检索结果-内蒙古大学图书馆

Author Correction: Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

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Nature communications 2021年第1期12卷 6827页

作者： Yong Suk Oh Jae-Hwan Kim Zhaoqian Xie Seokjoo Cho Hyeonseok Han Sung Woo Jeon Minsu Park Myeong Namkoong Raudel Avila Zhen Song Sung-Uk Lee Kabseok Ko Jungyup Lee Je-Sang Lee Weon Gi Min Byeong-Ju Lee Myungwoo Choi Ha Uk Chung Jongwon Kim Mengdi Han Jahyun Koo Yeon Sik Choi Sung Soo Kwak Sung Bong Kim Jeonghyun Kim Jungil Choi Chang-Mo Kang Jong Uk Kim Kyeongha Kwon Sang Min Won Janice Mihyun Baek Yujin Lee So Young Kim Wei Lu Abraham Vazquez-Guardado Hyoyoung Jeong Hanjun Ryu Geumbee Lee Kyuyoung Kim Seunghwan Kim Min Seong Kim Jungrak Choi Dong Yun Choi Quansan Yang Hangbo Zhao Wubin Bai Hokyung Jang Yongjoon Yu Jaeman Lim Xu Guo Bong Hoon Kim Seokwoo Jeon Charles Davies Anthony Banks Hyung Jin Sung Yonggang Huang Inkyu Park John A Rogers Center for Bio-Integrated Electronics Northwestern University Evanston IL USA. Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Daejeon Republic of Korea. Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana IL USA. Department of Materials Science and Engineering University of Illinois at Urbana Champaign Urbana IL USA. Querrey Simpson Institute for Bioelectronics Northwestern University Evanston IL USA. State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Dalian People's Republic of China. Ningbo Institute of Dalian University of Technology Ningbo People's Republic of China. Department of Biomedical Engineering Texas A&M University College Station TX USA. Department of Mechanical Engineering Northwestern University Evanston IL USA. Advanced 3D Printing Technology Development Division Korea Atomic Energy Research Institute Daejeon Republic of Korea. Qualcomm Institute La Jolla CA USA. Sibel Health Inc Niles IL USA. Department of Rehabilitation Medicine Gimhae Hansol Rehabilitation & Convalescent Hospital Gimhae Republic of Korea. Department of Planning and Development Gimhae Hansol Rehabilitation & Convalescent Hospital Gimhae Republic of Korea. Department of Rehabilitation Medicine Pusan national university hospital Busan Republic of Korea. Department of Materials Science and Engineering KAIST Institute for The Nanocentury (KINC) Korea Advanced Institute of Science and Technology Daejeon Republic of Korea. Department of Materials Science and Engineering Northwestern University Evanston IL USA. Department of Mechanical Engineering Kyung Hee University Yongin Republic of Korea. Department of Biomedical Engineering College of Future Technology Peking University Beijing People's Republic of China. School of Biomedical Engineering Korea University Seoul Republic of Korea. Interdisci

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Rules all PIs should follow

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science (New York, N.Y.) 2022年第6588期376卷 24-26页

作者： Jennifer S Chen Chih Ying Huang Shantanu Lanke Michael Sanjay Fernandopulle Yongsheng Ji Yuan Zhi Sara Granado Rodríguez Andrea Y Frommel Martin Lukačišin Yida Zhang Christina N Zdenek Xiao-Yu Wu Senthilkumar Seenuvasaragavan Yan Zhuang Cathrine Bergh Jaime Coulbois Salam Salloum-Asfar Bo Cao Katherine Davis Fernanda Oda Nikos Konstantinides Liping Zhang Divyansh Agarwal Joseph Nicholas Rainaldi Jan Kadlec Jelle Vekeman Vishal Anirudh Kanigicherla Kathryn Oi Kyle J Isaacson Rakesh Ganji Emma Dawson-Glass Yale School of Medicine New Haven CT 06510 USA. Department of Physics National Cheng Kung University Tainan 70101 Taiwan (Republic of China). Maharashtra 422101 India. Medical Scientist Training Program Northwestern University Feinberg School of Medicine Chicago IL 60611 USA. Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230026 China. School of Economics Guizhou University Guiyang Guizhou 550025 China. Department of Biology Universidad Autónoma de Madrid Madrid Madrid 28049 Spain. Faculty of Land and Food Systems University of British Columbia Vancouver BC V6T 1Z4 Canada. Faculty of Medicine Technion Haifa 3525433 Israel. Department of Biomedical Informatics Harvard University Brookline MA 02445 USA. School of Biological Sciences The University of Queensland St Lucia QLD 4072 Australia. Department of Mechanical and Mechatronics Engineering University of Waterloo Waterloo ON N2L 3G1 Canada. Mumbai 400076 India. Peking-Tsinghua Center for Life Sciences Peking University Beijing 100871 China. KTH Royal Institute of Technology 11428 Stockholm Sweden. Departamento de Ciencia Política y Relaciones Internacionales Universidad Autónoma de Madrid Ciudad Universitaria de Cantoblanco Madrid Spain. Qatar Biomedical Research Institute Hamad Bin Khalifa University Qatar Foundation Doha Qatar. Core Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an Shaanxi 710004 China. Imperial College London London UK. Department of Applied Behavioral Science University of Kansas Lawrence KS 66045 USA. Université Paris Cité Centre National de la Recherche Scientifique Institut Jacques Monod F-75013 Paris France. Department of Mechanical and Energy Engineering Southern University of Science and Technology Shenzhen Guangdong 518055 China. Harvard Medical School Massachusetts General Hospital Boston MA 02114 USA. Department of Biomedical Science University of Calif

We asked young scientists to write a rule that all principal investigators (PIs) should be required to follow to improve the experience of young scientists in their lab. Read a selection of their suggestions below. Fo...

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Corrigendum to "NH2-MIL-125(Ti) doped CdS/Graphene composite as electro and photo catalyst in basic medium under light irradiation" [Environ. Res. 200 (September 2021) 111719]

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Environmental research 2022年第PT A期204卷 112028页

作者： Ravi Nivetha Kannan Gothandapani Vimala Raghavan George Jacob Raja Sellapan A M Kannan Sudhagar Pitchaimuthu Saravanan Pandiaraj Aljawhara H Almuqrin Abdullah Alodhayb Muthumareeswaran Muthuramamoorthy Quyet Van Le Soon Kwan Jeong Andrews Nirmala Grace Centre for Nanotechnology Research Vellore Institute of Technology Vellore Tamil Nadu India. Ira A. Fulton Schools of Engineering Arizona State University USA. Research Centre for Carbon Solutions Institute of Mechanical Processing and Energy Engineering School of Engineering & Physical Sciences Heriot-Watt University Edinburgh EH14 4AS United Kingdom. Department of Self Development Skills CFY Deanship King Saud University Riyadh Saudi Arabia. Department of Physics College of Science Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia. Department of Physics and Astronomy College of Science King Saud University Riyadh 11451 Saudi Arabia. College of Science King Saud University Riyadh 11451 Saudi Arabia. Institute of Research and Development Duy Tan University Da Nang 550000 Viet Nam. Climate Change Technology Research Division Korea Institute of Energy Research Yuseong-gu Daejeon 305-343 South Korea. Electronic address: jeongsk@kier.re.kr. Centre for Nanotechnology Research Vellore Institute of Technology Vellore Tamil Nadu India. Electronic address: anirmalagladys@***.

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Commentaries on Viewpoint: Using V̇o2max as a marker of training status in athletes - can we do better?

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Journal of applied physiology (Bethesda, Md. : 1985) 2022年第1期133卷 148-164页

作者： Pedro L Valenzuela Manuel Mateo-March Xabier Muriel Mikel Zabala Alejandro Lucia David Barranco-Gil Grégoire P Millet Franck Brocherie Johannes Burtscher Martin Burtscher Benjamin J Ryan Rachel A Gioscia-Ryan Stephane Perrey Víctor Rodrigo-Carranza Fernando González-Mohíno José María González-Ravé Jordan Santos-Concejero Benedito S Denadai Camila C Greco Arturo Casado Carl Foster Raffaele Mazzolari Giulia Nicole Baldrighi Elisa Pastorio Davide Malatesta Aurélien Patoz Fabio Borrani Stephen J Ives Justin A DeBlauw Ricardo Dantas de Lucas Fernando Klitzke Borszcz Eduardo Marcel Fernandes Nascimento Luiz Guilherme Antonacci Guglielmo Tiago Turnes Richard T Jaspers Stephan van der Zwaard Romuald Lepers Julien Louis Anderson Meireles Hiago L. R. de Souza Géssyca T de Oliveira Marcelo P dos Santos Rhaí A Arriel Moacir Marocolo B Hunter S Meyler D Muniz-Pumares Renato M Ferreira Abigail S Sogard Stephen J Carter Timothy D Mickleborough Guilherme Pereira Saborosa Raphael Dinalli de Oliveira Freitas Paula Souza Alves dos Santos João Pedro de Souza Ferreira Francisco de Assis Manoel Sandro Fernandes da Silva Christoph Triska Bettina Karsten Dajo Sanders Elliot S Lipksi David J Spindler Matthijs K. C. Hesselink Rodrigo Zacca Márcio Fagundes Goethel David Bruce Pyne Brayden M Wood Peyton E Allen Jaden L Gabelhausen Alexandra M Keller Mast T Lige Alicia S Oumsang Greg L Smart Hunter L Paris Arthur H Dewolf Guillaume Toffoli Borja Martinez-Gonzalez Samuele M Marcora Daniela Terson de Paleville Ricardo J Fernandes Susana M Soares J. Arturo Abraldes Guilherme Matta Arthur Henrique Bossi D G McCarthy W Bostad J Gibala Mary Vagula Grupo de Investigación en Actividad física y Salud (PaHerg) Instituto de Investigación Hospital 12 de Octubre (imas12) Madrid Spain Faculty of Sport Sciences Universidad Europea de Madrid Madrid Spain Sport Science Department. Universidad Miguel Hernández Elche Spain Human Performance and Sports Science Laboratory Faculty of Sport Sciences University of Murcia Murcia Spain Department of Physical Education & Sport Faculty of Sport Sciences University of Granada Granada Spain Institute of Sport Sciences University of Lausanne Lausanne Switzerland Laboratory Sport Expertise and Performance (EA 7370) French Institute of Sport (INSEP) Paris France Department of Sport Science University of Innsbruck Innsbruck Austria Thermal and Mountain Medicine Division US Army Research Institute of Environmental Medicine Natick Massachusetts Department of Anesthesiology University of Michigan Ann Arbor Michigan EuroMov Digital Health in Motion University of Montpellier Montpellier France Sport Training Lab University of Castilla-La Mancha Toledo Spain Facultad de Ciencias de la Vida y de la Naturaleza Universidad Nebrija Madrid Spain Department of Physical Education and Sport University of the Basque Country UPV/EHU Vitoria-Gasteiz Spain Human Performance Laboratory São Paulo State University Rio Claro Brazil Center for Sport Studies Rey Juan Carlos University Madrid Spain University of Wisconsin-La Crosse La Crosse Wisconsin Department of Physical Education and Sport University of the Basque Country (UPV/EHU) Vitoria-Gasteiz Spain Department of Molecular Medicine University of Pavia Pavia Italy Department of Brain and Behavioural Sciences − Medical and Genomic Statistics Unit University of Pavia Pavia Italy Department of Biomedical Sciences for Health University of Milan Milan Italy Institute of Sport Sciences of University of Lausanne (ISSUL) University of Lausanne Lausanne Switzerland Health and Human Physiological Sciences Skidmore College Saratoga Springs New

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An Observation Data Driven Simulation and Analysis Framework for Early Stage <i>C. elegans</i>Embryogenesis

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Journal of Biomedical science and engineering 2018年第8期11卷 225-234页

作者： Dali Wang Zi Wang Xiaopeng Zhao Yichi Xu Zhirong Bao Department of Electric Engineering and Computer Science University of Tennessee Knoxville USA Environmental Science Division Oak Ridge National Laboratory Oak Ridge USA Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee Knoxville USA Developmental Biology Program Memorial Sloan Kettering Cancer Center NYC USA

Recent developments in cutting-edge live microscopy and image analysis provide a unique opportunity to systematically investigate individual cell’s dynamics as well as simulation-based hypothesis testing. After a summary of data generation and analysis in the observation and modeling efforts related to C. elegans embryogenesis, we develop a systematic approach to model the basic behaviors of individual cells. Next, we present our ideas to model cell fate, division, and movement using 3D time-lapse images within an agent-based modeling framework. Then, we summarize preliminary result and discuss efforts in cell fate, division, and movement modeling. Finally, we discuss the ongoing efforts and future directions for C. elegans embryo modeling, including an inferred developmental landscape for cell fate, a quasi-equilibrium model for cell division, and multi-agent, deep reinforcement learning for cell movement.

关键词： C. elegans Embryogenesis Agent-Based Modeling Deep Reinforcement Learning Observation-Driven Modeling Framework 3D Live Images

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Author Correction: Multidimensional nanoscopic chiroptics

Nature Reviews Physics

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Nature Reviews Physics 2022年 138页

作者： Yang Chen Qing Zhang Cheng-Wei Qiu Wei Du Oscar Ávalos-Ovando Alexander O. Govorov Jing Wu Qing-Hua Xu Na Liu Hiromi Okamoto Qihua Xiong Department of Electrical and Computer Engineering National University of Singapore Singapore Singapore CAS Key Laboratory of Mechanical Behaviour and Design of Materials Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore Singapore Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University Suzhou China Department of Physics and Astronomy Ohio University Athens OH USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu China Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR) Singapore Singapore Department of Chemistry National University of Singapore Singapore Singapore 2nd Physics Institute University of Stuttgart Stuttgart Germany Max Planck Institute for Solid State Research Stuttgart Germany Institute for Molecular Science and the Graduate University for Advanced Studies (SOKENDAI) Okazaki Aichi Japan State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University Beijing China Beijing Academy of Quantum Information Sciences (BAQIS) Beijing China

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LST-1 observations of an enormous flare of BL Lacertae in 2021

arXiv

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arXiv 2023年

作者： Nozaki, Seiya Asano, Katsuaki Escudero, Juan Emery, Gabriel Priyadarshi, Chaitanya Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Crespo, N. Alvarez Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Larriva, A. Baquero Baroncelli, L. de Almeida, U. Barres Barrio, J.A. Batkovic, I. Baxter, J. González, J. Becerra Bernardini, E. Bernardos, M.I. Medrano, J. Bernete Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Lavergne, M. de Bony De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Mengual, J. Delgado della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ramazani, V. Fallah Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Coromina, L. Freixas Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. López, R. Garcia Gasbarra, C. Gasparrini, D. Geyer, D. Paiva, J. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Llorente, J. Herrera Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Martinez, I. Jimenez Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Aix Marseille Univ CNRS IN2P3 CPPM Marseille France The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain P

The first prototype of LST (LST-1) for the Cherenkov Telescope Array has been in commissioning phase since 2018 and already started scientific observations with the low energy threshold around a few tens of GeV. In 2021, LST-1 observed BL Lac following the alerts based on multi-wavelength observations and detected prominent gamma-ray flares. In addition to the daily flux variability, LST-1 also detected sub-hour-scale intra-night variability reaching 3–4 times higher than the gamma-ray flux from the Crab Nebula above 100 GeV. In this proceeding, we will report the analysis results of LST-1 observations of BL Lac in 2021, especially focusing on flux variability. © 2023, CC BY.

关键词： Gamma rays

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In-situ TEM Heating Experiment to Study Effects of Cyclic Thermal Gradients on Ti-6Al-4V under Additive Manufacturing Growth Conditions

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Microscopy and Microanalysis 2018年第S1期24卷 1932-1933页

作者： Meiyue Shao Cheng-Han Li Curtis L. Frederick Sudarsanam S. Babu Joerg R. Jinschek Department of Material Science and Engineering The Ohio State University Columbus OH. Department of Material Science and Engineering University of Tennessee Knoxville TN. Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee Knoxville TN. Advanced Manufacturing Program Energy and Environmental Sciences Division Oak Ridge National Laboratory Knoxville TN.

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The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma

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Cellular oncology (Dordrecht, Netherlands) 2023年第4期46卷 933-951页

作者： Ti-Chun Chan Cheng-Tang Pan Hsin-Yu Hsieh Pichpisith Pierre Vejvisithsakul Ren-Jie Wei Bi-Wen Yeh Wen-Jeng Wu Lih-Ren Chen Meng-Shin Shiao Chien-Feng Li Yow-Ling Shiue Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. Institute of Precision Medicine College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Mechanical and Electro-Mechanical Engineering National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Advanced Semiconductor Packaging and Testing College of Semiconductor and Advanced Technology Research National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Biomedical Sciences College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Program in Translational Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Pathology Kaohsiung Armed Forces General Hospital Kaohsiung 80284 Taiwan. Institute of Medical Science and Technology School of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Medical Laboratory Sciences and Biotechnology Fooyin University Kaohsiung 83102 Taiwan. Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Department of Urology Kaohsiung Medical University Hospital Kaohsiung 80708 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan. Division of Physiology Livestock Research Institute Tainan 71246 Taiwan. Research Center Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. Institute of Precision Medicine College of Medicine Nat

PURPOSE:Urothelial carcinoma (UC) is a common disease in developed counties. This study aimed to identify autocrine roles and signaling pathways of gremlin 1, DAN family BMP antagonist (GREM1), which inhibits tumor growth and epithelial-mesenchymal transition (EMT) in UC. METHODS:Systematic in vitro and in vivo studies using genetic engineering, different urinary bladder urothelial carcinoma (UBUC)-derived cell lines, and mouse models were performed, respectively. Further, primary upper tract urothelial carcinoma (UTUC) and UBUC specimens were evaluated by immunohistochemistry. RESULTS:GREM1 protein levels conferred better disease-specific and metastasis-free survival rates and played an independent prognostic factor in UTUC and UBUC. Hypermethylation is the primary cause of low GREM1 levels. In different UBUC-derived cell lines, the autocrine/secreted and glycosylated GREM1 interacted with transforming growth factor beta 1 (TGFB1) and inhibited TGFβ/BMP/SMAD signaling and myosin light chain 9 (MYL9) transactivation, subsequently cell proliferation and epithelial-mesenchymal transition (EMT). Secreted and glycosylated GREM1 also suppressed tumor growth, metastasis, and MYL9 levels in the mouse model. Instead, cytosolic GREM1 promoted cell proliferation and EMT by activating the tumor necrosis factor (TNF)/AKT/nuclear factor kappa B (NFκB) axis. CONCLUSIONS:Clinical associations, animal models, and in vitro indications provided solid evidence to show that the epithelial autocrine GREM1 is a novel tumor suppressor in UCs. The glycosylated-GREM1 hampered cell proliferation, migration, invasion, and in vitro angiogenesis through interaction with TGFB1 to inactivate TGFβ/BMP/SMAD-mediated EMT in an autocrine manner.

关键词： Autocrine Epithelial-mesenchymal transition GREM1 TGFβ Urothelial carcinoma

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Generative adversarial networks for weakly supervised generation and evaluation of brain tumor segmentations on MR images

arXiv

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arXiv 2022年

作者： Yoo, Jay J. Namdar, Khashayar Wagner, Matthias W. Nobre, Liana Tabori, Uri Hawkins, Cynthia Ertl-Wagner, Birgit B. Khalvati, Farzad Institute of Medical Science University of Toronto TorontoM5S 1A8 Canada Department of Diagnostic Imaging Research Institute The Hospital for Sick Children TorontoM5G 1X8 Canada Department of Medical Imaging University of Toronto TorontoM5S 1A8 Canada Department of Computer Science University of Toronto TorontoM5S 1A8 Canada Department of Mechanical and Industrial Engineering University of Toronto TorontoM5S 1A8 Canada Vector Institute TorontoM5G 1M1 Canada The Arthur and Sonia Labatt Brain Tumor Research Centre The Hospital for Sick Children TorontoM5G 1X8 Canada Division of Hematology/Oncology The Hospital for Sick Children TorontoM5G 1X8 Canada Developmental and Stem Cell Biology Program The Hospital for Sick Children TorontoM5G 1X8 Canada Department of Medical Biophysics University of Toronto TorontoM5S 1A8 Canada Department of Laboratory Medicine and Pathobiology TorontoM5S 1A8 Canada Department of Paediatric Laboratory Medicine The Hospital for Sick Children TorontoM5G 1X8 Canada

Segmentation of regions of interest (ROIs) for identifying abnormalities is a leading problem in medical imaging. Using machine learning for this problem generally requires manually annotated ground-truth segmentations, demanding extensive time and resources from radiologists. This work presents a weakly supervised approach that utilizes binary image-level labels, which are much simpler to acquire, to effectively segment anomalies in 2D magnetic resonance images without ground truth annotations. We train a generative adversarial network (GAN) that converts cancerous images to healthy variants, which are used along with localization seeds as priors to generate improved weakly supervised segmentations. The non-cancerous variants can also be used to evaluate the segmentations in a weakly supervised fashion, which allows for the most effective segmentations to be identified and then applied to downstream clinical classification tasks. On the Multimodal Brain Tumor Segmentation (BraTS) 2020 dataset, our proposed method generates and identifies segmentations that achieve test Dice coefficients of 83.91%. Using these segmentations for pathology classification results with a test AUC of 93.32% which is comparable to the test AUC of 95.80% achieved when using true segmentations. Copyright © 2022, The Authors. All rights reserved.

关键词： Generative adversarial networks

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