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Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins

医用生物力学 2013年第S1期28卷 69-71页

作者： Jihye Seong Arash Tajik Jie Sun Jun-Lin Guan Martin J.Humphries Susan E.Craig Asha Shekaran Andrs J.García Ning Wang Yingxiao Wang Neuroscience Program University of Illinois Department of Mechanical Science and Engineering University of Illinois Department of Bioengineering & Beckman Institute for Advanced Science and Technology University of Illinois Division of Molecular Medicine and Genetics Departments of Internal Medicine and Cell & DevelopmentalBiologyUniversity of Michigan Medical School Wellcome Trust Centre for Cell-Matrix Research Faculty of Life SciencesUniversity of Manchester Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Department of Biomedical Engineering School of Life Science and TechnologyHuazhong University of Science and Technology Department of Integrative and Molecular Physiology Center for Biophysics and Computational BiologyInstitute for Genomic BiologyUniversity of Illinois Department of Bioengineering University of California

Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,***[1-3].Focal adhesions are the major sites of interaction between a cell and... 详细信息

Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,***^[1-3].Focal adhesions are the major sites of interaction between a cell and its extracellular matrix（ECM）microenvironment,thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor *** particular,it has been shown that matrix elasticity can control the cell fate^[4]by modulating the interactions between ECM proteins and their receptor integrins^[5,6].For example,different rigidity of polyacrylamide（PA）gels can lead to different density of ECM ancho-

关键词： integrin converting transmembrane biochemical modulating elasticity rigidity polyacrylamide outside purchased

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Abstracts from the Food Allergy and Anaphylaxis Meeting 2016 Abstracts

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CLINICAL AND TRANSLATIONAL ALLERGY 2017年第SUPPL 1期7卷 10-10页

作者： [Anonymous] Department of Pediatrics Children’s Hospital Roubaix France Division of Pulmonology and Allergology Department of Pediatrics Faculty of Medicine and Children’s Hospital Lille France Allergy Vigilance Network Vandoeuvre les Nancy France Université Lille 2 CHU Lille EA 2694 - Santé Publique: épidémiologie et qualité des soins Lille France Biostatistics Unit Maison Régionale de la Recherche Clinique CHRU Lille Lille France Department of Allergology Emile Durkheim Hospital Epinal France Centre d’Epidémiologie sur les Causes Médicales de Décès INSERM CHU de Bicêtre Le Kremlin-Bicêtre France The Allergy Vigilance Network University Hospital Nancy Nancy France Pediatric Pulmonology and Allergy Department Hôpital Jeanne de Flandre CHU Lille Lille France Charité - Universitätsmedizin Berlin Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Berlin Germany Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité – Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergy Allergie-Centrum-Charité Charité-Universiätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité Universitätsmedizin Berlin Berlin Germany University Hospital Basel Basel Switzerland Allergy Unit Department of Dermatology University Hospital Basel Switzerland Universitätsklinikum Salzburg Salzburg Austria Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark Odense University Hospital Odense Denmark Serviço de ImunoalergologiaCentro Hospitalar de São João E.P.E. Porto Portugal GRIAC Research Institute University of Groningen University Medical Center Groningen Groningen The Netherlands Serviço de Imunoalergologia Centr

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Graphene Oxide: Poly(Acrylic Acid)-Capped and Dye-Loaded Graphene Oxide-Mesoporous Silica: A Nano-Sandwich for Two-Photon and Photoacoustic Dual-Mode Imaging (Part. Part. Syst. Charact. 10/2014)

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Particle & Particle Systems Characterization 2014年第10期31卷

作者： Kim Truc Nguyen Sivaramapanicker Sreejith James Joseph Tingchao He Parijat Borah Eng You Guan Sun Woh Lye Handong Sun Yanli Zhao Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link 637371 Singapore Centre for Optical and Laser Engineering (COLE) School of Mechanical and Aerospace Engineering Nanyang Technological University 50 Nanyang Avenue 639798 Singapore Division of Physics and Applied Physics Centre for Disruptive Photonic Technologies (CDPT) School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link 637371 Singapore School of Materials Science and Engineering Nanyang Technological University 639798 Singapore

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Impact response measurement of contact lenses 5

Impact response measurement of contact lenses

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5th International Conference on Advanced Micro-Device engineering, AMDE 2013

作者： Watanabe, Kazuhide Miyashita, Naoki Bin, Du Hong Irisa, Kyohei Takita, Akihiro Yamaguchi, Takao Carcasona, Edwin Mitatha, Somsak Fujii, Yusaku Education Program of Electronics and Infomatics Mathematics and Physics Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Department of Electronics Faculty of Engineering Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Education Program of Mechanical Science and Technology School of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Department of Electronics Graduate School of Engineering Gunma University 1-5-1 Tenjin-cho Kiryu376-8515 Japan Division of Mechanical Science and Technology Faculty of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Department of Mechanical Engineering University of San Carlos Cebu City230-0100 Philippines Hybrid Computing Research Laboratory School of Computer Engineering Faculty of Engineering King Mongkut's Institute of Technology Ladkrabang Chalongkrung Road Bangkok Thailand

ISBN: (纸本)9783038354659

Impact response of contact lenses is measured using the Levitation Mass Method (LMM). In the LMM, a small mass collides with contact lenses and the impact force is measured with high accuracy as the inertial force of the moving part. A pneumatic linear bearing is used to achieve linear motion with sufficiently small friction acting on the moving part. Hysteresis loop and consumed energy as mechanical characteristics of contact lenses are also calculated.. © (2015) Trans Tech Publications, Switzerland.

关键词： Contact lenses

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11th German Conference on Chemoinformatics (GCC 2015) Abstracts

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JOURNAL OF CHEMINFORMATICS 2016年第SUPPL 1期8卷 1-27页

作者： [Anonymous] GDCh-CIC Division Associated Board Member Beilstein-Institut zur Förderung der Chemischen Wissenschaften Trakehner Str. 7-9 60487 Frankfurt Germany. ufechner@beilstein-institut.de. Division Medicinal Chemistry Amsterdam Institute for Molecules Medicines and Systems (AIMMS) VU University Amsterdam The Netherlands. Centre for Bioinformatics Uni Hamburg Bundesstr. 43 20146 Hamburg Germany. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. stefan.guessregen@***. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. GlaxoSmithKline Stevenage SG1 2NY UK. nicola.j.richmond@***. Discngine Paris 75011 France. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. marwin.segler@wwu.de. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. Bundeskriminalamt Wiesbaden Central Analytics II 65173 Wiesbaden Germany. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. shea@chem.ucsb.edu. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. Chemistry Department Ludwig-Maximilians-Universität München Butenandtstr. 7 81377 Munich Germany. Inorganic Chemistry and Center for Nanointegration University of Duisburg-Essen Essen Germany. CAM-D Technologies Essen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. achim.zielesny@w-hs.de. Leiden University Leiden Netherlands. j.fraaije@chem.leidenuniv.nl. Culgi BV Berlin Germany. Physikalische Chemie III TU Dortmund 44227 Dortmund Germany. stefan.kast@tu-dortmund.de. Centre for Molecular Informatics Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW United Kingdom. kcb27@cam.ac.uk. Centre for Molecular Informatics Department of Chemistry

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Comparison between PFC and PID Control System for Tendon-driven Balloon Actuator

Comparison between PFC and PID Control System for Tendon-dri...

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Annual Conference of the IEEE Industrial Electronics Society

作者： Jun-ya Nagase Kazuki Hamada Norihiko Saga Toshiyuki Satoh Koichi Suzumori Department of Mechanical and Systems Engineering Ryukoku University Department of Human System Interaction Kwansei Gakuin University Department of Machine Intelligence and Systems Engineering Akita Prefectural University Division of Manufacturing System and Physical Science Okayama University

ISBN: (纸本)9781479902255

In recent years, Japanese society has been aging, engendering a labor shortage of young workers. For a robot that is often in contact with people and which must provide safety and flexibility in nursing and welfare, the development of a soft, lightweight, and compact actuator has been sought. Particularly robots that are intended for use in the field of medical care and welfare should be safe when functioning around humans because they often come into contact with people. Therefore, a tendon-driven balloon actuator (balloon actuator) has been developed for a robot hand to be used in such environments. For this study, we developed a stroke control system for a balloon actuator using a predictive functional control (PFC). Predictive functional control is one model based on a predictive control (MPC) scheme, which predicts the future outputs of the actual plant over the prediction horizon and computes the control effort over the control horizon at every sampling instance. This paper reports the PFC control performance of the balloon actuator. We compared the control performance for the actuator with that of a PFC and PID control system.

关键词： Predictive functional control Pneumatic balloon Tendon-driven system Soft actuator

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High temperature ferromagnetic ordering in c-axis orientedZnO:Mnnanoparticle thin films by tailoring substrate temperature

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International Journal of Modern Physics: Conference Series 2014年第32期ijmpcs卷

作者： Usman Ilyas P. Lee T. L. Tan R. V. Ramanujan Sam Zhang R. Chen H. D. Sun R. S. Rawat National Institute of Education Nanyang Technological University 1 Nanyang Walk 637616 Singapore Department of Physics University of Engineering & Technology Lahore 54890 Pakistan School of Material Science and Engineering Nanyang Technological University 639798 Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University 639798 Singapore Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link 637371 Singapore

This study reports the enhanced ferromagnetic ordering in ZnO:Mn nanoparticle thin films, grown at different substrate temperatures using pulsed laser deposition. The optimum growth conditions were deduced from X-ray, photoemission and magnetic measurements. The X-ray measurements reveal that there was an optimum substrate temperature where the thin films showed relatively stronger texture, better crystallinity and lower strain. Substrate temperature tuned the deep level recombination centers in ZnO:Mn , which changed the optical quality by altering the electronic structure. The M-H curves, in the present study, revealed superior ferromagnetic response of 20-nm sized particles in ZnO:Mn thin film grown at a substrate temperature of 450 °C. Ferromagnetic ordering becomes weaker at higher/lower substrate temperatures due to the activation of native defects in ZnO host matrix.

关键词： Spintronics ZnO:Mn nanoparticle thin films structural defects substrate temperature

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Angular-Momentum-Dependent Orbital-Free Density Functional Theory

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physical Review Letters 2013年第6期111卷 066402-066402页

作者： Youqi Ke Florian Libisch Junchao Xia Lin-Wang Wang Emily A. Carter Department of Mechanical and Aerospace Engineering Program in Applied and Computational Mathematics and Andlinger Center for Energy and the Environment Princeton University Princeton New Jersey 08544 USA Material Science Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA

Orbital-free (OF) density functional theory (DFT) directly solves for the electron density rather than the wave function of many electron systems, greatly simplifying and enabling large scale first principles simulations. However, the required approximate noninteracting kinetic energy density functionals and local electron-ion pseudopotentials severely restrict the general applicability of conventional OFDFT. Here, we present a new generation of OFDFT called angular-momentum-dependent (AMD)-OFDFT to harness the accuracy of Kohn-Sham DFT and the simplicity of OFDFT. The angular momenta of electrons are explicitly introduced within atom-centered spheres so that the important ionic core region can be accurately described. In addition to conventional OF total energy functionals, we introduce a crucial nonlocal energy term with a set of AMD energies to correct errors due to the kinetic energy density functional and the local pseudopotential. We find that our AMD-OFDFT formalism offers substantial improvements over conventional OFDFT, as we show for various properties of the transition metal titanium.

关键词： DENSITY functional theory ELECTRON density KINETIC energy PSEUDOPOTENTIAL method TRANSITION metal compounds ELECTRON-ion collisions

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Optimization of a z-source DC circuit breaker

Optimization of a z-source DC circuit breaker

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IEEE Electric Ship Technologies Symposium, ESTS

作者： P. Prempraneerach M. G. Angle J. L. Kirtley G. E. Karniadakis C. Chryssostomidis Mechanical Engineering Department Rajamangala University of Technology Thunyaburi Pathumthani Thailand Electrical Engineering and Computer Science Department Research Laboratory for Electronics MIT Cambridge MA USA Division of Applied Mathematics Brown University Providence RI USA Department of Mechanical Engineering MIT MIT Sea Grant College Program Cambridge MA USA

DC faults may cause severe disruptions in continuity of service to vital loads in a shipboard integrated power system, hence detection, isolation, and protection against such faults must be incorporated in both medium-voltage DC (MVDC) and low-voltage DC (LVDC) systems. Here we consider the effectiveness of existing z-source breakers and propose several new designs more appropriate for fault detection in MVDC and LVDC systems. In particular, we perform an optimization study that aims to minimize dissipation and weight and we identify the key parameters for use in MVDC and LVDC systems. Preliminary verification and validation studies are also included.

关键词： Circuit faults Thyristors Switches Circuit breakers Capacitors Fault currents Optimization

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Digital holographic otoscope for measurements of the human tympanic membrane in-vivo

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2012 Annual Conference on Experimental and Applied Mechanics

作者： Dobrev, I. Harrington, E.J. Cheng, T. Furlong, C. Rosowski, J.J. Mechanical Engineering Department NanoEngineering Science and Technology - NEST Worcester Polytechnic Institute 100 Institute Road Worcester MA 01609 United States Eaton-Peabody Lab. Massachusetts Eye and Ear Infirmary 243 Charles Street Boston MA United States Speech and Hearing Bioscience and Technology Program MIT-Harvard Division of Health Sciences and Technology Cambridge MA United States

ISBN: (纸本)9781461442349

We are developing an advanced computer-controlled digital optoelectronic holographic system (DOEHS) with the ability to measure both shape and acoustically induced deformations of the tympanic membrane of several species, including humans. The DOEHS is to be deployed for use in the clinic. The clinical environment presents numerous challenges such as disturbances due to patient's heartbeat, breathing, patient's tremor as well as environmentally induced mechanical vibrations of several orders of magnitude larger (1-10 Hz, 0.1-10 μm) than the nanometer measuring resolution of the system. Design and optimization of the system for clinical use includes the development of a mechatronic otoscope positioner (MOP) system that allows for the interferometric otoscope head (OH) to be easily positioned near a patient's ear by an examiner and autonomously maintain mechanical stability during the duration of holographic measurements. In addition, we are also developing and implementing various acquisition strategies and algorithms for minimization of measurement disturbances in clinical conditions. The deployment and use of the MOP in a clinical environment allows for a large versatility of measurements while providing a wide range of completely new type of information regarding the properties of the TM and the state of a patients' hearing. The system will greatly help improve the quality of the treatments applied to the human middle-ear. ©The Society for Experimental Mechanics, Inc. 2013.

关键词： mechanical stability

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