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Immuno-Metabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease comorbidity

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Biological Psychiatry Global Open Science 2025年

作者： Angela Koloi Nabila P.R. Siregar Rick Quax Antonis I. Sakellarios Femke Lamers Arja Rydin Kevin Dobretz Costas Papaloukas Dimitrios I. Fotiadis Jos A. Bosch Unit of Medical Technology and Intelligent Information Systems Department of Materials Science and Engineering University of Ioannina Ioannina Greece Department of Biological Applications and Technology University of Ioannina Ioannina Greece Department of Clinical Psychology University of Amsterdam Amsterdam The Netherlands Computational Science Lab Institute of Informatics University of Amsterdam Amsterdam The Netherlands Biomedical Engineering of the Department of Mechanical Engineering and Aeronautics University of Patras Patras Greece Department of Psychiatry Amsterdam UMC location Vrije Universiteit Amsterdam Boelelaan 1117 Amsterdam The Netherlands Amsterdam Public Health Mental Health Program Amsterdam The Netherlands Cardiology Geneva University Hospitals Geneva Switzerland Department of Medicine University of Geneva Geneva Switzerland Biomedical Research Institute Foundation for Research and Technology - Hellas (FORTH) Ioannina Greece Department of medical Psychology Amsterdam University Medical Centers Amsterdam The Netherlands

Background Major depressive disorder (MDD) and cardiovascular diseases (CVD) often co-occur whereby comorbidity results in poorer clinical outcomes, presumably due to shared immune-metabolic pathways. Identifying shared biomarkers for MDD-CVD comorbidity may provide targets for prevention or treatment. Methods Using data from the Netherlands Study of Depression and Anxiety (NESDA: N=2,256, 66.3% female, mean age 41.75 ± 13.11 years), validated with the UK Biobank data (UKB, N=35,668, 56.14% female, mean age 63.95 ± 7.74 years), this study aimed to identify (i) biomarkers, closely associated with current MDD, and (ii) longitudinal pathways linking MDD and atherosclerotic CVD. Plasma metabolites (NMR, Nightingale) and inflammatory markers were used as exposures within a Machine Learning framework. Influential biomarkers were integrated into a temporal network analysis linking MDD to subsequent CVD, exploring longitudinal pathways through Causal Discovery, validated by sensitivity analysis and centrality assessment. External validation included mediation and regression analysis adjusting for covariates. Results Network analysis identified stable direct paths from MDD to CVD via TNF-α, tyrosine, and fatty acids, and indirect paths via acetate, HDL diameter, IL-6, alpha-1-acid glycoprotein (AGP), hs-CRP, and LDL triglycerides. Among these, acetate, tyrosine, AGP, and HDL diameter potentially mediate the MDD-CVD connection, as these were identified as key nodes within the network. UKB validation confirmed HDL diameter ( β = 0.004) and AGP ( β = 0.003) as significant depression-CVD mediators (both p < .001), after adjusting for age, sex, deprivation index, alcohol consumption, smoking status, physical activity, and BMI. Conclusions These analyses identified biomarkers shared in MDD and CVD and may drive comorbid pathology risk.

关键词： MDD biomarkers CVD Machine Learning mediators

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Fluorescence of CdSe/ZnS quantum dots in toluene: effect of cyclic temperature

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Energy Procedia 2019年 158卷 5895-5900页

作者： Ying Chen Weiling Luan Shaofu Zhang Fuqian Yang Key Laboratory of Pressure Systems and Safety (MOE) School of Mechanical and Power Engineering East China University of Science and Technology Shanghai 200237 P.R. China Materials Program Department of Chemical and Materials Engineering University of Kentucky Lexington KY 40513 USA

Quantum dots (QDs) are the potential material for the application in optical thermometry, and have been successfully applied to solar cells, LEDs, bio-labeling, structural health monitoring, etc. In this paper, we study the fluorescence properties of CdSe/ZnS QDs in toluene under the action of heating-cooling cycles. The experimental results show that, in a heating-cooling cycle, increasing temperature causes red-shift of the emission peak and the decrease of the PL intensity, and decreasing temperature causes blue-shift of the emission peak and the increase of the PL intensity. The surface structures of the QDs likely are dependent on the cycle numbers, which cause the change of the excited energy state of the QDs in toluene. The results presented in this paper reveals the strong effects of cyclic temperature on the photoluminescence characteristics of QDs.

关键词： QDs heating-cooling photoluminescence toluene

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Functional diagnosis of coronary artery stenoses using pressure drop coefficient: A pilot study in humans

Functional diagnosis of coronary artery stenoses using press...

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ASME 2011 Summer Bioengineering Conference, SBC 2011

作者： Kolli, Kranthi K. Effat, Mohamed Arif, Imran Helmy, Tarek Leesar, Massoud Back, Lloyd H. Banerjee, Rupak K. School of Dynamic Systems Mechanical Engineering Program University of Cincinnati Cincinnati OH United States Department of Internal Medicine Division of Cardiology University of Cincinnati Cincinnati OH United States Cincinnati Veteran Affairs Medical Center Cincinnati OH United States Jet Propulsion Laboratory California Institute of Technology Pasadena CA United States

ISBN: (纸本)9780791854587

Optimization of cut-off values for diagnostic parameters in determining stenosis severity depends on coupling functional (hemodynamic) and anatomical data. In this study, we sought to investigate the functional diagnostic parameter (CDP;the ratio of trans-stenotic pressure drop to distal dynamic pressure) by correlating with FFR (ratio of distal to proximal pressure of a stenotic section) and CFR (ratio of hyperemic blood flow velocity to that of resting condition). A 0.014-inch dual sensor (pressure and Doppler velocity) guidewire was used in 9 patients to obtain pressure drop and velocity at hyperemia. Functional index CDP was assessed from measured hyperemic pressure drop and velocity. CDP correlated linearly and significantly with FFR and CFR. Indicating that, measurements of CDP can provide a better assessment of stenosis severity. Copyright © 2011 by ASME.

关键词： Pressure drop

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NAVAL PROPULSION systems WATER-TREATMENT AND CONTROL

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NAVAL ENGINEERS JOURNAL 1985年第4期97卷 133-137页

作者： EICHINGER, BJ The Author is head of the Water Technology and Process Materials Section Naval Ship Systems Engineering Station (NAVSSES) in Philadelphia. She graduated from Marywood College in 1965 with a bachelor's degree in chemistry. Ms. Eichinger began her career with the Navy as an analytical chemist responsible for resolution of shipboard problems involving water water-formed deposits corrosion contamination and chemical cleaning. She with NAVSSES engineers corrected significant fleet problems arising from contaminants in submarine main hydraulic fluid systems and distillate fuel systems. Ms. Eichinger coordinated with the Naval Sea Systems Command to develop evaluate and implement the water treatment program now in use for all non-nuclear naval propulsion and auxiliary water and steam systems. She is a current member of the American Society of Mechanical Engineers and the author of the Naval Ships' Technical Manual chapter Boiler Water/Feedwater Test and Treatment.

The causes and effects of corrosion and contamination in conventional steam generator systems are described briefly. Treatment and control methodologies currently used by the Navy for feedwater, steam, condensate, and boiler water are detailed. Examples are cited of the manner in which Navy personnel are trained in interpretation of analytical data and in trend analysis in order that the ship can exercise preventive and corrective control of problems. Ancillary subjects discussed include chemical cleaning, mechanical cleaning, and out-of-service preservation. An overview of planned improvements is provided.

关键词： FEEDWATER TREATMENT

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Optimal design of an inter-board strain-relief for high-reliability surface mount attachment

Optimal design of an inter-board strain-relief for high-reli...

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Electronic Components and Technology Conference (ECTC)

作者： R.W. Kotlowitz K.L. Terrell Network Wireless Systems Business Unit AT and T Bell Laboratories Whippany NJ USA Graduate Program in Mechanical Engineering New Jersey Institute of Technology Newark NJ USA

The long-term reliability of surface mount (SM) interconnections remains an important issue in many electronics packaging technologies. Strain-reliefs with sufficient compliance can minimize the cyclic loads impressed on SM solder connections during operational temperature excursions, appreciably increasing the margin for long-term attachment reliability. Compliance evaluation was performed for an inter-board strain-relief, or bond-strap, in a commercial Low-Noise Amplifier (LNA) used in various AT&T wireless transmission systems. The bond-strap compliance was optimized, within practical forming and assembly constraints, to provide robust SM interconnection during the expected product service life.

关键词： Samarium Bonding Electronics packaging Surface-mount technology Temperature Performance evaluation Low-noise amplifiers Constraint optimization Assembly Robustness

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An Application of Monotone Functions Decomposition to the Reconstruction of Gene Regulatory Networks

An Application of Monotone Functions Decomposition to the Re...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： H. Chang G. Richard A. A. Julius C. Belta S. Amar Dept. of Mechanical Engineering Boston University Program in Bioinformatics Boston University Dept. of Electrical Computer and Systems Engineering Rensselaer Polytechnic Institute Dept. of Periodontology and Oral Biology Boston University

ISBN: (纸本)9781424441211

We describe the reconstruction of a gene regulatory network involved with the Toll-like Receptor signaling pathways. By applying our recent identification algorithm to a time series gene expression dataset, we identify regulatory interactions between genes and construct discrete-time piecewise affine regulatory functions. Our validation shows that our model predicts the expression levels of the genes involved in the network with good accuracy.

关键词： Gene Regulatory Networks Reconstructive Surgical Procedures MONOTONE FUNCTIONS Monotone Reconstructions Regulatory Gene Expression Regulation Gene Expression Profiles Ectopic Gene Expression decomposition

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Uncertainties and interdependence of porous parameters using Bayesian model-based analysis 48

Uncertainties and interdependence of porous parameters using...

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48th International Congress and Exhibition on Noise Control engineering, INTER-NOISE 2019 MADRID

作者： Ritchie, Kyle Xiang, Ning Horoshenkov, Kirill Hurrell, Alistair Department of Electrical Computer and Systems Engineering Rensselear Polytechnic Institute 110 8th St TroyNY12180 United States Graduate Program in Architectural Acoustics Rensselear Polytechnic Institute 110 8th St TroyNY12180 United States Department of Mechanical Engineering University of Sheffield Western Bank SheffieldS10 2TN United Kingdom

ISBN: (纸本)9788487985317

Traditional modeling for sound propagation in porous media has been done knowing the macroscopic physical parameters intrinsic to the material. Using Bayesian model-based analysis the uncertainties of these parameters and their effect on the accuracy of the selected model can be studied. The Horoshenkov Model [Horoshenkov, et al., JASA vol 139 (2016)], or similarly Miki Model [Miki, JASJ, vol 11, pp.25-28 (1990)], can be used to estimate the mean pore size and porosity of the material under test from measurements of surface impedance or absorption coefficient using glass beads of known diameter and layer thickness as an experimental model. The accuracy of these models can be compared using quantitative measures such as mean, variance and the interdependence of the estimated parameters. This paper discusses the error and likelihood of several models using the experimentally measured data sets. © INTER-NOISE 2019 MADRID - 48th International Congress and Exhibition on Noise Control engineering. All Rights Reserved.

关键词： Porous materials

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A New Damage Index for Structural Health Monitoring: A Comparison of Time and Frequency Domains

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Procedia Computer Science 2021年 179卷 930-935页

作者： Fergyanto E. Gunawan Tran Huu Nhan Muhammad Asrol Yasuhiro Kanto Insannul Kamil Sutikno Industrial Engineering Department BINUS Graduate Program - Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia 11480 Department of Automotive Engineering Faculty of Transportation Engineering Ho Chi Minh City University of Technology Ho Chi Minh City Viet Nam Mechanical Systems Engineering College of Engineering Ibaraki University Ibaraki Japan Department of Industrial Engineering Department Faculty of Engineering Andalas University Padang Indonesia Department of Mechanical Engineering Department Faculty of Engineering Institut Teknologi Sepuluh Nopember Surabaya Indonesia

With the adoption of the damage tolerance design principle, the health monitoring system has become an integral part of the operation of engineering structures. For the system to work, a damage indicator that describes the structural integrity level should be established and monitored. The damage indicator is usually derived from structural responses. Many quantities have been proposed for damage indicator including natural frequency, mode shape, curvature, strain energy, and t-, F-, and z-statistics. In this paper, we propose a new damage indicator in the time and frequency domains derived from the Euler-Bernoulli beam theory. We evaluate the method by using data obtained from a numerical simulation of a cracked beam. The beam deformation is nonlinear due to the contact between the crack faces during vibration. The proposed damage index is estimated in the domains for various observation points on the beam. Besides, the existence of the crack is also predicted by the widely used traditional method based on the change of the natural frequency and mode shape. A comparison is made between the present method and the existing ones. We conclude the present proposal is more sensitive to detect the crack.

关键词： Euler-Bernoulli Beam Structural Health Monitoring Damage Indicator Natural Frequency Finite Element Method

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Guest editorial: Latin American perspectives on sustainability in higher education

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International Journal of Sustainability in Higher Education 2023年第2期24卷 233-234页

作者： Izabela Simon Rampasso Rosley Anholon Osvaldo Luiz Gonçalves Quelhas Luis Velazquez Claudia Mac-Lean Departamento de Ingeniería Industrial Universidad Católica del Norte Antofagasta Chile School of Mechanical Engineering State University of Campinas Campinas Brazil Master Program in Management Systems and Doctoral Program in Sustainable Management Systems Federal Fluminense University Niterói Brazil Department of Industrial Engineering Division of Engineering University of Sonora Hermosillo Mexico GAIA Antarctic Research Center Universidad de Magallanes Punta Arenas Chile

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Energy Dissipation of Ship Structures subjected to Impact Loading: A Study Case in Side Collision

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Procedia Structural Integrity 2020年 27卷 171-178页

作者： Aditya Rio Prabowo Haris Nubli Jung Min Sohn Department of Mechanical Engineering Universitas Sebelas Maret Surakarta 57126 Indonesia Interdisciplinary Program of Marine Convergence Design Pukyong National University Busan 48513 South Korea Department of Naval Architecture and Marine Systems Engineering Pukyong National University Busan 48513 South Korea

The main goal of the present paper is to study the energy dissipation characteristic as the influence of parameters in the event of ship collisions. The review is conducted on accident case between Roll on-Roll off (Ro-Ro) Marisa Nusantara with Reefer Qi Hang at Sunda Strait, Indonesia May 3rd, 2014, as reference. It was later modeled and analyzed by nonlinear simulations finite element (FE) method was presented to be used as a reference to get the verified model. This collaboration study is considered as a good reference because it used real accident damage to compare the numerical results. The result in collision energy from the virtual simulation was later verified with the calculation result of the empirical formula. In the extended study, the collision region and material model are selected as influenced parameters to design collision scenarios. The characteristic of collision energy from these scenarios will be discussed. In the same section, the damage pattern is observed and reviewed to find the relation between several parameters to calculation results. It was shown that the influence of region and location of target points contributed significantly to energy dissipation. In contrast, the key finding in material properties is that when Young’s modulus between materials was the same and the difference of yield strength of materials was not significant, then other material properties contributed to the result.

关键词： Accidental loads ship collision Ro-Ro vessel double-hull structures crashworthiness energy dissipation

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