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Effects of molecular weight fraction on antioxidation capacity of rice protein hydrolysates

Scientific Reports 2023年第1期13卷 1-11页

作者： Chen, Hui-Ju dai, Fan-Jhen Chen, Cheng-You Fan, Siao-Ling Zheng, Ji-Hong Chau, Chi-Fai Lin, Yung-Sheng Chen, Chin-Shuh Department of Food Science and Biotechnology National Chung Hsing University Taichung 402204 Taiwan Healthmate Co. Ltd Changhua 500016 Taiwan Ph.D. Program in Materials and Chemical Engineering National United University Miaoli 360302 Taiwan Department of Chemical Engineering National United University Miaoli 360302 Taiwan Institute of Food Safety and Health Risk Assessment National Yang Ming Chiao Tung University Taipei 112304 Taiwan

Rice protein was used as a starting material to provide rice protein hydrolysates (Rph) through enzyme-assisted extraction. Rph was further fractionated using ultrafiltration membrane (UF) and classified by molecular weight (MW;MW < 1 kda, MW 1–10 kda, and MW > 10 kda). Peptides with MW < 1 kda possessed superior antioxidant properties (p < 0.05). Therefore, UF demonstrated great efficacy in selectively separating antioxidant peptides. A Pearson correlation analysis revealed that the total phenolic concentration was correlated with oxygen radical absorbance capacity (ORAC;r = 0.999, p < 0.05). Amino acid contents had negative correlations with the scavenging activity (specifically, IC50) of 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radicals (r = − 0.986 to − 1.000). Reducing power was related to aromatic amino acid contents (r = 0.997, p < 0.05). In this study, enzymatic hydrolysis was discovered to be an effective method of extracting and isolating natural antioxidant proteins from broken rice, thus preserving the nutritional quality of rice and making those proteins more accessible in future applications. © 2023, The Author(s).

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Fabrication of tantalum silicate films with low TCR and low resistivity by magnetron sputtering

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Vacuum 2024年 226卷

作者： Chen, Cheng-Lung Huang, Cheng Chen, Sheng-Chi Liu, Yen-Chen Chuang, Min-Chen Wen, Chao-Kuang Huang, Wei-Sheng Yang, Wen-Sheng Chen, Yang-Yuan Graduate School of Materials Science National Yunlin University of Science and Technology Yunlin64002 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology 243 New Taipei City Taiwan College of Engineering and Center for Green Technology Chang Gung University 333 Taoyuan Taiwan International Ph.D. Program in Plasma and Thin Film Technology Ming Chi University of Technology 243 New Taipei City Taiwan TPH Research & Develop Dept. Chien Hwa Coating Technology Inc. Hsinchu300 Taiwan National Engineering Research Center for Rare Earth Materials Grirem Advanced Materials Co. Ltd. General Research Institute for Nonferrous Metals Beijing100088 China Institute of Physics Academia Sinica 115 Taipei Taiwan

Tantalum silicate (Ta–Si–O) thin film materials have gained significant interest in hybrid renewable energy systems and thin-film resistors due to their exceptional thermal stability and adjustable electrical properties. In this study, we investigated the effects of target compositions and sputtering power densities on the material structures, chemical compositions, microstructures, and electrical properties of Ta–Si–O films. Two target compositions, Ta65(SiO2)35 and Ta80(SiO2)20, were utilized in the deposition process. Notably, we observed substantial variations in the temperature coefficient of resistance (TCR) value and resistivity of Ta–Si–O thin films with different Ta concentrations. Most importantly, when the Ta content of the film is controlled at 62 ± 0.6 % by using this target, the resistivity of the Ta0.62Si0.20O0.18 film can be as small as 2.31 ± 0.05 × 10−4 Ω-cm and has an extremely small TCR of 22 ± 0.4 ppm/°C, which shows an excellent opportunity for the development of precision thin film resistors. A TCR value close to zero can be finely tuned by controlling the Ta concentration in the Ta–Si–O film. These intriguing electrical behaviors were found to be highly correlated with the predominant formation of metallic Ta5Si3 as the main structural phase in the films. This work presents a simple and effective approach to produce Ta–Si–O thin films with near-zero TCR, making them highly suitable for applications under high-temperature conditions. Our findings contribute to the development of tailored thin film materials with desirable electrical properties for advanced electronic and energy devices. © 2024 Elsevier Ltd

关键词： Thin films

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Emulating Neuromorphic and In-Memory Computing Utilizing defect engineering in 2d-Layered WSeOx and WSe2 Thin Films by Plasma-Assisted Selenization Process

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Advanced Functional materials 2023年第38期33卷

作者： Chaudhary, Mayur Yang, Tzu-Yi Chen, Chieh-Ting Lai, Po-Chien Hsu, Yu-Chieh Peng, Yu-Ren Kumar, Ashish Lee, Chih-Hao Chueh, Yu-Lun Department of Materials Science and Engineering National Tsing-Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing-Hua University Hsinchu30013 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu30013 Taiwan

The neuromorphic and in-memory computing using memristors are promising for the building of the next generation computing systems. However, the diffusion dynamics of metal ions/atoms inside the switching medium impose variability in conducting filament (CF) formation, thus limiting their use in von-Neumann architecture. The precise modulation on the diffusion of metal ions/atoms and their reduction/oxidation probability holds promise to overcome the speed, size, and energy issues of present-day computers. Here, this study shows that the diffusion of metal ions can be modulated by defects inside the switching medium and confines metal filaments in a precise 1d channel. This filament confinement by the defect engineering leads to an anomalous switching mechanism with two interchangeable modes: unipolar threshold and bipolar modes. The variation between two modes can be modulated by controlling defects in the structures, leading to a uniform switching with low SET/RESET voltage variations of 17.3% and −17.6%, respectively. Moreover, the convolutional neural network is implemented to emulate synaptic plasticity and image recognition to achieve recognition accuracy of 87% due to a highly linear weight update, demonstrating its potential for in-memory computing. © 2023 Wiley-VCH GmbH.

关键词： Image recognition

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Current Progress of COPd Early detection: Key Points and Novel Strategies

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International Journal of COPd 2023年 18卷 1511-1524页

作者： Lin, Ching-Hsiung Cheng, Shih-Lung Chen, Chiung-Zuei Chen, Chia-Hung Lin, Sheng-Hao Wang, Hao-Chien Division of Chest Medicine Changhua Christian Hospital Changhua 500 Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 402 Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Department of Recreation and Holistic Wellness MingDao University Changhua Taiwan Department of Internal Medicine Far Eastern Memorial Hospital Taipei 220 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan 320 Taiwan Division of Pulmonary Medicine Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine China Medical University Hospital Taichung 404 Taiwan Department of Internal Medicine National Taiwan University Hospital Taipei 100 Taiwan

Chronic obstructive pulmonary disease (COPd) is a major cause of morbidity and mortality worldwide, with approxi-mately 70% to 80% of adults with COPd being undiagnosed. Patients with undiagnosed COPd are at increased risk of poor outcomes and a worsened quality of life, making early detection a crucial strategy to mitigate the impact of COPd and reduce the burden on healthcare systems. In the past decade, increased interest has been focused on the development of effective strategies and instrument for COPd early detection. However, identifying undiagnosed cases of COPd is still challenging. Both screening and case-finding approaches have been adopted to identify undiagnosed COPd, with case-finding being recommended by the 2023 Global Initiative for Chronic Obstructive Lung disease (GOLd) guideline and the updated United States Preventive Services Task Force (USPTF) recommendation. Nonetheless, the approaches, criteria, and instruments used for early detection of COPd are varied. However, advances in the taxonomy and risk factors of COPd are continuously being investigated. It is important to continuously assess the current state of knowledge on COPd early detection, given the challenges associated with identifying undiagnosed COPd. This review aims to highlight recent advances in early detection of COPd. To discuss the current challenge and opportunity in COPd early detection, providing an overview of existing literature on COPd case-finding strategies, including the approaches, criteria for subjects, and instruments. The review also summarizes the current progress in COPd case-findings and proposes a COPd case-finding flowchart as an efficient method for identifying at risk COPd patients. © 2023 Lin et al.

关键词： at-risk case-finding COPd early detection undiagnosed

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Jing-Si Herbal Tea Suppresses H2O2-Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes

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Environmental Toxicology 2024年第12期39卷 5347-5356页

作者： Kao, Shih-Wen Chang, Yu-Chun Lin, Feng-Huei Huang, Tai-Lung Chen, Tung-Sheng Lin, Shinn-Zong Lin, Kuan-Ho Kuo, Wei-Wen Ho, Tsung-Jung Huang, Chih-Yang Graduate Institute of Aging Medicine China Medical University Taichung Taiwan Department of Orthopedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Division of Biomedical Engineering and Nanomedicine Research National Health Research Institute Miaoli Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu chi University Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans;however, its undesired activation results in tissue damage and cell death. The onset of chronic inflammation and oxidative stress are the key characteristics of autoimmune inflammatory diseases such as rheumatoid arthritis (RA), for which an effective treatment is yet to be developed. Therefore, in this study, we investigated the protective effects and molecular mechanisms of a novel herbal preparation, Jing-Si herbal tea (JS), against H2O2-induced inflammation and cellular damage in HIG-82 synoviocytes. We found that JS did not show any significant alterations in cell viability at 2O2-induced pathological oxidative stress (ROS) in HIG-82 cells. Interestingly, JS treatment not only reduced the ROS levels but also significantly repressed the protein expressions of collagen degrading proteases in a dose-dependent manner. Treatment with JS showed enhanced cell viability against H2O2-induced toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and Bcl-2 were increased, whereas MMP-13, AdAMTS-2, Cytochrome C, and cleaved Caspase 3 were decreased by JS under inflammatory agents H2O2, MIA, LPS, and TNF-α treatment, respectively, in HIG-82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2-treated HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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phase-engineered heterostructures of Mo2C by plasma-assisted selenization and sulfurization processes toward excellent hydrogen evolution reaction

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Nano Energy 2024年 122卷

作者： Kimbulapitiya, K.M.M.d.K. Rehman, Bushra Wani, Sumayah Shakil Chen, Chieh-Ting Cyu, Ruei-Hong Manikandan, Arumugam date, Manisha Kondiba Peng, Yu-Ren Kumara, R.J.G.L.R. Chuang, Feng-Chuan Chueh, Yu-Lun Department of Physics National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Materials Science and Engineering National Tsing-Hua University Hsinchu Taiwan College of Semiconductor Research National Tsing-Hua University Hsinchu30013 Taiwan Center for Nanotechnology Materials Science and Microsystem National Tsing-Hua University Hsinchu Taiwan Ph.D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan Physics Division National Center for Theoretical Sciences Hsinchu30013 Taiwan Center for Theoretical and Computational Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Physics National Tsing Hua University Hsinchu30013 Taiwan

due to the outstanding semiconducting and metallic properties, 2d materials such as Transition Metal dichalcogenides (TMds) and Transition Metal Carbides (TMCs) appear to be promising candidate for Nano-scale electronics devices. Among them, 2d - Mo2C (Molybdenum carbide) has attracted attention as a new member of the MXene group, owing to its potential applications for superconductors, electronics devices, and catalysts for Hydrogen evolution Reactions (HER). Structural modification toward the creation of novel heterostructures with phase engineering opens new pathways for different applications. Herein, we prepared a large area Mo2C film by chemical vapor deposition method. The upper region of Mo2C layers can be oxidized to create Mo2C/MoOx heterostructures. Furthermore, those oxide layers were further transformed into MoSe2 and MoS2 by plasma-assisted selenization and sulfurization processes at different temperatures with a fixed plasma power of 150 W. The heterostructures demonstrated outstanding electrocatalytic activity for HER due to an existed metallic phase and active sites present after plasma-assisted selenization and sulfurization processes at the low temperature. The performance of the HER decreases at high temperatures owing to their semiconducting phase. The pristine Mo2C showed a Tafel slope of 72 mV dec−1 and an overpotential of 276 mV at 10 mA/cm2, while the Mo2C/MoSe2 heterostructure synthesized at 350 °C350 °exhibited an improved Tafel slope of 66 mV dec−1 and overpotential of 257 mV at 10 mA/ cm2. Additionally, the Mo2C/MoS2 heterostructure prepared at 350 °C also demonstrated a 263 mV improvement in overpotential at 10 mA/cm2. All the heterostructures showed excellent stability over a period of 10 h except Mo2C/MoOx. This work opens new strategies to fabricate high-quality MXene and TMds heterostructures with metal-semiconductor interface. © 2024

关键词： Molybdenum compounds

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Novel visible-light-induced P-doped g-C3N4/α-Bi2O3 nanocomposite photocatalysts for enhanced degradation of refractory endocrine disruptors—benzophenones

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Applied Surface science 2023年 607卷

作者： Berekute, Abiyu Kerebo Yu, Kuo-Pin Chuang, Yi-Hsueh Lin, Kun-Yi International Ph.D. Program in Environmental Science and Technology National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental and Occupational Health Sciences National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental Engineering National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Department of Environmental Engineering and Innovation and Development Center of Sustainable Agriculture & Research Center of Sustainable Energy and Nanotechnology National Chung Hsing University 250 Kuo-Kuang Road Taichung Taiwan

The Z-scheme heterojunction design can not only minimize photogenerated electron-hole pair recombination but also ensure strong redox abilities for driving photocatalytic reactions. Hence, novel P-g-C3N4/α-Bi2O3 binary nanocomposites were successfully fabricated by a combined hydrothermal-calcination method. The as-synthesized samples were systematically characterized by X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, transmission electron microscopy, ultraviolet–visible spectroscopy, photoluminescence (PL) spectroscopy, N2 isotherm measurement, electrochemical impedance spectroscopy (EIS), thermogravimetric analysis, and electron paramagnetic resonance. The photocatalytic efficiency of the as-prepared samples was assessed via decontamination of refractory and endocrine-disrupting benzophenones (BPs) under visible light irradiation. The 25 wt% P-g-C3N4/α-Bi2O3 nanocomposite exhibited higher photocatalytic activity for 4-hydroxybenzophenone (4H-BP) and benzophenone-1 degradation than P-g-C3N4 and α-Bi2O3. The apparent enhancement of the photocatalytic activity might be mainly attributed to the enhanced light-harvesting ability and the heterojunction formation, which significantly facilitates photogenerated charge carrier separation and transfer, as confirmed by the PL and EIS findings. Notably, 25 wt% P-g-C3N4/α-Bi2O3 exhibited robust reusability and stability with high efficiency in 4H-BP removal after four repeated photocatalytic cycles. © 2022 Elsevier B.V.

关键词： Heterojunctions

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Crystal structure-controlled synthesis of NiMoO4/NiO hierarchical microspheres for high-performance supercapacitors and photocatalysts

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Journal of Energy Storage 2024年 97卷

作者： Lee, Kuen-Chan Huang, Jen-Hsien Wu, Yen-Ju Wang, Kuan-Syun Cho, Er-Chieh Hsu, Shih-Chieh Liu, Ting-Yu Department of Science Education National Taipei University of Education No. 134 Sec. 2 Heping E. Road Da-an District Taipei City106 Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Green Material Technology Green Technology Research Institute CPC Corporation No.2 Zuonan Rd. Nanzi District Kaohsiung City81126 Taiwan 1-2-1 Sengen Tsukuba Ibaraki305-0047 Japan Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Chemical and Materials Engineering Tamkang University No. 151 Yingzhuan Road Tamsui District New Taipei City25137 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan City32003 Taiwan College of Engineering & Center for Sustainability and Energy Technologies Chang Gung University Taoyuan33302 Taiwan

Global environmental challenges and energy crises have driven researchers to develop multifunctional and highly efficient nanomaterials. This study presents dual-functional NiMoO4 (NMO)/NiO hierarchical microspheres that can serve as supercapacitors and photocatalysts prepared using a microwave-assisted hydrothermal method. The α- and β-phase contents of NMO can be regulated by controlling the post-annealing temperature and ph value of the precursor solution. The as-prepared NMO/NiO nanocomposites exhibited dual Faradaic redox reactions attributed to NMO and NiO, leading to remarkable supercapacitor performance. In addition, the constructed heterojunction between NMO and NiO also improved charge separation, leading to excellent photocatalytic capability. Based on the results, NMO with a higher β-phase content showed better supercapacitive and photocatalytic performance owing to its higher conductivity. The optimal NMO/NiO composite displayed a specific capacitance of 943 F g−1 at 1 A/g and excellent cycling stability, with 83.1 % retention at 5 A/g after 4000 cycles. Additionally, it demonstrated an outstanding photocatalytic capability for the degradation of methylene blue (MB), achieving a rate constant of (0.0113 min−1). © 2024 Elsevier Ltd

关键词： Supercapacitor

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CompressedMediQ: Hybrid Quantum Machine Learning Pipeline for High-dimensional Neuroimaging data

CompressedMediQ: Hybrid Quantum Machine Learning Pipeline fo...

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Acoustics, Speech, and Signal Processing Workshops (ICASSPW), IEEE International Conference on

作者： Kuan-Cheng Chen Yi-Tien Li Tai-Yu Li Chen-Yu Liu Po-Heng Henry Lee Cheng-Yu Chen Department of Electrical and Electronic Engineering Imperial College London London UK Centre for Quantum Engineering Science and Technology (QuEST) Imperial College London London UK Translational Imaging Research Center Taipei Medical University Hospital Taipei Taiwan Research Center for Neuroscience Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan National Center for High-Performance Computing NARlabs Hsinchu Taiwan Graduate Institute of Applied Physics National Taiwan University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Taipei Taiwan Department of Radiology National Defense Medical Center Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Taiwan

ISBN: (数字)9798331519315

ISBN: (纸本)9798331519322

This paper introduces CompressedMediQ, a novel hybrid quantum-classical machine learning pipeline specifically developed to address the computational challenges associated with high-dimensional multi-class neuroimaging data analysis. Standard neuroimaging datasets, such as large-scale MRI data from the Alzheimer’s disease Neuroimaging Initiative and Neuroimaging in Frontotemporal dementia, present significant hurdles due to their vast size and complexity. CompressedMediQ integrates classical HPC nodes for advanced MRI pre-processing and Convolutional Neural Network (CNN)-PCA-based feature extraction and reduction, addressing the limited-qubit availability for quantum data encoding in the NISQ era. This is followed by Quantum Support Vector Machine (QSVM) classification. By utilizing quantum kernel methods, the pipeline optimizes feature mapping and classification, enhancing data separability and outperforming traditional neuroimaging analysis techniques. Experimental results highlight the pipeline’s superior accuracy in dementia staging, validating the practical use of quantum machine learning in clinical diagnostics. despite the limitations of NISQ devices, this proof-of-concept demonstrates the transformative potential of quantum-enhanced learning, paving the way for scalable and precise diagnostic tools in healthcare and signal processing.

关键词： Neuroimaging Support vector machines Quantum computing Accuracy Magnetic resonance imaging Pipelines Machine learning Medical services Signal processing Standards

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Assessing the skin-whitening property of plant extracts from taiwanese species using zebrafish as a rapid screening platform

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Arabian Journal of Chemistry 2023年第9期16卷

作者： Hsiao, Sui-Wen Kuo, I-Chih Syu, Li-Ling Lee, Tzong-Huei Cheng, Chia-Hsiung Mei, Hui-Ching Lee, Ching-Kuo Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei11031 Taiwan School of Biomedical Engineering University of British Columbia VancouverBC Canada Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Institute of Fisheries Science National Taiwan University Taipei10617 Taiwan Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Science Education National Taipei University of Education Taipei10671 Taiwan School of Pharmacy Taipei Medical University Taipei11031 Taiwan

Zebrafish can be used as a phenotype-based fast-screening platform for the discovery of skin-whitening products by observing the formation of melanin in vivo through a dissecting microscope. In this study, we first evaluated commercial whitening ingredients to confirm the potency of the zebrafish model. The zebrafish screening system verified that verbascoside and 5 other commonly used commercial skin-whitening compounds– including sodium ascorbate, azelaic acid, transamin, kojic acid, and PTU- significantly reduce melanin content in a dose-dependent manner. We subsequently conducted preliminary screening of 123 natural sources to identify those with whitening property. Through a two-step screening process, anti-melanogenesis effects of 4 and 9 candidates at low and high concentration were verified respectively. The toxicity, mortality, and malformation of zebrafish embryo were also evaluated. We further investigated the components of C. manghas L. and found 6 major compounds, one of which was manghaslin, a compound known for its melanin-suppressing effect on zebrafish without cytotoxicity. With these properties, manghaslin is a promising candidate as a skin lightening agent or a treatment for melanoma. © 2023 The Authors

关键词： Melanin

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