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Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing

Acta Pharmaceutica Sinica B 2023年第5期13卷 1887-1902页

作者： Yub Raj Neupane Harish K.Handral Syed Abdullah Alkaff Wei Heng Chng Gopalakrishnan Venkatesan Chenyuan Huang Choon Keong Lee Jiong-Wei Wang Gopu Sriram Rhonnie Austria Dienzo Wen Feng Lu Yusuf Ali Bertrand Czarny Giorgia Pastorin Department of Pharmacy National University of SingaporeSingapore 117559Singapore Department of Pharmaceutical Sciences and Experimental Therapeutics the University of Iowa College of PharmacyIowa CityIA 52242USA Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore 119077Singapore Antimicrobial Resistance Interdisciplinary Research Group(AMR-IRG) Singapore-MIT Alliance for Research and TechnologySingapore 138602Singapore Department of Surgery National University of SingaporeSingapore 119228Singapore Cardiovascular Research Institute National University Heart CentreSingapore 117599Singapore Nanomedicine Translational Research Programme Centre for NanoMedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117609Singapore Department of Physiology National University of SingaporeSingapore 117593Singapore Faculty of Dentistry National University of SingaporeSingapore 119085Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Singapore Eye Research Institute(SERI) Singapore General HospitalSingapore 169856Singapore NUSNNI-NanoCore National University of SingaporeSingapore 117574Singapore

Wound healing is a dynamic process that involves a series of molecular and cellular events aimed at replacing devitalized and missing cellular components and/or tissue ***,extracellular vesicles(EVs),naturally cell-secreted lipid membrane-bound vesicles laden with biological cargos including proteins,lipids,and nucleic acids,have drawn wide attention due to their ability to promote wound healing and tissue ***,current exploitation of EVs as therapeutic agents is limited by their low isolation yields and tedious isolation *** circumvent these challenges,bioinspired cell-derived nanovesicles(CDNs)that mimic EVs were obtained by shearing mesenchymal stem cells(MSCs)through membranes with different pore *** characterisations and highthroughput proteomics confirmed that MSC-CDNs mimicked ***,these MSC-CDNs were efficiently uptaken by human dermal fibroblasts and demonstrated a dose-dependent activation of MAPK signalling pathway,resulting in enhancement of cell proliferation,cell migration,secretion of growth factors and extracellular matrix proteins,which all promoted tissue *** note,MSC-CDNs enhanced angiogenesis in human dermal microvascular endothelial cells in a 3D PEGfibrin scaffold and animal model,accelerating wound healing in vitro and in *** findings suggest that MSC-CDNs could replace both whole cells and EVs in promoting wound healing and tissue regeneration.

关键词： Extracellular vesicles Cell-derived nanovesicles Bionanotechnology Mesenchymal stem cells Fibroblasts Cell proliferation Cell migration ECM Wound healing

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Quantum defects in 2D transition metal dichalcogenides for THz-technologies

arXiv

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arXiv 2023年

作者： Zhang, Jingda Quek, Su Ying Department of Physics National University of Singapore 117551 Singapore Centre for Advanced 2D Materials National University of Singapore 117546 Singapore Department of Materials Science and Engineering National University of Singapore 117575 Singapore Integrative Sciences and Engineering Programme NUS Graduate School National University of Singapore 119077 Singapore NUS College National University of Singapore 138593 Singapore

Terahertz technologies are important for a number of emerging applications, such as for next generation communications. We predict that transition metal substitutional defects in two-dimensional transition metal dichalcogenides (TMDs) can serve as quantum defects for terahertz technologies. Central to this prediction is the finding that the zero field splittings between spin sublevels in such defects are typically in the sub-terahertz to terahertz range due to the large spin-orbit coupling in these systems. As a proof of concept, we consider different transition metal impurities from across the periodic table, in prototypical TMDs, MoS2 and WSe2. Using first principles calculations, we demonstrate that selected spin triplet defects can potentially serve as qubits operating in the terahertz regime. We also propose defects that can potentially be quantum sources of terahertz radiation. Our research broadens the scope of advancements in quantum information science and lays a foundation for their integration with THz technologies. Copyright © 2023, The Authors. All rights reserved.

关键词： Transition metals

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Non-invasive monitoring of Diabetes through analysis of the exhaled breath by electronic nose 18

Non-invasive monitoring of Diabetes through analysis of the ...

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18th International Conference on Electrical engineering/Electronics, Computer, Telecommunications and Information Technology, ECTI-CON 2021

作者： Eamsa-Ard, Tanthip Sriphrapradang, Chutintorn Phukkaphan, Natnaree Kerdcharoen, Teerakiat Mahidol University Materials Science and Engineering Programme and Center of Nanoscience and Nanotechnology Faculty of Science Bangkok10400 Thailand Mahidol University Division of Endocrinology and Metabolism Faculty of Medicine Ramathibodi Hospital Bangkok10400 Thailand Mahidol University and Research Network of NANOTEC at Mahidol University Faculty of Science Department of Physics Bangkok Thailand

ISBN: (纸本)9780738111278

This paper reveals the development and design of an electronic nose prototype for non-invasive diabetes detection based on measurement of the exhaled breath. This system consists of eight metal oxide gas sensors covering the sensing range for the volatile organic compounds (VOCs) existed in human's exhaled breath. These platforms can be integrated the facemask connected to electronic nose device which used to realtime monitoring. This prototype offers platforms that can be applied to investigate the monitoring exhaled breath human, which have potential to monitoring human health. The experiment obtained the optimizing the condition to detect the exhaled breath. Preliminary results with prototype electronic nose to detect the exhaled breath. It shows an excellent performance to detect an exhaled breath sample. Moreover, it has successfully to discriminate the exhaled breath pattern of diabetes and healthy controls. Soon, this approach may become particularly useful in health application to serve as a noninvasive device for screening patients with diabetes. © 2021 IEEE.

关键词： Volatile organic compounds

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Achieving High Thermal Conductivity of Al-50si Alloy Through Heat Treatment and its Microstructural Evolution

SSRN

引用

SSRN 2023年

作者： Ding, Chao Hao, Huali Ma, Rui Ye, Changqing Li, Shukui Lu, Zhouguang Yu, Changyang Yu, Peng Yang, Weimin Ye, Shulong Faculty of Materials Science Shenzhen MSU-BIT University Shenzhen518172 China Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen518055 China School of Civil Engineering Wuhan University Wuhan420072 China Postdoctoral Programme Guosen Securities Co. Ltd. Shenzhen518048 China Shenzhen ElementPlus Material Technology Co. Ltd. Shenzhen518107 China Physics Labotory Industrial Training Center Shenzhen Polytechnic Shenzhen518055 China

Al-50Si alloys were prepared by powder extrusion and characterized for electronic packaging. The optimization of powder size, extrusion temperature, and heat treatment parameters was performed to enhance the microstructure and thermo-physical properties. The alloy exhibits a high relative density >99%, a low coefficient of thermal expansion (CTE) © 2023, The Authors. All rights reserved.

关键词： Thermal conductivity

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Ultrafast laser synthesis of zeolites

arXiv

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arXiv 2025年

作者： Galioglu, Sezin Hagverdiyev, Mehdi Doğan, Meryem M. Yavuz, Özgün Seleme Nizam, Ü. Makey, Ghaith Choura, Aladin Laçin, Mesut Kurç, Burcu Akata Elahi, Parviz Ömer Ilday, F. Ilday, Serim UNAM-National Nanotechnology Research Center Institute of Materials Science and Nanotechnology Bilkent University Ankara06800 Turkey Faculty of Electrical Engineering and Information Technology Ruhr University Bochum44801 Germany Faculty of Physics and Astronomy Ruhr University Bochum44801 Germany Micro and Nanotechnology Programme Middle East Technical University Ankara06800 Turkey Faculty of Engineering Özyeğin University İstanbul34794 Turkey

Research has demonstrated that zeolite nucleation and growth can be controlled by fine-tuning chemical composition, temperature, and pressure, resulting in structures with diverse porosities and functionalities. Nevertheless, current energy delivery methods lack the finesse required to operate on the femto- and picosecond timescales of silica polymerisation and depolymerisation, limiting their ability to direct synthesis with high precision. To overcome this limitation, we introduce an ultrafast laser synthesis technique capable of delivering energy at these timescales with unprecedented spatiotemporal precision. Unlike conventional or emerging approaches, this method bypasses the need for specific temperature and pressure settings, as nucleation and growth are governed by dynamic phenomena arising from nonlinear light-matter interactions—such as convective flows, cavitation bubbles, plasma formation, and shock waves. These processes can be initiated, paused, and resumed within fractions of a second, effectively "freezing" structures at any stage of self-assembly. Using this approach, we traced the entire nucleation and growth pathway of laser-synthesized TPA-silicate-1 zeolites, from early oligomer formation to fully developed crystals. The unprecedented spatiotemporal control of this technique unlocks new avenues for manipulating reaction pathways and exploring the vast configurational space of zeolites. © 2025, CC BY-NC-ND.

关键词： Self assembly

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Polyphthalonitrile-Based Novel Carbon Molecular Sieve Membranes: Microstructure Characteristics and Gas Permeation Behavior

SSRN

引用

SSRN 2024年

作者： Hu, Chun-Po Liang, Yen Nan Yang, Hong-Li Wei-Song, Hung Lim, Jacob Song Kiat He, Zeming Hu, Xiao Matthew Interdisciplinary Graduate Programme Graduate College Nanyang Technological University 637141 Singapore School of Materials Science and Engineering Nanyang Technological University 639798 Singapore Nanyang Technological University 637141 Singapore R&D Center for Membrane Technology Chung Yuan Christian University Chung-Li32023 Taiwan Advanced Membrane Materials Research Center Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Temasek Laboratories Nanyang Technological University 50 Nanyang Drive 637553 Singapore

Carbon molecular sieve (CMS) membranes hold great promise for energy-efficient gas separation, contributing to the mitigation of greenhouse gas emissions. Exploring new types of microstructurally tunable polymeric precursors is critical for adjusting the microstructure characteristics and gas separation performance of CMS membranes. In this study, novel CMS membranes derived from a crosslinkable polyphthalonitrile (PPN) precursor with a thermally tunable microstructure arrangement are reported. We demonstrate that the aforementioned two key features of PPN can be utilized to adjust microstructure characteristics that determine the gas permeation behavior of the PPN-CMS membranes through a controlled thermal treatment protocol. The thermally induced enlargement of the average intermolecular distance of the PPN network and the ordered π-π stacking arrangement are beneficial to the formation of a narrow pore size distribution in the PPN-CMS membrane, particularly in the ultramicropore ( © 2024, The Authors. All rights reserved.

关键词： Microstructure

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Polyphthalonitrile as a novel precursor for carbon membranes: Tunable microstructure characteristics and gas permeation behavior

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Carbon 2024年 228卷

作者： Hu, Chun-Po Liang, Yen Nan Yang, Hong-Li Hung, Wei-Song Lim, Jacob Song Kiat He, Zeming Hu, Xiao Matthew Interdisciplinary Graduate Programme Graduate College Nanyang Technological University 637141 Singapore School of Materials Science and Engineering Nanyang Technological University 639798 Singapore Nanyang Technological University 637141 Singapore R&D Center for Membrane Technology Chung Yuan Christian University Chung-Li 32023 Taiwan Advanced Membrane Materials Research Center Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Temasek Laboratories Nanyang Technological University 50 Nanyang Drive 637553 Singapore

Carbon molecular sieve (CMS) membranes hold great promise for energy-efficient gas separation, contributing to mitigating greenhouse gas emissions. Exploring new types of microstructurally tunable polymeric precursors is critical for understanding the evolution of carbon microstructure arrangement and adjusting the gas permeation behavior of CMS membranes. As a precursor for CMS membranes, polyphthalonitrile (PPN) resin with both tunable intermolecular distance and π-π stacking arrangement is reported for the first time. We have demonstrated that the aforementioned two key features of the thermally crosslinked PPN network are beneficial to forming PPN-CMS membranes with enlarged intermolecular distance and small-sized, narrow-distributed ultramicropores ( © 2024

关键词： Pore size

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Effect of various ratios of poly(3-hexylthiophene)with polyvinyl alcohol gel-polymer electrolytes in flexible sodium-ion batteries using Samanea saman tree-leaf-derived carbon quantum dots decorated with SnO_(2)and NaVO_(3)

引用

Clean Energy 2022年第1期6卷 226-237页

作者： Baskar Thangaraj Nutthapon Wongyao Pravin Raj Solomon Wachira Chaiworn Surawut Chuangchote Werasak Surareungchai Pilot Plant Development and Training Institute King Mongkut’s University of Technology ThonburiBangkhuntien-chaitalay RoadThakamBangkok 10150Thailand Fuel Cells and Hydrogen Research and Engineering Center Pilot Plant Development and Training InstituteKing Mongkut’s University of Technology ThonburiBangkok 10140Thailand Department of Research and Development Velammal Medical College Hospital and Research InstituteMadurai 625009Tamil NaduIndia Department of Tool and Materials Engineering Faculty of EngineeringKing Mongkut’s University of Technology ThonburiBangmodBangkok 10140Thailand Research Center of Advanced Materials for Energy and Environmental Technology King Mongkut’s University of Technology ThonburiBangmodBangkok 10140Thailand School of Bioresources and Technology Nanoscience&Nanotechnology Graduate ProgrammeFaculty of ScienceKing Mongkut’s University of Technology ThonburiBangkhuntien-chaitalay RoadThakamBangkok 10150Thailand

Gel-polymer electrolytes with high thermal stability and mechanical properties were considered suitable in rechargeable batteries so as to overcome the problems encountered in liquid *** a previous study,flexible sodium-ion batteries(FSIBs)were fabri-cated using electrodes made of carbon quantum dots(CQDs)decorated with SnO_(2) and NaVO_(3) utilizing a polyvinyl alcohol(PVA)/P3HT gel-polymer electrolyte at a ratio of 1:*** addition,various separators such as indium-doped tin oxide/polyoxyethylene tridecyl ether(ITO/PTE),rice paper(RP),silicone with three big holes(SIL BH),silicone with many small holes(SIL SH)and cellulose paper(CP)were tested in flexible Na-ion *** SIL SH delivered a high specific discharge capacity of 4246 mAh g^(-1) in the initial cycle at 2 V and maintained a value of 71 mAh g^(-1) in the 50th *** the aim of improving the cyclic ability of FSIBs,different weight ratios of PVA/P3HT(1:0.025,1:0.05,1:0.1,1:0.15,1:0.2)were tried in this work using the electrodes CQDs@SnO_(2) and CQDs@NaVO_(3).The above ratios were referred to as B25,B50,B100,B150 and B200,*** SH was used as a *** voltammetry studies indicated that B150 had a high specific capacitance of 13062 F g^(-1).B25 and B100 exhibited high discharge capacities(171 mAh g^(-1))and(151 mAh g^(-1))compared to that of other ratios B50(75 mAh g^(-1)),B150(88 mAh g^(-1))and B200(54 mAh g^(-1))in the 50th cycle at 2.0 *** study reveals the scope of developing FSIBs of high capacity and cyclability at different voltages using carbonaceous electrodes and gel-polymer electrolytes with different ratios of PVA/*** focus of the present study is to bring out the optimum ratio of PVA/P3HT for maximizing the cyclic ability of FSIBs.

关键词： biomass carbon quantum dots gel-polymer electrolytes energy storage flexible Na-ion battery

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Data-driven discovery of high performance layered van der Waals piezoelectric NbOI2

arXiv

引用

arXiv 2022年

作者： Wu, Yaze Abdelwahab, Ibrahim Kwon, Ki Chang Verzhbitskiy, Ivan Wang, Lin Liew, Weng Heng Yao, Kui Eda, Goki Loh, Kian Ping Shen, Lei Quek, Su Ying Department Of Physics National University Of Singapore Singapore Singapore Centre For Advanced 2D Materials Graphene Research Centre Singapore Singapore Department Of Mechanical Engineering National University Of Singapore Singapore Singapore Engineering Science Programme National University Of Singapore Singapore Singapore Department Of Chemistry National University Of Singapore Singapore Singapore Singapore Singapore NUS Graduate School Integrative Sciences And Engineering Programme National University Of Singapore Singapore Singapore Department Of Materials Science And Engineering National University Of Singapore Singapore Singapore

Using high-throughput first-principles calculations to search for layered van der Waals materials with the largest piezoelectric stress coefficients, we discover NbOI2to be the one among 2940 monolayers screened. The piezoelectric performance of NbOI2is independent of thickness, and its electromechanical coupling factor of near unity is a hallmark of optimal interconversion between electrical and mechanical energy. Laser scanning vibrometer studies on bulk and few-layer NbOI2crystals verify their huge piezoelectric responses, which exceed internal references such as In2Se3and CuInP2S6. Furthermore, we provide insights into the atomic origins of anti-correlated piezoelectric and ferroelectric responses in NbOX2(X = Cl, Br, I), based on bond covalency and structural distortions in these materials. Our discovery that NbOI2has the largest piezoelectric stress coefficients among 2D materials calls for the development of NbOI2-based flexible nanoscale piezoelectric devices. © 2022, CC BY.

关键词： Van der Waals forces

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Exploring Thixotropic Timescale: Phenomenological Insights and Analytical Perspectives

arXiv

引用

arXiv 2023年

作者： Joshi, Yogesh M. Department of Chemical Engineering Indian Institute of Technology Kanpur Uttar Pradesh Kanpur208016 India Materials Science Programme Indian Institute of Technology Kanpur Uttar Pradesh Kanpur208016 India Centre for Nanosciences Indian Institute of Technology Kanpur Uttar Pradesh Kanpur208016 India

Thixotropy is characterized by an increase in viscosity when a material is subjected to no flow (quiescent) or weak flow conditions and a decrease in viscosity when it is subjected to strong flow conditions. The characteristic timescale associated with the thixotropic phenomenon, particularly how the viscosity increases with time, has been termed the thixotropic timescale. In the literature, several approaches have been suggested for estimating the thixotropic timescale. The most prominent approach, however, infers it from a specific form of a kinetic expression for structure parameter evolution. In this paper, we study the various kinds of structural kinetic models, and by carrying out a careful analysis of the same, we propose a parameter for the thixotropic timescale that is associated with the most generic form of the kinetic expression for structure parameter evolution. We observe that when the viscosity of the structural kinetic model undergoes continuous increase with time and eventually diverges under quiescent conditions, which we believe is the most practical scenario, our analysis suggests that increasing the thixotropic timescale weakens the thixotropic character of a system. We also propose a new phenomenological measure of the thixotropic timescale: τthix = (dlnη/dt)-1, where η is viscosity and t is time. The proposed definition allows a straightforward and unique way to determine thixotropic timescale through experiments and agrees well with the conventional notion of thixotropy. Copyright © 2023, The Authors. All rights reserved.

关键词： Viscosity

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