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Molecular architecture of mammalian pyruvate dehydrogenase complex

Protein & Cell 2025年第1期16卷 72-78页

作者： Maofei Chen Yutong Song Sensen Zhang Yitang Zhang Xudong Chen Minghui Zhang Meng Han Xin Gao Sai Li Maojun Yang Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Tsinghua UniversityBeijing 100084China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShenzhen University Health Science CenterShenzhen 518060China Protein Research Technology Center Protein Chemistry and Omics PlatformSchool of Life SciencesTsinghua UniversityBeijing 100084China Computer Science Program ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Computational Bioscience Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Cryo-EM Facility Center Southern University of Science and TechnologyShenzhen 518055China Beijing Life Science Academy Beijing 102209China

Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).

关键词： sequentially oxidative Dalton

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Néel Spin-Orbit Torque in Antiferromagnetic Quantum Spin and Anomalous Hall Insulators

arXiv

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arXiv 2024年

作者： Tang, Junyu Zhang, Hantao Cheng, Ran Department of Physics and Astronomy University of California RiversideCA92521 United States Department of Electrical and Computer Engineering University of California RiversideCA92521 United States Department of Materials Science and Engineering University of California RiversideCA92521 United States

Interplay between magnetic ordering and topological electrons not only enables new topological phases but also underpins electrical control of magnetism. Here we extend the Kane-Mele model to include the exchange coupling to a collinear background antiferromagnetic (AFM) order, which can describe transition metal trichalcogenides. Owing to the spin-orbit coupling and staggered on-site potential, the system could exhibit the quantum anomalous Hall and quantum spin Hall effects in the absence of a net magnetization. Besides the chiral edge states, these topological phases support a staggered Edelstein effect through which an applied electric field can generate opposite non-equilibrium spins on the two AFM sublattices, realizing the Néel-type spin-orbit torque (NSOT). Contrary to known NSOTs in AFM metals driven by conduction currents, our NSOT arises from pure adiabatic currents devoid of Joule heating, while being a bulk effect not carried by the edge currents. By virtue of the NSOT, the electric field of a microwave can drive the AFM dynamics with a remarkably high efficiency. Compared to the ordinary AFM resonance driven by the magnetic field, the new mechanism can enhance the resonance amplitude by more than one order of magnitude and the absorption rate of the microwave power by over two orders of magnitude. Our findings unravel an incredible way to exploit AFM topological phases to achieve ultrafast magnetic dynamics. © 2024, CC BY-NC-SA.

关键词： Antiferromagnetism

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The Implementation of TOGAF for Enterprise System Planning on XYZ Campus

The Implementation of TOGAF for Enterprise System Planning o...

引用

Networking, electrical engineering, computer science, and Technology (IConNECT), International Conference on

作者： Tamsir Hasudungan Sirait Ford Lumban Gaol Suhono Harso Supangkat Benny Ranti Binus Graduate Program Computer Science Bina Nusantara University Jakarta Indonesia Computer Science Department Bina Nusantara University Jakarta Indonesia School of Electrical Engineering and Informatics Bandung Institute of Technology Bandung Indonesia Computer Science Department Universitas Indonesia Jakarta Indonesia

Universities can employ information technology as one means of achieving their goals and objectives. Universities can get advantages from information technology, such as effective resource management and information management for decision-making. However, don't forget that the campus must consider what technology is appropriate to assist them achieve their goals, particularly in the current industrial era 4.0 where technology is available with many different choices. The campus requires an enterprise architecture in order to design, manage, and coordinate information technology infrastructure, applications, and processes strategically and thoroughly. The adoption of enterprise information system architecture (EA) is also intended to improve the quality of services provided to internal and external stakeholders. In this case, Enterprise Architecture can help an organization to match its information technology resources with business processes and strategies to achieve their goals. This research was conducted using TOGAF ADM, also known as the Open Group Architecture Framework Architecture Development Method. This method offers best practices for creating enterprise architecture and emphasizes several steps that include creating an architectural vision, information systems, business architecture modeling to help XYZ campus manage all their information technology.

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Joint Source Decomposition of Concurrent EEG-FMRI Data in Epilepsy and Control Groups

Joint Source Decomposition of Concurrent EEG-FMRI Data in Ep...

引用

IEEE International Symposium on Biomedical Imaging

作者： J. Mason Harding Haatef Pourmotabbed Yamin Li Kimberly Rogge-Obando Kate Wang Sarah E. Goodale Shiyu Wang Camden Bibro Bergen Allee Caroline Martin Victoria L. Morgan Dario J. Englot Catie Chang Department of Electrical and Computer Engineering Vanderbilt University Department of Biomedical Engineering Vanderbilt University Department of Computer Science Vanderbilt University Neuroscience Graduate Program Vanderbilt University Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Department of Neurological Surgery Vanderbilt University Medical Center Department of Radiology Vanderbilt University Medical Center

ISBN: (数字)9798331520526

ISBN: (纸本)9798331520533

EEG and fMRI are complementary, noninvasive technologies for investigating human brain function. These modalities have been used to uncover large-scale functional networks and their disruptions in clinical populations. Given the high temporal resolution of EEG and high spatial resolution of fMRI, integrating these modalities can provide a more holistic understanding of brain activity. This work explores a multimodal source decomposition technique for extracting shared modes of temporal variation between fMRI BOLD signals and EEG spectral power fluctuations in the resting state. The resulting components are then compared between patients with focal epilepsy and controls, revealing multimodal network differences between groups.

关键词： Neuroimaging Brain Fluctuations Epilepsy Functional magnetic resonance imaging Electroencephalography Pattern recognition Hemodynamics Spatial resolution Signal resolution

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Dynamic Mapping of Temperature Using Phase-Change materials

Dynamic Mapping of Temperature Using Phase-Change Materials

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CLEO: science and Innovations, S and I 2022

作者： Nobile, Nicholas Erickson, John Ríos, Carlos Zhang, Yifei Hu, Juejun Xiong, Feng Youngblood, Nathan Univ. of Pittsburgh Dept. of Electrical and Computer Engineering Benedum Hall 3700 O'Hara St. PittsburghPA15261 United States Department of Materials Science & Engineering University of Maryland College ParkMD United States Institute for Research in Electronics and Applied Physics University of Maryland College ParkMD United States Department of Materials Science & Engineering MIT CambridgeMA United States

GST pixels are fabricated on metallic heaters where the optical reflection is observed and used to extract dynamic temperature changes. Our results provide a new way to measure the thermal response of microsystems in ... 详细信息

ISBN: (纸本)9781557528209

关键词： Phase change materials

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Doping Shortens the Metal/Metal Distance and Promotes OH Coverage in Non-Noble Acidic Oxygen Evolution Reaction Catalysts

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Journal of the American Chemical Society 2023年第14期145卷 7829-7836页

作者： Wang, Ning Ou, Pengfei Miao, Rui Kai Chang, Yuxin Wang, Ziyun Hung, Sung-Fu Abed, Jehad Ozden, Adnan Chen, Hsuan-Yu Wu, Heng-Liang Huang, Jianan Erick Zhou, Daojin Ni, Weiyan Fan, Lizhou Yan, Yu Peng, Tao Sinton, David Liu, Yongchang Liang, Hongyan Sargent, Edward H. Department of Electrical and Computer Engineering University of Toronto 35 St George Street TorontoONM5S 1A4 Canada School of Materials Science and Engineering Key Laboratory of Efficient Utilization of Low and Medium Grade Energy Ministry of Education Tianjin University Tianjin300350 China Department of Mechanical and Industrial Engineering University of Toronto 5 King’s College Road TorontoONM5S 3G8 Canada School of Chemical Sciences The University of Auckl Auckland1010 New Zealand Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu300 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei10617 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science & Engineering Tianjin University Tianjin300354 China

Acidic water electrolysis enables the production of hydrogen for use as a chemical and as a fuel. The acidic environment hinders water electrolysis on non-noble catalysts, a result of the sluggish kinetics associated with the adsorbate evolution mechanism, reliant as it is on four concerted proton-electron transfer steps. Enabling a faster mechanism with non-noble catalysts will help to further advance acidic water electrolysis. Here, we report evidence that doping Ba cations into a Co3O4 framework to form Co3-xBaxO4 promotes the oxide path mechanism and simultaneously improves activity in acidic electrolytes. Co3-xBaxO4 catalysts reported herein exhibit an overpotential of 278 mV at 10 mA/cm2 in 0.5 M H2SO4 electrolyte and are stable over 110 h of continuous water oxidation operation. We find that the incorporation of Ba cations shortens the Co-Co distance and promotes OH adsorption, findings we link to improved water oxidation in acidic electrolyte. © 2023 American Chemical Society.

关键词： Catalysts

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Enhancing Acute Ischemic Stroke Diagnosis Using IoMT and Deep Learning Technologies

Enhancing Acute Ischemic Stroke Diagnosis Using IoMT and Dee...

引用

Telecommunications Conference (ITC-Egypt), International

作者： Mohamed M. El-Sheikh Aya Bayoumy Nada M. Ahmed Amany Mohamed Eldeeb Fatma I. Rabea Amira A. Nawar Mohamed G. Khattap Hend Galal Eldeen Mohamed Ali Hassan Mariam Mostafa Nayra Ibrahim Reem Ramadan Yomna Refaat Mennatallah Khaled Ali Maher Mohamed Abd Elaziz Ahmed Gamal Abdellatif Ibrahim Radiology and Medical Imaging Faculty of Applied Health Sciences Galala University Suez Egypt Biomedical Informatics Faculty of Computer Science and Engineering Galala University Suez Egypt Artificial Intelligence Science Program Faculty of Computer Science and Engineering Galala University Suez Egypt Department of Electronics and Electrical Communications Engineering Air Defense College Alexandria Egypt

ISBN: (数字)9798350351408

ISBN: (纸本)9798350351415

This paper introduces an alternative technique for diagnosing Acute Ischemic Stroke within the IoMT environment. In the proposed approach, the collected data is transmitted to a cloud-based center where the technique utilizes EfficientNet, a deep learning model, designed to extract features from MRI images thereby enhancing the detection of acute ischemic infarctions. The performance of EfficientNet is compared against two other models, CNN and MobileNet, demonstrating its superior efficacy through metrics such as accuracy, precision, recall, and F1-score, which stand at 92.31%, 92.28%, 92.33%, and 92.30%, respectively.

关键词： Deep learning Accuracy Magnetic resonance imaging Soft sensors Medical services Feature extraction Regulation

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Top-Down Fabrication of Diamond Nanostructures

SSRN

引用

SSRN 2024年

作者： Biswas, Abhijit Li, Chenxi Pieshkov, Tymofii Mei, Zhaobo Xu, Mingfei Li, Tao Murukeshan, Jishnu Vajtai, Robert Zhao, Yuji Ajayan, Pulickel M. Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States

Diamond nanostructures can have exciting applications in electronics and thermal management, but their controlled fabrication can be challenging. Here, we present a top-down approach for the fabrication of diamond nanorod (DNR) clusters, via use of metal masks (Al, Ag, Au, and Cr) and reactive-ion etching (RIE). Prolonged RIE on Ag and Cr masks yields distinct etching profiles, and DNR clusters are selectively formed from Ag masks, with individual nanorods having dimensions of ~100 nm diameter and ~1.5 µm length. Detailed electron microscopy shows thin layer of amorphous carbon (a-C) around single crystalline DNR cores. Chemical analyses also show presence of oxygen on the surface of the DNRs. Fabrication of the DNR clusters with scalable top-down approach could lead to new nanodiamond-based applications. © 2024, The Authors. All rights reserved.

关键词： Nanorods

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Strategies to anode protection in lithium metal battery:A review

引用

InfoMat 2021年第12期3卷 1333-1363页

作者： Jiawei Li Zhao Kong Xiaoxi Liu Bocong Zheng Qi Hua Fan Elias Garratt Thomas Schuelke Keliang Wang Hui Xu Hong Jin Xi'an Jiaotong University Suzhou AcademySuzhouChina Nano Science and Technology Institute University of Science and Technology of ChinaSuzhouChina College of Materials Science and Engineering Huaqiao UniversityXiamenChina Fraunhofer USA Inc.Center MidwestMichigan State UniversityEast LansingMichiganUSA Department of Electrical Engineering and Computer Engineering Michigan State University East LansingMichiganUSA Department of Chemical Engineering and Materials Science Michigan State University East LansingMichiganUSA

Lithium metal batteries(LMBs)are considered the most promising energy stor-age devices for applications such as electrical vehicles owing to its tremendous theoretical capacity(3860 mAh g−1).However,the serious safety issues and poor cycling performance caused by the dendritic crystal growth during deposi-tion are concerned for any rechargeable batteries with a lithium metal *** make widespread adoption a possibility,considerable efforts have been devoted to suppressing lithium(Li)dendrite *** this review,the recent strategies to developing dendrite free Li anode,including constructing an artifi-cial solid electrolyte interface,current collector modification,separator film improvement,and electrolyte additive,are *** merits and short-comings for different strategies are reviewed and a general summary and per-spective on the next generation rechargeable batteries are presented.

关键词： dendrite Li metal batteries solid electrolyte interface

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Optimized Transmission Strategy for UAV-RIS 2.0 Assisted Communications Using Rate Splitting Multiple Access

arXiv

引用

arXiv 2023年

作者： Huroon, Aamer Mohamed Huang, Yu-Chih Wang, Li-Chun Department of Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Taiwan Institute of Communications Engineering National Yang Ming Chiao Tung University Taiwan Department of Electrical and Computer Engineering National Yang Ming Chiao Tung University Taiwan

In this paper, we study the transmission strategy of a ground-based beyond diagonal reconfigurable intelligent surface (BD-RIS), a.k.a RIS 2.0, in a network where multiple unmanned aerial vehicles (UAVs) simultaneously transmit signals to the respective groups of users. It is assumed that each group is assigned subcarriers orthogonal to those assigned to other groups and rate splitting multiple access (RSMA) is adopted within each group. A corresponding mixed integer nonlinear programming problem (MINLP) is formulated, which aims to jointly optimize 1) allocation of BD-RIS elements to groups, 2) BD-RIS phase rotations, 3) rate allocation in RSMA, and 4) precoders. To solve the problem, we propose using generalized benders decomposition (GBD) augmented with a manifold-based algorithm. GBD splits the MINLP problem into two sub-problems, namely the primal and the relaxed master problem, which are solved alternately and iteratively. In the primal problem, we apply block coordinate descent (BCD) to manage the coupling of variables effectively. Moreover, we recognize the manifold structure in the phase rotation constraint of BD-RIS, enabling the Riemannian conjugate gradient (RCG). Simulation results demonstrate the effectiveness of the proposed approach in maximizing spectral efficiency. Copyright © 2023, The Authors. All rights reserved.

关键词： Iterative methods

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