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Macromol. Theory Simul. 3/2016

Macromolecular Theory and Simulations 2016年第3期25卷

作者： Ramaswamy I. Venkatanarayanan Sitaraman Krishnan Arvind Sreeram philip A. Yuya Nimitt G. Patel Adama Tandia John B. McLaughlin Department of Chemical and Biomolecular Engineering Clarkson University Potsdam NY 13699 USA Department of Mechanical and Aeronautical Engineering Clarkson University Potsdam NY 13699 USA Materials Science and Engineering Ph.D. Program Clarkson University Potsdam NY 13699 USA Corning Incorporated 1 Science Center Drive Corning NY 14831 USA

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

关键词： Lung adenocarcinoma Lung cancer Mendelian randomization Pathway analysis Tuberculosis

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Frontispiece: Quantum Crystallography: Current developments and Future Perspectives

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Chemistry – A European Journal 2018年第43期24卷

作者： Alessandro Genoni Lukas Bučinský Nicolas Claiser Julia Contreras-García Birger dittrich Paulina M. dominiak Enrique Espinosa Carlo Gatti Paolo Giannozzi Jean-Michel Gillet dylan Jayatilaka Piero Macchi Anders Ø. Madsen Lou Massa Chérif F. Matta Kenneth M. Merz Jr. philip N. H. Nakashima Holger Ott Ulf Ryde Karlheinz Schwarz Marek Sierka Simon Grabowsky Université de Lorraine CNRS Laboratoire LPCT 1 Boulevard Arago F-57078 Metz France Institute of Physical Chemistry and Chemical Physics Slovak University of Technology FCHPT SUT Radlinského 9 SK-812 37 Bratislava Slovakia Université de Lorraine CNRS Laboratoire CRM2 Boulevard des Aiguillettes BP 70239 F-54506 Vandoeuvre-lès-Nancy France Sorbonne Universités UPMC Université Paris 06 CNRS Laboratoire de Chimie Théorique (LCT) 4 Place Jussieu F-75252 Paris Cedex 05 France Anorganische und Strukturchemie II Heinrich-Heine-Universität Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany Biological and Chemical Research Centre Department of Chemistry University of Warsaw ul. Żwirki i Wigury 101 02-089 Warszawa Poland CNR-ISTM Istituto di Scienze e Tecnologie Molecolari via Golgi 19 Milano I-20133 Italy Istituto Lombardo Accademia di Scienze e Lettere via Brera 28 20121 Milano Italy Department of Mathematics Computer Science and Physics University of Udine Via delle Scienze 208 I-33100 Udine Italy Structure Properties and Modeling of Solids Laboratory CentraleSupelec Paris-Saclay University 3 rue Joliot-Curie 91191 Gif-sur-Yvette France School of Molecular Sciences University of Western Australia 35 Stirling Highway Perth WA 6009 Australia Department of Chemistry and Biochemistry University of Bern Freiestrasse 3 CH-3012 Bern Switzerland Department of Pharmacy University of Copenhagen Universitetsparken 2 2100 Copenhagen Denmark Hunter College & the Ph.D. Program of the Graduate Center City University of New York New York USA Department of Chemistry and Physics Mount Saint Vincent University Halifax Nova Scotia B3M 2J6 Canada Department of Chemistry Dalhousie University Halifax Nova Scotia B3H 4J3 Canada Department of Chemistry Saint Mary's University Halifax Nova Scotia B3H 3C3 Canada Département de Chimie Université Laval Québec QC G1V 0A6 Canada Department of Chemistry and Department of Biochemistry and Molecular Biology Michigan Stat

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The upregulation of Myb and Peg3 may mediate EGCG inhibition effect on mouse lung adenocarcinoma

The upregulation of Myb and Peg3 may mediate EGCG inhibition...

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IEEE International Conference on Bioinformatics and Biomedicine

作者： Hong Zhou Joseph Manthey Ekaterina Lioutikova William Yang Kenji Yoshigoe Mary Qu Yang Hong Wang Department of Mathematical Sciences School of Health and Natural Sciences University of Saint Joseph Department of Computer Science George Washington Donaghey College of Engineering and Information Technology University of Arkansas at Little Rock and University of Arkansas for Medical Sciences Middle South Bioinformatics Center and Joint Bioinformatics Ph.D. Program George Washington Donaghey College of Engineering and Information Technology University of Arkansas at Little Rock and University of Arkansas for Medical Sciences Susan L. Cullman Laboratory for Cancer Research Department of Chemical Biology and Center for Cancer Prevention Research Ernest Mario School of Pharmacy Rutgers The State University of New Jersey

ISBN: (纸本)9781467368001

The antioxidant activity of green tea polyphenol epigallocatechin-3-gallate (EGCG) has been found to be critical in inhibiting carcinogenesis. In our previous study, we identified a set of protein coding genes and microRNAs whose expressions were significantly modulated in response to the EGCG treatment in tobacco carcinogen-induced lung adenocarcinoma in A/J mice. In this study, we further conducted some statistical analysis on our microarray data and employed The Cancer Genome Atlas (TCGA) lung adenocarcinoma datasets as additional control. We postulated that if a gene mediates EGCG's cancer inhibition, its expression level change caused by EGCG should be opposite to what occurred in the carcinogenesis. With this assumption, we identified Myb and Peg3 as the primary genes involved in the cancer inhibitory activities of EGCG.

关键词： EGCG Myb Peg3 Lung adenocarcinoma

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phototronics: Enhanced Broad Band photodetection through Piezo-phototronic Effect in CdSe/ZnTe Core/Shell Nanowire Array (Adv. Electron. Mater. 4/2015)

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Advanced Electronic materials 2015年第4期1卷

作者： Satish C. Rai Kai Wang Jiajun Chen Jason K. Marmon Manish Bhatt Sarah Wozny Yong Zhang Weilie Zhou Advanced Materials Research Institute University of New Orleans New Orleans LA 70148 USA Nanoscale Science Ph.D. Program University of North Carolina Charlotte NC 28223 USA Department of Electrical and Computer Engineering/Optoelectronic Center University of North Carolina Charlotte NC 28223 USA

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An Evaluation Model for Improving the Green Building by Integrating dEMATEL Based ANP and VIKOR

An Evaluation Model for Improving the Green Building by Inte...

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International Symposium on Computer, Consumer and Control (IS3C)

作者： Ah Taur Yan Mei Jung Lai Chiu Yue Lin Ph.D. Program in Civil and Hydraulic Engineering FCU Taichung Taiwan R.O.C. Department of Urban Planning and Spatial Information FCU Taichung Taiwan R.O.C. Department of Environmental Engineering and Science FCU Taichung Taiwan R.O.C.

ISBN: (纸本)9781479952786

In order to promote the green building policy of water and green construction project in the "Challenge 2008- National development Plan" of the Executive Yuan of Taiwan, and to cooperate with the green silicon island construction objective, the green building design orientation and deployment is the most important topic at present. This study used environmental assessment indicator system for green buildings to collect expert opinions from the industry, government units, and academia, then used the Green Building System Assessment of Taiwan for an empirical model to analysis "Green Building" and to reveal methods of improving gaps in each dimensions and criteria to achieving the aspired levels in performance. This study used the MCdM (multiple criteria decision making) model combining dEMATEL-based ANP (called dANP) with VIKOR to identify the problems in green building system assessment and to generate the improvement factors. The dEMATEL expert questionnaire was used to analyse four major dimensions and nine major indexes. The results of dANP showed that the waste reduction accounts for the highest weight (0.269), it is the most important influencing factor among the four dimensions. Three green buildings were also evaluated by VIKOR. This study identified the improvement factors with influence by evaluating the green building system, and provided the administrators with improvement strategies, so as to minimize the consumption of earth resources, and promote the development of sustainable buildings.

关键词： Green buildings Buildings Air pollution Waste reduction Indexes Biodiversity

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A novel power-effective and reliable wireless thermal convection angular accelerometer without Any movable parts and grooved cavity 1

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2012 1st International Conference on Intelligent Technologies and engineering Systems, ICITES 2012

作者： Lin, Jium-Ming Lin, Cheng-Hung Department of Communication Engineering Chung-Hua University Hsin-Chu 30012 Taiwan Ph.D. Program in Engineering Science College of Engineering Chung-Hua University Hsinchu Taiwan

ISBN: (数字)9781461467472

ISBN: (纸本)9781461467465

This chapter integrated an active RFId tag with a thermal convection angular accelerometer on a flexible substrate. The first new idea was to make the device directly on a flexible substrate without any movable parts, so it is very easy to make and reliable. The second idea used the flexible substrate such as polyimide, since its thermal conductivity is much lower than silicon, and thus, it can save more power. The third new idea and the most powerful one is that the angular accelerometer is integrated with an active RFId tag on the same flexible substrate;thus, the device becomes a more useful wireless angular acceleration sensor. By using the traditional square chamber filled with carbon dioxide, the device sensitivity is 18.8 C/(rad/s2) and the response time is 158 μs. © 2013 Springer science+Business Media New York.

关键词： Thermal conductivity

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A cross-coupled MIMO fuel cell system design by using intelligent fuzzy-neural controller 1

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2012 1st International Conference on Intelligent Technologies and engineering Systems, ICITES 2012

ISBN: (数字)9781461467472

ISBN: (纸本)9781461467465

This chapter proposes a MIMO fuel cell design by integrating both Ziegler-Nichols-based PId and intelligent fuzzy-neural controllers. Comparing with the other PId methods by Matlab simulation, the proposed system performances are better and robust by using scaled conjugate gradient algorithm to determine the neural network weighting factors and biases;even the system has stack current disturbance variation and gas valve hysteresis effects. © 2013 Springer science+Business Media New York.

关键词： Fuel cells

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A Variant-Hop Algorithm in Forming Bluetooth Sensor Networks

A Variant-Hop Algorithm in Forming Bluetooth Sensor Networks

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International Conference on Networking, Architecture, and Storage (NAS)

作者： Chih-Min Yu Yih-Bin Yu Dept. of Communication Engineering Chung-Hua University Ph.D. Program in Engineering Science Chung-Hua University

Blue web is a self-organizing Bluetooth-based multihop network equipped with a scatter net formation algorithm and a hybrid routing protocol. Blue web uses a designated root node to initiate scatter net formation and two mechanisms are introduced. One is the role exchange mechanism in which only slave nodes serve as the role of relay through the whole scatter net. The other one is the return connection mechanism in which we convert the scatter net from a tree-shaped to a web-shaped topology. In this paper, a variant-hop algorithm in forming Bluetooth sensor scatter net is proposed. Based on the design of Blue web, this algorithm is a tier-based method to determine new roots and each new root spontaneously generates their individual web-shaped subnets. The heuristic method describes the variant-hop algorithms. With a constant k, a counter variable v, and return variable r as parameters, the variant-hop algorithm generates appropriate roots locally and evenly configures the subnet size. Computer simulation shows that this method achieves good network scalability and generates an efficient scatter net configuration for Bluetooth-based multihop sensor networks.

关键词： Topology Algorithm design and analysis Bluetooth Network topology Relays Radiation detectors

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/dCBLd1) and rs2179920 (HLA-dPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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