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Piezoelectric and triboelectric nanogenerators: Promising technologies for self-powered implantable biomedical devices

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Nano Energy 2024年 119卷

作者： Khan, Arshad Joshi, Ravindra Sharma, Manish Kumar Ganguly, Anindita Parashar, Parag Wang, Ting-Wei Lee, Sangmin Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan Department of Chemical Engineering National Taiwan University Taipei10167 Taiwan

Implantable biomedical devices (IBDs) have garnered wide-scale attention in recent years due to their enormous contribution to the biomedical sector. However, an uninterrupted and reliable power source has consistently been the primary barrier for IBDs, which is greatly alleviated by batteries. The widespread application of battery-powered IBDs is hindered by several limitations, including bulkiness, limited capacity and shelf-life, and expenditure associated with surgery-based battery recharge/replacement. To address these challenges, state-of-the-art self-powering technologies have emerged, including implantable piezoelectric nanogenerators (iPENGs) and implantable triboelectric nanogenerators (iTENGs). These technologies enable IBDs to operate autonomously by harnessing the minute mechanical movements of internal organs, such as heartbeat, respiration, blood circulation, muscle contraction/relaxation, and lung vibration. This review focuses on the recent advancements in iTENGs and iPENGs for the development of self-powered IBDs with a wide range of applications, including energy harvesting from biomechanical and ultrasound sources and energy storage using batteries and capacitors. This study also explores the extensive sensing applications of IBDs in various areas including cardiac, gastrointestinal, bladder, and ligament-strain monitoring. Finally, therapeutic applications of IBDs, such as nerve stimulation, bone stimulation, cartilage therapy, tissue regeneration, muscle stimulation, drug delivery, and diabetes management are discussed. © 2023 Elsevier Ltd

关键词： Nanogenerators

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Optimal stimulation of Citrus reticulate for bioenergy extraction in MFCs and antioxidant activity via traditional Chinese medicine processing methods

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Journal of the Taiwan Institute of Chemical Engineers 2023年 143卷

作者： Tsai, Po-Wei Rogio, Kristian Gil G. Hsieh, Cheng-Yang Cruz, Kathlia A. De Castro Lee, Chia-Jung Hsueh, Chung-Chuan Huang, Ting-Ning Lu, Wei-Zhun Xie, Zong-Lin Jheng, Yong-Ni Chen, Bor-Yann Department of Medical Science Industries College of Health Sciences Chang Jung Christian University Tainan711 Taiwan School of Chemical Biological and Materials Engineering and Sciences Mapúa University 1002 Metro Manila Philippines PhD. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei110 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei110 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei110 Taiwan Department of Chemical and Materials Engineering National I-Lan University I-Lan 260 Taiwan

Background: Value added production of polyphenolic rich citrus peels in the form of agricultural waste valorization and as a medicinal herb holds exceptional practicality. Potential applications as natural electron shuttles for bioenergy production further valorizes citrus peels in a bid to promote sustainable energy generation. This first-attempt study thus tended to decipher the stimulating effects of traditional medicinal processing methods to augment the electron mediating capabilities of Citrus reticulate peels. Methods: Dried C. reticulate peels were subjected to stir-frying with individual adjuvants (e.g., vinegar, honey, soil, and bran) and analyzed via phytochemical analysis, antioxidant activity, and anti-inflammatory activity. Moreover, microbial fuel cells were used to evaluate the electron shuttling characteristics of the processed C. reticulate for bioenergy extraction. Significant findings: It was indicated that solid adjuvants (e.g., bran and soil) coupled with stir-frying were found to increase the phytochemical content (e.g., total phenols, flavonoids, and condensed tannins) of C. reticulate peels. Consequently, according to comparative analysis, bran stir-fried extracts with optimal processing methods further stimulate the ES characteristics of C. reticulate for bioenergy extraction. Enhanced power generation capacity was attributed to the chemical and physical changes of the bioactive compounds as a result of the processing methods. Furthermore, principal component analysis reveals that FRAP assay and total flavonoid content serve as a preliminary investigation for revealing the electron transport characteristics of C. reticulate. © 2023

关键词： Principal component analysis

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Expansion cooling prospects for large scale applications

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International Journal of Thermofluids 2023年 20卷

作者： Alami, Abdul Hai Alrashid, Rashid Mdallal, Ayman Yasin, Ahmad Ayoub, Mohamad Alasad, Shamma Aljaghoub, Haya Alashkar, Adnan Abdelkareem, Mohammad Ali Olabi, Abdul Ghani Orhan, Mehmet Department of Sustainable and Renewable Energy Engineering University of Sharjah P.O. Box 27272 Sharjah United Arab Emirates Sustainable Energy and Power Systems Research Centre RISE University of Sharjah P.O. Box 27272 Sharjah United Arab Emirates Department of Mechanical Engineering American University of Sharjah P.O. Box 26666 Sharjah United Arab Emirates Department of Mechatronics Engineering American University of Sharjah P.O. Box 26666 Sharjah United Arab Emirates Department of Industrial Engineering and Engineering Management University of Sharjah P.O. Box 27272 Sharjah United Arab Emirates Materials Science and Engineering PhD Program American University of Sharjah P.O. Box 26666 Sharjah United Arab Emirates Chemical Engineering Department Minia University Elminia Egypt Mechanical Engineering and Design School of Engineering and Applied Science Aston University Aston Triangle BirminghamB4 7ET United Kingdom

Air conditioning in general and cooling in particular are the biggest energy sinks among all electricity consumers. Mitigating energy needs of this sector by active or passive means is a necessity. This paper offers a comprehensive review of various cooling technologies for large scale applications and compares them in terms of economy, environmental footprint and most importantly, energy requirements. There is a main focus on the potential of using expansion cooling, which is defined in conjunction with cooling effects generated during the expansion process of a gas. The interest in such cooling technology stems from the double benefit of utilizing a large-scale compressed air energy storage (CAES) system that can also provide cooling via the expansion of air. This consequently manifests in reducing the electrical demand required for cooling applications. Such a concept is beneficial for hot climates, where most of the electrical demand is reserved for offsetting the cooling load. © 2023 The Author(s)

关键词： Compressed air energy storage

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Synthesis of Gadolinium-Doped Molybdenum Diselenide Nanospheres for Ultrasensitive Electrochemical Determination of Essential Amino Acid in Human Serum and Milk Samples

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Journal of the Electrochemical Society 2023年第5期170卷 057501-057501页

作者： Jeromiyas, Nithiya Govindasamy, Mani Alothman, Asma A. Ouladsmane, Mohamed Huang, Chi-Hsien National Kaohsiung University of science and Technology Kaohsiung City81157 Taiwan Department of Chemistry Korea University Seongbuk-gu Seoul Korea Republic of Faculty International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam Chennai602105 India Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Biochemical Technology R&D Center Ming Chi University of Technology New Taipei City243303 Taiwan

The electrocatalytic activity and electronic conductivity of 2D transition metal chalcogenides are usually enhanced by as follows the ideal strategy such as doping or substitution heterogeneous atoms. Here, a rare Earth metal ion of gadolinium (Gd3+) was doped with MoSe2 and synthesized through the hydrothermal method. The morphology and nanostructure of Gd3+ with MoSe2 spheres were analyzed under X-ray diffraction, Fourier-transform infrared spectroscopy, X-ray photoelectron, High-resolution transmission electron microscopy analysis, Field emission scanning electron microscopy, and energy-dispersive spectroscopy. Furthermore, the Gd3+ doped MoSe2 sphere modified glassy carbon electrode (Gd@MoSe2/GCE) was used for the sensing of tryptophan. The Gd@MoSe2 modified GCE shows remarkable sensing performance of tryptophan resulting in a linear range (20 nM-220 μM) with a low detection limit (6.7 nM). Under the optimal condition, the developed electrochemical sensor was successfully used to determine tryptophan (TRP) in blood serum and milk samples. The electrochemical biosensing results suggest that the doping of the Gd3+ doped MoSe2 sensor is a promising electrocatalyst in biological and food samples. © 2023 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

关键词： Amino acids

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High-resolution dynamic imaging of chromatin DNA communication using Oligo-LiveFISH

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Cell 2025年

作者： Zhu, Yanyu Balaji, Ashwin Han, Mengting Andronov, Leonid Roy, Anish R. Wei, Zheng Chen, Crystal Miles, Leanne Cai, Sa Gu, Zhengxi Tse, Ariana Yu, Betty Chentzu Uenaka, Takeshi Lin, Xueqiu Spakowitz, Andrew J. Moerner, W.E. Qi, Lei S. Department of Bioengineering Stanford University Stanford 94305 CA United States Department of Chemistry Stanford University Stanford 94305 CA United States Biophysics PhD Program Stanford University Stanford 94305 CA United States Computational Biology Program Public Health Sciences Division and Translational Data Science IRC Fred Hutchinson Cancer Center Seattle 98109 WA United States Department of Chemical Engineering Stanford University Stanford 94305 CA United States Department of Materials Science and Engineering Stanford University Stanford 94305 CA United States Institute for Stem Cell Biology & Regenerative Medicine and Department of Pathology Stanford University School of Medicine Stanford 94305 CA United States Sarafan ChEM-H Stanford University Stanford 94305 CA United States Chan Zuckerberg Biohub San Francisco 94080 CA United States

Three-dimensional (3D) genome dynamics are crucial for cellular functions and disease. However, real-time, live-cell DNA visualization remains challenging, as existing methods are often confined to repetitive regions, suffer from low resolution, or require complex genome engineering. Here, we present Oligo-LiveFISH, a high-resolution, reagent-based platform for dynamically tracking non-repetitive genomic loci in diverse cell types, including primary cells. Oligo-LiveFISH utilizes fluorescent guide RNA (gRNA) oligo pools generated by computational design, in vitro transcription, and chemical labeling, delivered as ribonucleoproteins. Utilizing machine learning, we characterized the impact of gRNA design and chromatin features on imaging efficiency. Multi-color Oligo-LiveFISH achieved 20-nm spatial resolution and 50-ms temporal resolution in 3D, capturing real-time enhancer and promoter dynamics. Our measurements and dynamic modeling revealed two distinct modes of chromatin communication, and active transcription slows enhancer-promoter dynamics at endogenous genes like FOS. Oligo-LiveFISH offers a versatile platform for studying 3D genome dynamics and their links to cellular processes and disease. © 2025 Elsevier Inc.

关键词： CRISPR imaging DNA communication dynamic tracking enhancer-promoter interaction high-resolution imaging live DNA imaging non-repetitive genome imaging Oligo-LiveFISH polymer modeling primary cell

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Compressed air energy storage systems (CAES) and assessment of expansion cooling as an ancillary process

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science Talks 2024年 10卷

作者： Abdul Hai Alami Ahmad Yasin Siren Khuri Ayman Mudallal Mohamad Ayoub Adnan Alashkar Rashid AlRashid Shamma Abdalla Sustainable and Renewable Energy Engineering Department University of Sharjah Sharjah P.O. Box 27272 United Arab Emirates Materials Science and Engineering PhD Program American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates Mechanical Engineering Department American University of Sharjah Sharjah 26666 United Arab Emirates

This work introduces compressed air energy storage (CAES) systems and their role in mitigating the lag between energy supply and demand. The concept of energy storage relies on storing energy during periods of low demand to supply it during periods of high demand, where CAES stands as a scalable solution with the ability to house ancillary systems in order to harvest useful effects such as expansion cooling. CAES on its own compares well with electrochemical batteries, while bearing a simpler system design and less stringent operational requirements; however, with the integration of thermal management the role of CAES can be extended to produce chilled water that can be used for cooling applications. Not only does expansion cooling broaden the utilization of CAES, it has also enhanced the energetic efficiency of the system by 4%. Future work within the scope of CAES includes the integration of heat pipes and latent heat energy storage, and experimenting with different working gases.

关键词： Compressed air energy storage (CAES) Mechanical energy storage Expansion cooling Thermal management

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Progress in experimental assessments of buoyancy work energy storage

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science Talks 2024年 10卷

作者： Abdul Hai Alami Mohamad Ayoub Adnan Alashkar Shamma Abdalla Ahmad Yasin Ayman Mdallal Sustainable and Renewable Energy Engineering Department University of Sharjah Sharjah P.O. Box 27272 United Arab Emirates Materials Science and Engineering PhD Program American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates Mechanical Engineering Department American University of Sharjah Sharjah 26666 United Arab Emirates

This work reiterates the potential of buoyancy work energy storage (BWES) systems which has been presented in previously published experimental-based literature. The concept of buoyancy work can be grasped when studying the operation of mobility devices such as hot air balloons or boats, where buoyancy plays a key role in keeping them afloat. Conventional experimental BWES systems that were studied in previous literature consist of a water tank, a submergible buoy, a motor/generator carrying out the charging/discharging processes, respectively, and a data acquisition interface. It is interesting to see the progression of this technology at lab scale, where initial designs included the use of a barrel as the water tank, and Styrofoam cut-outs as buoys. One design utilized a ring with multiple Styrofoam buoys attached to it, and it was later enhanced by adding helical engravings to the buoys' surface to affect its interaction with water positively during descension and ascension. The latest study added to this timeline of ongoing development investigates the effect of different buoy materials, surface coatings, buoy infill gasses, and load.

关键词： Buoyancy work energy storage Mechanical energy storage Offshore wind turbines Battery alternatives

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Emergence of Non-photoresponsive Catalytic Techniques for Environmental Remediation and Energy Generation

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Chemistry - An Asian Journal 2023年第9期18卷 e202300090页

作者： Kumar Sharma, Manish Khan, Imran Kaswan, Kuldeep Roy Barman, Snigdha Saha, Subhajit Hsieh, Wu-Chiao Chueh, Yu-Lun Wang, Yu-Lin Lee, Sangmin Choi, Dukhyun Lin, Zong-Hong Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Renewable Energy Maulana Abul Kalam Azad University of Technology West Bengal741249 India Department of Obstetrics and Gynecology Chang Gung Memorial Hospital and College of Medicine Chang Gung University Taoyuan333 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Mechanical Engineering Sungkyunkwan University Suwon16419 Korea Republic of Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan

Catalysis plays a crucial role in all the major applications and challenges in the environment, including energy generation and environmental remediation. Although photocatalysts and electrocatalysts are useful in addressing energy and environmental issues, they have some major drawbacks, such as low efficiency and easy charge recombination which limits their applications. Hence, it is imperative to design and explore new catalytic techniques that include non-photoresponsive catalysts. In this review, the detailed possibilities, characteristics and prospects of non-photoresponsive catalysts, such as piezocatalysts, thermocatalysts, pyrocatalysts, and tribocatalysts along with hybrid catalysts are described. The overall mechanism of each catalytic technique and its applications in different fields such as energy generation, environmental remediation, and carbon dioxide reduction are discussed. © 2023 Wiley-VCH GmbH.

关键词： Electrocatalysts

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Corrigendum to "Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery" [Int. J. Biol. Macromol. 181 (2021) 835-846]

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International journal of biological macromolecules 2022年 206卷 1040-1041页

作者： Trong-Ming Don Wan-Ju Chang Pei-Ru Jheng Yi-Cheng Huang Er-Yuan Chuang Department of Chemical and Materials Engineering Tamkang University New Taipei City Taiwan College of Life Sciences Department of Food Science National Taiwan Ocean University Keelung Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International PhD Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Research Center of Biomedical Device Taipei Medical University Taipei Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei Taiwan. Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei Taiwan. Electronic address: ychuang@mail.ntou.edu.tw. Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei Taiwan. Electronic address: eychuang@tmu.edu.tw.

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Assessment of circulating extracellular vesicles from calorie-restricted mice and humans in ischaemic injury models

Journal of Extracellular Biology

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Journal of Extracellular Biology 2023年第5期2卷 e86页

作者： Jaimes, Manuel S. V. Liao, Chia-Te Chen, Max M. Czosseck, Andreas Lee, Tsung-Lin Chou, Yu-Hsiang Chen, Yung-Ming Lin, Shuei-Liong Lai, James J. Lundy, David J. Graduate Institute of Biomedical Materials & Tissue Engineering Taipei Medical University Taipei Taiwan Division of Nephrology Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei Taiwan Division of Nephrology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan TMU Research Center of Urology and Kidney (TMU-RCUK) Taipei Medical University Taipei Taiwan Division of Nephrology Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan Department of Bioengineering University of Washington Seattle WA United States Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei Taiwan International PhD Program in Biomedical Engineering Taipei Medical University Taipei Taiwan Center for Cell Therapy Taipei Medical University Hospital Taipei Taiwan

Calorie restriction (CR) and fasting affect lifespan, disease susceptibility and response to acute injury across multiple animal models, including ischaemic injuries such as myocardial infarction or kidney hypoxia. The cargo and function of circulating extracellular vesicles (EV) respond to changes in host physiology, including exercise, injury, and other interventions. Thus, we hypothesised that EVs induced following CR may reflect some of the beneficial properties of CR itself. In a pilot study, EVs were isolated from mice following 21 days of 30 % CR, and from eight human donors after 72 h water-only fasting. EV size, concentration and morphology were profiled by NTA, western blot and cryoEM, and their function was assessed using multiple assays related to ischaemic diseases. We found that EVs from post-fasting samples better protected cardiac cells from hypoxia/reperfusion (H/R) injury compared to pre-fasting EVs. However, there was no difference when used to treat H/R-injured kidney epithelial cells. Post-fasting derived EVs slowed the rate of fibroblast migration and slightly reduced macrophage inflammatory gene expression compared to pre-fasting derived EVs. Lastly, we compared miRNA cargos of pre- and post-fasting human serum EVs and found significant changes in a small number of miRNAs. We conclude that fasting appears to influence EV cargo and function, with varied effects worthy of further exploration. © 2023 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

关键词： calorie restriction cardiomyocyte diet extracellular vesicle fasting hypoxia ketone macrophage microRNA serum

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