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Generating 3D brain tumor regions in MRI using vector-quantization Generative Adversarial Networks

Computers in Biology and Medicine 2025年 185卷 109502-109502页

作者： Zhou, Meng Wagner, Matthias W. Tabori, Uri Hawkins, Cynthia Ertl-Wagner, Birgit B. Khalvati, Farzad Department of Computer Science University of Toronto 40 St George St. TorontoONM5S 2E4 Canada Neurosciences & Mental Health Research Program The Hospital for Sick Children 686 Bay St. TorontoONM5G 0A4 Canada Department of Diagnostic and Interventional Radiology The Hospital for Sick Children 170 Elizabeth St. TorontoONM5G 1H3 Canada Division of Neuroradiology Neurooncology The Hospital for Sick Children 170 Elizabeth St. TorontoONM5G 1H3 Canada Paediatric Laboratory Medicine Division of Pathology The Hospital for Sick Children 170 Elizabeth St. TorontoONM5G 1H3 Canada Institute of Medical Science University of Toronto 1 King's College Circle TorontoONM5S 1A8 Canada Department of Medical Imaging University of Toronto 263 McCaul St. TorontoONM5T 1W7 Canada Department of Mechanical and Industrial Engineering University of Toronto 5 King's College Road TorontoONM5S 3G8 Canada Institute of Diagnostic and Interventional Neuroradiology University Hospital Augsburg Stenglinstraße 2 Augsburg86156 Germany

Medical image analysis has significantly benefited from advancements in deep learning, particularly in the application of Generative Adversarial Networks (GANs) for generating realistic and diverse images that can augment training datasets. The common GAN-based approach is to generate entire image volumes, rather than the region of interest (ROI). Research on deep learning-based brain tumor classification using MRI has shown that it is easier to classify the tumor ROIs compared to the entire image volumes. In this work, we present a novel framework that uses vector-quantization GAN and a transformer incorporating masked token modeling to generate high-resolution and diverse 3D brain tumor ROIs that can be used as additional data for tumor ROI classification. We apply our method to two imbalanced datasets where we augment the minority class: (1) low-grade glioma (LGG) ROIs from the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2019 dataset;(2) BRAF V600E Mutation genetic marker tumor ROIs from the internal pediatric LGG (pLGG) dataset. We show that the proposed method outperforms various baseline models qualitatively and quantitatively. The generated data was used to balance the data to classify brain tumor types. Our approach demonstrates superior performance, surpassing baseline models by 6.4% in the area under the ROC curve (AUC) on the BraTS 2019 dataset and 4.3% in the AUC on the internal pLGG dataset. The results indicate the generated tumor ROIs can effectively address the imbalanced data problem. Our proposed method has the potential to facilitate an accurate diagnosis of rare brain tumors using MRI scans. © 2024

关键词： Generative adversarial networks

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Unraveling the Orbital Physics in a Canonical Orbital System KCuF3

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physical Review Letters 2021年第10期126卷 106401-106401页

作者： Jiemin Li Lei Xu Mirian Garcia-Fernandez Abhishek Nag H. C. Robarts A. C. Walters X. Liu Jianshi Zhou Krzysztof Wohlfeld Jeroen van den Brink Hong Ding Ke-Jin Zhou Diamond Light Source Harwell Campus Didcot OX11 0DE United Kingdom Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China Institute for Theoretical Solid State Physics IFW Dresden Helmholtzstrasse 20 D-01069 Dresden Germany H. H. Wills Physics Laboratory University of Bristol Bristol BS8 1TL United Kingdom School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China The Materials Science and Engineering Program Mechanical Engineering University of Texas at Austin Austin Texas 78712 USA Institute of Theoretical Physics Faculty of Physics University of Warsaw Pasteura 5 PL-02093 Warsaw Poland Institute for Theoretical Physics and Würzburg-Dresden Cluster of Excellence ct.qmat TU Dresden 01069 Dresden Germany

We explore the existence of the collective orbital excitations, orbitons, in the canonical orbital system KCuF3 using the Cu L3-edge resonant inelastic x-ray scattering. We show that the nondispersive high-energy peaks result from the Cu2+ dd orbital excitations. These high-energy modes display good agreement with the ab initio quantum chemistry calculation, indicating that the dd excitations are highly localized. At the same time, the low-energy excitations present clear dispersion. They match extremely well with the two-spinon continuum following the comparison with Müller ansatz calculations. The localized dd excitations and the observation of the strongly dispersive magnetic excitations suggest that the orbiton dispersion is below the resolution detection limit. Our results can reconcile with the strong local Jahn-Teller effect in KCuF3, which predominantly drives orbital ordering.

关键词： Orbital order Mott insulators Crystal-field theory Resonant inelastic x-ray scattering

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Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials

SSRN

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SSRN 2025年

作者： Saarimäki, Laura Aliisa Fratello, Michele del Giudice, Giusy Di Lieto, Emanuele Afantitis, Antreas Alenius, Harri Chiavazzo, Eliodoro Gulumian, Mary Karisola, Piia Lynch, Iseult Mancardi, Giulia Melagraki, Georgia Netti, Paolo A. Papadiamantis, Anastasios G. Peijnenburg, Willie Santos, Hélder A. Serchi, Tommaso Shahbazi, Mohammad-Ali Stoeger, Tobias Valsami-Jones, Eugenia Vivo, Paola Vrček, Ivana Vinković Vogel, Ulla Wick, Peter Winkler, David A. Serra, Angela Greco, Dario Faculty of Medicine and Health Technology Tampere University Tampere33520 Finland Division of Pharmaceutical Biosciences Faculty of Pharmacy University of Helsinki Helsinki00790 Finland NovaMechanics Ltd Nicosia Cyprus Institute of Environmental Medicine Karolinska Institutet Stockholm171 77 Sweden Research Program Medical Faculty University of Helsinki Helsinki00290 Finland Politecnico di Torino Corso Duca degli Abruzzi 24 Torino10129 Italy National Institute for Occupational Health National Health Laboratory Services Johannesburg South Africa School of Geography Earth and Environmental Sciences University of Birmingham Birmingham United Kingdom Division of Physical Sciences and Applications Hellenic Military Academy Vari Greece Interdisciplinary Research Centre on Biomaterials-CRIB University of Napoli Federico II P.le Tecchio 80 Napoli80125 Italy Institute of Environmental Sciences Leiden University Leiden Netherlands National Institute of Public Health and the Environment Center for Safety of Products and Substances Bilthoven Netherlands University of Groningen Groningen Netherlands Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki Finland Luxembourg Institute of Science and Technology 5 Avenue des Hauts Fourneaux Eschsur-Alzette4362 Luxembourg Munich Germany Solar Cells Faculty of Engineering and Natural Sciences Tampere University P.O. Box 541 TampereFI-33014 Finland Institute for Medical Research and Occupational Health Zagreb Croatia National Research Centre for the Working Environment Copenhagen ODK-2100 Denmark Lerchenfeldstrasse 5 St. Gallen9014 Switzerland La Trobe Institute of Molecular Science La Trobe University Bundoora3086 Australia Monash Institute of Pharmaceutical Sciences Monash University Parkville3052 Australia School of Pharmacy University of Nottingham NottinghamNG7 2QL United Kingdom Tampere Institute for Advanced Study

The development of new approach methodologies (NAMs) to replace current in vivo testing for the safety assessment of engineered nanomaterials (ENMs) is hindered by the scarcity of validated experimental data for a broad range of ENMs. We introduce a framework to address this challenge by harnessing the collective expertise of professionals from multiple complementary and related fields (‘wisdom of crowds’ or WoC). By integrating expert insights, we aim to fill data gaps and generate consensus concern scores for diverse ENMs, thereby enhancing the predictive power of nanosafety computational models. Our investigation reveals an alignment between expert opinion and experimental data, providing robust estimations of concern levels. Building upon these findings, we employ predictive machine learning models trained on the newly defined concern scores, ENM descriptors, and gene expression profiles, to quantify potential harm across various toxicity endpoints. These models further revealed key genes potentially involved in underlying toxicity mechanisms. Notably, genes associated with metal ion homeostasis, inflammation, and oxidative stress emerge as predictors of ENM toxicity across diverse endpoints. This study showcases the value of integrating expert knowledge and computational modeling to address the complexity of nanomaterial safety. Our work suggests that this interdisciplinary approach enhances the accuracy and efficiency of safety assessment in the rapidly evolving landscape of nanotechnology. © 2025, The Authors. All rights reserved.

关键词： Nanoclay

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Large-eddy simulation and modeling of Taylor-Couette ow with an outer stationary cylinder

arXiv

引用

arXiv 2019年

作者： Cheng, W. Pullin, D.I. Samtaney, R. Mechanical Engineering Physical Science and Engineering Division King AbdullahUniversity of Science and Technology Thuwal23955-6900 Saudi Arabia Graduate Aerospace Laboratories California Institute of Technology CA91125 United States

We present wall-resolved large-eddy simulations (LES) of the incompressible Navier-Stokes equations together with empirical modeling for turbulent Taylor-Couette (TC) ow where the inner cylinder is rotating with angular velocity i and the outer cylinder is stationary. With Ri;Ro the inner and outer radii respectively, the radius ratio is ν = 0:909. The subgrid-scale (SGS) stresses are represented using the stretched-vortex subgrid-scale model while the ow is resolved close to the wall. LES is implemented in the range Rei = 105-3 × 106where Rei = Ωi Ri d/Ν and d = Ro-Ri is the cylinder gap. It is shown that the LES can capture the salient features of the TC ow, including the quantitative behavior of span-wise Taylor rolls, the log-variation in the mean velocity profile and the angular momentum redistribution due to the presence of Taylor rolls. A simple empirical model of the turbulent, TC ow is developed consisting of near-wall, loglike turbulent wall layers separated by an annulus of constant angular momentum. The model is closed by a proposed scaling relation concerning the thickness of the wall layer on the inner cylinder. Model results include the Nusselt number Nu (torque required to maintain the ow) and various measures of the wall-layer thickness as a function of both the Taylor number Ta and ν. These agree reasonably with experimental measurements, direct numerical simulation (DNS) and the present LES over a range of both Ta and ν. In particular, the model shows that, at fixed ν Copyright © 2019, The Authors. All rights reserved.

关键词： Large eddy simulation

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Scaling and spatial intermittency of thermal dissipation in turbulent convection

arXiv

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arXiv 2019年

作者： Bhattacharya, Shashwat Samtaney, Ravi Verma, Mahendra K. Department of Mechanical Engineering Indian Institute of Technology Kanpur Kanpur208016 India Mechanical Engineering Division of Physical Science and Engineering King Abdullah University of Science and Technology Thuwal23955 Saudi Arabia Department of Physics Indian Institute of Technology Kanpur Kanpur208016 India

We derive scaling relations for the thermal dissipation rate in the bulk and in the boundary layers for moderate and large Prandtl number (Pr) convection. Using direct numerical simulations of Rayleigh-Bénard convection, we show that the thermal dissipation in the bulk is suppressed compared to passive scalar dissipation. The suppression is stronger for large Pr. We further show that the dissipation in the boundary layers dominates that in the bulk for both moderate and large Pr. The probability distribution functions (PDFs) of thermal dissipation rate, both in the bulk and in the boundary layers, are stretched exponential, similar to passive scalar dissipation. Copyright © 2019, The Authors. All rights reserved.

关键词： Boundary layers

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Corrigendum to "Enhanced defect annihilation capability of the graphene/copper interface: An in situ study" [Scripta Materialia 203 (2021) 114001]

引用

Scripta Materialia 2022年 211卷

作者： K.M. Yang P.Z. Tang Q. Zhang H.Y. Ma E.Q. Liu M. Li X. Zhang Jin Li Y. Liu T.X. Fan Reza Namakian State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 P.R. China Nuclear Science and Engineering Division Argonne National Laboratory Argonne Illinois 60439 United States School of Materials Engineering Purdue University West Lafayette IN 47907 United States Institute of Special Environments Physical Sciences Harbin Institute of Technology Shenzhen 518055 P.R. China Department of Mechanical & Industrial Engineering at Louisiana State University Baton Rouge LA 70803 United States

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Terahertz Cavity Phonon Polaritons in Lead Telluride in the Deep-Strong Coupling Regime

arXiv

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arXiv 2025年

作者： Baydin, Andrey Manjappa, Manukumara Mishra, Sobhan Subhra Xu, Hongjing Doumani, Jacques Tay, Fuyang Kim, Dasom Rappl, Paulo H.O. Abramof, Eduardo Singh, Ranjan Hernandez, Felix G.G. Kono, Junichiro Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Smalley–Curl Institute Rice University HoustonTX77005 United States Rice Advanced Materials Institute Rice University HoustonTX77005 United States Instrumentation and Applied Physics Department Indian Institute of Science Bangalore560012 India Center for Disruptive Photonic Technologies The Photonics Institute Nanyang Technological University 639798 Singapore Department of Physics and Astronomy Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley–Curl Institute Rice University HoustonTX77005 United States Group of Research and Development in Materials and Plasma National Institute for Space Research São José dos Campos São Paulo12201-970 Brazil Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore Instituto de Física Universidade de São Paulo São Paulo05508-090 Brazil Department of Material Science and NanoEngineering Rice University HoustonTX77005 United States

Lead telluride is an important thermoelectric material due to its large Seebeck coefficient combined with its unusually low thermal conductivity that is related to the strong anharmonicity of phonons in this material. Here, we have studied the resonant and nonperturbative coupling of transverse optical phonons in lead telluride with cavity photons inside small-mode-volume metallic metasurface cavities that have photonic modes with terahertz frequencies. We observed a giant vacuum Rabi splitting on the order of the bare phonon and cavity frequencies. Through terahertz time-domain spectroscopy experiments, we systematically studied the vacuum Rabi splitting as a function of sample thickness, temperature, and cavity length. Under the strongest light–matter coupling conditions, the strength of coupling exceeded the bare phonon and cavity frequencies, putting the system into the deep-strong coupling regime. These results demonstrate that this uniquely tunable platform is promising for realizing and understanding predicted cavity-vacuum-induced ferroelectric instabilities and exploring applications of light–matter coupling in the ultrastrong and deep-strong coupling regimes in quantum technology. Copyright © 2025, The Authors. All rights reserved.

关键词： Phonons

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Capturing 3D atomic defects and phonon localization at the 2D heterostructure interface

arXiv

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arXiv 2021年

作者： Tian, Xuezeng Yan, Xingxu Varnavides, Georgios Yuan, Yakun Kim, Dennis S. Ciccarino, Christopher J. Anikeeva, Polina Li, Ming-Yang Li, Lain-Jong Narang, Prineha Pan, Xiaoqing Miao, Jianwei Department of Physics & Astronomy California NanoSystems Institute University of California Los AngelesCA90095 United States Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing100190 China Department of Materials Science and Engineering University of California - Irvine IrvineCA92697 United States Irvine Materials Research Institute University of California - Irvine CA92697 United States Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA02138 United States Department of Materials Science and Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Research Laboratory of Electronics Massachusetts Institute of Technology CambridgeMA02139 United States Department of Chemistry and Chemical Biology Harvard University CambridgeMA02138 United States Physical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia Department of Mechanical Engineering University of Hong Kong Pokfulam Road Hong Kong Department of Physics and Astronomy University of California - Irvine IrvineCA92697 United States

The 3D local atomic structures and crystal defects at the interfaces of heterostructures control their electronic, magnetic, optical, catalytic and topological quantum properties, but have thus far eluded any direct experimental determination. Here we determine the 3D local atomic positions at the interface of a MoS2-WSe2 heterojunction with picometer precision and correlate 3D atomic defects with localized vibrational properties at the epitaxial interface. We observe point defects, bond distortion, atomic-scale ripples and measure the full 3D strain tensor at the heterointerface. By using the experimental 3D atomic coordinates as direct input to first principles calculations, we reveal new phonon modes localized at the interface, which are corroborated by spatially resolved electron energy-loss spectroscopy. We expect that this work will open the door to correlate structure-property relationships of a wide range of heterostructure interfaces at the single-atom level. Main Text: A major challenge in materials design and engineering is to tailor the 3D atomic structures at the interface to achieve the desired properties. Although 2D lateral and vertical heterostructures have been actively studied for fundamental interest and practical applications (1-9), our current understanding of the atomic structure at the heterointerface has been primarily relied on aberration-corrected electron microscopy and scanning probe microscopy (6-11), which provide either 2D projection images or surface structure. On the computational side, density functional theory (DFT) can be used to predict the properties of heterostructures (12-15), but requires knowledge of the 3D local atomic coordinates. Due to the difficulty in directly measuring these 3D coordinates, such studies often use perfect crystal lattices (12-14), statistically incorporate crystal defects into the interface (15), and relax the atomic configurations to the minimum energy states. However, real heterointerfaces have neit

关键词： Density functional theory

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Biotribology of the ageing skin—Why we should care

引用

Biotribology 2019年 17卷 75-90页

作者： Limbert, Georges Masen, Marc A. Pond, Damien Graham, Helen K. Sherratt, Michael J. Jobanputra, Rikeen McBride, Andrew National Centre for Advanced Tribology at Southampton (nCATS) Department of Mechanical Engineering Faculty of Engineering and Physical Sciences University of Southampton Southampton SO17 1BJ United Kingdom Bioengineering Science Research Group Department of Mechanical Engineering Faculty of Engineering and Physical Sciences University of Southampton Southampton SO17 1BJ United Kingdom Laboratory of Biomechanics and Mechanobiology Division of Biomedical Engineering Department of Human Biology Faculty of Health Sciences University of Cape Town Observatory 7935 South Africa Tribology Group Department of Mechanical Engineering Faculty of Engineering Imperial College London South Kensington Campus London SW7 2AZ United Kingdom Centre for Research in Computational and Applied Mechanics University of Cape Town Rondebosch 7701 South Africa Division of Musculoskeletal and Dermatological Sciences School of Biological Sciences Faculty of Biology Medicine and Health The University of Manchester Oxford Road Manchester M13 9PT United Kingdom Division of Cell Matrix Biology and Regenerative Medicine School of Biological Sciences Faculty of Biology Medicine and Health The University of Manchester Oxford Road Manchester M13 9PT United Kingdom Glasgow Computational Engineering Centre Division of Infrastructure and Environment School of Engineering University of Glasgow Glasgow G12 8QQ United Kingdom

Ageing of populations has emerged as one of the most pressing societal, economic and healthcare challenges currently facing most nations across the globe. The ageing process itself results in degradation of physiological functions and biophysical properties of organs and tissues, and more particularly those of the skin. Moreover, in both developed and emerging economies, population ageing parallels concerning increases in lifestyle-associated conditions such as Type 2 diabetes, obesity and skin cancers. When considered together, these demographic trends call for even greater urgency to find clinical and engineering solutions for the numerous age-related deficits in skin function. From a tribological perspective, detrimental alterations of skin biophysical properties with age have fundamental consequences on how one interacts with the body's inner and outer environments. This stems from the fact that, besides being the largest organ of the human body, and also nearly covering its entirety, the skin is a multifunctional interface which mediates these interactions. The aim of this paper is to present a focused review to discuss some of the consequences of skin ageing from the viewpoint of biotribology, and their implications on health, well-being and human activities. Current and future research questions/challenges associated with biotribology of the ageing skin are outlined. They provide the background and motivation for identifying future lines of research that could be taken up by the biotribology and biophysics communities. © 2019 Elsevier Ltd

关键词： Ageing Ageing Biotribology Friction Geriatrics Health mechanical properties Microstructure Pressure ulcer Skin Skin tear Tactile perception Well-being Wrinkle

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Performance of joint gamma-ray observations with MAGIC and LST-1 telescopes 38

Performance of joint gamma-ray observations with MAGIC and L...

引用

38th International Cosmic Ray Conference, ICRC 2023

作者： Di Pierro, F. Berti, A. de Menezes, R. Jobst, E. Ohtani, Y. Sitarek, J. Suda, Y. Visentin, E. Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. INFN Torino Via P. Giuria 1 Torino Italy Max-Planck-Institut für Physik Föhringer Ring 6 München Germany Università degli Studi di Torino Dipartimento di Fisica Via P. Giuria 1 Torino Italy University of Tokyo Institute for Cosmic Ray Research 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan University of Lodz Faculty of Physics and Applied Informatics ul. Pomorska 149-153 Lodz Poland Hiroshima University Physics Program Graduate School of Advanced Science and Engineering Hiroshima739-8526 Japan Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari

The prototype Large-Sized Telescope (LST-1) of the Cherenkov Telescope Array Observatory (CTAO) is in commissioning phase at the Observatorio del Roque de Los Muchachos at 2200 m a.s.l. in La Palma (Canary Islands, Spain). LST-1 is a 23-m diameter telescope and is the first of four that will compose the LST part of the CTAO Northern array. The LST subarray is optimized to provide the best sensitivity for gamma rays in the 20 GeV - 200 GeV energy range. The MAGIC telescopes, which are located approximately 100 m from the LST-1, is operating as a two 17-m telescope stereoscopic system for more than 14 years. LST-1 and MAGIC routinely perform joint observations of gamma-ray sources to exploit the potential of the three-telescope system. This contribution describes the analysis pipeline and evaluates the performance of the system using Monte Carlo simulations and data on the Crab Nebula. The sensitivity achieved during joint observations with MAGIC and LST-1 is about 30% higher than that of MAGIC alone. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Stereo image processing

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