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arXiv 2020年

作者： Chen, Chao Zhao, Di Chen, Wei Khong, Sei Zhen Qiu, Li The Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong The Hong Kong University of Science and Technology Shenzhen Research Institute Shenzhen518063 China The Department of Control Science and Engineering Shanghai Institute of Intelligent Science and Technology Tongji University Shanghai200092 China The Department of Mechanics and Engineering Science Beijing Innovation Center for Engineering Science and Advanced Technology Peking University Beijing100871 China

In this paper, we propose a definition of phase for a class of stable nonlinear systems called semi-sectorial systems, from an input-output perspective. The definition involves the Hilbert transform as a critical instrument to complexify real-valued signals since the notion of phase arises most naturally in the complex domain. The proposed nonlinear system phase, serving as a counterpart of L2-gain, quantifies the passivity and is highly related to the dissipativity. It also possesses a nice physical interpretation which quantifies the tradeoff between the real energy and reactive energy. A nonlinear small phase theorem is then established for feedback stability analysis of semi-sectorial systems. Additionally, its generalized version is proposed via the use of multipliers. These nonlinear small phase theorems generalize a version of the classical passivity theorem and a recently appeared linear time-invariant small phase theorem. Copyright © 2020, The Authors. All rights reserved.

关键词： Nonlinear systems

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Spectroscopic detection of pigments in tissues: correlation with tissue aging and cancer development

Spectroscopic detection of pigments in tissues: correlation ...

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International Conference on Laser Optics

作者： L. M. Oliveira T. M. Gonç alves A. R. Botelho I. S. Martins H. F. Silva I. Carneiro S. Carvalho R. Henrique V. V. Tuchin ISEP Center of Innovation in Engineering and Industrial Technology Porto Portugal Physics Department Polytechnic of Porto - School of Engineering (ISEP) Porto Portugal Department of Electrical and Computer Engineering Porto University - School of Engineering Porto Portugal Department of Pathology and Cancer Biology and Epigenetics Group Portuguese Oncology Institute of Porto Porto Portugal Dept. of Pathological Cytological and Thanatological Anatomy Polytechnic of Porto - School of Health (ESS) Porto Portugal Deptartment of Pathology Santa Luzia Hospital (ULSAM) Viana do Castelo Portugal Dept. of Pat hol. and Molecular Immunology Porto University - Institute of Biomedical Sciences Abel Salazar Porto Portugal Science Medical Center Saratov State University Saratov Russia Laboratory of Laser Molecular Imaging and Machine Learning National Research Tomsk State University Tomsk Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control FRC &#x2018 Saratov Scientific Centre&#x2019 of the Russian Academy of Sciences Saratov Russia

ISBN: (数字)9781665466646

ISBN: (纸本)9781665466653

The direct calculation of the absorption coefficient spectra of various tissues from spectral measurements allowed to retrieve the contents of melanin and lipofuscin. In the rabbit brain cortex, 1.8 times higher melanin content is explained by the neuron degeneration process. Similar melanin and lipofuscin contents were found in the rabbit pancreas as a result of the tissue aging process. The conversion of 83 % of the melanin in the human normal kidney into lipofuscin in the cancer kidney indicates that lipofuscin can be considered a kidney cancer marker in humans.

关键词： Rabbits Absorption Neurons Lasers Aging Pigments Optics

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Developments and applications of the OPTIMADE API for materials discovery, design, and data exchange

arXiv

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arXiv 2024年

作者： Evans, Matthew L. Bergsma, Johan Merkys, Andrius Andersen, Casper W. Andersson, Oskar B. Beltrán, Daniel Blokhin, Evgeny Boland, Tara M. Balderas, Rubén Castañeda Choudhary, Kamal Díaz, Alberto Díaz García, Rodrigo Domínguez Eckert, Hagen Eimre, Kristjan Montero, María Elena Fuentes Krajewski, Adam M. Mortensen, Jens Jørgen Duarte, José Manuel Nápoles Pietryga, Jacob Qi, Ji de Jesús Trejo Carrillo, Felipe Vaitkus, Antanas Yu, Jusong Zettel, Adam de Castro, Pedro Baptista Carlsson, Johan Cerqueira, Tiago F.T. Divilov, Simon Hajiyani, Hamidreza Hanke, Felix Jose, Kevin Oses, Corey Riebesell, Janosh Schmidt, Jonathan Winston, Donald Xie, Christen Yang, Xiaoyu Bonella, Sara Botti, Silvana Curtarolo, Stefano Draxl, Claudia Cobas, Luis Edmundo Fuentes Hospital, Adam Liu, Zi-Kui Marques, Miguel A.L. Marzari, Nicola Morris, Andrew J. Ong, Shyue Ping Orozco, Modesto Persson, Kristin A. Thygesen, Kristian S. Wolverton, Chris Scheidgen, Markus Toher, Cormac Conduit, Gareth J. Pizzi, Giovanni Gražulis, Saulius Rignanese, Gian-Marco Armiento, Rickard Chemin des Étoiles 8 Louvain-la-Neuve1348 Belgium Matgenix SRL 185 Rue Armand Bury Gozée6534 Belgium École Polytechnique Fédérale de Lausanne Avenue de Forel 3 Lausanne1015 Switzerland Institute of Biotechnology Life Sciences Center Vilnius University Sauletekio av. 7 VilniusLT-10257 Lithuania SINTEF P.O. Box 4760 Torgarden TrondheimNO-7465 Norway Materials Design and Informatics unit Department of Physics Chemistry and Biology Linköping University Sweden Baldiri i Reixac 10-12 Barcelona08028 Spain Tilde Materials Informatics Straßmannstraße 25 Berlin10249 Germany Materials Platform for Data Science Sepapaja 6 Tallinn15551 Estonia Computational Atomic-Scale Materials Design Technical University of Denmark Kgs. Lyngby Denmark Av. Miguel de Cervantes 120 Complejo Industrial Chihuahua Chihuahua Chih. 31136 Mexico Material Measurement Laboratory National Institute of Standards and Technology GaithersburgMD20899 United States Department of Mechanical Engineering and Materials Science Duke University DurhamNC27708 United States Center for Extreme Materials Duke University DurhamNC27708 United States École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Universidad Autónoma de Chihuahua Facultad de Ciencias Quimicas Chihuahua31125 Mexico Department of Materials Science and Engineering The Pennsylvania State University University ParkPA16802 United States Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Department of NanoEngineering University of California 9500 Gilman Drive La Jolla San DiegoCA92093-0448 United States National Institute for Materials Science 1-2-1 Sengen Ibaraki Tsukuba305-0047 Japan Dassault Systèmes Germany GmbH Am Kabellager 11-13 Cologne51063 Germany CFisUC Department of Physics University of Coimbra Rua Larga Coimbra3004-516 Portugal Dassault Systèmes 22 Science Park CB4 0FJ United Kingdom Theory of Condensed Matter Cavendis

The Open Databases Integration for Materials Design (OPTIMADE) application programming interface (API) empowers users with holistic access to a growing federation of databases, enhancing the accessibility and discoverability of materials and chemical data. Since the first release of the OPTIMADE specification (v1.0), the API has undergone significant development, leading to the v1.2 release, and has underpinned multiple scientific studies. In this work, we highlight the latest features of the API format, accompanying software tools, and provide an update on the implementation of OPTIMADE in contributing materials databases. We end by providing several use cases that demonstrate the utility of the OPTIMADE API in materials research that continue to drive its ongoing development. © 2024, CC BY.

关键词： Electronic data interchange

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Wide-angle giant photonic spin Hall effect

arXiv

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arXiv 2022年

作者： Chen, Zhihao Chen, Yu Wu, Yaodong Zhou, Xinxing Sun, Handong Low, Tony Chen, Hongsheng Lin, Xiao Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control Ministry of Education Synergetic Innovation Center for Quantum Effects and Applications School of Physics and Electronics Hunan Normal University Changsha410081 China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Engineering Technology Research Center for 2D Material Information Function Devices and Systems of Guangdong Province Institute of Microscale Optoelectronics Shenzhen University Shenzhen518060 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore Department of Electrical and Computer Engineering University of Minnesota MinneapolisMN55455 United States Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation ZJU-Hangzhou Global Scientific and Technological Innovation Center College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China International Joint Innovation Center ZJU-UIUC Institute The Electromagnetics Academy at Zhejiang University Zhejiang University Haining314400 China

Photonic spin Hall effect is a manifestation of spin-orbit interaction of light and can be measured by a transverse shift δ of photons with opposite spins. The precise measurement of transverse shifts can enable many spin-related applications, such as precise metrology and optical sensing. However, this transverse shift is generally small (i.e. δ/λ -1, λ is the wavelength), which impedes its precise measurement. To-date proposals to generate giant spin Hall effect (namely with δ/λ > 102) have severe limitations, particularly its occurrence only over a narrow angular cone (with a width of ∆0 70◦ by exploiting the interface between free space and uniaxial epsilon-near-zero media. The underlying mechanism is ascribed to the almost-perfect polarization splitting between s and p polarized waves at the designed interface. Remarkably, this almost-perfect polarization splitting does not resort to the interference effect and is insensitive to the incident angle, which then gives rise to the wide-angle giant photonic spin Hall effect. Copyright © 2022, The Authors. All rights reserved.

关键词： Polarization

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GZMK^high CD8⁺ T effector memory cells are associated with CD15^high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome (vol 13, 6752, 2022)

引用

NATURE COMMUNICATIONS 2022年第1期13卷 1-20页

作者： Tiberti, Silvia Catozzi, Carlotta Croci, Ottavio Ballerini, Mattia Cagnina, Danilo Soriani, Chiara Scirgolea, Caterina Gong, Zheng He, Jiatai Macandog, Angeli D. Nabinejad, Amir Lauson, Carina B. Nava Quinte, Arianna Bertalot, Giovanni Petz, Wanda L. Ravenda, Simona P. Licursi, Valerio Paci, Paola Rasponi, Marco Rotta, Luca Fazio, Nicola Ren, Guangwen Fumagalli-Romario, Uberto Schaefer, Martin H. Campaner, Stefano Lugli, Enrico Nezi, Luigi Manzo, Teresa Department of Experimental Oncology European Institute of Oncology- IRCCS Milano Italy Center for Genomic Science of IIT CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine) Fondazione Istituto Italiano di Tecnologia (IIT) Milano Italy Laboratory of Translational Immunology IRCCS- Humanitas Research Hospital- Milan Italy The Jackson Laboratory Bar Harbor ME USA Department of Molecular & Biomedical Sciences University of Maine Orono ME 04469 USA Department of Pathology APSS Trento Hospital & Health Care Trento Italy Digestive Surgery Division European Institute of Oncology-IRCCS Milan Italy Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors European Institute of Oncology-IRCCS Milan Italy Institute of Molecular Biology and Pathology (IBPM) National Research Council (CNR) of Italy Rome Italy Department of Computer Control and Management Engineering Sapienza - University of Rome Rome Italy Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy

CD8+T cells are a major prognostic determinant in solid tumors, including colorectal cancer (CRC). However, understanding how the interplay between different immune cells impacts on clinical outcome is still in its infancy. Here, we describe that the interaction of tumor infiltrating neutrophils expressing high levels of CD15 with CD8+T effector memory cells (TEM) correlates with tumor progression. Mechanistically, stromal cell-derived factor-1 (CXCL12/SDF-1) promotes the retention of neutrophils within tumors, increasing the crosstalk with CD8+T cells. As a consequence of the contact-mediated interaction with neutrophils, CD8+T cells are skewed to produce high levels of GZMK, which in turn decreases E-cadherin on the intestinal epithelium and favors tumor progression. Overall, our results highlight the emergence of GZMKhighCD8+TEMin non-metastatic CRC tumors as a hallmark driven by the interaction with neutrophils, which could implement current patient stratification and be targeted by novel therapeutics.

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Randomised benchmarking for characterizing and forecasting correlated processes

arXiv

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arXiv 2023年

作者： Zhang, Xinfang Wu, Zhihao White, Gregory A.L. Xiang, Zhongcheng Hu, Shun Peng, Zhihui Liu, Yong Zheng, Dongning Fu, Xiang Huang, Anqi Poletti, Dario Modi, Kavan Wu, Junjie Deng, Mingtang Guo, Chu Institute for Quantum Information State Key Laboratory of High Performance Computing College of Computer Science and Technology National University of Defense Technology Changsha410073 China School of Physics and Astronomy Monash University VIC3800 Australia Dahlem Center for Complex Quantum Systems Freie Universität Berlin Berlin14195 Germany Institute of Physics Chinese Academy of Sciences Beijing100190 China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics Synergetic Innovation Center for Quantum Effects and Applications Hunan Normal University Changsha410081 China Science Mathematics and Technology Cluster and Engineering Product Development Pillar Singapore University of Technology and Design 8 Somapah Road 487372 Singapore Centre for Quantum Technologies National University of Singapore 117543 Singapore MajuLab CNRS-UNS-NUS-NTU International Joint Research Unit UMI 3654 Singapore Quantum for NSW Sydney2000 Australia

The development of fault-tolerant quantum processors relies on the ability to control noise. A particularly insidious form of noise is temporally correlated or non-Markovian noise. By combining randomized benchmarking with supervised machine learning algorithms, we develop a method to learn the details of temporally correlated noise. In particular, we can learn the time-independent evolution operator of system plus bath and this leads to (i) the ability to characterize the degree of non-Markovianity of the dynamics and (ii) the ability to predict the dynamics of the system even beyond the times we have used to train our model. We exemplify this by implementing our method on a superconducting quantum processor. Our experimental results show a drastic change between the Markovian and non-Markovian regimes for the learning accuracies. Copyright © 2023, The Authors. All rights reserved.

关键词： Benchmarking

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Analysis of Transient Processes in Stable Scalar Linear Discrete-Time Systems

Analysis of Transient Processes in Stable Scalar Linear Disc...

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作者： Pavel SHCHERBAKOV Ming YUCHI Institute of Control Sciences RAS Federal Research Center "Computer Science and Control " ISA RAS Huazhong University of Science and Technology Department of Biomedical Engineering

We consider stable linear scalar systems described by homogenous difference equations with nonzero initial conditions. We show that, at finite time instants, solutions can deviate far from the equilibrium. For classes of root locations and initial conditions, closed-form estimates are obtained for the magnitude of deviations and the instant of the maximum deviation. Simple conditions on the presence of deviations are formulated and the issues are discussed of how typical are these effects.

关键词： Linear discrete-time systems Stability Nonzero initial conditions Peaks Deviations

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An optimized energy management strategy for fuel cell hybrid vehicles 6

An optimized energy management strategy for fuel cell hybrid...

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2019 6th International Conference on Advanced Composite Materials and Manufacturing engineering, ACMME 2019

作者： Xiao, Wenxin Wang, Lei Liu, Dongyin Zhang, Wenwen Chinese-German College Tongji University Shanghai China Department of Electrical and Computer Engineering Technische Universität München Munich Germany Research Center of Control Science and Intelligent System University of Electronic Science and Technology of China Chengdu China College of Electronics and Information Engineering Tongji University Shanghai China

Fuel cell hybrid vehicles are environmentally friendly and have good development prospects. Their energy management is very important, but there are currently few studies on this topic. In this paper, an optimized energy management strategy specifically applied to fuel cell hybrid vehicles is proposed. Fuel cell hybrid vehicles have some different characteristics from ordinary hybrid vehicles, which need to be considered in energy management. For the fuel cell to remain activated during driving, its output power must remain above a minimum power. In addition, it takes some time for the fuel cell to start up. These characteristics are considered in the vehicle model. The energy management strategy proposed in this paper maximizes energy use efficiency by controlling the SOC value of the battery. The SOC value of the battery is in the proper range during driving. At high speeds, fuel is consumed as a source of energy and the battery is charged to keep its SOC at a high level. When approaching the destination or when the vehicle is traveling at a low speed, the battery is discharged to reduce fuel consumption. Applying this strategy to the ECE-15 and EUDCL environments, the simulation results show that this optimized energy management strategy improves the energy efficiency of the fuel cell and enables the battery to operate at the appropriate power. © Published under licence by IOP Publishing Ltd.

关键词： Fuel cells

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Data mining-based model and risk prediction of colorectal cancer by using secondary health data:A systematic review

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Chinese Journal of Cancer research 2020年第2期32卷 242-251页

作者： Hailun Liang Lei Yang Lei Tao Leiyu Shi Wuyang Yang Jiawei Bai Da Zheng Ning Wang Jiafu Ji School of Public Administration and Policy Renmin University of ChinaBeijing 100872China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Beijing Office for Cancer Prevention and ControlPeking University Cancer Hospital&InstituteBeijing 100142China Departm ent of Public Policy City University of Hong KongHong Kong SAR999077China Johns Hopkins Primary Care Policy Center BaltimoreMD 21205USA Ddepartment of Neurosurgery Johns Hopkins MedicineBaltimoreMD 21205USA Department of Biostatistics Johns Hopkins Bloomberg School of Public HealthBaltimoreMD 21205USA Department of Computer Science Johns Hopkins Whiting School of EngineeringBaltimoreMD 21205USA Key Laboratory of Carcinogenesis and Translational Research(Ministiy of Education/Beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:Prevention and early detection of colorectal cancer(CRC)can increase the chances of successful treatment and reduce *** data mining technologies have been utilized to strengthen the early detection of CRC in primary *** synthesis on the model’s effectiveness is *** systematic review synthesizes studies that examine the effect of data mining on improving risk prediction of ***:The PRISMA framework guided the conduct of this *** obtained papers via Pub Med,Cochrane Library,EMBASE and Google *** appraisal was performed using Downs and Black’s quality *** evaluate the performance of included models,the values of specificity and sensitivity were comparted,the values of area under the curve(AUC)were plotted,and the median of overall AUC of included studies was ***:A total of 316 studies were reviewed for full *** articles were *** studies implement techniques including artificial neural networks,Bayesian networks and decision *** articles reported the overall model ***,the median AUC is 0.8243[interquartile range(IQR):0.8050-0.8886].In the two articles that reported comparison results with traditional models,the data mining method performed better than the traditional models,with the best AUC improvement of 10.7%.Conclusions:The adoption of data mining technologies for CRC detection is at an early *** numbers of included articles and heterogeneity of those studies implied that more rigorous research is expected to further investigate the techniques’effects.

关键词： Systematic review colorectal cancer disease detection data mining

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Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning

TechRxiv

引用

TechRxiv 2021年

作者： Fan, Rui Bowd, Christopher Christopher, Mark Brye, Nicole Proudfoot, James A. Rezapour, Jasmin Belghith, Akram Goldbaum, Michael H. Chuter, Benton Girkin, Christopher A. Fazio, Massimo A. Liebmann, Jeffrey M. Weinreb, Robert N. Gordon, Mae O. Kass, Michael A. Kriegman, David Zangwill, Linda M. Hamilton Glaucoma Center Viterbi Family Department of Ophthalmology Shiley Eye Institute University of California La Jolla San DiegoCA United States Department of Computer Science and Engineering University of California La Jolla San DiegoCA United States Department of Control Science and Engineering College of Electronics and Information Engineering Tongji University Shanghai201804 China Department of Ophthalmology Universitätsmedizin der Johannes Gutenberg-Universität Mainz Rheinland-Pfalz Mainz Germany Department of Ophthalmology School of Medicine The University of Alabama at Birmingham BirminghamAL United States Department of Biomedical Engineering School of Engineering The University of Alabama at Birmingham BirminghamAL United States Bernard and Shirlee Brown Glaucoma Research Laboratory Edward S. Harkness Eye Institute Columbia University Medical Center New YorkNY United States Department of Ophthalmology and Visual Sciences Washington University School of Medicine Washington University St. LouisMO United States

Importance: Automated deep learning (DL) analyses of fundus photographs potentially can reduce the cost and improve the efficiency of reading center assessment of endpoints in clinical trials. Objective: To investigate the diagnostic accuracy of DL algorithms trained on fundus photographs from the Ocular Hypertension Treatment Study (OHTS) to detect primary open-angle glaucoma (POAG). Study Design: Diagnostic/prognostic Study Setting and Participants: 1,636 OHTS participants from 22 sites with a mean follow-up (range) of 10.7 (0.0, 14.3) years. 66,715 photographs from 3,272 eyes were used to train and test a ResNet-50 model to detect the OHTS Endpoint Committee POAG determination based on optic disc (n=287 eyes, 3,502 photographs) and/or visual field (n=198 eyes, 2,300 visual fields) changes. Three independent test sets were used to evaluate the generalizability of the model. Main Outcome and Measures: Areas under the receiver operating characteristic curve (AUROC) and sensitivities at fixed specificities were calculated to compare model performance. Evaluation of false-positive rates was used to determine whether the DL model detected POAG before the Endpoint Committee POAG determination. Results: The DL model achieved an AUROC (95% CI) of 0.88 (0.82, 0.92) for the overall OHTS POAG endpoint. For the OHTS endpoints based on optic disc changes or visual field changes, AUROCs were 0.91 (0.88, 0.94) and 0.86 (0.76, 0.93), respectively. False-positive rates (at 90% specificity) were higher in photographs of eyes that later developed POAG by disc or visual field (19.1%) compared to eyes that did not develop POAG (7.3%) during their follow-up. The diagnostic accuracy of the DL model developed on the optic disc endpoint applied to 3 independent datasets was lower with AUROC ranging from 0.74 to 0.79. Conclusion and Relevance: The model’s high diagnostic accuracy using OHTS photographs suggests that DL has the potential to standardize and automate POAG determination for cl

关键词： Ophthalmology

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