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The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem

iscience 2024年第9期27卷

作者： Kuo, Cheng-Liang Lin, Ying-Chen Lo, Yu Kang Lu, Yu-Zhi Babuharisankar, Ananth Ponneri Lien, Hui-Wen Chou, Han-Yu Lee, Alan Yueh-Luen National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan 35053 Taiwan Department of Life Sciences College of Health Sciences & Technology National Central University Taoyuan Zhongli 32001 Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung 40402 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 40402 Taiwan Department of Biotechnology College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan

Mitochondria play important roles in cell fate, calcium signaling, mitophagy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a signaling organelle in the cell and communicate with other organelles to constitute the mitochondrial information processing system (MIPS) that transduce input-to-output biological information. The success in immunotherapy, a concept of systemic therapy, has been proved to be dependent on paracrine interactions within the tumor microenvironment (TME) and distant organs including microbiota and immune components. We will adopt a broader view from the concept of TME to tumor micro- and macroenvironment (TM²E) or tumor-organ ecosystem (TOE). In this review, we will discuss the role of mitochondrial signaling by mitochondrial ROS, calcium flux, metabolites, mtdNA, vesicle transportation, and mitochondria-derived peptide in the TME and TOE, in particular immune regulation and effective cancer immunotherapy. © 2024 The Author(s)

关键词： Cancer Immune response Microenvironment

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Ecological Risk Assessment and Corrective Actions of dioxins Polluted Sediment in the Brine Water Storage Pond of Chemical Plant

SSRN

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SSRN 2022年

作者： Huang, Wen-Yen Huang, Chi-Wei Lin, Chitsan Li, Yi-Lin Huang, Tsung-Po Bui, Xuan-Thanh Ngo, Huu Hao Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan 268 Ly Thuong Kiet Street District 10 Ho Chi Minh City700000 Viet Nam Linh Trung Ward Ho Chi Minh City700000 Viet Nam School of Civil and Environmental Engineering University of Technology Sydney SydneyNSW2007 Australia

despite the high toxicity of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCdd/Fs, or dioxins), the case studies about PCdd/Fs contamination in sediment are still few and its ecological impacts are not fully elucidated. To improve the risk management of PCdd/Fs pollution in sediment, the present study conducted the environmental risk assessment of the brine water storage pond near a chemical plant with high PCdd/Fs pollution potential before and after corrective actions. The results showed the PCdd/Fs accumulation in the fish and crab from the brine water storage pond, and the PCdd/Fs concentrations in biota were all higher than the food safety standard in Taiwan (3.5 pg-TEQ/g). Furthermore, the different indexes showed high degree of pollution including contamination factor (CF), modified degree of contamination (mCd), and pollution index (PI) in the PCdd/Fs polluted sediment. High biological risk indexes such as potential ecological risk index (RI) and risk quotient (RQ) were also observed in the PCdd/Fs contaminated sediment before the corrective actions. After the corrective actions such as institutional/engineering control and remediation, the CF, mCd, and PI decreased by 20–41%. The RI and RQ were also decreased by 41–56%. In conclusion, the corrective actions applied in the present study could help decrease the pollution and ecological risk of PCdd/Fs in the polluted sediment of the study site, which might further decrease the environmental risk to an acceptable level for the stakeholders if keeping implementation of the corrective actions. © 2022, The Authors. All rights reserved.

关键词： Risk management

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Electrochemical detection of antimalarial drug (Amodiaquine) using dy-MOF@MWCNTs composites to prevent erythrocytic stages of plasmodium species in human bodies

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Microchemical Journal 2024年 202卷

作者： Peter, X. Thatheyus Kuo, Chih-Yu Malar, P. Govindasamy, Mani Rajaji, Umamaheswari Yusuf, Kareem Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur 603203 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia

Herein, we report on fabrication of dysprosium-based metal–organic framework (dy-MOF)@multiwalled carbon nanotubes (MWCNT) composites modified with glassy carbon electrode (dy-MOF@MWCNT/GC) as a working electrode for Antimalarial drug detection. dy-MOF@MWCNT composites was prepared by sonochemical process along with ultrasonication. The composite structure, phase purity, morphology and composition of the composites were confirmed by X-ray diffraction, Scanning electron microscope, and X-ray photoelectron spectroscopy. Further, dy@MWCNT composites were deposited on a glassy carbon electrode by drop casting method, and used as an electrode material to efficiently detect Amodiaquine (Add) by electrochemical techniques such as CV and dPV. The as-prepared dy@MWCNT composite material showed the oxidation peak current of Add to be ∼ 60 % higher than other unmodified GC electrodes and showed a low charge transfer resistance (R_ct) of 24 Ω. The dy@MWCNT provided a broad linear range of 0.4 to 20 µM with a limit of detection of 0.377 μM and sensitivity of 1.817 μA.μM⁻¹ for the detection of Add. According to the ph study, the amount of electrons and protons involved in the electrochemical processes of Add was calculated and a plausible mechanism for Add electro-oxidation was proposed. Thus, the prepared sensor exhibited practical usefulness by determining the Add drug in human urine samples. Hence, the results shows that the dy@MWCNT- modified sensor has good electrocatalytic activity for the redox of Add. © 2024 Elsevier B.V.

关键词： Amodiaquine Antimalarial drug Carbon nanomaterials Electrochemical sensor Metal organic framework

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Lorentz TEM Investigation of Magnetic domains in Epitaxial C-Axis Oriented Co-Cr Thin Films

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Microscopy and Microanalysis 2020年第S2期6卷 446-447页

作者： Greg J. Kusinski Ph.D. Student Department of Material Science and Engineering University of California Berkeley California 94720. National Center for Electron Microscopy Lawrence Berkeley National Laboratory Berkeley California 94720.

Continuous increase in recording densities of the Co-based longitudinal media requires a drastic scaling down of the grain size in order to keep the required signal to noise ratio. However, this approach to increase the areal density will collapse when the grain size reaches the superparamagnetic limit. As an alternative, based on the analysis of the demagnetization mechanisms, Iwasaki and Takemura suggested the possibility of perpendicular magnetic recording (PMR), and computer simulation, predict areal densities of more than 300Gbit/in for this configuration. The c-axis oriented Co-based hep alloys with the magnetocrystaline anisotropy larger than the demagnetizing energy, are good candidates for the PMR media. However, before this type of materials can be realized, the magnetic domain structure must be well characterized. In this paper detailed analyses of the characteristics and shape of the magnetic domains present in the c-axis oriented CoCr films with thickness relevant for the recording industry are discussed.

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Frequency-responsive sorption of metal ions onto magnetic polyvinyltetrazole microspheres through a solenoid-wrapped glass tube with magnetophoresis force

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Journal of Water Process engineering 2024年 63卷

作者： Chen, Chih-Wei Wang, Chih-Feng Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei 106 Taiwan Division of Neurosurgery Department of Surgery Chi Mei Medical Center Tainan 710 Taiwan Institute of Advanced Semiconductor Packaging and Testing National Sun Yat-sen University Kaohsiung 804 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung 40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung 940227 Taiwan

Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetophoresis force (FMEP) is introduced to accelerate the adsorption of metal i... 详细信息

Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetophoresis force (F_MEP) is introduced to accelerate the adsorption of metal ions on adsorbents under an alternating magnetic field (AMF). A solenoid-wrapped glass tube (SWGT) containing adsorbents is designed to generate F_MEP in a flowing system. Magnetic Fe₃O₄ nanoparticles (MFs) are coated on polyacrylonitrile microspheres (PANs) as precursors (PAN@MFs) by Pickering emulsion polymerization. The core@shell polyvinyltetrazole@MFs (PVT@MFs) are obtained as the adsorbents after subsequent cyano-tetrazole conversion of PAN@MFs for the adsorption of Pb(II), Cu(II), and Cr(III) ions. The theoretical adsorption rate constants of these metal ions onto the PVT@MFs in the presence of F_MEP are enhanced by approximately three times under an AMF at 1 kHz and 87.6 G. At a high frequency of 10 kHz, hyperthermia occurs on the PVT@MFs, facilitating the desorption of metal ions from the adsorbents. Compared with reuse using an acidic solution, the magnetic PVT@MFs can be reused up to 10 times by switching the frequency of the AMF between 1 and 10 kHz. Our proposed platform provides a novel methodology with a magnetic adsorbent for metal ions to rapidly improve either the adsorption or desorption processes. © 2024

关键词： Adsorption rate Hyperthermia Magnetic susceptibility Polyvinyltetrazole

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Self-Healable Sandfish Scale-Inspired Scalable Triboelectric Layer for Hybrid Energy Harvesting in desert Environment (Small 4/2025)

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Small 2025年第4期21卷

作者： An-Rong Chen Parag Parashar Manish Kumar Sharma Jing-Siang Shih Hsuan-Yu Yeh Yen-Jui Lin Kuldeep Kaswan Kai-Po Fan Po-Yu Chen Zong-Hong Lin Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu 30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu 30013 Taiwan

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Embedding diselenide Cross-Linked Polymer Nanoparticles In-Situ Using Ring-Opening Metathesis Polymerization (Romp) of Norbornene derived Block Copolymers for Ros-Responsive doxorubicin (dox) drug delivery

SSRN

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SSRN 2025年

作者： Rao, Neralla Vijayakameswara Mathew, Jacob Le, Trong-Nghia Lee, Cheng-Kang Huang, Ru Department of Chemical Engineering National Taiwan University of Science and Technology Taipei Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan National Taiwan University of Science and Technology Taiwan

Norborene-derived block polymers with selenol-containing components and norbornene-polyethylene (PNEG) components are proposed for the development of diselenide-crosslinked polymer nanoparticles (dC PNPs), in situ, which are responsive to the abnormal ROS levels in the tumoral region, as anticancer drug carriers. These nanoparticles can be designed to release anticancer drugs selectively in the tumor microenvironment, minimizing systemic toxicity and enhancing therapeutic efficacy. The diselenide bonds in the polymer degrade in response to high levels of reactive oxygen species (ROS), which are characteristic of cancerous tissues, thereby releasing the drug at the target site. In micelles, doxorubicin (dOX) is effectively encapsulated in the hydrophobic core and the shell is strengthened by diselenide crosslinks (dOX- dC PNPs). A dLS particle stability study demonstrated that structural integrity was maintained for three days under physiological conditions. However, the hydrophobic diselenide bond successfully fragmented into hydrophilic selenic acid derivatives under ROS conditions, leading to the release of the payload from the drug-containing matrix. Validation of the drug release showed that 52% of the payload was released at a H2O2 concentration of 10 µM, ensuring the reactive matrix reaction;s optimal accuracy. A toxicity study on a normal cell line (L929) confirmed the polymer's biocompatibility, while the encapsulated model exhibited significant toxicity to a cancer cell line (Hela). In contrast to free dOX, dOX-loaded polymer nanoparticles (PNPs) displayed a lower toxicity threshold, attributed to their capacity for gradual drug release over time. Furthermore, a comparison of cellular uptake reveals that while free dOX provides immediate drug availability, dOX loaded PNPs offer a more controlled and sustained release mechanism. In cancer therapy, this characteristic enhances therapeutic efficacy while minimizing side effects associated with high concentrati

关键词： Tissue culture

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Electrochemical biosensor based on an atomic layered composite of graphene oxide/graphene as an electrode material towards selective and sensitive detection of miRNA-21

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Microchemical Journal 2024年 199卷

作者： Huang, Min-Shin Govindasamy, Mani Chinnapaiyan, Sathishkumar Lin, Yi-Ting Lu, Shao-Yang Samukawa, Seiji Huang, Chi-Hsien Department of Materials Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai-602105 Tamil Nadu India Institute of Fluid Science Tohoku University Sendai 980-8577 Japan College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan City 33305 Taiwan College of Engineering Chang Gung University Taoyuan City 33302 Taiwan

development of an efficient technique towards the detection of miRNAs is highly significant for the timely diagnosis and prognosis of cancers. In this study, we utilized the chemical vapor deposition (CVd) technique to grow bilayer graphene (BLG) on copper foil and subsequently transferred the BLG to fluorine doped tin oxide (FTO) substrate via a facile wet transfer technique. The upper layer of the BLG was modified to graphene oxide (GO) with a low damage plasma treatment (LdPT) process to serve as a biomolecule receiving layer and the lower graphene layer (G) serves as an electron transport layer. The developed GO/G/FTO platform offers superior sensing ability towards the miRNA-21. The results demonstrated that the proposed GO/G/FTO substrate detect the miRNA-21 with a wide linear range (10 fM ∼ 1 nM), low limit of detection (3.18 fM), high sensitivity (0.6 mApM⁻¹cm⁻²), selectivity and stability via the differential pulse voltammetry method. Additionally, the sensors can efficiently discriminate the target miRNA-21 from its complementary base mismatched counterparts. The proposed approach serves as an excellent tool for the early diagnosis of diseases. © 2024 Elsevier B.V.

关键词： Atomic layer oxidation Biosensor Cancer biomarkers Electrochemical Graphene oxide Plasma treatment

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MOF-derived spinel NiMn2O4/CoMn2O4 heterojunction and its application in a high-performance photocatalyst and supercapacitor

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Journal of Environmental Chemical engineering 2023年第5期11卷

作者： Lee, Kuen-Chan Hsiao, Yu-Sheng Sung, Ming-Yen Chen, Yi-Lun Wu, Nian-Jheng Huang, Jen-Hsien Cho, Er-Chieh Weng, Huei Chu Hsu, Shih-Chieh Department of Science Education National Taipei University of Education No. 134 Section 2 Heping E. Road Da-an District Taipei City106 Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Materials Science and Engineering National Taiwan University of Science and Technology No. 43 Section 4 Keelung Road Da-an District Taipei10607 Taiwan Department of Clinical Pharmacy School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Université Paris-Saclay CNRS Institut des Sciences Moléculaires d′Orsay Orsay91405 France Department of Green Material Technology Green Technology Research Institute CPC Corporation No. 2 Zuonan Rd. Nanzi District Kaohsiung City81126 Taiwan Department of Mechanical Engineering Chung Yuan Christian University No. 200 Chungpei Rd Chungli District Taoyuan City32023 Taiwan Department of Chemical and Materials Engineering Tamkang University No. 151 Yingzhuan Road Tamsui District New Taipei City25137 Taiwan

Metal oxide heterojunctions have attracted considerable attention in photocatalyst and supercapacitor applications. In this study, NiMn2O4/CoMn2O4 (NMO/CMO) heterojunctions were synthesized using ternary metal-organic frameworks (MOFs) as precursors. After calcination at 500 °C, the as-prepared NMO/CMO composite maintains the porous sheet-like morphology of the ternary MOF, exhibiting a highly porous structure. The heterostructured NMO/CMO composite demonstrates enhanced photocatalytic performance compared with pure NMO and CMO. This enhancement may be attributed to the well-aligned energy levels at the NMO/CMO interface, which effectively reduces charge recombination and facilitates the efficient transport of photogenerated carriers. In addition, the NMO/CMO heterojunction exhibits enhanced supercapacitor performance owing to the increased number of active redox sites and reduced charge transfer resistance. When tested at 3 A/g, the NMO/CMO composite displays a higher capacitance (756.4 F/g) than pure NMO (579.6 F/g) and CMO (519.6 F/g) and remarkable rate capability, maintaining a capacitance of 639 F/g even at 10 A/g. Notably, asymmetric supercapacitors fabricated using NMO/CMO and activated carbon can achieve an energy density of 32.18 W h/kg at 750 W/kg and superior cycling life, retaining 92.1% of its initial capacitance after 3000 cycles. © 2023 Elsevier Ltd

关键词： Heterojunctions

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Oxidation Behaviour of Al2O3-Forming Cr-Based Alloys at Elevated Temperatures

SSRN

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SSRN 2023年

作者： Liu, Che-Jen Huang, Kai-Yu Lin, Wei-Chih Lo, Kai-Chi Hsu, Wei-Lin Gorsse, Stéphane Yeh, An-Chou Ph.D. Program in Prospective Functional Materials Industry National Tsing Hua University 101 Sec. 2 Kuang-Fu Road Hsinchu30013 Taiwan High Entropy Materials Center National Tsing Hua University 101 Sec. 2 Kuang-Fu Road Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University 101 Sec. 2 Kuang-Fu Road Hsinchu30013 Taiwan University of Bordeaux CNRS Bordeaux INP ICMCB UMR 5026 PessacF-33600 France

This research focused on oxidation behaviours of Al-bearing Cr-based alloys at 1100-1400 ˚C for up to 24 hours. Experimental observations indicate that Al2O3 protective oxide formed mainly on the matrix BCC phase, and complex oxides formation occurred in the vicinity of C14 Laves phase, such as Cr2O3, AlTaO4, CrTaO4, and Ta2O5, leading to some internal Al2O3 and AlN formation. Although the increase in Al content could promote the formation of protective Al2O3, it also caused oxide spallation due to CTE mismatch. This study may provide some insights in the development of future oxidation-resistant Cr-based alloy compositions. © 2023, The Authors. All rights reserved.

关键词： Aluminum oxide

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