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An Improvement of Three-Factor Remote User Authentication Protocol Using ECC

International Journal of Network Security 2024年第3期26卷 528-534页

作者： Hwang, Min-Shiang Lin, Cheng-Ying Wu, Chia-Chun Department of Computer Science & Information Engineering Asia University Taichung Taiwan 500 Lioufeng Rd. Wufeng Taichung Taichung 41354 Taiwan Department of Medical Research China Medical University Hospital China Medical University Taiwan Ph.D. Program in Artificial Intelligence Asia University Taichung Taiwan 500 Lioufeng Rd. Wufeng Taichung Taichung 41354 Taiwan Kinmen892 Taiwan

With the development of the Internet, many patients’ private medical data are maliciously stolen by attackers. Therefore, Liu et al. proposed an improved ECC-based three-factor user authentication scheme. The main advantage of their scheme is that it provides the same or better security than other schemes using more secondary keys. However, this article will show that Liu et al.’s scheme is vulnerable to denial of service attacks. In addition, their protocol uses public key cryptography, which is inefficient. Finally, the method is not immune to counterfeit smart card attacks. In this paper, we also improve their protocol from the perspective of practicality and security. © (2024), (International Journal of Network Security). All rights reserved.

关键词： Authentication

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Short-Chain dense Brush Pegylation on Rigid Nanocarriers Overcomes Anti-Peg Antibody Recognition for Immune-Stealth drug delivery

SSRN

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SSRN 2025年

作者： Chen, Ting-Yu Chang, Chi-Yuan Wen, Ting-Chun Xu, Li Lin, Yu-Han Peng, Cheng-Liang Yeh, Yi-Qi Chen, Chueh-Hsuan Chuang, Kuo-Hsiang Wu, Si-Han Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan Department of Isotope Application National Atomic Research Institute Taoyuan Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Research Center for Applied Science Academia Sinica Taiwan PhD Program in Clinical Drug Development of Chinese Herbal Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

The immunogenicity of polyethylene glycol (PEG) remains a critical challenge in nanomedicine, as pre-existing anti-PEG antibodies can compromise therapeutic efficacy through accelerated blood clearance (ABC) and life-threatening hypersensitivity. Here, we address this challenge by engineering the PEG architecture, creating short-chain dense brush PEGylation (PEG500) on rigid mesoporous silica nanoparticles (MSNs). Unlike conventional PEG2000-liposomes, MSN-PEG500 evades antibodies via three synergistic mechanisms: (1) short-chain PEG500 reduces epitope accessibility, (2) high grafting density (4.43 chains/nm2, according to TGA) forms an dense steric shield, and (3) the rigid silica surface prevents PEG burial. ELISA studies demonstrated that, at equivalent nanoparticle concentrations, MSN-PEG500 exhibits a 26-fold reduction in anti-PEG IgG (6.3) binding and a 1000-fold reduction in anti-PEG IgM (AGP3) binding compared to Lipodox (PEG2000), both of which target the PEG backbone. Furthermore, radiolabeled MSN-PEG500 achieved prolonged circulation and 25% tumor accumulation (Id/g) at 24 hours. In strongly immunized mice, doxorubicin-loaded MSN-PEG500 preserved therapeutic efficacy and 100% survival, whereas Lipodox induced fatal hypersensitivity. Mechanistic investigations revealed that complement activation drives PEG2000 immunotoxicity, and pretreatment with the C3 inhibitor compstatin effectively mitigated temperature drops from 10°C to 2°C in immunized hosts. By demonstrating that nanoscale control of polymer conformation dictates immunological fate, this work provides a clinically translatable blueprint for developing immune-evasive nanomedicines. © 2025, The Authors. All rights reserved.

关键词： Silica nanoparticles

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Performance Enhancement of Electrochemiluminescence with the Immunosensor Controlled Using Magnetized Masks for the determination of Epithelial Cancer Biomarker EpCAM

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Analytical Chemistry 2023年第2期95卷 986-993页

作者： Huang, Chun-Yao Lin, Feng-Yen Chang, Chi-Jung Lu, Chien-Hsing Chen, Jem-Kun Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei110 Taiwan Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei110 Taiwan Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei110 Taiwan Department of Biomedical Sciences and Engineering National Central University 300 Zhongda Road Taoyuan City320317 Taiwan Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Taichung40724 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital 1650 Taiwan Boulevard Sect. 4 Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

The performance of an electrochemiluminescence (ECL) immunosensor was improved with a particle gradient. SiO2-coated magnetic beads were adopted as nanocarriers for gradient manipulation and immobilized with the primary antibody. Cadmium telluride quantum dots were coated with a layer of protein G for conjugation and orientation of the secondary antibody as signal labels. ECL immunosensor gradients on the electrode were formed by magnetolithography (ML) with magnetized nickel masks of column and stripe arrays. The immunosensor generally aggregated as an island on the substrate, leading to a decrease of efficiency in the characteristic signals. Stripe arrays of magnetized nickel were designed to generate cylindrical magnetic flux on the substrate to improve the particle manipulation with the gradient. Various gradients of the sandwich-structured immunosensor substantially affected the electrochemical performance. Compared to the gradient-free immunosensor, the gradient of the immunosensor generated by ML using a 3 μm stripe array mask enhanced the ECL intensity ∼2.2 times. The results of quantification of epithelial cell adhesion molecules (EpCAM) with the gradient immunosensor showed a broad linear range (15-420 pg mL-1), a low limit of detection (5.5 pg mL-1), and high reliability for EpCAM-spiked serum samples, indicating that the immunosensor gradient substantially enhances the performance of the ECL assay. © 2022 American Chemical Society.

关键词： Immunosensors

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Identification of potential source regions and long-range transport routes/channels of marine PM2.5 at remote sites in East Asia

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science of the Total Environment 2024年 915卷

作者： Yen, Po-Hsuan Yuan, Chung-Shin Soong, Ker-Yea Jeng, Ming-Shiou Cheng, Wen-Hsi Institute of Environmental Engineering National Sun Yat-sen University Kaohsiung Taiwan Aerosol Science Research Center National Sun Yat-sen University Kaohsiung Taiwan Institute of Marine Biology National Sun Yat-sen University Kaohsiung City Taiwan Biodiversity Research Center Academia Sinica Nangang Taipei Taiwan Green Island Marine Research Station Biodiversity Research Center Academia Sinica Green Island Taitung Taiwan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung City Taiwan

Long-range transport (LRT) of air masses in East Asia and their impacts on marine PM2.5 were explored. Situated in the leeward region of East Asia, Taiwan Island marked by its elevated Central Mountain Range (CMR) separates air masses into two distinct air currents. This study aims to investigate the transport of PM2.5 from the north to the leeward region. Six transport routes (A-F) were identified and further classified them into three main channels (i.e. East, West, and South Channels) based on their transport routes and potential sources. Green Island (Site GR) and Hengchun Peninsula (Site HC) exhibited similarities in their transport routes, with Central China, North China, and Korean Peninsula being the major source regions of PM2.5, particularly during the Asian Northeastern Monsoons (ANMs). dongsha Island (Site dS) was influenced by both Central China and coastal regions of East China, indicating Asian continental outflow (ACO) as the major source of PM2.5. The positive matrix factorization (PMF) analysis of PM2.5 resolved that soil dust, sea salts, biomass burning, ship emissions, and secondary aerosols were the major sources. Northerly Channels (i.e. East and West Channels) were primarily influenced by ship emissions and secondary aerosols, while South Channel was dominated by oceanic spray and soil dust. The results of W-PSCF and W-CWT analysis indicated that three remote sites experienced significant contributions from Central China in the highest PM2.5 concentration range (75–100%). In contrast, PM2.5 in the 0–25% and 25–50% ranges primarily originated from the open seas, with ship emissions being the prominent source. It suggested that northern regions with heavy industrialization and urbanization have impacts on high PM2.5 concentrations, while open seas are the main sources of low PM2.5 concentrations. © 2024 Elsevier B.V.

关键词： Factorization

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A Review on Analytical Approaches for Ambient Ozone Open data in Taiwan

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Current Pollution Reports 2024年第3期10卷 374-386页

作者： Nguyen, duy-Hieu Liao, Chih-Hsiang Bui, Xuan-Thanh Yuan, Chung-Shin Lin, Chitsan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung Taiwan (R.O.C.) Department of Environmental Engineering and Science Chia-Nan University of Pharmacy and Science Tainan Taiwan (R.O.C.) Key Laboratory of Advanced Waste Treatment Technology & Faculty of Environment and Natural Resources Ho Chi Minh City University of Technology (HCMUT) Ho Chi Minh City Vietnam Vietnam National University Ho Chi Minh City (VNU-HCM) Ho Chi Minh City Vietnam Institute of Environmental Engineering National Sun Yat-Sen University Kaohsiung Taiwan (R.O.C.) Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan (R.O.C.)

The air quality in Taiwan is significantly impacted by ambient ozone (O3) pollution, which poses a challenge in terms of control due to the involvement of precursors and influencing factors in its photochemical process. This review investigates the measures that have been implemented in Taiwan over the past two decades to address this issue and evaluate their effectiveness in reducing O3 concentrations. Furthermore, it highlights relevant studies that have employed advanced methods to examine the O3 problem. Comprehending the complex formation of O3 and its driving factors is crucial in efficiently managing O3 pollution. Nevertheless, accurately quantifying the impacts of these factors can be challenging due to their interconnections. To bridge this gap in knowledge, conducting a robust causality analysis becomes imperative to accurately quantify the causal influence of major factors. Furthermore, eliminating seasonal variations can improve the precision and accuracy of trend analyses concerning long-term changes in O3 concentrations. deep learning, in particular, holds significant advantages in predicting O3 concentrations as it can capture non-linear and long-term memory characteristics effectively. In summary, attaining acceptable O3 levels in Taiwan is challenging due to its geographical location, which makes it susceptible to air pollution from both local sources as well as distant upwind areas. The utilization of advanced methods is essential for comprehensively studying the evolution of O3 and formulating effective mitigation measures. While there is a necessity to develop new analytical methods, implementing existing robust methodologies can also provide valuable insights into the dynamics and impacts of O3. By leveraging these approaches, we can enhance our comprehension of O3 pollution in Taiwan and develop effective strategies to mitigate its harmful effects on air quality.

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Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model

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Translational Psychiatry 2024年第1期14卷 68页

作者： Hsieh, Christine Chin-jung Lo, Yu-Chun Wang, Hsin-Hui Shen, Hsin-Ying Chen, You-Yin Lee, Yi-Chao Biomedical Translation Research Center Academia Sinica Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan Neuroscience Research Center Taipei Medical University Taipei Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Tuberous sclerosis complex (TSC) is a genetic disease that causes benign tumors and dysfunctions in many organs, including the brain. Aside from the brain malformations, many individuals with TSC exhibit neuropsychiatric symptoms. Among these symptoms, autism spectrum disorder (ASd) is one of the most common co-morbidities, affecting up to 60% of the population. Past neuroimaging studies strongly suggested that the impairments in brain connectivity contribute to ASd, whether or not TSC-related. Specifically, the tract-based diffusion tensor imaging (dTI) analysis provides information on the fiber integrity and has been used to study the neuropathological changes in the white matter of TSC patients with ASd symptoms. In our previous study, curcumin, a diet-derived mTOR inhibitor has been shown to effectively mitigate learning and memory deficits and anxiety-like behavior in Tsc2 ^+/− mice via inhibiting astroglial proliferation. Recently, gut microbiota, which is greatly influenced by the diet, has been considered to play an important role in regulating several components of the central nervous system, including glial functions. In this study, we showed that the abnormal social behavior in the Tsc2 ^+/− mice can be ameliorated by the dietary curcumin treatment. Second, using tract-based dTI analysis, we found that the Tsc2 ^+/− mice exhibited altered fractional anisotropy, axial and radial diffusivities of axonal bundles connecting the prefrontal cortex, nucleus accumbens, hypothalamus, and amygdala, indicating a decreased brain network. Third, the dietary curcumin treatment improved the dTI metrics, in accordance with changes in the gut microbiota composition. At the bacterial phylum level, we showed that the abundances of Actinobacteria, Verrucomicrobia, and Tenericutes were significantly correlated with the dTI metrics FA, Ad, and Rd, respectively. Finally, we revealed that the expression of myelin-associated proteins, myelin bassic p

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design of Optical System of Augmented Reality Near Eye device

Design of Optical System of Augmented Reality Near Eye Devic...

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Educational Innovation (ECEI), IEEE Eurasian Conference on

作者： Chao-Kai Chang Feng-Ming Yeh Jiann-Hwa Lue Hsuan-Fu Wang Ya-Hui Hsieh Chun-Yu Chiang der-Chin Chen Chuen-Lin Tien Department of Optometry Yuanpei University of Medical Technology Hsinchu Taiwan Department of Optometry Taiwan University of Science and Technology Taichung Taiwan Department of Aeronautical Engineering National Formosa University Yunlin Taiwan Department of Healthcare Information and Management Ming Chuan University Taoyuan Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering Feng Chia University Taichung Taiwan

Augmented reality (AR) is a technology that instantly merges digital pictures with the real scene. The perspective near-eye display is a key module of AR, through which computer-generated pictures or videos can be displayed in the existing environment. The purpose of this research is to establish the system structure of an augmented reality near-eye display device and to design the off-axis two-piece reflective aspherical mirror. Because AR glasses are wearable and are worn close to the eyes, not only the optical performance of the display but also the clear vision of the user needs to be considered. In this study, an off-axis two-piece reflective aspherical mirror is used as the optical system of the AR for displaying the digital image. The micro-display is placed at the focal point of the optical system to form a digital image, and the horizontal movement of the micro-display along the optical axis is controlled by a precise displacement mechanism so that the patient with uncorrected myopia or hyperopia can see the digital picture and real scene. Because the right and left micro-displays move horizontally independently, the user can see the images on the AR device, which becomes the biggest feature of this study.

关键词： Performance evaluation Technological innovation Optical design digital images Optical imaging Optical reflection Augmented reality

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A novel strategy towards the fabrication of highly stable and sensitive non-enzymatic glucose sensor based on Ni3N thin films using high power impulse magnetron sputtering

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Applied Surface science 2024年 669卷

作者： Pardhi, Nishchal Cheng, Wei-Chun Chen, Sheng-Chi Akshay Joshi, Shikha Govindasamy, Mani Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City243303 Taiwan College of Engineering and Center for Green Technology Chang Gung University Taoyuan333 Taiwan Department of Materials Engineering Indian Institute of Science Bangalore560012 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Glucose level surveillance in mankind is considered the greatest need of recent times to achieve healthy lifestyle goals due to its health-related concern for humans. To fulfill the need, Nickel-based compounds emerge with excellent bio-mimic properties. However, due to the poor electrical properties of oxides and hydroxides of Ni, developing a supporting base that can enhance electron transportation is mandatory. The present work is dedicated to non-enzymatic glucose detection by electrochemical means on the Ni3N thin film on an Indium-doped Tin Oxide (ITO) substrate as a working electrode in an alkaline medium. The Ni3N films use HiPIMS as a deposition technique due to its high ionization rate of sputtered species and dense plasma which helps the Ni ions to react with nitrogen in the formation of a perfect Ni3N phase, and it is a green process that can contribute to sustainable manufacturing. Ni3N thin film deposited at a 60 % N2 flow ratio shows the largest crystallinity and catalytic properties, which helps this modified electrode to have significant potential for glucose detection. The Ni3N modified electrode acquires a lower linear range of 0.001–1.25 mM with sensitivity and Limit of detection (LOd) of 337.46 µAmM–1cm−2, and 0.78 µM, respectively, and a higher linear range of 1.25–7.3161 mM with a sensitivity of 158.58 µAmM–1cm−2. The amperometric measurements reveal the fast response of the electrode towards glucose detection at 2.46 secs. The key measures of the electrode according to the corresponding measurements are satisfactory selectivity, reproducibility, repeatability, and operational stability. The modified electrode shows a significant response for real samples such as commercially available honey, apple juice, and biological fluids. © 2024 Elsevier B.V.

关键词： Thin films

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Fabrication of sandwich-structured capacitor containing core@shell polystyrene@graphene oxide microspheres for switchable removal of dyes from water by dielectrophoresis force

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Separation and Purification Technology 2024年 331卷

作者： Chen, Wei-Liang Cheng, Chih-Chia Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei 106 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Chung Shan Medical University Hospital Taichung City402 Taiwan Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine and Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

Absorption rates for traditional adsorbents were predominately determined by the concentration gradient from bulk to absorbents and surface area. A novel sandwich-structured capacitor (SSC) containing adsorbents is designed to reduce the time consuming of absorption of pollutants by dielectrophoresis force (FdEP). Graphene oxide (GO) are coated on polystyrene microspheres (PSs) as the core/shell PS@GO adsorbents that were encapsulated within the SSC to treat the solution of dye-emulsified micells (dEM). The FdEP results the assembling of PS@GOs and dEMs under polarization and enhance the adsorption rate ca. 1 ∼ 2 times with polarization at 3 V and 200 kHz. Additionally, most adsorbents are recycled with secondary pollution. Only two-fifth pure water volume of the wastewater through the SSC could achieve the recycling of the adsorbents at 900 kHz. The high complex permittivity of GO coating at high frequency allows ultrafast alternative spinning of the induced dipoles in the PS@GOs facilitates desorption and hinders the re-adsorption of the dEM during the recycling of PS@GOs. The PS@GOs was reused ca. 10 times at 20 mL min−1 of flow rate through the SSC without damages between 200 and 900 kHz. The designed SSC containing PS@GOs accomplishes either reusing of adsorbents or concentrating of dyes with low secondary pollution in practice through frequency manipulation. © 2023 Elsevier B.V.

关键词： Graphene

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Exfoliated MXene nanosheet by double layer forces for preparing magnetic adsorbents of toxic metal ions and recycling with hyperthermic effect

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Separation and Purification Technology 2024年 349卷

作者： Chen, Chih-Wei Chang, Chi-Jung Liaw, Shien-Kuei Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Division of Neurosurgery Department of Surgery Chi Mei Medical Center Tainan710 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Seatwen Taichung40724 Taiwan Department of Electronic and Computer Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine and Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

The conventional etching method for exfoliating MXene using hydrofluoric acid solution is time-consuming and inefficient in productivity. A double layer force is generated through polarization among the heterogeneous layers of MXene due to their different dielectric properties. The exfoliated MXene by the polarization method in an acidic solution was employed to synthesize magnetic MXene (MXFe) with Fe3O4 nanoparticles. MXFe was coated on polyacrylonitrile microspheres (PANs) as precursors (PAN@MXFe) by Pickering emulsion polymerization. The core@shell polyvinyltetrazole@MXFe (PVT@MXFe) was obtained as the adsorbent after subsequent cyano-tetrazole conversion of PAN@MFs for the removal of toxic metal ions. The maximum adsorption capacities of Hg(II) on the MXFe and PVT@MXFe coating 2 wt% of MXFe were 579 and 324 mg/g, respectively, indicating the high use efficiency of MXFe. At 8.5 kHz of high frequency, hyperthermia occurs on the PVT@MXFe, facilitating the desorption of the toxic metal ions from the adsorbents. Compared with reuse using an acidic solution, the PVT@MXFe can be reused repeatedly 10 times without obvious damage under the AMF. Our proposed polarization exfoliation method not only provides a novel methodology to exfoliate MXene but also develops an ideal adsorbent for universal adsorption, simple separation, stable regeneration, and low secondary pollution. © 2024 Elsevier B.V.

关键词： Synthesis (chemical)

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