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Jing-Si Herbal Tea Suppresses H2O2-Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes

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Environmental Toxicology 2024年第12期39卷 5347-5356页

作者： Kao, Shih-Wen Chang, Yu-Chun Lin, Feng-Huei Huang, Tai-Lung Chen, Tung-Sheng Lin, Shinn-Zong Lin, Kuan-Ho Kuo, Wei-Wen Ho, Tsung-Jung Huang, Chih-Yang Graduate Institute of Aging Medicine China Medical University Taichung Taiwan Department of Orthopedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Division of Biomedical Engineering and Nanomedicine Research National Health Research Institute Miaoli Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu chi University Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans;however, its undesired activation results in tissue damage and cell death. The onset of chronic inflammation and oxidative stress are the key characteristics of autoimmune inflammatory diseases such as rheumatoid arthritis (RA), for which an effective treatment is yet to be developed. Therefore, in this study, we investigated the protective effects and molecular mechanisms of a novel herbal preparation, Jing-Si herbal tea (JS), against H2O2-induced inflammation and cellular damage in HIG-82 synoviocytes. We found that JS did not show any significant alterations in cell viability at 2O2-induced pathological oxidative stress (ROS) in HIG-82 cells. Interestingly, JS treatment not only reduced the ROS levels but also significantly repressed the protein expressions of collagen degrading proteases in a dose-dependent manner. Treatment with JS showed enhanced cell viability against H2O2-induced toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and Bcl-2 were increased, whereas MMP-13, ADAMTS-2, Cytochrome C, and cleaved Caspase 3 were decreased by JS under inflammatory agents H2O2, MIA, LPS, and TNF-α treatment, respectively, in HIG-82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2-treated HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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Modulating the macroscopic anisotropy of liquid crystalline polymers by polarized light

Responsive Materials

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Responsive materials 2024年第4期2卷

作者： Yiyi Xu Mengshi Jin Jinyu Wang Shuai Huang Quan Li Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University Nanjing China Materials Science Graduate Program Kent State University Kent Ohio USA

Photoalignment technology is serving as an emerging technology for programming liquid crystalline polymer (LCP) materials due to its advantages including noncontact, high resolution, spatial control, programmability, and high efficiency. In this review, we report the research progress in implementing polarized light to design the anisotropy of LCPs, which is categorized based on the photoalignment mechanisms. The alignment approaches and the different stimulus-responsive behaviors of the materials after photoalignment are discussed. Additionally, we have summarized the applications of photoaligned LCPs such as liquid crystal displays, optical components, intelligent soft actuators, and beyond. Finally, the challenges and future directions of the technology are outlined.

关键词： liquid crystalline polymer photoalignment photoisomerization photocrosslinking photodegradation

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Hot Carrier Injection (HCI) Reliability of Fabricated Y-gate HEMT with Various Top Length

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ECS Journal of Solid State science and Technology 2023年第3期12卷 035001-035001页

作者： Chen, Yu-Lin Yeh, Wen-Kuan Chen, Ke-Horng Hsu, Heng-Tung Hsu, Chin-Tsai Godwin Raj, D. Chou, Hung-Ting Wu, Jui-Sheng Yu, Tien-Han Godfrey, D. Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan International College of Semiconductor Technology National Yang Ming Chiao Tung University Hsinchu Taiwan National Applied Research Laboratories Hsinchu Taiwan Dept of ECE Amal Jyothi College of Engineering Kerala India National Chung Shan Institute of Science and Technology Taoyuan Taiwan Deparment of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Dept of Electronics and Communication Engineering Dayananda Sagar University Bengaluru India

Device degradation due to hot carrier injection (HCI) in different Y-gate HEMT devices is thoroughly analyzed. To further understand the HCI reliability of the Y-gate HEMT devices, the device is fabricated with AlGaN/GaN structure with different top lengths (Ltop). An HCI stress time of 6000 s was conducted on these devices, while V t stability in other stress time domains, leakage current, and transconductance degradation are also discussed. In this work, we have demonstrated that increasing the LTop length could avoid the virtual gate effect and disperse the influence of the electric field under HCI stress. Furthermore, the effects of trapping in various locations, such as in the bulk SiN or AlGaN/GaN interface has been discussed. These trapping effects caused by the HCI stress might be the source of the Vth shift. Overall, The large Y-gate HEMT showed the lowest degradation of DC characteristics after the long HCI stress test. © 2023 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

关键词： High electron mobility transistors

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Multi-core synthesis and maximum satisfiability applied to optimal sizing of solar photovoltaic systems

TechRxiv

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TechRxiv 2021年

作者： Trindade, Alessandro Galvão, Edilson Cordeiro, Lucas The Post-graduate Program in Electrical Engineering Manaus Brazil Department of Electricity Federal University of Amazonas Manaus Brazil School of Computer Science The University of Manchester United Kingdom

Annual global energy consumption growth is around 1.3% with forecasts until 2040. Photovoltaic systems became a suitable alternative to nuclear and fossil energy generation. In order to support this technology’s dissemination, we develop and evaluate an automated formal synthesis approach that assists in decision-making for off-grid systems. Our proposed approach, called PVz, is based on a variant of the counterexample-guided inductive synthesis;it has a multi-core feature, which can obtain the optimal sizing of photovoltaic systems focusing on Life Cycle Cost analysis. Given the electrical needs of a home, we seek a set of electrical equipment with the best possible combination of devices that meet the specified requirements. We calculate all costs related to maintenance over 20 years. The results presented are based on seven case studies;some of them are real ones from the Amazon region in Brazil. The same case studies were solved by a commercial optimization tool. Our technique and the commercial tool results were validated with popular simulation software to perform a fair comparison. Furthermore, we analyze some topics such as run-time, optimal solution, and configuration of the resulting systems. We claim that our technique is advantageous compared to the existing approaches in the literature. © 2021, CC BY-NC-SA.

关键词： Decision making

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Photoelectrochemical X-Ray Absorption Spectroscopy of Graphene/Si Heterojunction Platform with Multifunctional Atomic Bridging Layer for Efficient Solar-Powered Co2 Conversion

SSRN

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SSRN 2025年

作者： Wu, Heng-Liang Wu, Po-Hsien Chen, Hsuan-Yu Yu, Sheng-Yu Chang, Chen Liu, Tsung-Hsin Song, Ruo-Nong Lin, Jr-Wen Cyue, Zih-Wei Chan, Kwun-Man Chen, Cheng-Ying Chan, Ting-Shan Chen, Jeng-Lung Pao, Chih Wen Chen, Chun-Wei Department of Materials Science and Engineering National Taiwan University Taipei106319 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei106319 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei106319 Taiwan Academia Sinica Taipei11529 Taiwan Department of Optoelectronics and Materials Technology National Taiwan Ocean University Keelung202301 Taiwan National Synchrotron Radiation Laboratory Research Center Hsinchu300092 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan Department of Chemistry National Taiwan University Taipei106319 Taiwan

The facile integration and stability of Si-based photoelectrode architectures are the remaining challenges in the photoelectrochemical (PEC) conversion of CO2 to fuels. In this work, the single-atomic-layer graphene is used as a functional bridging layer to integrate both Si photocathodes and photoanodes, which enable the direct electrodeposition of metal-based electrocatalysts (Cu, Ag and InSn alloys) and a semiconductor-based catalyst (NiFe-LDH) on the graphene/Si heterojunction electrodes for PEC CO2 reduction and O2 evolution reaction, respectively. Photoelectrochemical X-ray absorption spectroscopy results show that the electrodeposited catalysts on the graphene layer are active and leads to efficient transport of photogenerated electrons from Si junctions to electrocatalysts. We demonstrate a PEC device with a full-cell configuration consisting of InSn/graphene/Si heterojunction photocathode and NiFe-LDH/graphene/Si heterojunction photoanode, exhibiting a reduced photovoltage of ~1080 mV compared to the electrochemical counterparts. A self-powered overall PEC CO2 reduction with a promising solar-to-fuel conversion efficiency of 3.2% can be obtained by integrating the graphene/Si heterojunction photocathode and photoanode with a Si photovoltaic. By combining the inherent chemical inertness of graphene with its role as an atomic bridging layer, the facile integration of Si photoelectrodes with various catalysts presents a promising platform for stable and efficient solar-to-fuel conversion. © 2025, The Authors. All rights reserved.

关键词： X ray absorption spectroscopy

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Preparation of a New Hybrid Mgalldh@Magnetite Activated Charcoal by Hydrothermal Method for Stability and Adsorption Mechanism of Congo Red

SSRN

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SSRN 2024年

作者： Ahmad, Nur Kameda, Tomohito Rahman, Mir Tamzid Rahman, Farzana Lesbani, Aldes Graduate School of Mathematics and Natural Science FMIPA Universitas Sriwijaya Sumatera Selatan Palembang30139 Indonesia Research Center of Inorganic Materials and Complexes Universitas Sriwijaya Sumatera Selatan Palembang30139 Indonesia Graduate School of Environmental Studies Tohoku University 6-6-20 Aoba Aramaki Aobaku Sendai980-8579 Japan Department of Chemistry Jahangirnagar University Dhaka Savar1342 Bangladesh Department of Nutrition and Food Engineering Daffodil International University Birulia1216 Bangladesh Master Program of Material Science Graduate School of Universitas Sriwijaya Sumatera Selatan Palembang30139 Indonesia

Background The removal of hazardous dyes from water by magnetic adsorbents has received significant interest due to their low cost and ease of separation from the solution phase. This study explores the efficacy of a novel hybrid adsorbent, magnetite and activated charcoal-modified MgAl layered double hydroxide (MgAlLDH@MAC), for removing congo red (CR) from aqueous solutions. Methods MgAlLDH@MAC was successfully prepared via a co-precipitation to hydrothermal method and characterized using FE-SEM, FE-STEM, VSM, BET, XRD, FTIR, XPS, and HPLC analysis. Significant findings The incorporation of magnetite and activated charcoal was successful, resulting in excellent adsorption performance for CR and easy separation from the solution due to its magnetic properties. The adsorbent achieved a maximum adsorption capacity of 625 mg/g, which is in line with the Langmuir isotherm and pseudo-second-order kinetic model. Moreover, the adsorbent demonstrated excellent stability and reusability, retaining 91.78% efficiency after five adsorption-desorption. This study offers a fresh viewpoint on creating high-performance LDH adsorbents that remove dyes quickly and effectively using carbon and magnetite materials. © 2024, The Authors. All rights reserved.

关键词： Magnetite

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Force-Trainable Liquid Crystal Elastomer Enabled by Mechanophore-Induced Radical Polymerization

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Angewandte Chemie 2025年

作者： Yiyi Xu Yinliang Huang Jinyu Wang Dr. Shuai Huang Prof. Hong Yang Prof. Quan Li Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 China Materials Science Graduate Program Kent State University Kent OH 44242 USA

In nature, organisms adapt to environmental changes through training to learn new abilities, offering valuable insights for developing intelligent materials. However, replicating this “adaptive learning” in synthetic materials presents a significant challenge. This study introduces a feasible approach to train liquid crystal elastomers (LCEs) by integrating a mechanophore tetraarylsuccinonitrile into their main chain, addressing the challenge of enabling synthetic materials to exchange substances with their environment. Inspired by biological training, the LCEs can self-strengthen and acquire new functionalities through mechanical stress-induced radical polymerization. The research not only enhances the mechanical performance of LCEs, but also endows them with the ability to learn properties such as flexibility, light responsiveness, and fluorescence. These advancements are crucial for overcoming the limitations of current materials, paving the way for the creation of advanced intelligent soft materials with autonomous self-improvement, akin to the adaptive skills of living organisms.

关键词： force-induced chemical reaction mechanical stress-induced radical polymerization liquid crystal elastomer soft actuator smart material

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Pulsed Terahertz Time Domain Spectroscopy for Evaluating Treatment Efficacy: Initial Validation in Monitoring Pancreatic Ductal Adenocarcinoma

Pulsed Terahertz Time Domain Spectroscopy for Evaluating Tre...

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International Conference on Infrared and Millimeter Waves

作者： Debamitra Chakraborty Bradley N. Mills Jing Cheng Ivan Komissarov Scott A. Gerber Roman Sobolewski Materials Science Graduate Program University of Rochester Rochester New York USA Laboratory for Laser Energetics University of Rochester Rochester New York USA Department of Surgery University of Rochester Medical Center Rochester New York USA Department of Electrical and Computer Engineering University of Rochester Rochester New York USA

Pancreatic Ductal Adenocarcinoma (PDAC) is a highly invasive malignancy with limited curative effectiveness. Here, we report the viability of using pulsed Terahertz (THz) time domain spectroscopy (THz TDS) to monitor the efficacy of Stereotactic Body Radiation Therapy (SBRT) in treating PDAC in murine models. Our study shows that THz imaging can provide reliable and reproducible results to differentiate the changes in untreated and SBRT-treated PDAC tissue using THz refractive index and absorption coefficient as mapping parameters with statistical significance. Hence the study highlights that pulsed THz-TDS can be used as a technique to monitor tumor responses to immunotherapy, providing a comprehensive assessment of the tumor’s reaction to the treatment.

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Nernst-Ettingshausen effect in thin Pt and W films at low temperatures

arXiv

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arXiv 2023年

作者： Luo, Renjie Legvold, Tanner J. Chen, Liyang Natelson, Douglas Department of Physics and Astronomy Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Electrical and Computer Engineering Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

As spin caloritronic measurements become increasingly common techniques for characterizing material properties, it is important to quantify potentially confounding effects. We report measurements of the Nernst-Ettingshausen response from room temperature to 5 K in thin film wires of Pt and W, metals commonly used as inverse spin Hall detectors in spin Seebeck characterization. Johnson-Nyquist noise thermometry is used to assess the temperature change of the metals with heater power at low temperatures, and the thermal path is analyzed via finite-element modeling. The Nernst-Ettingshausen response of W is found to be approximately temperature-independent, while the response of Pt increases at low temperatures. These results are discussed in the context of theoretical expectations and the possible role of magnetic impurities in Pt. Copyright © 2023, The Authors. All rights reserved.

关键词： Inverse problems

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Analysis of the dispersion of carbon nanotubes in soil-cement composites for different types and concentrations of polycarboxylate superplasticizers

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Journal of Building engineering 2025年

作者： Ana Raina Carneiro Vasconcelos Ryan Araújo Matos Nádia Pitombeira Mariana Vella Silveira Luís Paulo Mourão Lais Costa Alain Ledoux Esequiel Mesquita Post-Graduate Program in Civil Engineering Department of Hydraulic and Environmental Engineering Federal University of Ceara 60400-900 Fortaleza Brazil Laboratory of Buildings Durability and Digitalization Campus Russas Federal University of Ceara 62900-000 Russas Brazil Post-Graduate Program in Chemistry Department of Organic and Inorganic Chemistry Federal University of Ceara 60440-900 Fortaleza Brazil Post-Graduate Program in Materials Engineering and Science Federal University of Ceara Department of Metallurgical and Materials Engineering 60440-554 Fortaleza Brazil Laboratoire de Sécurité des Procédés Chimiques - LSPC INSA 76000 Rouen France Laboratory of Digital Experience Institute of Architecture and Urbanism and Design Campus Benfica Federal University of Ceara 60020-181 Fortaleza Brazil

This study investigates the dispersion of multi-walled carbon nanotubes (MWCNTs) in soil-cement composites using different concentrations of three polycarboxylate ether superplasticizer admixtures. Physicochemical characterization of superplasticizer admixtures (SP), MWCNT suspensions, and their application in soil-cement composites was performed to identify stable and optimized MWCNT dispersions with SP concentrations. Over four weeks, analyses of hydrodynamic diameter indicated the efficacy of selected admixtures in dispersing MWCNTs compared to aqueous solutions. Ultraviolet-visible (UV-vis) spectroscopy confirmed that the most efficient suspension maintained its stability over 60 days without significant changes in the composite's behavior. The incorporation of superplasticizer admixtures led to a reduction in zeta potential and an increase in steric stability in the MWCNT suspensions. Scanning electron microscopy illustrated MWCNTs interconnect microparticles, emphasizing the crucial role of dispersants in achieving proper dispersion. Remarkably, the superplasticizer admixture at 0.3% concentration emerged as the most effective dispersant. Raman and AFM analyses agreed that the concentration of superplasticizers directly impacts dispersion and defect density in MWCNTs. The results demonstrate the efficient dispersion of MWCNTs in soil-cement composites with the selected superplasticizer admixtures, ensuring stability and uniform distribution.

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