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Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer ***,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas *** this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine *** the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation *** also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target *** an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL ***,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite Nanogenerator Gas therapy In vivo

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A Comparative Study of the Effect of Compounding Methods and Processing of PLA/GNPs on the Micromorphology and Electrical Conductivity 38

A Comparative Study of the Effect of Compounding Methods and...

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38th Technical Conference of the American Society for Composites, ASC 2023

作者： Anurakparadorn, Kanat Taub, Alan Department of Materials Science and Engineering Macromolecular Science and Engineering Program University of Michigan 2300 Hayward St Ann ArborMI48109 United States Department of Mechanical Engineering University of Michigan 2350 Hayward St Ann ArborMI48109 United States

ISBN: (纸本)9781605956916

In this work, the effects of different compounding and processing techniques on the DC electrical conductivity and density of polylactic acid (PLA)/graphene nanoplatelets (GNPs) composites were studied. It is found from the study that compounding by solution mixing via an ultrasonication technique can provide slightly higher DC electrical conductivity after compression molding than mixing through a twin-screw extruder due to better dispersion quality. In addition, a composite pellet from twin screw extrusion showed a slight increase in DC electrical conductivity and anisotropy when processed by filament extrusion due to the shear alignment of GNPs during the extrusion. The fused deposition modeling (FDM) process yields high anisotropy because the crystallization along the printing path allows gaps and polymer coating between the extruded lines and layers. It was found that the 7.5 wt% GNPs composites exhibited the best properties because it provides the best dispersion quality to meet the percolation threshold. Furthermore, the micromorphology of each sample was also studied to observe the dispersion and porosity inside the composite provided by each fabrication technique. This study can be used as a reference for compounding and processing techniques. © 2023 by DEStech Publications, Inc. and American Society for Composites. All rights reserved.

关键词： Mixing

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Development Experimental Investigations of Truss Bridge Model for Vibration-Based Structural Health Monitoring 5th

Development Experimental Investigations of Truss Bridge Mode...

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5th International Conference on Sustainable Civil engineering Structures and Construction Materials, SCESCM 2020

作者： Sukamta Alfiannur, Angga Widyanto, Susilo Adi Lie, Han Ay Department of Civil Engineering Diponegoro University Semarang Indonesia Master Program in Civil Engineering Diponegoro University Semarang Indonesia Department of Mechanical Engineering Diponegoro University Semarang Indonesia

ISBN: (纸本)9789811679230

In recent years the need for Structural Health Monitoring (SHM) has become increasingly important. Given current technological developments, a visual inspection can no longer be a reference due to inaccurate accuracy levels. In this case, there is a need for an early warning in detecting fast and accurate damage compared to visual inspection. This study proposes a vibration-based structural health monitoring analytical framework by introducing a modal analysis approach based on the bridges structural response. The test begins with making a small-scale model of a steel frame type bridge using the similarity model theory to project a prototype bridge. In this research, a damage simulation is given to the model to project damage to the structure. Static and dynamic tests are carrying to obtain the response characteristics of the structure. The assessment has delayed consequences exhibit that the variety of the supported discharge shows that contrasts look like the bend of the predominant recurrence that influences the FFT bend. Output values in natural frequency, mode shapes, and capital damping ratios were adopted as damage indicators. As a comparison, we are testing the model using FE simulation with a tolerance level of 10%. This research is using to build an SHM database system of the existing bridge structure model. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Modal analysis

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Kinetostatic Model of Redundant Actuation Modes in a Lockable Variable Geometry Truss Manipulator Driven by Flexible Limbs 24th

Kinetostatic Model of Redundant Actuation Modes in a Lockabl...

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24th IFToMM China International Conference on Mechanism and Machine Science and engineering, IFToMM CCMMS 2024

作者： Zhao, Yinjun Xi, Fengfeng Hao, Guangbo Tian, Yingzhong Li, Long Wang, Jieyu School of Mechanical Engineering University of Shanghai for Science and Technology Shanghai China School of Mechatronic Engineering and Automation Shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai University Shanghai China Department of Aerospace Engineering Toronto Metropolitan University Toronto ON Canada School of Engineering and Architecture-Electrical and Electronic Engineering University College Cork Cork Ireland

ISBN: (纸本)9789819614639

Manipulators consisting of multiple large deformation limbs can flexibly change their shapes and separate actuation systems from mechanism body, making them particularly suitable for requirements of compact design space, and continuous and versatile deformation. However, the low structural stiffness restricts their practical applications. To enhance the stiffness, we have integrated lockable variable geometry truss (LVGT) supports within the manipulator design. Depending on the number of locked branches within the LVGT, the active flexible limbs may exhibit redundant actuation modes, meaning that the number of working actuators exceeds the DOF of the internal LVGT. The redundant actuation modes, while beneficial for enabling heavier load manipulation, poses challenges in mechanical analysis, necessitating a comprehensive consideration of factors such as motion constraints from rigid joints, nonlinear coupling deformations in the flexible limbs, and control strategies for the redundant actuators. In this paper, we construct a mechanical analysis framework tailored for such operating modes. This framework enables the kinetostatic analyses under the consideration of distributing redundant actuation forces. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Flexible limb actuation Kinetostatic model Redundant actuation

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Design of an Embedded Control System for a Linear MR Damper Powered by Energy Harvested from Vibrations

Design of an Embedded Control System for a Linear MR Damper ...

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International Carpathian Control Conference (ICCC)

作者： Łukasz Jastrzębski Arkadiusz Kozieł Department of Process Control Faculty of Mechanical Engineering and Robotics AGH University of Krakow Krakow Poland

ISBN: (数字)9798350350708

ISBN: (纸本)9798350350715

The work concerns design and realization of embedded control system (ECS) dedicated to a self-powered vibration reduction system equipped with a magnetorheological damper. Unlike a typical MR damper control system whose electrical circuits are powered from an external energy source, the developed system is powered by energy extracted from a vibrating structure and converted into electrical energy using an electromagnetic harvester. The ECS contains a rectifier, a driver unit, a 32-bit microcontroller, and an internal power supply system which are integrated in an engineered PCB. The sensors (MEMS accelerometers) employed in the control system are powered by DC voltage provided by the ECS. The paper presents the structure, components, and functions of the ECS

关键词： Vibrations Micromechanical devices Power supplies Microcontrollers Rectifiers Control systems Shock absorbers

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Simulation of an Electrostatic Drum For Photovoltaic Panel Dust Removal

Simulation of an Electrostatic Drum For Photovoltaic Panel D...

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Smart Power & Internet Energy Systems (SPIES), International Conference on

作者： Abdurahman Albaradi James A. Mynderse Department of Mechanical Engineering Al-Baha University Al-Baha Saudi Arabia Mechanical Robotics and Industrial Engineering Lawrence Technological University Southfield MI USA

ISBN: (数字)9798350368864

ISBN: (纸本)9798350368871

Demand for electrical energy is increasing with growth in global population and development in the industrial sector. Large-scale solar power plants, including photovoltaic (PV) panels, are a clean alternative to fossil fuels and can be located in desert regions with abundant solar irradiance, such as Saudi Arabia. However, dust deposition on the PV surface is high in desert regions and limits power output. Cleaning PV panels is essential to have the benefit of the high insulation and mitigate the dust accumulation impact. In this study, an electrostatic drum, similar to those in the electrophotographic printing process, is considered for cleaning PV panels. Simulation is used to identify optimum drum parameters such as drum diameter, drum to PV air gap, drum thickness and applied voltage. The cleaning performance of the electrostatic drum is compared to existing embedded and detachable electrodynamic shields.

关键词： Performance evaluation Photovoltaic systems Surface cleaning Solar irradiance Printing Electrodynamics Voltage Trajectory Deserts Electrostatics

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Method Assessment of Bridge Conditions Using Vibration Mode Patterns 5th

Method Assessment of Bridge Conditions Using Vibration Mode ...

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5th International Conference on Sustainable Civil engineering Structures and Construction Materials, SCESCM 2020

作者： Sukamta Billahi, Bagus Acung Widyanto, Susilo Adi Lie, Han Ay Department of Civil Engineering Diponegoro University Semarang Indonesia Master Program in Civil Engineering Diponegoro University Semarang Indonesia Department of Mechanical Engineering Diponegoro University Semarang Indonesia

ISBN: (纸本)9789811679230

The current bridge structure maintenance method is done by visual observation only, this often has limitations and the results obtained are less accurate. This research was conducted to obtain a vibratory mode data base which will be used as a basis for compiling the failure patterns of the bridge structure. Vibration mode measurements are carried out on the prototype and the bridge model using an accelerometer sensor mounted on the bridge structure. Accelerometer installed at several points to get variations in the vibrate mode. Dynamic load frequency variations are given to get vibrational mode variations. The results of the vibration mode measurement analysis show the similarity between the prototype and the model, so that the bridge model can be used to study structural failure patterns. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Dynamic loads

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A Novel Design of Elliptical S-Chiral MetaComposite: The Finite Element/Experimental Data Approach 38

A Novel Design of Elliptical S-Chiral MetaComposite: The Fin...

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38th Technical Conference of the American Society for Composites, ASC 2023

作者： Mello, Nathalia Avila, Antonio Ferreira Universidade Federal de Minas Gerais Mechanical Engineering Graduate Studies Program MG Belo Horizonte31270-901 Brazil Centro Federal de Educação Tecnológica de Minas Gerais Department of Mechanical Engineering MG Belo Horizonte30510-000 Brazil Universidade Federal de Minas Gerais Department of Mechanical Engineering MG 31279-901 Brazil

ISBN: (纸本)9781605956916

This paper addresses a new concept of chiral metastructure the so-called elliptical S-shape chiral. All five groups of metamaterials studied exhibited large anisotropy. This the anisotropic behavior is controlled by the ellipses' eccentricities. Moreover, the anisotropic response is also more evident when the loading axes are considered. For x-axis compressive loading conditions, the stiffness decreases as the ellipse eccentricity increases. The Poisson ratio's magnitude increases with the increase of a/b aspect ratio, showing a very high auxeticity when the ellipse is close to a flat configuration. In this case, the Poisson ratio was near to -18. For y-axis compressive loadings, the stiffness increases with the decrease of a/b aspect ratio leading to a flexible metastructure. The Poisson ratio's values decreases with the increasing of a/b aspect ratio, but all values were near zero (between -0.35 and -0.05). It seems that the transversal section practically does not change when the metastructure is compressed through y-direction. © 2023 by DEStech Publications, Inc. and American Society for Composites. All rights reserved.

关键词： Poisson ratio

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A Lead-Time-Aware Decomposition Approach to Optimize Disruption Response in Supply Chains

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IEEE Transactions on Automation Science and engineering 2025年

作者： Estrada-Garcia, Juan-Alberto Bi, Mingjie Tilbury, Dawn M. Barton, Kira Shen, Siqian University of Michigan Department of Industrial and Operations Engineering Ann ArborMI48109 United States University of Michigan Robotics Department Ann ArborMI48109 United States University of Michigan Robotics Department and the Department of Mechanical Engineering Ann ArborMI48109 United States

Supply chain (SC) risk management is influenced by both spatial and temporal attributes of different entities (suppliers, retailers, and customers). Each entity has given capacity and lead time to process and transport products to downstream entities. In disruptive events, lead times and capacities may vary, which affects the overall performance of SC. There have been many studies on SC disruption mitigation, but often without considering lead time and the magnitude of lateness. In this paper, we formulate a mixed integer programming (MIP) model to optimize SC operations via a routing and scheduling approach, to model the delivery time of products at different entities as they flow throughout the SC network. We minimize a weighted sum of multiple objectives that involve costs related to transportation, shortages, and delivery lateness. We further develop a Benders decomposition algorithm for speeding up the computation of the NP-hard MIP model. We also develop a discrete-event simulation framework to evaluate the performance of solutions to the MIP model under lead time uncertainty. Through extensive numerical studies, we show how the attributes of SC entities affect the performance, so that we can improve the SC design and operations under various uncertainties. © 2004-2012 IEEE.

关键词： Mixed-integer linear programming

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Studies of exposure UV light, soil Burial, and storage ability effect on characteristics of biocomposite films

Studies of exposure UV light, soil Burial, and storage abili...

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3rd International Conference on Chemical engineering and Applied Sciences, ICChEAS 2022

作者： Fitriani, Fitriani Aprilia, Sri Arahman, Nasrul Bilad, Muhammad Roil Djuned, Fauzi Fathanah, Umi Meilina, Hesti Amin, Amri Doctoral Program School of Engineering Post Graduate Program Universitas Syiah Kuala Banda Aceh23111 Indonesia Department of Chemical Engineering Engineering Faculty Universitas Syiah Kuala Banda Aceh23111 Indonesia Faculty of Integrated Technologies Universiti Brunei Darussalam Bandar Seri BegawanBE1410 Brunei Mechanical Engineering Department Engineering Faculty University of Abulyatama Lampoh Keude-Aceh Besar Indonesia

UV exposure, soil burial, and storage ability tests were carried out on biocomposite films with different concentrations of nanocrystal cellulose to study their biodegradability and morphological properties compared to neat whey protein films. The addition of nanocrystal cellulose as a natural filler to the whey protein based film can change a variety of properties such as strength, shelf life, biodegradability, and resistance to environmental conditions that are required in food packaging. The degradation films were assessed by UV exposure and soil burial tests. On the other hand, packaging ability is analyzed through storage tests under controlled conditions. After the analysis, changes in physical, chemical, and morphological properties were observed in the biocomposite film. From these results, we can conclude that the whey protein film with the addition of 3% nanocrystal cellulose would be a more favorable choice because of its better properties and suitability for the proposed biodegradable food packaging application. © 2023 Elsevier Ltd. All rights reserved.

关键词： Cellulose

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