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Unlocking the potential of bacterial cellulose: synthesis, functionalization, and industrial impact

International Journal of Biological Macromolecules 2025年第PT 3期311卷 143951页

作者： Kumaravel, Ashokkumar Lin, Shin-Ping Santoso, Shella Permatasari Shanmugasundaram, Saranya Hsu, Hsien-Yi Hsieh, Chang-Wei Chou, Yu-Chieh Lin, Hui-Wen Cheng, Kuan-Chen Institute of Food Science and Technology National Taiwan University Daan District Taipei10617 Taiwan School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Chemical Engineering Master Program Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Department of Chemical Engineering Faculty of Engineering Widya Mandala Catholic University Surabaya Kalijudan 37 Surabaya60114 Indonesia Department of Chemical Engineering University of Ulsan 93 Daehak-ro Nam-gu Ulsan44610 Korea Republic of City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Food Science and Biotechnology National Chung-Hsing University Taichung City40227 Taiwan Department of Food Science National Ilan University Yilan City260007 Taiwan Institute of Medicine Chung Shan Medical University Taichung40201 Taiwan Department of Medical Research Chung Shan Medical University Hospital Taichung40201 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei10607 Taiwan Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung41350 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung40402 Taiwan Department of Food Science Fu Jen Catholic University 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City242062 Taiwan

In recent years, bacterial cellulose (BC), a crystalline and nanoscale fibrillar polymer, has garnered significant interest due to its superior physical, chemical, and mechanical properties compared to plant cellulose. Inherent features of BC, which include high biodegradability, mechanical strength, and biocompatibility, make it a suitable material for use in a wide variety of applications, particularly in the domains of biomedicine and environmental science. However, realizing its full potential requires targeted chemical or physical modifications. Recent developments have focused on in-situ and ex-situ BC modification for various applications. Incorporating functional compounds into cellulose during BC synthesis enhances its strength and functional properties. Additionally, the material properties of BC, such as water content, thermal stability, and antibacterial capabilities, can be enhanced through post-synthesis modifications, including chemical acetylation, phosphorylation, and integration with other biopolymers. Currently, the applicability of BC is being improved using new modification techniques, which involve genetically engineered strains to enhance polymer characteristics and market potential. The review highlights recent advancements in BC research and novel modification strategies that enhance its applications in advanced biomedical engineering and sustainable packaging. © 2025

关键词： Acetylation

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Association between parental well-being and preschooler stress measured as hair cortisol concentration: A prospective cohort study

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Stress and health : journal of the International Society for the Investigation of Stress 2024年第5期40卷 e3462页

作者： Yun-Shiang Kang Ling-Chu Chien Jian-Pei Huang Yen-Tzu Fan Wen-Yi Lin Pairote Chakranon Heng-Kien Au Yi-Yung Chen Hsing Jasmine Chao Pilyoung Kim Yi-Hua Chen School of Public Health College of Public Health Taipei Medical University Taipei Taiwan. Neuroscience Research Center Taipei Medical University Taipei Taiwan. Nutrition Research Center Taipei Medical University Hospital Taipei Taiwan. Department of Obstetrics and Gynecology Mackay Memorial Hospital Taipei Taiwan. Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan. Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Obstetrics and Gynecology Taipei Medical University Hospital Taipei Taiwan. Department of Obstetrics and Gynecology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Psychology College of Arts Humanities and Social Sciences University of Denver Denver Colorado USA. Department of Psychology Ewha Womans University Seoul South Korea. Research Center of Health Equity College of Public Health Taipei Medical University Taipei Taiwan.

Hair cortisol concentration (HCC) is a valuable biomarker for evaluating chronic stress in preschoolers. However, few studies have explored early life HCC and its associated factors. This prospective cohort study analysed the HCC in children aged 6-48 months and its associations with parental HCC as well as positive and negative parental mental health outcomes. We used data from the ongoing Longitudinal Examination Across Prenatal and Postpartum Health in Taiwan (LEAPP-HIT) project, conducted in Taipei between 2020 and 2024. Hair samples were collected from both parents and children in 177 families (91 samples obtained during pregnancy and 86 during the postpartum period). The parents also completed self-reported questionnaires. Multiple linear regression was conducted to analyse the data. We observed a significant positive correlation between parents' and preschoolers' HCC. Furthermore, maternal depression (adjusted beta coefficient [aβ] = 0.09, 95% confidence interval [CI] = 0.02, 0.16) and perceived stress (aβ = 0.15, 95% CI = 0.02, 0.26) were positively associated with preschoolers' HCC. By contrast, higher maternal eudaimonia was associated with lower HCC in preschoolers (aβ = -0.11, 95% CI = -0.20, -0.01). For parents, maternal depression, anxiety, and perceived stress were independently associated with an increased HCC during the postnatal period, whereas maternal eudaimonia was negatively associated with HCC. Our results indicate that both mothers and fathers affect children's responses to stress. Assessment of cortisol stress hormone concentrations through hair samples can be a key means of detecting preschoolers' stress levels and enabling early intervention.

关键词： anxiety eudaimonia fathers hair cortisol concentration perceived stress preschoolers

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Constructing a Smart Home Control System with the Internet of Things

Constructing a Smart Home Control System with the Internet o...

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IEEE Asia-Pacific Conference on Antennas and Propagation (APCAP)

作者： Huan-Po Hsu Kun-Ming Yu Wen Ouyang Cheng Jie Xu Ph.D. Program in Engineering Science Chung Hua University Hsinchu Taiwan Chung-Hua University Hsinchu Taiwan Faculty of Computer and Software Engineering Huaiyin Institute of Technology Jiangsu China

The development of Internet of Things (IoT) makes the application of smart homes grow rapidly. It is very popular to install smart appliances in the house. However, building a smart control system at home not only costs a lot but also has many limitations. For this reason, this study proposes a smart homes control system to easily integrate IoT, WSN, smart robot and single-board computer to implement smart home applications. We use wireless technology and automatic equipment to avoid excessive communication cable and to make the house more intelligent to keep in-house movement unimpeded and indoor space tidy and to let appliance adjust appropriate environment settings automatically. This system brings intelligence and convenience to home, making living environment more comfortable.

关键词： Robot sensing systems Smart homes Control systems Robot kinematics Wireless sensor networks Internet of Things

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Surface modification of alginate sponge using tannic acid and dodecanethiol for diesel oil spill separation from water

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International Journal of Biological Macromolecules 2025年 317卷 144453页

作者： Wijaya, Ronald Cheng, Kuan-Chen Santoso, Shella Permatasari Lin, Shin-Ping Putro, Jindrayani Nyoo Lie, Jenni Hsieh, Chang-Wei Hsu, Hsien-Yi Go, Alchris Woo Angkawijaya, Artik Elisa Chemical Engineering Department National Taiwan University of Science and Technology Taipei10607 Taiwan Institute of Food Science and Technology National Taiwan University Daan District Taipei City10617 Taiwan Institute of Biotechnology National Taiwan University No. 1 Sec. 4 Roosevelt Rd. Taipei Taiwan Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Rd. Taichung Taiwan Department of Food Science Fu Jen Catholic University No. 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City242062 Taiwan Chemical Engineering Department Faculty of Engineering Universitas Katolik Widya Mandala Surabaya Jl. Kalijudan No. 37 East Java Surabaya60114 Indonesia Chemical Engineering Master Program Faculty of Engineering Universitas Katolik Widya Mandala Surabaya Jl. Kalijudan No. 37 East Java Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Universitas Katolik Widya Mandala Surabaya Jl. Kalijudan No. 37 East Java Surabaya60114 Indonesia School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Food Science and Biotechnology National Chung Hsing University South Dist Taichung City402202 Taiwan Department of Food Science National Ilan University Shennong Road Yilan City260007 Taiwan Department of Medical Research China Medical University Hospital Taichung City404333 Taiwan City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China School of Engineering University of San Carlos - Talamban Campus Gov. M. Cuenco Cebu City

An environmentally friendly absorbent sponge was successfully developed for diesel spill remediation via alginate polymer crosslinking followed by surface modification using tannic acid and dodecanethiol (TA/do). The optimal sponge was obtained with a 3 h crosslinking duration, achieving a balance between absorption performance and structural durability, while longer crosslinking times led to increased density and reduced efficiency. Surface modification imparted hydrophobicity to the alginate sponge, confirmed by a water contact angle of 120.2°, and the successful incorporation of TA/do was confirmed from FTIR and XPS analysis. The modified sponge (AA-3-TA/do) exhibited a diesel absorption capacity of 17.54 g/g—a 36 % increase over the unmodified form—and retained ∼90 % of this capacity after 34 absorption–desorption cycles. Kinetic modeling showed that diesel was rapidly absorbed during early contact, with faster uptake than water. A cytotoxicity assay confirmed its non-toxic nature, indicating environmental compatibility. This study demonstrates that a simple, scalable modification using accessible materials can significantly enhance oil sorbent performance without requiring complex techniques or hazardous reagents. © 2025 Elsevier B.V.

关键词： Toxicity

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Anti-Inflammatory Glycosides from Gomphandra mollis Merr.: Structural Elucidation and Mechanistic Insights

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phytochemistry 2025年 239卷 114583页

作者： Quoc-dung Tran Huynh Thuy-Tien Thi phan Man-Hsiu Chu Thanh-Vu Nguyen Truc-Ly Thi duong Su-Jung Hsu Yun-Han Wang Ngoc-Thac pham Bien-Thuy Nguyen Bui dang-Khoa Nguyen Thanh-Hoa Vo Ta-Wei Liu Ching-Kuo Lee Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam. Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan. School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan. Biotechnology Center Of Ho Chi Minh City Ho Chi Minh 700000 Vietnam. Faculty of Traditional medicine Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam Faculty of Pharmacy Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam. School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Institute of Fisheries Science National Taiwan University Taipei 106 Taiwan. Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam. School of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Vietnam. University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam Center for Discovery and Development of Healthcare Product Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam. Institute of Pharmaceutical Sciences Department of Pharmacognosy University of Graz Universitätsplatz 4 8010 Graz Austria. Electronic address: d301110010@tmu.edu.tw. Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Department of Chemistry Chung Yuan Christ

Eight previously unreported glycosides, designated gomphandranosides I-VIII, along with nine known compounds, were isolated from the roots of Gomphandra mollis Merr. Their structures were elucidated through comprehensive spectroscopic analyses, including NMR, HR-ESI-MS, Cd, dP4+ probability, and ECd calculations. The anti-inflammatory activities of the isolated compounds were assessed using nitric oxide inhibition assays in LPS-stimulated RAW264.7 macrophages. Compounds 5, 10, and 16 exhibited significant anti-inflammatory activity with IC values of 7.56 ± 0.9, 15.0 ± 1.2, and 14.2 ± 0.9 μM, respectively. Network pharmacology, gene ontology, Kyoto Encyclopedia of Genes and Genomes analysis, and molecular docking studies identified IL-6, TNF-α, MMP9, PTGS2, and HIF1A as key targets, with potentially involved in the NF-κB and IL-17 signaling pathways. These findings highlight G. mollis as a promising candidate for the treatment of inflammation-related diseases.

关键词： Gomphandra mollis Stemonuraceae anti-inflammatory activity molecular docking network pharmacology

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Corrigendum to "Ultrafast absorption mechanism of oil-emulsified micelles onto ferrous absorbents with dielectrophoresis force in the presence of polarization" [J Hazard Mater 460 (2023) 132436]

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Journal of hazardous materials 2024年 464卷 132601页

作者： Chun-Yao Huang Feng-Yen Lin Chien-Hsing Lu Jem-Kun Chen Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Section 4 Keelung Road Taipei 106 Taiwan ROC Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei 110 Taiwan ROC Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei 110 Taiwan ROC Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 110 Taiwan ROC Department of Biomedical Sciences and Engineering National Central University 300 Zhongda Road Taoyuan City 320317 Taiwan ROC. Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei 110 Taiwan ROC. Department of Obstetrics and Gynecology Taichung Veterans General Hospital 1650 Taiwan Boulevard Sect. 4 Taichung 40705 Taiwan ROC Ph.D. Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan ROC. Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei 110 Taiwan ROC. Electronic address: jkchen@mail.ntust.edu.tw.

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The Application of Last Observation Carried Forward Method for Missing data Estimation in the Context of Industrial Wireless Sensor Networks

The Application of Last Observation Carried Forward Method f...

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IEEE Asia-Pacific Conference on Antennas and Propagation (APCAP)

作者： Hong Zhou Kun-Ming Yu Ming-Gong Lee Chin-Chuan Han Ph.D. Program in Engineering Science College of Engineering Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering Chung Hua University Hsinchu Taiwan Leisure and Recreation Management Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering National United University Miaoli Taiwan

Thanks to advances in wireless communication technologies, the wireless sensor network (WSNs) have been attracting a lot of attention from academic communities and successfully applied to various domains. Along with developments of the Industry 4.0, the WSNs start to play a vital role in the construction of smart factories and realization of intelligent manufacturing. Although, the industrial WSNs (IWSNs) presents great quantity of advantages, there still have some drawbacks to overcome such as challenges of the quality of data for IWSNs. In order to resolve the data missing problems in the context of IWSNs, the Last Observation Carried Forward method is adopted to estimate the missing value and reconstruct the sensing dataset which takes into account the temporal characteristics of sensing data in IWSNs. Through experiments, this method is proved to be an easy and effective measurement for missing value imputation of the large multi-dimensional sensing data achieved by the IWSNs.

关键词： Wireless sensor networks Estimation Industries Temperature sensors Smart manufacturing

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Arrival time estimation and reminders on public bus system 7

Arrival time estimation and reminders on public bus system

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2017 7th International Workshop on Computer science and engineering, WCSE 2017

作者： Lin, Bo-Wei Huang, ding-Ray Yang, Yun-Chung Huang, Yi-Chin Kiong, Ye Chin Lin, Jim-Min Tsai, Ming-Fong Department of Information Engineering and Computer Science Feng Chia University Taichung Taiwan Industrial Ph.D. Program of Internet of Things Feng Chia University Taichung Taiwan

ISBN: (纸本)9789811136719

The public bus service, which is one of the most frequently used public transportation methods, is an indispensable part of public lifestyle. Hence, government and companies have integrated the public bus service with smart device applications, enabling the public to check information such as bus schedules and instant information at any time. Their aim is to improve the efficiency of the public bus service. Unfortunately, their efforts have faced a variety of problems, such as the distrust of the public regarding the provided information, traffic situation, and unexpected incidents which disturb the bus schedule. In order to overcome the mentioned problems, a smart bus stop signboard system will be designed. The smart signboard will show the current position of the bus and provides a reservation service, which the public may access using smart devices. The proposed system allows bus drivers to obtain information about a particular bus stop to determine whether they should drive to that bus stop. Because the traffic situation and the embarkment and disembarkment of passengers affects the arrival time of the bus, the proposed system will take the change in the number of bus passengers and travel time into account in order to predict the arrival time of the bus.

关键词： Travel time

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Multi-objective design of synthetic biological circuits

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IFAC-PapersOnLine 2017年第1期50卷 9871-9876页

作者： Lormeau C. Rybiński M. Stelling J. Department of Biosystems Science and Engineering ETH Zurich SIB Swiss Institute of Bioinformatics Life Science Zurich Ph.D. program ”Systems Biology” Basel 4058 Switzerland Department of Biosystems Science and Engineering ETH Zurich SIB Swiss Institute of Bioinformatics Basel 4058 Switzerland

Computational methods enable the design of synthetic biological circuits demonstrating a specific dynamic behavior. Current methods are based on the assembly of parts characterized in different contexts, which often fail to operate as predicted when combined. Here we introduce a circuit design method that compensates for parts uncertainty by identifying circuit topologies whose behavior is robust to variations in parameters. Our heuristic topological filtering approach efficiently yields robust circuit designs in a Bayesian framework, and enables to reliably assess trade-offs between performance, robustness, and experimental feasibility, thus increasing the probability of success of circuit implementation. © 2017

关键词： Biocybernetics Computer-aided circuit design Multiobjective optimisations Robustness Synthetic biology

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BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters

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Allergy 2023年第7期78卷 2036-2040页

作者： Yuan-Ting Hsu Chao-Chien Wu Chin-Chou Wang Wen-Yu Chung Chau-Chyun Sheu Yi-Hsin Yang Ming-Yen Cheng Ruay-Sheng Lai Sum-Yee Leung Chi-Cheng Lin Yu-Feng Wei Ching-Hsiung Lin Sheng-Hao Lin Jeng-Yuan Hsu Wei-Chang Huang Chia-Cheng Tseng Yung-Fa Lai Meng-Hsuan Cheng Huang-Chi Chen Chih-Jen Yang Chian-Heng Su Chien-Jen Wang Shih-Chang Hsu Chih-Hsing Hung Chon-Lin Lee Ming-Shyan Huang Shau-Ku Huang National Institute of Environmental Health Sciences National Health Research Institutes Miaoli Taiwan. Department of Internal Medicine Division of Pulmonary and Critical Care Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan. Department of Public Health Kaohsiung Medical University Kaohsiung Taiwan. Department of Computer Science and Information Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan. Department of Internal Medicine Division of Pulmonary and Critical Care Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan. Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. Department of Mathematics Hong Kong Baptist University Hong Kong China. Division of Chest Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan. Department of Internal Medicine Chest Division Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital Pingtung Taiwan. Department of Internal Medicine E-Da Cancer Hospital I-Shou University Kaohsiung Taiwan. Department of Internal Medicine Division of Chest Medicine Changhua Christian Hospital Changhua Taiwan. Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan. Department of Recreation and Holistic Wellness MingDao University Changhua Taiwan. Department of Medical Research Division of Clinical Research Taichung Veterans General Hospital Taichung Taiwan. Department of Internal Medicine Division of Chest Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Medical Technology Jen-Teh Junior College of Medicine Nursing and Management Miaoli Taiwan. School of Medicine Chung Shan Medical University Taichung Taiwan. Ph.D. Program in Translational Medicine National Chung Hsing Universi

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