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Mechano-responsive hydrogel for direct stem cell manufacturing to therapy

Bioactive materials 2023年第6期24卷 387-400页

作者： Yufeng Shou Ling Liu Qimin Liu Zhicheng Le Khang Leng Lee Hua Li Xianlei Li Dion Zhanyun Koh Yuwen Wang Tong Ming Liu Zheng Yang Chwee Teck Lim Christine Cheung Andy Tay Department of Biomedical Engineering National University of Singapore117583Singapore Institute for Health Innovation&Technology National University of Singapore117599Singapore School of Civil Engineering and Architecture Wuhan University of Technology430070WuhanChina NUS Tissue Engineering Program National University of Singapore117510Singapore Lee Kong Chian School of Medicine Nanyang Technological University636921Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University639798Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Mechanobiology Institute National University of Singapore117411Singapore

Bone marrow-derived mesenchymal stem cell(MSC)is one of the most actively studied cell types due to its regenerative potential and immunomodulatory *** cell expansion methods using 2D tissue culture plates and 2.5D microcarriers in bioreactors can generate large cell numbers,but they compromise stem cell potency and lack mechanical preconditioning to prepare MSC for physiological loading expected in *** overcome these challenges,in this work,we describe a 3D dynamic hydrogel using magneto-stimulation for direct MSC manufacturing to *** our technology,we found that dynamic mechanical stimulation(DMS)enhanced matrix-integrinβ1 interactions which induced MSCs spreading and *** addition,DMS could modulate MSC biofunctions including directing MSC differentiation into specific lineages and boosting paracrine activities(e.g.,growth factor secretion)through YAP nuclear localization and FAK-ERK *** our magnetic hydrogel,complex procedures from MSC manufacturing to final clinical use,can be integrated into one single platform,and we believe this‘all-in-one’technology could offer a paradigm shift to existing standards in MSC therapy.

关键词： Mesenchymal stem cell Dynamic mechanical stimulation Magnetic hydrogel Stem cell manufacturing Cell therapy

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Additively manufacturable high-strength aluminum alloys with thermally stable microstructures enabled by hybrid machine learning-based design

arXiv

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arXiv 2024年

作者： Taheri-Mousavi, S. Mohadeseh Xu, Michael Hengsbach, Florian Houser, Clay Ge, Zhaoxuan Glaser, Benjamin Wei, Shaolou Schaper, Mirko LeBeau, James M. Olson, Greg B. Hart, A. John Department of Mechanical Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Department of Materials Science and Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Department of Materials Science and Engineering Carnegie Mellon University 5000 Forbes Avenue PittsburghPA15213 United States Department of Mechanical Engineering Carnegie Mellon University 5000 Forbes Avenue PittsburghPA15213 United States Department of Mechanical Engineering Paderborn University Mersinweg 9 Paderborn33100 Germany Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States

Additively manufactured (AM) aluminum alloys with high strength and thermal stability have broad applications in turbine engines, vacuum pumps, heat exchangers, and many other industrial systems. Employing precipitates with an L12 structure to block dislocation motions is a widespread strategy to strengthen aluminum. However, to achieve high strength, a high volume fraction of small precipitates is required, and these characteristics are generally mutually exclusive. Here, we show that for certain compositions of Al alloys, L12 phases initially precipitate as submicron metastable ternary phases under the rapid solidification conditions of powder bed AM, yet the subsequent L12 phases that precipitate during heat treatment of the sample remain at the nanoscale, imparting high strength. For strength to be retained at elevated temperature, these nanoprecipitates must have low coarsening rates. To inversely design the composition of an alloy to have these target microstructural features, we used hybrid calculation of phase diagram (CALPHAD)-based integrated computational materials engineering (ICME) and Bayesian optimization techniques. We tested our approach by designing an Al-Er-Zr-Y-Yb-Ni model alloy, and the selected composition was manufactured in powder form as AM feedstock. The strength of specimens manufactured via laser powder bed fusion (LPBF) from the designed composition is comparable to that of wrought Al 7075, yet without cracking that occurs upon LPBF of Al 7075. After high-temperature (400°C) aging the designed alloy is 50% stronger than the strongest known benchmark printable Al alloy1. This stable strengthening strategy is applicable to a wide range of alloys and rapid solidification processes, and our hybrid ML/CALPHAD numerical framework can be used for the efficient and robust design of alloy microstructures and properties, expanding the capabilities of additive as well as traditional manufacturing. © 2024, CC BY-NC-ND.

关键词： Aluminum alloys

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Undulating Seal Whiskers Evolved Optimal Wavelength-to-Diameter Ratio for Efficient Reduction in Vortex-Induced Vibrations (Adv. Sci. 2/2024)

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ADVANCED science 2024年第2期11卷 e2304304页

作者： Kamat, Amar M. Zheng, Xingwen Bos, Julian Cao, Ming Triantafyllou, Michael S. Kottapalli, Ajay Giri Prakash Bioinspired MEMS and Biomedical Devices Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands Discrete Technology and Production Automation Group Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA USA MIT Sea Grant College Program Massachusetts Institute of Technology (MIT) Cambridge MA USA Bioinspired MEMS and Biomedical Devices Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands MIT Sea Grant College Program Massachusetts Institute of Technology (MIT) Cambridge MA USA

Seals are well-known for their remarkable hydrodynamic trail-following capabilities made possible by undulating flow-sensing whiskers that enable the seals to detect fish swimming as far as 180 m away. In this work, the form-function relationship in the undulating whiskers of two different phocid seal species, viz. harbor and gray seals, is studied. The geometry and material properties of excised harbor and grey seal whiskers are systematically characterized using blue light 3D scanning, optical and scanning electron microscopy, and nanoindentation. The effect of the undulating geometry on the whiskers’ vibration in uniform water flow is studied using both experimental (piezoelectric MEMS and 3D-printed piezoresistive sensors developed in-house) and numerical (finite element method) techniques. The results indicate that the dimensionless ratio of undulation wavelength to mean whisker diameter (λ/Dm) in phocid seals may have evolved to be in the optimal range of 4.4–4.6, enabling an order-of-magnitude reduction in vortex-induced vibrations (compared to a similarly-shaped circular cylinder) and, consequently, an enhanced flow sensing capability with minimal self-induced noise. The results highlight the importance of the dimensionless λ/Dm ratio in the biomimetic design of seal whisker-inspired vibration-resistant structures, such as marine risers and wake detection sensors for submarines.

关键词： 3D printing biological fluid dynamics biomimetics microelectromechanical systems (MEMS) seal whiskers vortex-induced vibrations

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用于先进交互式元宇宙平台的多模态集成传感和反馈指环系统

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science Bulletin 2023年第2期68卷 133-135,M0003页

作者：何冠宇赫玉欣刘虎郭占虎 College of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China College of Chemical Engineering and Pharmaceutics Henan University of Science and TechnologyLuoyang 471023China Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK

Nowadays,the newly interactive metaverse platform,which provides an immersive experience via the virtual reality(VR)technology that integrates the virtual world with the real world,shows huge potential applications in... 详细信息

关键词：指环多模态交互式

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Experimental study and modelling of the ferritic steel anisotropic behavior under associated and non-associated flow rule

Experimental study and modelling of the ferritic steel aniso...

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International Conference on Processing and Manufacturing of Advanced materials Processing, Fabrication, Properties, Applications, THERMEC 2021

作者： Soltani, Houssem Chahaoui, Oualid Matougui, Nedjoua Department of Materials Science and Engineering Higher School of Mining and Metallurgy Algeria Faculty of Mechanical Engineering Abbes Laghrour University Algeria

ISBN: (纸本)9783035736304

In the present study, two different yield criteria were investigated to model and compare the yield thresholds functions for the plastic behavior of rolled sheets. These two different yield criteria as described via Hill48 yield quadratic and F. Barlat Yld2000-2d non-quadratic criterion. For this purpose, an experimental device of simple tensile test and the studied material are described. The experimental results in terms of Yield stress and Anisotropic coefficient are estimated from the Associated Flow Rule (AFR) and Non-Associated Flow Rule (NAFR). However, it is found that the criterion of Yld2000-2d is the most appropriate model in comparison with the experimental results. © 2021 Trans Tech Publications Ltd, Switzerland.

关键词： Anisotropy

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A novel laser light absorption model for composite materials in the context of laser ultrasonic testing

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Optik 2025年 326卷

作者： Zarei, Alireza Pilla, Srikanth Center for Composite Materials University of Delaware NewarkDE19716 United States Department of Mechanical Engineering University of Delaware NewarkDE19716 United States Department of Materials Science and Engineering University of Delaware NewarkDE19716 United States Department of Chemical and Biomolecular Engineering University of Delaware NewarkDE19716 United States

When a laser pulse impinges on a composite material, a portion of the light is absorbed by the matrix, while the remainder is absorbed by the embedded fibers. Conventional models overlook the substantial differences in optical properties between these two constituents. This paper, however, introduces a novel analytical model for laser light absorption in fiber-reinforced composite materials. This macroscopic model incorporates distinct optical absorptivity for both the matrix and embedded fibers, offering adaptability to various scenarios without introducing additional computational cost to simulations. The dynamic thermal expansion and elastic wave generation inside the material is considered to study the effects of the presented model on the generated waves. Investigations are conducted on a Carbon Fiber Reinforced Plastic (CFRP) plate with variable epoxy layer thickness using Nd:YAG and mid-IR lasers. Results demonstrate a significant enhancement in temperature distribution within the material, elucidating experimental observations previously unexplained by conventional models. Under consistent laser energy, pulse duration, and beam radius, the Nd:YAG laser induces notably higher temperatures in the CFRP-epoxy interface compared to the mid-IR laser. Furthermore, thicker epoxy layers result in lower temperatures and higher displacement amplitudes, aligning with the desirable characteristics for laser ultrasonic testing applications. © 2025 Elsevier GmbH

关键词： Carbon fiber reinforced plastics

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Variant selection map of external load during Ni_(4)Ti_(3) precipitation in nitinol:a theoretical and phase field study

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Acta Mechanica Sinica 2024年第7期40卷 19-28页

作者： Xuewei Zhou Tianlong Zhang Li Cheng Xusheng Yang Jiaming Zhu School of Civil Engineering Shandong UniversityJinan 250061China Department of Mechanical Engineering Hong Kong University of Science and TechnologyHong KongChina State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Shenzhen Research Institute of Shandong University Shenzhen 518057China Institute of Materials Intelligent Technology Shenyang 110004China

The morphology of Ni_(4)Ti_(3) precipitates is important in tuning the martensitic transformation(MT)behavior and mechanical properties of *** ageing is effective in engineering the morphology of Ni_(4)Ti_(3) precipitates due to the variant selection effect of external load which is still *** this work,maps of variant selection effect of external load applied along all crystallographic directions are obtained by using a combination of theoretical analyses and phase field *** is found that maps produced by uniaxial tension and uniaxial compression are quite *** number and types of Ni_(4)Ti_(3) variants preferred by external load vary as the loading direction ***,factors influencing the strength of variant selection effect are *** work provides insights on understanding the Ni_(4)Ti_(3) precipitation process and sheds light on the engineering of morphology of Ni_(4)Ti_(3) precipitates for desired mechanical and functional properties.

关键词： Ni_(4)Ti_(3) Variant selection NiTi alloy Phase field model Precipitation morphology

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In Situ Characterization of Photo-induced Ion Migration in Hybrid Perovskites

In Situ Characterization of Photo-induced Ion Migration in H...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Kim, Taeyong Park, Soyeon Iyer, Vasudevan Jiang, Qi Choudhry, Usama Shaheen, Basamat Eichman, Gage Gnabasik, Ryan Lawrie, Benjamin Zhu, Kai Liao, Bolin Department of Mechanical Engineering University of California Santa BarbaraCA93106 United States National Renewable Energy Laboratory GoldenCO80401 United States Centerfor Nanophase Materials Sciences Oak Ridge National Laboratory Oak RidgeTN37830 United States Materials Science and Technology Division Oak Ridge National Laboratory Oak RidgeTN37830 United States Department of Mechanical Engineering Seoul National University Seoul08826 Korea Republic of

We characterize photo-induced ion migration in hybrid perovskites using in situ laser illumination inside an SEM. We observed long-range migration of halide ions and elucidated the transport pathways of various ions. ... 详细信息

ISBN: (纸本)9781957171258

关键词： Perovskite

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Vibrational entropies of oxygen vacancy formation in metal oxides

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Physical Review materials 2024年第5期8卷 055407-055407页

作者： Bianca Baldassarri Jiangang He Christopher Wolverton Graduate Program in Applied Physics Northwestern University Evanston Illinois 60208 USA Department of Materials Science and Engineering Northwestern University Evanston Illinois 60208 USA

Oxygen vacancies play a key role in many energy-related applications, and the investigation of the thermodynamic forces driving their formation across different materials can be tackled through the use of ab initio methods. In this context, however, computational studies targeting finite-temperature properties such as entropy remain scarce. Wider-ranging studies are of interest to deepen the understanding of the role of the entropy of oxygen vacancy formation and its different components in processes like the ones involved in solar thermochemical hydrogen (STCH) production, and to investigate the existence of common trends and differences between materials. In this work, we use density functional theory and harmonic phonon calculations to compute the vibrational entropy of oxygen vacancy formation (ΔSvib) for 10 different metal oxide compounds. The computation is carried out by taking the difference between the vibrational entropy of a vacancy-containing and a pristine structure, while the entropic contribution from the final gaseous state of the oxygen lost from the material is accounted for separately with a gas entropy term. We first examine the temperature dependence of ΔSvib and highlight the presence of an initial peak around room temperature, followed by a steady decrease resulting from the presence of an additional O atom (the one becoming vacant) in the defect-free structure. We then inspect the atomic contributions to ΔSvib, and highlight similarities and differences between compounds. Finally, we consider other significant sources of entropy, and find ΔSvib to provide a smaller, yet non-negligible, contribution to the total entropy of vacancy formation. We also compare the temperature dependence of ΔSvib to that of the gas entropy, and show that the two largely counterbalance each other at high temperatures.

关键词： Entropy Hydrogen production Density functional theory

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Effects of Cu addition on microstructure and mechanical properties of Er-modified Al-10Mg_(2)Si cast alloys

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Journal of Central South University 2022年第3期29卷 795-806页

作者： WU Xiao-feng WANG Zhen-cheng CHENG Ting WANG Ke-yan XIANG Jun ZHAO Rong-da CHEN Shun-hua WU Fu-fa School of New Energy Vehicles Nanchang Institute of Science and TechnologyNanchang 330013China School of Materials Science and Engineering Liaoning University of TechnologyJinzhou 121001China School of Mechanical Engineering Hefei University of TechnologyHefei 230009China

The solidification microstructure and mechanical properties of hypoeutectic Al-10Mg_(2)Si cast alloys with different Cu contents and 0.45 wt.% Er were investigated using an optical microscope, scanning electron microscope, and an electronic universal testing machine. Results showed that Cu and Er could significantly reduce the grain size of the eutectic Mg;Si phase from 15.4 μm for the base alloy to 5.8 μm for the alloy with 1.5 wt.% Cu and 0.45 wt.% ***, the needle-like β-Al5Fe Si phase was modified to fine sized irregular shaped Cu, Er and Fe-rich particles with the additions of Cu and Er. The strength and ductility of the Al-10Mg_(2)Si as-cast alloys were simultaneously improved by the additions of Cu and Er, and the ultimate tensile strength, yield strength and elongation increase from 223 MPa,136 MPa and 2.1% to 337 MPa, 169 MPa and 4.7%, respectively. The heterogeneous nucleation of Mg_(2)Si on Al P was avoided by forming Cu, Er and P-containing phases, due to the additions of Cu and Er. Moreover, the Cu and Er atomic clusters and their intermetallic segregated on the surface of the eutectic Mg_(2)Si and inhibited the growth of the eutectic Mg_(2)Si, which were responsible for the modification of the eutectic Mg_(2)Si.

关键词： Al-Mg_(2)Si alloy Cu Er eutectic Mg_(2)Si mechanical properties

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