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Pharmacological Research - Reports 2025年 3卷

作者： Oluwakemi Ebenezer Abel Kolawole Oyebamiji Adesoji Alani Olanrewaju Omowumi Temitayo Akinola Samson Olusegun Afolabi Ayodeji Arnold Olaseinde Jack Tuszynski Department of Physics University of Alberta Edmonton AB T6G 2E1 Canada Department of Chemistry and Industrial Chemistry Bowen University PMB 284 Iwo Osun State Nigeria Good Health and Wellbeing Research Clusters (SDG 03) Bowen University PMB 284 Iwo Nigeria Microbiology Programme Bowen University PMB 284 Iwo Osun State Nigeria Infochemistry Scientific Center ITMO University Saint Petersburg 191002 Russia Department of Material Science and Engineering Clemson University SC USA DIMEAS Politecnico di Torino Turin 10129 Italy Silesian University of Technology Gliwice 44-100 Poland

Introducing siRNAs into cells could degrade specific messenger RNA (mRNA) molecules, reducing the expression of the corresponding protein encoded by those mRNA molecules. Norovirus is the leading cause of both epidemic and pandemic acute gastroenteritis, which is inflammation of the stomach and intestine worldwide, and, as of present, no efficient vaccine is available to combat this norovirus disease. Since siRNA, therapeutics have gained significant attention for their potential to target and silence disease-causing genes. Our study utilizes different computational tools to design siRNA agents against the polyprotein of norovirus without causing off-target effects. According to the results of GC (guanine-cytosine) content, fold-free energy, binding energy, melting temperature, efficacy predictions, and molecular docking against human argonaute 2 protein (AGO2), two siRNA molecules are expected to exert the most effective action. The effectiveness and efficiency of siRNAs against norovirus need to be further examined in vivo before their use as alternative and practical molecular therapeutic agents.

关键词： SiRNA Polyprotein Norovirus Computational studies Gene silencers

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Improving microstructural homogeneity and reducing grain size of Zn-3Mg alloy through ECAP

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AIP Conference Proceedings 2023年第1期2643卷

作者： M. S. Dambatta S. Izman S. T. Auwal D. Kurniawan S. Ramesh U. Abdullahi H. Mas Ayu A. Shah A. Y. Gidado Auwal Ibrahim Musa Alhaji Ibrahim 1Faculty of Engineering Department of Mechanical Engineering Kano University of Science and Technology Wudil 3244 Kano State Nigeria 2Faculty of Mechanical Engineering Universiti Teknologi Malaysia Skudai 81310 Malaysia 3Mechanical Engineering Programme Area Universiti Teknologi Brunei Gadong 1410 Brunei Darussalam 4Faculty of Engineering Universiti Teknologi Brunei Tungku Highway Gadong BE1410 Brunei Darussalam 5Center of Advanced Manufacturing and Material Processing Department of Mechanical Engineering Faculty of Engineering University of Malaya 50603 Kuala Lumpur Malaysia 6Department of Mechanical Engineering Faculty of Engineering Ahmadu Bello University Zaria Nigeria 7Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang 26600 Pekan Pahang Malaysia 8Faculty of Technical and Vocational Universiti Pendidikan Sultan Idris 35900 Tanjong Malim Perak Malaysia

Recently, Zn and its alloys have been investigated due to its lower degradation rate than that of Mg-based alloys. However, it as-cast grainsize and microstructure homogeneity still required further enhancement. This research works aims to improve these properties on eutectic Zn-3Mg alloy via equal channels angular pressing (ECAP). Cast Zn-3Mg sample was heat treated at 370°C for 15hrs and quenched in water before ECAP processing at temperature of 200°C. Results revealed that, heat treatment followed by ECAP was effective in reducing the grain size of the as-cast alloy to 2 µm from 48 µm after 2-passes. This two-step processing remarkably increases the sample microstructure homogeneity. The study revealed that heat treatment followed by 2-ECAP passes was beneficial in enhancing the mechanical properties and degradation behaviour of Zn3Mg alloy as potential use for biodegradable implants material.

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Novel Design for CSRR Based Electronically Steered Compact S-band Microwave Resonator

Novel Design for CSRR Based Electronically Steered Compact S...

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Asia-Pacific Microwave Conference

作者： N. K. Tiwari Yash Tiwari Prakrati Azad M. Jaleel Akhtar Department of Electrical Engineering Institute of Technology Kanpur India Material Science Programme Indian Institute of Technology Kanpur India

Novel design of electronically tunable compact RF resonator operating in the S-band (2.7-3.1 GHz) of microwave frequency range is proposed. The proposed design makes use of the CSRR loaded microstrip line coupled to the varactor diode, where the electronic steering in the designated frequency band is facilitated by changing the biasing voltage of the varactor. With improved design topology, the proposed structure is able to provide an improved tunable range using the single CSRR resonator. In this work, the lumped capacitors are introduced at both the end of microstrip signal line to isolate the DC voltage from the applied RF signals without deteriorating the performance of the resonator. The proposed resonator is designed using the 3D electromagnetic solver CST-MWS (Computer Simulation technology-Microwave Studio), and accordingly various parameters are optimized to obtain the desired performance. After freezing various design parameters, the proposed resonator structure is fabricated on a commercially available FR-4 substrate. The testing of the fabricated structure is carried out using the network analyzer with a biasing voltage range of 0-28 V. A close match is observed between the measured and the simulated scattering parameters. The proposed resonator structure can be used for various applications in RF and microwave frequency range such as to design tunable filters and sensor for testing dispersive materials.

关键词： Resonator Varactor diode RF choke CSRR

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A dual band differential rectifying circuit for RF energy harvester

A dual band differential rectifying circuit for RF energy ha...

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Asia-Pacific Conference on Microwave

作者： Sandhya Chandravanshi M. Jaleel. Akhtar Department of Material Science Programme Indian Institute of Technology Kanpur India Department of Electrical Engineering Indian Institute of Technology Kanpur India

A compact dual band differential rectifying circuit operating in the GSM-1.8 GHz and ISM-2.45 GHz bands for RF energy harvesting application is proposed. The differential rectifier comprises of optimized dual band matching circuit for maximum power transfer to the load. The basic circuit is deigned and simulated using the Advanced Design System (ADS) software. The dimension of the overall circuit is 80 × 60 × 1.6 mm3, which is fabricated on a low cost FR-4 substrate. The fabricated circuit is finally tested to measure the RF and dc characteristics. The detailed analysis of the measured results shows that a maximum efficiency of up to 56 % can be achieved using the two tone measurement method for a typical available RF input power of 10 dBm.

关键词： Radio frequency Dual band Power measurement Rectifying circuits Energy harvesting Rectifiers Software

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Design of Efficient Rectifier Circuit in the GSM Band for Energy Harvesting Applications

Design of Efficient Rectifier Circuit in the GSM Band for En...

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IEEE MTT-S International Microwave and RF Conference

作者： Sandhya Chandravanshi M. Jaleel Akhtar Department of Material Science Programme Indian Institute of Technology Kanpur Kanpur Uttar Pradesh India Department of Electrical Engineering Indian Institute of Technology Kanpur Kanpur Uttar Pradesh India

a single band compact rectifying circuit operating in the GSM-900 band of frequency is proposed. The proposed RF rectifying circuit employs two-stage Dickson charge pump configuration along with the optimized impedance matching unit comprising of lumped components. The RF rectifying circuit is designed using the Advanced Design System (ADS) software, and is fabricated on a low cost FR-4 substrate. The dimension of the fabricated circuit is 6× 4× 1.6 cm3 thus making it quite compact. The overall performance of the designed circuit is evaluated for different types of load conditions. The maximum RF to DC conversion efficiency of 60% is achieved at 0 dBm input RF power for a 5 kΩ load.

关键词： Radio frequency Rectifiers Rectifying circuits Voltage measurement Energy harvesting Charge pumps Rectennas

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Novel spoof plasmonic based compact slow wave structure for terahertz and microwave applications 16

Novel spoof plasmonic based compact slow wave structure for ...

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16th Mediterranean Microwave Symposium, MMS 2016

作者： Pal, Picon Singh, S.P. Tiwari, N.K. Akhtar, M Jaleel Material Science Programme Indian Institute of Technology Kanpur Kanpur India Department of Electrical Engineering Indian Institute of Technology Kanpur Kanpur India

ISBN: (纸本)9781509025862

A novel compact slow wave structure (SWS) based on spoof plasmonic waveguide with meander lines in the terahertz (THz) and microwave frequency range is proposed. The use of the meander lines increases the effective length of the proposed structure thereby providing more path length for efficient trapping of the spoof surface plasmon polaritrons (SPPs). The meander line based SPPs structure is designed in THz and microwave frequency range using the full wave electromagnetic field simulator, the CST Studio. The area of proposed SWS is found to be reduced by 75% as compared to that of the conventional rectangular based surface plasmonic waveguide structure. The experimental verification of the proposed SWS is carried out in the microwave frequency band by fabricating the scaled up version, and measuring the transmission coefficient data using the network analyzer. © 2016 IEEE.

关键词： Electromagnetic wave polarization

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Designing Sub‐2 nm Organosilica Nanohybrids for Far‐Field Super‐Resolution Imaging

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Angewandte Chemie 2019年第2期132卷

作者： Liangliang Liang Wei Yan Xian Qin Xiao Peng Han Feng Yu Wang Ziyu Zhu Lingmei Liu Yu Han Qinghua Xu Junle Qu Xiaogang Liu Department of Chemistry National University of Singapore Singapore 117543 Singapore Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Singapore 637141 Singapore SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics Shenzhen University Shenzhen 518060 China Engineering Technology Research Center for 2D Material Information Function Devices and Systems of Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China King Abdullah University of Science and Technology Physical Sciences and Engineering Division Advanced Membranes and Porous Materials Center Thuwal Saudi Arabia

Stimulated emission depletion (STED) microscopy enables ultrastructural imaging of biological samples with high spatiotemporal resolution. STED nanoprobes based on fluorescent organosilica nanohybrids featuring sub‐2 nm size and near‐unity quantum yield are presented. The spin–orbit coupling (SOC) of heavy‐atom‐rich organic fluorophores is mitigated through a silane‐molecule‐mediated condensation/dehalogenation process, resulting in bright fluorescent organosilica nanohybrids with multiple emitters in one hybrid nanodot. When harnessed as STED nanoprobes, these fluorescent nanohybrids show intense photoluminescence, high biocompatibility, and long‐term photostability. Taking advantage of the low‐power excitation (0.5 μW), prolonged singlet‐state lifetime, and negligible depletion‐induced re‐excitation, these STED nanohybrids present high depletion efficiency (>96 %), extremely low saturation intensity (0.54 mW, ca. 0.188 MW cm −2 ), and ultra‐high lateral resolution (ca. λ em /28).

关键词： Hochauflösende Bildgebung Nanohybride Organosiliciumdioxid Spin-Bahn-Kopplung STED-Mikroskopie

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Novel spoof plasmonic based compact slow wave structure for terahertz and microwave applications

Novel spoof plasmonic based compact slow wave structure for ...

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Mediterrannean Microwave Symposium (MMS)

作者： Picon Pal S P Singh N K Tiwari M Jaleel Akhtar Material Science Programme Indian Institute of Technology Kanpur Kanpur India Department of Electrical Engineering Indian Institute of Technology Kanpur Kanpur India

ISBN: (纸本)9781509025879

关键词： Plasmons Microwave frequencies Gratings Optical waveguides Dispersion Surface waves

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Thickness-dependent energetics for Pb adatoms on low-index Pb nanofilm surfaces: First-principles calculations

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Physical Review B 2017年第20期96卷 205409-205409页

作者： Wei Li Li Huang Raj Ganesh S. Pala Guang-Hong Lu Feng Liu James W. Evans Yong Han Department of Physics Southern University of Science and Technology Shenzhen Guangdong 518055 People's Republic of China Department of Chemical Engineering Indian Institute of Technology Kanpur UP 208016 India Material Science Programme Indian Institute of Technology Kanpur UP 208016 India Department of Physics Beihang University Beijing 100191 China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing 100191 China Department of Materials Science and Engineering University of Utah Salt Lake City Utah 84112 USA Department of Physics and Astronomy Iowa State University Ames Iowa 50011 USA Ames Laboratory–U.S. Department of Energy Iowa State University Ames Iowa 50011 USA

Adsorption, interaction, and diffusion of adatoms on surfaces control growth and relaxation of epitaxial nanostructures and nanofilms. Previous reports of key diffusion barriers for Pb diffusion on low-index Pb surfaces are limited in scope and accuracy. Thus, we apply density functional theory (DFT) to calculate the adsorption and diffusion energetics for a Pb adatom on Pb(111), Pb(100), and Pb(110) nanofilms with different thicknesses. We find that these quantities exhibit damped oscillatory variation with increasing film thickness. For Pb(111) films, energetics along the minimum energy path for Pb adatom diffusion between adjacent fcc and hcp sites varies significantly with film thickness, its form differing from other metal-on-metal(111) systems. For Pb(111) and Pb(100) nanofilms, diffusion barriers obtained for both adatom hopping and exchange mechanism differ significantly from previous DFT results. Hopping is favored over exchange for Pb(111), and the opposite applies for Pb(100). For Pb(110) nanofilms, Pb adatom hopping over an in-channel bridge is most facile, then in-channel exchange, then cross-channel exchange, with cross-channel hopping least favorable. We also assess lateral Pb adatom interactions, and characterize island nucleation during deposition on Pb(111).

关键词： Adsorption Surface diffusion Surface growth Thin films Density functional theory

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Permittivity Measurement of Common Solvents Using the CSRR Based Sensor

Permittivity Measurement of Common Solvents Using the CSRR B...

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IEEE International Symposium on Antennas and Propagation

作者： M. A. H. Ansari Abhishek Kumar Jha M. J. Akhtar Material science programme Indian Institute of Technology Kanpur India-208016 Department of Electrical Engineering Indian Institute of Technology Kanpur India-208016

ISBN: (纸本)9781479978168

In this paper, the microwave characterization of common polar and non-polar solvents has been carried out using the planar resonant sensor. The proposed sensor resonates at 2.65 GHz due to the etched complementary split ring resonator (CSRR) in the ground plane of the microstrip-line. The test solvent is filled into a container which covers the CSRR and is mechanically pressed against the ground plane with water proof adhesive filling the gap between them. The solvent inside the container changes the capacitance of the CSRR which causes a shift in the resonant frequency. This frequency shift is used for the measurement of the dielectric properties of solvent samples. The proposed sensor is numerically verified and experimentally tested to estimate the dielectric properties of various standard solvents with a typical error of 2-4%.

关键词： Solvents Permittivity measurement Sensors Ground plane CONTAINERS dielectric properties FREQUENCY SHIFT capacitance

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