocordyceps sinensis Mycelia on Hepatosteatosis Development in a High-Fat Dietary Habit

Environmental Toxicology 2025年第0期 2025 Feb 21页

作者： Lin, Yi-Ling Sutopo, Christoper Caesar Yudho Kao, Yi-Feng Tseng, Jung-Kai Chen, Yi-Chen Department of Animal Science and Technology National Taiwan University Taipei Taiwan Undergraduate and Graduate Programs of Nutrition Science National Taiwan Normal University Taipei Taiwan Seafood Technology Division Fisheries Research Institute Ministry of Agriculture Keelung Taiwan Department of Optometry Asia University Taichung Taiwan Master Program in Global Agriculture Technology and Genomic Science International College National Taiwan University Taipei Taiwan

The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges. This study explored the ameliorative effects of Ophiocordyceps sinensis mycelia (TCM-NA01 formula: 1.4 mg adenosine and 55.2 mg polysaccharide/capsule) on hepatosteatosis development in a high-fat diet (HFD)-fed mice. TCM-NA01 supplementation significantly reduced (p © 2025 Wiley Periodicals LLC.

关键词： Mycelium

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An alleviative effect of Lonicerae japonicae flos water extract against liver fibrogenesis in vitro and in vivo

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Environmental Toxicology 2024年第5期39卷 2881-2892页

作者： Lin, Yi-Ling Wu, Yi-Hsieng Samuel Chao, Ming-Yuan Yang, Deng-Jye Liu, Cheng-Wei Tseng, Jung-Kai Chen, Yi-Chen Department of Animal Science and Technology National Taiwan University Taipei Taiwan Undergraduate and Graduate Programs of Nutrition Science National Taiwan Normal University Taipei Taiwan Institute of Food Safety and Health Risk Assessment National Yang Ming Chiao Tung University Taipei Taiwan Department of Smart and Quality Agriculture MingDao University Changhua Taiwan Department of Optometry Asia University Taichung Taiwan Master Program in Global Agriculture Technology and Genomic Science International College National Taiwan University Taipei Taiwan

Lonicerae japonicae (L. japonicae) flos is a medical and food homology herb. This study investigated the phenolic acid and flavonoid contents in L. japonicae flos water extract solution (LJWES) and the preventive effects of LJWES against liver fibrogenesis via FL83B cells and rats. LJWES contains many polyphenols, such as chlorogenic acid, morin, and epicatechin. LJWES increased cell viability and decreased cytotoxicity in thioacetamide (TAA)-treated FL83B cells (75 mM) (p © 2024 Wiley Periodicals LLC.

关键词： Rats

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A functional chicken-liver hydrolysate-based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti-inflammation, and antiapoptosis

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Environmental Toxicology 2024年第3期39卷 1759-1768页

作者： Wu, Yi-Hsieng Samuel Lin, Yi-Ling Kao, Yi-Feng Chen, Jr-Wei Chen, Yi-Chou Chen, Yi-Chen Department of Animal Science and Technology National Taiwan University Taipei City Taiwan Institute of Food Safety and Health Risk Assessment National Yang Ming Chiao Tung University Taipei City Taiwan Undergraduate and Graduate Programs of Nutrition Science National Taiwan Normal University Taipei City Taiwan Seafood Technology Division Fisheries Research Institute Ministry of Agriculture Keelung City Taiwan Department of Animal Industry Ministry of Agriculture Taipei City Taiwan Great Billion Biotech Co. Limited. New Taipei City Taiwan Master Program in Global Agriculture Technology and Genomic Science International College National Taiwan University Taipei City Taiwan

Tons of broiler livers are produced yearly in Taiwan but always considered waste. Our team has successfully patented and characterized a chicken-liver hydrolysate (CLH) with several biofunctions. Chronic alcohol consumption causes hepatosteatosis or even hepatitis, cirrhosis, and cancers. This study was to investigate the hepatoprotection of CLH-based supplement (GBHP01™) against chronic alcohol consumption. Results showed that GBHP01™ could reduce (p © 2023 Wiley Periodicals LLC.

关键词： Metabolism

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FAR-RED INSENSITIVE 219 and phytochrome B corepress shade avoidance via modulating nuclear speckle formation

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Plant physiology 2023年第2期192卷 1449-1465页

作者： Kai-Chun Peng Wei Siao Hsu-Liang Hsieh Institute of Plant Biology College of Life Science National Taiwan University Taipei 106 Taiwan. Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Ghent Belgium. Center for Plant Systems Biology VIB 9052 Ghent Belgium. Department of Life Science College of Life Science National Taiwan University Taipei 106 Taiwan. Master Program in Global Agriculture Technology and Genomic Science National Taiwan University Taipei 106 Taiwan.

Plants can sense the shade from neighboring plants by detecting a reduction of the red:far-red light (R:FR) ratio. Phytochrome B (phyB) is the primary photoreceptor that perceives shade light and regulates jasmonic acid (JA) signaling. However, the molecular mechanisms underlying phyB and JA signaling integration in shade responses remain largely unknown. Here, we show the interaction of phyB and FAR-RED INSENSITIVE 219 (FIN219)/JASMONATE RESISTANT1 (JAR1) in a functional demand manner in Arabidopsis (Arabidopsis thaliana) seedling development. Genetic evidence and interaction studies indicated that phyB and FIN219 synergistically and negatively regulate shade-induced hypocotyl elongation. Moreover, phyB interacted with various isoforms of FIN219 under high and low R:FR light. Methyl jasmonate (MeJA) treatment, FIN219 mutation, and PHYBOE digalactosyldiacylglycerol synthase1-1 (dgd1-1) plants, which show increased levels of JA, altered the patterns of phyB-associated nuclear speckles under the same conditions. Surprisingly, PHYBOE dgd1-1 showed a shorter hypocotyl phenotype than its parental mutants under shade conditions. Microarray assays using PHYBOE and PHYBOE fin219-2 indicated that PHYB overexpression substantially affects defense response-related genes under shade light and coregulates expression of auxin-responsive genes with FIN219. Thus, our findings reveal that phyB substantially crosstalks with JA signaling through FIN219 to modulate seedling development under shade light.

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Tomato NADPH oxidase SlWfi1 interacts with the effector protein RipBJ of Ralstonia solanacearum to mediate host defence

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Plant, cell & environment 2024年第12期47卷 5007-5020页

作者： Guan-Ming Su Li-Wen Chu Chih-Cheng Chien Pei-Shan Liao Yu-Chuan Chiu Chi-Hsin Chang Tai-Hsiang Chu Chien-Hui Li Chien-Sheng Wu Jaw-Fen Wang Yi-Sheng Cheng Chuan-Hsin Chang Chiu-Ping Cheng Institute of Plant Biology College of Life Science National Taiwan University Taipei Taiwan. Institute of Ecology and Evolutionary Biology College of Life Science National Taiwan University Taipei Taiwan. Bacteriology Unit AVRDC-The World Vegetable Center Tainan Taiwan. Department of Life Science College of Life Science National Taiwan University Taipei Taiwan. Department of Research Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan. Global Agriculture Technology and Genomic Science Master Program International College National Taiwan University Taipei Taiwan. Master Program for Plant Medicine College of Bio-Resources & Agriculture National Taiwan University Taipei Taiwan.

Reactive oxygen species (ROS) play a crucial role in regulating numerous functions in organisms. Among the key regulators of ROS production are NADPH oxidases, primarily referred to as respiratory burst oxidase homologues (RBOHs). However, our understanding of whether and how pathogens directly target RBOHs has been limited. In this study, we revealed that the effector protein RipBJ, originating from the phytopathogenic bacterium Ralstonia solanacearum, was present in low- to medium-virulence strains but absent in high-virulence strains. Functional genetic assays demonstrated that the expression of ripBJ led to a reduction in bacterial infection. In the plant, RipBJ expression triggered plant cell death and the accumulation of HO, while also enhancing host defence against R. solanacearum by modulating multiple defence signalling pathways. Through protein interaction and functional studies, we demonstrated that RipBJ was associated with the plant's plasma membrane and interacted with the tomato RBOH known as SlWfi1, which contributed positively to RipBJ's effects on plants. Importantly, SlWfi1 expression was induced during the early stages following R. solanacearum infection and played a key role in defence against this bacterium. This research uncovers the plant RBOH as an interacting target of a pathogen's effector, providing valuable insights into the mechanisms of plant defence.

关键词： H2O2 RBOHs ROS T3SS bacterial wilt cell death

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Author Correction: Universal DNA methylation age across mammalian tissues

Nature aging

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Nature aging 2023年第11期3卷 1462页

作者： A T Lu Z Fei A Haghani T R Robeck J A Zoller C Z Li R Lowe Q Yan J Zhang H Vu J Ablaeva V A Acosta-Rodriguez D M Adams J Almunia A Aloysius R Ardehali A Arneson C S Baker G Banks K Belov N C Bennett P Black D T Blumstein E K Bors C E Breeze R T Brooke J L Brown G G Carter A Caulton J M Cavin L Chakrabarti I Chatzistamou H Chen K Cheng P Chiavellini O W Choi S M Clarke L N Cooper M L Cossette J Day J DeYoung S DiRocco C Dold E E Ehmke C K Emmons S Emmrich E Erbay C Erlacher-Reid C G Faulkes S H Ferguson C J Finno J E Flower J M Gaillard E Garde L Gerber V N Gladyshev V Gorbunova R G Goya M J Grant C B Green E N Hales M B Hanson D W Hart M Haulena K Herrick A N Hogan C J Hogg T A Hore T Huang J C Izpisua Belmonte A J Jasinska G Jones E Jourdain O Kashpur H Katcher E Katsumata V Kaza H Kiaris M S Kobor P Kordowitzki W R Koski M Krützen S B Kwon B Larison S G Lee M Lehmann J F Lemaitre A J Levine C Li X Li A R Lim D T S Lin D M Lindemann T J Little N Macoretta D Maddox C O Matkin J A Mattison M McClure J Mergl J J Meudt G A Montano K Mozhui J Munshi-South A Naderi M Nagy P Narayan P W Nathanielsz N B Nguyen C Niehrs J K O'Brien P O'Tierney Ginn D T Odom A G Ophir S Osborn E A Ostrander K M Parsons K C Paul M Pellegrini K J Peters A B Pedersen J L Petersen D W Pietersen G M Pinho J Plassais J R Poganik N A Prado P Reddy B Rey B R Ritz J Robbins M Rodriguez J Russell E Rydkina L L Sailer A B Salmon A Sanghavi K M Schachtschneider D Schmitt T Schmitt L Schomacher L B Schook K E Sears A W Seifert A Seluanov A B A Shafer D Shanmuganayagam A V Shindyapina M Simmons K Singh I Sinha J Slone R G Snell E Soltanmaohammadi M L Spangler M C Spriggs L Staggs N Stedman K J Steinman D T Stewart V J Sugrue B Szladovits J S Takahashi M Takasugi E C Teeling M J Thompson B Van Bonn S C Vernes D Villar H V Vinters M C Wallingford N Wang R K Wayne G S Wilkinson C K Williams R W Williams X W Yang M Yao B G Young B Zhang Z Zhang P Zhao Y Zhao W Zhou J Zimmermann J Ernst K Raj S Horvath Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Altos Labs San Diego Institute of Science San Diego CA USA. Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA USA. Department of Statistics University of California Riverside Riverside CA USA. Zoological SeaWorld Parks and Entertainment Orlando FL USA. Altos Labs Cambridge Institute of Science Cambridge UK. Bioinformatics Interdepartmental Program University of California Los Angeles CA USA. Department of Biological Chemistry University of California Los Angeles Los Angeles CA USA. Department of Biology University of Rochester Rochester NY USA. Department of Neuroscience Peter O'Donnell Jr. Brain Institute University of Texas Southwestern Medical Center Dallas TX USA. Department of Biology University of Maryland College Park MD USA. Loro Parque Fundacion Puerto de la Cruz Spain. Department of Biology University of Kentucky Lexington KY USA. Division of Cardiology Department of Internal Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Marine Mammal Institute Oregon State University Newport OR USA. School of Science and Technology Clifton Campus Nottingham Trent University Nottingham UK. School of Life and Environmental Sciences the University of Sydney Sydney New South Wales Australia. Department of Zoology and Entomology University of Pretoria Hatfield South Africa. Busch Gardens Tampa Tampa FL USA. Department of Ecology and Evolutionary Biology University of California Los Angeles Los Angeles CA USA. Rocky Mountain Biological Laboratory Crested Butte CO USA. Altius Institute for Biomedical Sciences Seattle WA USA. Epigenetic Clock Development Foundation Los Angeles CA USA. Center for Species Survival Smithsonian Conservation Biology Institute Front Royal VA USA. Department of Evolution Eco

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