Functionalizing chemotherapeutics-loaded liposomes with monoclonal antibodies can enhance their specificity and minimize side effects. Targeting the human epidermal growth factor receptor 2 (HER2), overexpressed in HE...
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abstract-Functionalizing chemotherapeutics-loaded liposomes with monoclonal antibodies can enhance their specificity and minimize side effects. Targeting the human epidermal growth factor receptor 2 (HER2), overexpres...
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ISBN:
(数字)9798331516994
ISBN:
(纸本)9798331517007
abstract-Functionalizing chemotherapeutics-loaded liposomes with monoclonal antibodies can enhance their specificity and minimize side effects. Targeting the human epidermal growth factor receptor 2 (HER2), overexpressed in HER2-positive breast cancer, is achievable by coating liposomes with an anti-HER2 monoclonal antibody. This study focused on synthesizing doxorubicin (DOX)-loaded immunoliposomes functionalized with anti-HER2 (HER-lip). The release of the drug from these immunoliposomes was triggered by high-frequency ultrasound (HFUS) and microbubbles, which acted as exogenous cavitation-enhancing agents. The platform was evaluated for size, lipid content, protein concentration, stability, and controlled release profiles. In vitro assessments were also performed, including the MTT assay for cell viability and flow cytometry to evaluate drug uptake. This innovative drug delivery system shows potential for combined therapeutic and diagnostic applications, improving personalized cancer care and treatment
In this study, we synthesized several active sites of molybdenum disulfide (MoS2) nanoflowers (NFs) decorated with Ni(OH)2 nanoparticles (NPs) to form heterostructures. Our results revealed that Ni(OH)2/MoS2 NF hetero...
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In this research we developed two triphenylamine (TPA)-linked conjugated microporous polymers (CMPs), TPA-TAB and TPA-TBN, through Suzuki couplings of tris(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amine (...
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Blood platelet count significantly affects the development of severe conditions like myocardial infarction, peripheral arterial ischemia, respiratory compromise, stroke, diabetes, coronavirus disease 2019 (COVID-19), ...
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Blood platelet count significantly affects the development of severe conditions like myocardial infarction, peripheral arterial ischemia, respiratory compromise, stroke, diabetes, coronavirus disease 2019 (COVID-19), along with chemotherapy patients and those suffering cardiovascular diseases (CVDs). These conditions necessitate frequent monitoring of platelet counts to guide diagnostic and therapeutic decisions. However, existing techniques are relatively time-consuming, lack of accuracy and require precise operation. The emergence of these severe diseases underscored the need to develop advanced platelet count-monitoring techniques which are rapid, highly precise, and conveniently portable for point-of-care applications. In this study, we emphasized the development of a triboelectric microfluidic nanosensor (TMNS) for platelet quantification through the assessment of flow resistance. The functionality of TMNS device is based on immobilization of platelets on a collagen layer coated inside a microfluidic channel. The triboelectric voltage output is measured as a detection signal of the flow resistance and is enhanced by incorporating high surface area copper oxide nanowires (CuO NWs) on the interior of copper tubes. These copper tubes serve as terminal electrodes and for flow guiding. The flow resistance of plasma solutions is elevated when the platelet concentration increases due to heightened adherence of platelets onto the collagen layer. Variations in flow resistance induce alterations in contact electrification, causing changes in output voltage at load terminals. Fine-tuning of the TMNS device was achieved by optimizing the channel width and length, flowing liquid viscosity, and voltage measurement technique. Platelet quantification sensing data were acquired through the combination of platelet-rich plasma (PRP) and platelet-poor plasma (PPP) solutions. The described device exhibits promising capabilities for platelet-count monitoring in whole-blood samples c
In the prosthetic field, quantifying interfacial pressure distribution between the amputee's residual limb and the socket's internal environment is imperative for developing new technologies. However, the comm...
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作者:
Raed AbokwiekRami H. HawilehJamal A. AbdallaGraduate student
Material Science and Engineering PhD Program American University of Sharjah P.O.Box 26666 Sharjah United Arab Emirates Professor
Department of Civil Engineering American University of Sharjah P.O.Box 26666 Sharjah United Arab Emirates
A finite element model (FEM) is developed to analyze the problem of seepage flow of water under concrete dams with sheet piles. The model was developed using the finite element software ANSYS, based on equivalent ther...
A finite element model (FEM) is developed to analyze the problem of seepage flow of water under concrete dams with sheet piles. The model was developed using the finite element software ANSYS, based on equivalent thermal analysis and correlation with seepage performance. The issue of water seepage under concrete dams is addressed mathematically. In this study, the effects of several parameters on porous soil seepage velocity distribution are studied. Sheet pile parameters were varied in depth, location and number of sheet piles. The sheet pile with variables of 0, 1, 2, and 3 pieces, location of 0, 0.5, and 1 of dam width, and the depth of the sheet piles varying as 2 and 4 m, respectively. The developed FE models were verified by a previous study and used for further parametric studies. It was concluded that increased sheet pile depth reduces the seepage flow. In addition, the location of the sheet pile is an important factor in seepage velocity, as it might increase the flow away from dam toe in a similar fashion to dam depth effects. Moreover, increasing the number of sheet piles further reduces the seepage velocity in comparison to usage of a single sheet pile. The sheet pile configuration and parameters are integrated with each other and each factor influence the others, resulting in various seepage flow patterns. This study demonstrates that FE modeling can effectively predict seepage flow under concrete dams with sheet piles.
Vanadate-based photocatalysts have recently attracted substantial attention owing to their outstanding photocatalytic activity for degrading organic pollutants and generating energy via photocatalytic processes. Howev...
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Background To achieve efficient solar-to-chemical energy conversion in photocatalysis, it is crucial to develop visible-light-driven catalysts with excellent charge transport properties and superior activity. Methods ...
Background To achieve efficient solar-to-chemical energy conversion in photocatalysis, it is crucial to develop visible-light-driven catalysts with excellent charge transport properties and superior activity. Methods Here, p-n heterostructured Bi 2 O 3 /BiVO 4 (BO/BVO) composites were synthesized via a spray-drying method, incorporating synergistic effects of oxygen vacancies and asphaltene-derived carbon coating. Significant findings The built-in electric field at the p −type BO and n-type BVO interface, combined with the electron sink effect of the coated graphitic carbon layer, enhances charge transfer while suppressing charge recombination. As a result, the carbon coated BO/BVO (C-BO/BVO) heterojunction reveals markedly improved efficiency for photodegradation of methylene blue (MB) in comparison with pure BO and BVO. Under visible light irradiation, the C-BO/BVO composite achieves an MB decomposition efficiency of 92.1 %, which is approximately 1.78, 2.23, and 2.98 times higher than that of BO/BVO, pure BVO, and pure BO, respectively. As a result, the C-BO/BVO composites exhibit superior degradation performance for MB and tetracycline (TC), achieving high rate constants of 6.51 × 10 −2 min −1 and 7.55 × 10 −3 min −1 , respectively. The C-BO/BVO photocatalysts also exhibit exceptional antibacterial activity against Escherichia coli ( E. coli ). Additionally, their biocompatibility has been assessed using an in vivo zebrafish embryo model, highlighting their potential for future biomedical applications.
作者:
Wu, BCYoung, GSSchmidt, WChoppella, KDr. Bi-Chu Wu:received a PhD in Mechanical Engineering from the University of Maryland
College Park in 1991. She has worked on projects involving naval architecture design optimization solid mechanics and database development. Presently a senwr engineer with Angle Incorporated Dr Wu's research interests are in design optimization and fuzzy logic applications. Dr. Gin-Shu Young:
a senior engineer with Angle Incorporated holds a PhD in Mechanical Engineering from the University of Maryland College Park. As a guest researcher with National Institute of Standards and Technologies from 1990 to 1993 he worked on vision-based navigation for autonomous vehicles. His experience also includes applications of optimization fuzzy logic neural network and genetic algorithm methods to engineering system design Mr. William Schmidt:co-founded Angle Incorporated in 1990 and has served as Vice PresidentlChiefScientist during this tame. He holds a B.Sc. in Applied Science from the Naval Acadt?my and an M.Sc. in Physics from the Naval Post Graduate School. He has cner 20 years experience in technical leadership
material and personnel management. He has led the application of computer aided design (CAD) and Product Model Information Exchange to the shipbuilding industry. His experience also includes leading the amlication of model based operational analysis to support the Live Fire Test Program for DDG 51 Class Destroyers. Mr. Krishna M. Choppella:is a Sofware Engineer at Eidea Laboratories
Incotporated where he works on componentbased distributed enterpvise frameworks. He has been involved in creating data analysis tools for the US Nay by integrating CAD modeis databases and graphical front ends. His work in the Masters degree program in Mechanical Engineering at the University of Texas at Austin was in di0ddase.r spectroscopy of combustion products in porous-matri burners. He received his Bachelors degree in Electrical Engineering in India. He was a Research Associate at the Centre for Laser Technology and Project Engi
Ship design is often multidisciplinary involving several design elements with various types of objectives and constraints (O/C) some easily described as mathematical formulas, others better modeled as descriptive asse...
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Ship design is often multidisciplinary involving several design elements with various types of objectives and constraints (O/C) some easily described as mathematical formulas, others better modeled as descriptive assertions. This paper describes a method based on fuzzy functions and an integrated performance index to model O/C using descriptive assertions to be used with mathematical formulas in optimization. Another issue addressed in this paper concerns the coordination of design elements when sequentially coupled, that is, when one leads the other and the performance of the follower depends greatly on the design of the leader. Based on neuro-fuzzy techniques, the method described here coordinates and optimizes sequentially coupled elements. The two methods are applied to machinery arrangement (MA) and pipe routing (PR). Preliminary models for optimization of MA and PR are described considering convenience, producibility: engine room size, interference and location as factors in the O/C set. Some test results from MA/PR applications are presented and discussed. The methods are generic and can be extended to other elements in ship design. They are mutually independent and may be used separately Two advantages of their use are an improvement in overall performance and a reduction in the need for redesign of elements.
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