Diabetic foot ulcers (DFUs) are a multifactorial medical problem that require multifaceted approaches for effective healing. Most research on DFU healing has concentrated on promoting wound closure, with less emphasis...
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Diabetic foot ulcers (DFUs) are a multifactorial medical problem that require multifaceted approaches for effective healing. Most research on DFU healing has concentrated on promoting wound closure, with less emphasis on the quality of repaired tissue. This is problematic, however, since quality of the repaired tissues can have potential to improve wound healing outcomes and limit re-ulceration. If more functionally active dermis replaces the lost tissue, this can effectively maximize strength, organization, and overall structure of the plantar surface. Additionally, DFUs commonly show multi-strain infection, which further exacerbates the non-healing status of these wounds. Treatment of chronic wounds can be benefitted by application of oxygen and localized infection treatment, both can be achieved via our methacrylated chitosan-based (MACF) hydrogel. A non-healing diabetic infected wound model was used to explore extracellular matrix (ECM) organization, tensile strength, and metabolomic profiles at a 21-day endpoint as a marker for maturation and improved functionality of repaired tissues over normal scar formation. Effective remediation of infection was achieved with 14 days of polyhexamethylene biguanide (PHMB) application with improved wound repair compared to continuous treatment. Prolonged (21 day) application of PHMB showed resulting necrosis, although standard application times for patients with infected wounds can reach up to 28 continuous days. Biaxial mechanical analysis showed improved isotropic strength of infected tissues treated with MACF with PHMB stopped on D14, supported by collagen fiber orientation in second harmonics generation (SHG) imaging. Oxygenating MACF treatments also improved collagen deposition through the enhancement of the hydroxyproline fibrillary collagen synthesis pathway. These structural and mechanical results demonstrate a promising potential treatment for infected diabetic foot ulcers which shows improved dermal functionality.
Magnetic actuation of marbles and droplets has been found to have broad applications in magnetic digital microfluidics with promising engineering and biomedical applications like biochemistry, microfluidic systems, ta...
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This study presents a novel approach to achieve self-balance by employing a proportional integral derivative (PID) control system. Simply put, the innovative design consists of two electric ducted fans (EDF) that prop...
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This work aims to discuss a proposed solution for wave equations that utilize discretization by means of the finite difference method, weighted by a parameter η, with sweeping done according to the time-stepping meth...
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Introduction: Endotracheal suctioning is a procedure to remove pulmonary secretions, which can lead to complications such as hypoxemia. To minimize this risk, a double-lumen pulmonary secretion suction device was deve...
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This paper introduces a hybrid control strategy that integrates the unique features of natural logarithm sliding mode control (lnSMC) and fuzzy logic systems. The lnSMC control approach ensures that the vibration ampl...
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ISBN:
(数字)9788993215380
ISBN:
(纸本)9798331517939
This paper introduces a hybrid control strategy that integrates the unique features of natural logarithm sliding mode control (lnSMC) and fuzzy logic systems. The lnSMC control approach ensures that the vibration amplitude remains within a bound, as determined by the parameters of the lnSMC switching function. Furthermore, the fuzzy logic system is employed to approximate the nonlinearities and uncertainties inherent in the suspension system components, such as the spring and damper. The stability of the closed-loop system is analyzed using the Lyapunov stability theorem, guaranteeing convergence within a finite time. To validate the effectiveness of the proposed controller, a simulation study was carried out using a quarter-car suspension model, considering the system’s nonlinearities, parameter uncertainties, and various external disturbances. The results indicate that the proposed controller significantly improves ride comfort while maintaining suspension deflection and road holding within critical safety limits.
This paper presents a control strategy applicable to systems operating in dynamically coupled environments for which only low-fidelity models describing the environmental dynamics and system rewards are available. The...
This paper presents a control strategy applicable to systems operating in dynamically coupled environments for which only low-fidelity models describing the environmental dynamics and system rewards are available. The control problem is posed as a two player game wherein the plant and the environment are considered to be agents that seek to maximize their individual reward. Under this paradigm, the control decisions of the plant are then identified using a level-k cognition modeling approach, where historical sensor data is leveraged to augment predictions of the reward maximizing control input. We demonstrate the proposed framework via simulation of a multi-turbine wind farm wherein the objective is to maximize energy production when only low-fidelity models of the wake effect induced by the interactions between upstream turbines and the wind environment are accessible.
The paper intends to outline workspace of a planar parallel mechanism taking into account both: first type and second type of singularities. These questions influence in an important mode, inverse and direct kinematic...
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Physically assistive robots in home environments can enhance the autonomy of individuals with impairments, allowing them to regain the ability to conduct self-care and household tasks. Individuals with physical limita...
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Tissue engineering, with its crucial components (cells, scaffold and signaling molecules), is still a challenging field, and choosing the suitable manufacturing technique for bone scaffolds is a crucial issue, as such...
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