Spatially variable composites of Calcium Magnesium Titanates(CMT) with dielectric permittivity 15, 20 and 70 and commercial ferrite were produced by Dry Powder Deposition (DPD) method followed by cosintering at elevat...
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Beta thalassemia patients have a major global impact on health and mortality and are characterized by absence of beta globin chain production. In most patients, multiple blood transfusions can induce differences of im...
Beta thalassemia patients have a major global impact on health and mortality and are characterized by absence of beta globin chain production. In most patients, multiple blood transfusions can induce differences of immune response Therefore, they are often associated with bone marrow expansion and immunodeficiency in terms of lymphocyte subsets and cytokine levels in the peripheral blood and presence of alloantibodies. We have previously shown that children with beta thalassemia major have had decreased NK cells. natural killer (NK) cells are lymphocyte subpopulations that are important effectors of innate immune responses against infectious pathogens and tumor cells. The cytotoxic activity of NK cells is regulated by the equilibrium between positive and negative signals from multiple receptors expressed on their cell surface; signals that can trigger the cytolytic machinery as well as cytokine or chemokine secretion. The activator receptors of NK cells are natural cytotoxicity receptors (NCR) and NKG2D. NCR are represented by NKp46, NKp44, and NKp30. These receptors, upon engagement by their specific ligands, induce a strong activation of NK-mediated cytotoxic activity. NKp44, a triggering receptor selectively expressed by activated NK cells. NK cells can make cytolytic function by regulating pro-inflammatory cytokines as IFN-gamma, TNF-alpha and IL10. This study was carried out to investigate details NK cell function of 27 transfusion-dependent children with beta thalassemia. Data from 18 age- and sex-balanced children served as controls. For this purpose, we analyzed their cytolytic function against K562 cells in both pure NK cells (CD56 + CD16 + CD3 − ) and PBMC. Before and after the assessment of NK activity, we have examined the levels of NK activating receptors expressed on NK cells. The expression levels of the activation receptors (NKp30, NKp44, NKG2D) on CD56 + CD16 + CD3 − NK cells was quantified by multicolour immunofluorescent analysis using flow cytome
In this work, analog application for the sliding mode control (SMC) of piezoelectric actuators is presented. DSP application of the algorithm suffers from ADC and DAC conversions and faces speed limitations. Moreover,...
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In this work, analog application for the sliding mode control (SMC) of piezoelectric actuators is presented. DSP application of the algorithm suffers from ADC and DAC conversions and faces speed limitations. Moreover, piezoelectric actuators are known to have very large bandwidth close to the DSP operation frequency. Therefore, with the direct analog application, improvement of the performance is expected and high frequency operation will be achieved. First an appropriate SMC is designed to have continuous control output and then experimental results for position tracking using DSP and analog application are presented for comparison.
Broaching is one of the most recognized machining processes that can yield high productivity and high quality when applied properly. One big disadvantage of broaching is that all process parameters, except cutting spe...
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Broaching is one of the most recognized machining processes that can yield high productivity and high quality when applied properly. One big disadvantage of broaching is that all process parameters, except cutting speed, are built into the broaching tools. Therefore, it is not possible to modify the cutting conditions during the process once the tool is manufactured. Optimal design of broaching tools has a significant impact to increase the productivity and to obtain high quality products. In this paper, an optimization model for broaching design is presented. The model results in a non-linear non-convex optimization problem. Analysis of the model structure indicates that the model can be decomposed into smaller problems. The model is applied on a turbine disc broaching problem which is considered as one of the most complex broaching operations.
A new global positioning system (GPS) antenna is proposed to cover the three GPS bands (L1, L2, and L5, namely 1575, 1227, and 1176 MHz) with the L5 band to be added after 2006. The developed antenna size is only $1.5...
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A new global positioning system (GPS) antenna is proposed to cover the three GPS bands (L1, L2, and L5, namely 1575, 1227, and 1176 MHz) with the L5 band to be added after 2006. The developed antenna size is only $1.5^primeprimetimes 1.5^primeprime$ in aperture corresponding to $lambda/7timeslambda/7$ $(lambda=hboxfree hboxspace hboxwavelength)$ and $lambda/13 hboxthick$. Quadrature feeding is employed to ensure right-hand circular polarized (RHCP) radiation. The final miniature antenna exhibits a gain greater than 2 dBi, and to our knowledge this is the smallest such size for circular polarized (CP) operation covering all three bands. Detailed parametric simulations leading to the best design along with measurements for the constructed antenna are presented.
In this work, we are presenting a sliding mode controller approach for bilateral control. The controller consists of sliding mode force and hybrid (force/position) controllers for master and slave sides, respectively....
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Breakdown voltage is a unique well-known indicator for gases. Previous work indicate that miniaturized gas ionization sensors, which are made up of two electrodes one of which accommodates vertically aligned carbon na...
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Breakdown voltage is a unique well-known indicator for gases. Previous work indicate that miniaturized gas ionization sensors, which are made up of two electrodes one of which accommodates vertically aligned carbon na...
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Breakdown voltage is a unique well-known indicator for gases. Previous work indicate that miniaturized gas ionization sensors, which are made up of two electrodes one of which accommodates vertically aligned carbon nanotubes (CNTs), reduce breakdown voltage thanks to electric field concentration at sharp tips. Modeling of the ionization of the breakdown voltage and optimization of CNTs distribution are reported here. Modeling of CNTs for computational simulations creates a common high aspect-ratio problem due to CNT's microscale length and nanoscale diameter. This problem is solved by comparison of several models and validation of the most reliable one. Three dimensional modeling with periodic boundary conditions is proven quite suitable for actual span of CNTs on a SiO/sub 2/ substrate. Using the model an optimal distribution of CNTs is obtained.
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