Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the advancment of reactive oxygen species (ROS) mediated X...
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Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial in chemodynamic therapy (CDT), yet endogenous H2O2 levels are not sufficient to attain better anticancer efficacy. Specifically, there is a need to amplify Fenton reactivity within tumors, leveraging the unique attributes of the TME. Herein, for the first time, we design RuxCu1-xO2-Ce6/CPT (RCpCCPT) anticancer nanoagent for TME-mediated synergistic therapy based on heterogeneous Ru-Cu peroxide nanodots (RuxCu1-xO2 NDs) and chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The Ru-Cu peroxide NDs (RCp NDs, x = 0.50) possess the highest oxygen vacancy (OV) density, which grants them the potential to form massive Lewis’s acid sites for peroxide adsorption, while the dispersibility and targetability of the NDs were improved via surface modification using hyaluronic acid (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, and Cu+/2+ ions, which cooperatively facilitate hydroxyl radical (•OH) formation and deactivate antioxidant GSH enzymes through a cocatalytic loop, resulting in excellent tumor therapeutic efficacy. Furthermore, when combined with laser treatment, RCpCCPT produces singlet oxygen (1O2) for PDT, which induces cell apoptosis at tumor sites. Following ROS generation, the TK linkage is disrupted, releasing up to 92% of the CPT within 48 h. In vitro investigations showed that laser-treated RCpCCPT caused 81.5% cell death from PDT/CDT and chemotherapy (CT). RCpCCPT in cancer cells produces red-blue emission in images of cells taking them in, which allows for fluorescence image-guided Xdynamic treatment. The overall results show that RCp NDs and RCpCCPT are more biocompatible and have excellent Xdynamic the
Direct imaging of transient electronic coherences in molecules has been challenging, with the potential to control electron motions and influence reaction outcomes. We propose a novel time-resolved vortex electron dif...
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Direct imaging of transient electronic coherences in molecules has been challenging, with the potential to control electron motions and influence reaction outcomes. We propose a novel time-resolved vortex electron diffraction technique to spatially resolve transient electronic coherences in isolated molecules. By analyzing helical dichroism diffraction signals, the contribution of electronic populations cancels out, isolating the purely electronic coherence signals. This allows direct monitoring of the time evolution and decoherence of transient electronic coherences in molecules.
In this paper, Nd1-xBaxFeO3 (x=0, 0.05, 0.10, 0.15) were prepared via the sol-gel method. No impurity phase was generated by XRD analysis, and all of them were solid-dissolved in the perovskite structure. Since the ra...
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Fe-based composite coatings were fabricated on 5 CrNiMo die steel by laser beam melting a precursor mixture of ferrotitanium,ferrochromium,ferromolybdenum,B4 C and Y2 O3 *** structure and properties of the coatings we...
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Fe-based composite coatings were fabricated on 5 CrNiMo die steel by laser beam melting a precursor mixture of ferrotitanium,ferrochromium,ferromolybdenum,B4 C and Y2 O3 *** structure and properties of the coatings were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive spectrometer(EDS),resistance furnace and high-temperature *** results show that(Ti,Mo)C particles with flower-like and(Ti,Mo)B2 with block-like shapes are in situ formed during laser *** faction of multiple ceramic particles increases with the increasing of Y2 *** cumulative oxidation mass of the coating with 2 wt% Y2 O3 is decreased by one-third than that of the coating without Y2 *** oxidation layer of the coating with Y2 O3 is getting ***,high temperature wear volume loss of the coating with 2 wt% Y2 O3 is about 40% that of the coating without Y2 *** coating with 2 wt% Y2 O3 shows a smoother wear scar and few flat grooves are observed after high temperature wear test.
To endow Ti-based orthopedic implants with strong bactericidal activity,a ZnO nanorods-patterned coating(namely ZNR)was fabricated on Ti utilizing a catalyst-and template-free method of micro-arc oxidation(MAO)and hyd...
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To endow Ti-based orthopedic implants with strong bactericidal activity,a ZnO nanorods-patterned coating(namely ZNR)was fabricated on Ti utilizing a catalyst-and template-free method of micro-arc oxidation(MAO)and hydrothermal treatment(HT).The coating comprises an outer layer of ZnO nanorods and a partially crystallized inner layer with nanocrystalline TiO_(2) and Zn_(2)TiO_(4) embedded amorphous matrix containing Ti,O and *** HT,Zn^(2+)ions contained in amorphous matrix of the as-MAOed layer migrate to surface and react with OHin hydrothermal solution to form ZnO nuclei growing in length at expense of the migrated Zn^(2+).ZNR exhibits intense bactericidal activity against the adhered and planktonic *** in vitro and in *** crucial contributors to kill the adhered bacteria are ZnO nanorods derived mechano-penetration and released reactive oxygen species(ROS).Within 30 min of *** incubation,ROS is the predominant bactericidal contributor with quantitative contribution value of ~20%,which transforms into mechano-penetration with prolonging time to reach quantitative contribution value of ~96% at 24 *** addition,the bactericidal contributor against the planktonic bacteria of ZNR is relied on the released Zn^(2+).This work discloses an in-depth bactericidal mechanism of ZnO nanorods.
The number of published Machine Learning Interatomic Potentials (MLIPs) has increased significantly in recent years. These new data-driven potential energy approximations often lack the physics-based foundations that ...
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To facilitate versatile application of polyimide (PI) under harsh conditions, the PI-PDA@PSF@TO coating was successfully developed. The results illustrate the successful formation of PSF@TO microcapsules by encapsulat...
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By adjusting the inter-wire arc (IWA) posture, the skew-coupling arc (SCA) is proposed to address the polar effect in the cross arc, enabling decoupling control of heat, force, and mass transfer. Despite the advanceme...
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A NiTi@Mg interpenetrating phase composite with high strength and lightweight was prepared by additive manufacturing(AM)and infiltration technology,and the interface bonding,three-point bending properties and cyclic c...
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A NiTi@Mg interpenetrating phase composite with high strength and lightweight was prepared by additive manufacturing(AM)and infiltration technology,and the interface bonding,three-point bending properties and cyclic compressive properties of NiTi@Mg composites were *** results show that the metallurgically bonded interface is formed at the NiTi/Mg *** bending strength and compressive strength of the NiTi@Mg composite are 2.5 and 1.7 times higher than those of the NiTi scaffold,*** the bending deformation process,a large number of dislocations are observed to accumulate in the soft Mg area at the ***,the finite element model showed that the stress accumulation area,where the bending crack is initiated,is located at the interface of NiTi and *** strengthening mechanism of NiTi@Mg composites is attributed to the twinning strengthening of Mg and heterogeneous structure strengthening.
The exploration of hybrid composites holds great promise in the pursuit of synergistic energy-harvesting solutions, providing an efficient approach to tap into multiple energy sources. One striking example is the BTO ...
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