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arXiv 2018年

作者： Arora, Siddharth Visanji, Naomi P. Mestre, Tiago A. Tsanas, Athanasios AlDakheel, Amaal Connolly, Barbara S. Gasca-Salas, Carmen Kern, Drew S. Jain, Jennifer Slow, Elizabeth J. Faust-Socher, Achinoam Lang, Anthony E. Little, Max A. Marras, Connie Somerville College University of Oxford Oxford United Kingdom Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Centre Toronto Western Hospital TorontoON Parkinson's Disease and Movement Disorders Center Division of Neurology Department of Medicine Ottawa Hospital Research Institute University of Ottawa Brain and Mind Institute Ottawa Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh United Kingdom Division of Neurology Department of Medicine Hamilton Health Sciences McMaster University HamiltonON Canada Movement Disorders Center Department of Neurology University of Colorado Anschutz Medical Campus AuroraCO United States Engineering and Applied Science Aston University Birmingham UK Media Lab Massachusetts Institute of Technology CambridgeMA United States

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts. Copyright © 2018, The Authors. All rights reserved.

关键词： Enzymes

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Design of a Rotational Modulation Collimator Utilizing Asymmetric Masks for the Gamma-Ray/Neutron Dual Imaging Technique

Design of a Rotational Modulation Collimator Utilizing Asymm...

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IEEE Nuclear science Symposium

作者： Hyun Suk Kim Gyemin Lee Sung-Joon Ye Geehyun Kim Program in Biomedical Radiation Sciences Seoul National University Seoul Korea Electronic and IT Media Engineering Seoul National University of Science and Technology Seoul Korea Nuclear Engineering Sejong University Seoul Korea

We are currently developing a dual-particle imager based on the rotational modulation collimator (RMC) technique employing Cs_2LiYCl_6:Ce (CLYC) detector. A symmetric mask design has been conventionally used for RMC, however, it has an intrinsic problem of not being able to distinguish two symmetric sources located with respect to the rotation axis. In the present study, we propose a new design of collimator masks to solve the artifact problem in the source location estimation imposed by the symmetric pattern of collimator masks. We used the Monte Carlo N-Particle 6.1 (MCNP6) code to obtain modulation patterns, and we applied the maximum likelihood expectation maximization (MLEM) algorithm to reconstruct radiation images from the modulation patterns. The asymmetric mask design we proposed in this paper showed enhanced performance in image reconstruction by removing intrinsic artifacts from the symmetric mask design and will be used as a fundamental design for the future development of the dual-particle RMC system.

关键词： Modulation Collimators Detectors Image reconstruction Imaging Monte Carlo methods Gamma-rays

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Proposal of Algorithm for Designating the Person in Charge of Page Turn of PEANUTS Considering the Concert program

Proposal of Algorithm for Designating the Person in Charge o...

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International Conference on Complex, Intelligent and Software Intensive Systems, CISIS

作者： Yasue Iijima Shigeru Fujita Susumu Konno Graduate School of Doctorial Program in Engineering Chiba Institute of Technology Narashino Chiba Japan Department of Computer Science Chiba Institute of Technology Narashino Chiba Japan Department of Advanced Media Chiba Institute of Technology Narashino Chiba Japan

ISBN: (纸本)9781509009886

In recent years, with the spread of applications such as electronic musical scores has been developed. However, existing electronic musical score applications were developed considering individual use (principally by pianists), and when using electronic musical score systems for a wind orchestra, for example, the load placed on the musical performers are effectively the same as when using paper scores. Therefore, in this study we were taking advantage of the characteristics of the tablet terminal, was carried out a proposal and trial production of the electronic musical score system PEANUTS for wind orchestra. Music of the data to be used in the PEANUTS is presupposed to reuse the score of paper that is currently being used. In PEANUTS, was focused on page turn as a load applied to the performer when playing musical piece in wind orchestra, we have proposed system of designating the person in charge of page turn to reduce the load based on algorithm of designating the person in charge of page turn for single music. However, the concert of wind orchestra usually play multiple music. In this paper, we were carried out the evaluation experiment considering the concert program. We were consider to resolve bias of the load value on the part of the performers by considering the concert program.

关键词： Turning Music Load modeling Standards Proposals Bars Algorithm design and analysis

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Measuring facial skin temperature changes caused by mental work-load with infrared thermography

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2016年第11期136卷 1581-1585页

作者： Mizuno, Tota Sakai, Takeru Kawazura, Shunsuke Asano, Hirotoshi Akehi, Kota Matsuno, Shogo Mito, Kazuyuki Kume, Yuichiro Itakura, Naoaki Management Science and Engineering Program University of Electro-Communications 1-5-1 Chofugaoka Chofu Tokyo102-0076 Japan Department of Electronics and Information Engineering Faculty of Engineering Kagawa University 2217-20 Hayashi-cho Takamatsu Kagawa761-0301 Japan Department of Media and Image Technology Faculty of Engineering Tokyo Polytechnic University 1583 Iiyama Atsugi Kanagawa243-0297 Japan

We evaluated the temperature change of facial parts as affected by mental work-load (MWL) using infrared thermography. Under MWL, autonomic nerves are active, and the skin surface temperature changes with muscular contraction. In particular, the nasal part of the face experiences the most intense change. Based on this, in previous studies MWL was evaluated by using nasal skin temperature. However, we considered whether other parts of the face experience temperature change under MWL. Therefore, in this study, to identify which other parts of the face experience temperature change, we performed an experiment to acquire facial thermal images when subjects perform a mental arithmetic calculation task. Our results indicate that, in addition to the nasal part, the temperatures around the lips and cheek might also increase under MWL. © 2016 The Institute of Electrical Engineers of Japan.

关键词： Thermography (imaging)

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Monte Carlo simulation of rotational modulation collimator (RMC) patterns for the gamma-ray/neutron dual-particle imager

Monte Carlo simulation of rotational modulation collimator (...

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IEEE Symposium on Nuclear science (NSS/MIC)

作者： Hyun Suk Kim Hong Yeop Choi Gyemin Lee Sung-Joon Ye Geehyun Kim Program in Biomedical Radiation Sciences Seoul National University Seoul Korea Department of Nuclear Engineering Sejong University Seoul Korea Department of Electronic and IT Media Engineering Seoul National University of Science and Technology Seoul Korea

This work is to develop a gamma-ray/neutron dual-particle imager, based on Rotating Modulation Collimators (RMC) and Pulse Shape Discrimination (PSD)-capable scintillators, for the nuclear security and safeguard application. We started with performing fundamental simulations on the RMC, to optimize the collimator design and the computing time for the Monte Carlo simulation. We obtained batches of RMC-modulated patterns to study the simulated behavior of the modulated pattern depending on various source locations. Simulated modulation profiles were used to verify the imaging algorithm developed on the basis of the Maximum-Likelihood Expectation Maximization (MLEM) method. An introduction to the current project and the simulation scheme will be presented, followed by brief comments on preliminary results of the simulated profiles.

关键词： Modulation Imaging Collimators Monte Carlo methods Neutrons Security

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Motion compensation in a tomographic ultrasound imaging system: toward volumetric scans of a limb for prosthetic socket design

Motion compensation in a tomographic ultrasound imaging syst...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Bryan J. Ranger Micha Feigin Nikita Pestrov Xiang Zhang Victor Lempitsky Hugh M. Herr Brian W. Anthony the Harvard-MIT Health Sciences and Technology Program Massachusetts Institute of Technology and Harvard Medical School Cambridge MA 02139 USA the Department of Media Arts and Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA the Skolkovo Institute of Science and Techonology Skolkovo 143025 Russian Federation the Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA the Department of Media Arts and Sciences and Harvard-MIT Health Sciences and Technology Program Massachusetts Institute of Technology and Harvard Medical School Cambridge MA 02139 USA

ISBN: (纸本)9781424492695

Current methods of prosthetic socket fabrication remain subjective and ineffective at creating an interface to the human body that is both comfortable and functional. Though there has been recent success using methods like magnetic resonance imaging and biomechanical modeling, a low-cost, streamlined, and repeatable process has not been fully demonstrated. Medical ultrasonography, which has significant potential to expand its clinical applications, is being pursued to acquire data that may quantify and improve the design process and fabrication of prosthetic sockets. This paper presents a new multi-modal imaging approach for acquiring volumetric images of a human limb, specifically focusing on how motion of the limb is compensated for using optical imagery.

关键词： human body that limb is compensated using optical imagery

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Principles of high–fidelity, high–density 3–d neural recording

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BMC Neuroscience 2014年第1期15卷 1-2页

作者： Caroline Moore-Kochlacs Nancy Kopell Justin P Kinney Ed S Boyden Jorg Scholvin Jacob G Bernstein Scott K Arfin Young Gyu Yoon Graduate Program for Neuroscience Boston University Boston MA 02215 USA McGovern Institute Massachusetts Institute of Technology MA 02139 USA Department of Mathematics and Statistics Boston University Boston MA 02215 USA Media Lab Massachusetts Institute of Technology MA 02139 USA Brain and Cognitive Science Massachusetts Institute of Technology MA 02139 USA Biological Engineering Massachusetts Institute of Technology MA 02139 USA Electrical Engineering and Computer Science Massachusetts Institute of Technology MA 02139 USA

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Proceedings from the 9th annual conference on the science of dissemination and implementation: Washington, DC, USA. 14-15 December 2016

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Implement Sci 2017年第SUPPL 1期12卷 48-48页

作者： David Chambers Lisa Simpson Gila Neta Ulrica von Thiele Schwarz Antoinette Percy-Laurry Gregory A. Aarons Ross Brownson Amanda Vogel Shannon Wiltsey Stirman Kenneth Sherr Rachel Sturke Wynne E. Norton Allyson Varley Cynthia Vinson Lisa Klesges Suzanne Heurtin-Roberts M. Rashad Massoud Leighann Kimble Arne Beck Claire Neely Jennifer Boggs Carmel Nichols Wen Wan Erin Staab Neda Laiteerapong Nathalie Moise Ravi Shah Susan Essock Margaret Handley Amy Jones Jay Carruthers Karina Davidson Lauren Peccoralo Lloyd Sederer Todd Molfenter Ashley Scudder Sarah Taber-Thomas Kristen Schaffner Amy Herschell Eva Woodward Jeffery Pitcock Mona Ritchie JoAnn Kirchner Julia E. Moore Sobia Khan Shusmita Rashid Jamie Park Melissa Courvoisier Sharon Straus Daniel Blonigen Allison Rodriguez Luisa Manfredi Andrea Nevedal Joel Rosenthal David Smelson Christine Timko Nicole Stadnick Jennifer Regan Miya Barnett Anna Lau Lauren Brookman-Frazee Erick Guerrero Karissa Fenwick Yinfei Kong Gregory Aarons Rebecca Lengnick-Hall Benjamin Henwood Nina Sayer Craig Rosen Robert Orazem Brandy Smith Lindsey Zimmerman David Lounsbury Rachel Kimerling Jodie A. Trafton Steven Lindley Rahul Bhargava Hal Roberts Laura Gibson Gabriel J. Escobar Vincent Liu Benjamin Turk Arona Ragins Patricia Kipnis Ashley Ketterer Gruszkowski Michael W. Kennedy Emily Rentschler Drobek Lior Turgeman Aleksandra Sasha Milicevic Terrence L. Hubert Larissa Myaskovsky Youxu C. Tjader Robert J. Monte Kathryn G. Sapnas Edmond Ramly Diane R Lauver Christie M Bartels Shereef Elnahal Andrea Ippolito Hillary Peabody Carolyn Clancy Randall Cebul Thomas Love Douglas Einstadter Shari Bolen Brook Watts Vera Yakovchenko Angela Park William Lukesh Donald R. Miller David Thornton Mari-Lynn Drainoni Allen L. Gifford Shawna Smith Julia Kyle Mark S Bauer Daniel Eisenberg Celeste Liebrecht Michelle Barbaresso Amy Kilbourne Elyse Park Giselle Perez Jamie Ostroff Sarah Greene Michael Parchman Brian Austin Eric Larson Stefanie Ferreri Chris Shea Megan Smith Kea Turner Jennifer Bacci Kyle Bigham Geoffr Division of Cancer Control and Population Sciences National Cancer Institute Rockville MD 20850 USA AcademyHealth Washington DC 20009 USA Department of Learning Informatics Management and Ethics Karolinska Institutet Stockholm 17177 Sweden Department of Psychiatry University of California San Diego San Diego CA 92093 USA George Warren Brown School of Social Work Washington University in St. Louis St. Louis MO 63130 USA Center for Global Health National Cancer Institute Rockville MD 20850 USA Dissemination and Training Division VA National Center for PTSD Palo Alto CA 94305 USA Department of Global Health University of Washington Seattle WA 98105 USA Center for Global Health Studies Fogarty International Center National Institutes of Health Bethesda MD 20912 USA School of Public Health University of Alabama at Birmingham Birmingham AL 35243 USA School of Public Health University of Memphis Memphis TN 38152 USA USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project Bethesda Maryland 20814 USA Institute for Health Research Kaiser Permanente Denver CO 80231 USA ICSI Institute for Clinical Systems Improvement Bloomington MN 55425 USA Medicine University of Chicago Chicago IL 60637 USA Medicine Columbia University Medical Center New York NY 10032 USA Psychiatry Columbia University New York NY 10032 USA General Internal Medicine Epidemiology and Biostatistics University of California San Francisco San Francisco CA 94110 USA New York State Office of Mental Health New York NY 10001 USA Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA Center for Health Enhancement System Studies University of Wisconsin Madison WI 53706 USA Department of Psychiatry University of Pittsburgh Pittsburgh PA 15213 USA Psychology University at Buffalo Buffalo NY 14260 USA Department of Psychology West Virginia University Morgantown WV 26506 USA MIRECC VA North Little Rock AR 72114 USA QUERI for Team-Based Behavioral Health Centr

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Experimental selection and verification of maximum-heart-rate formulas for use with karvonen formula

Experimental selection and verification of maximum-heart-rat...

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10th International Conference on Informatics in Control, Automation and Robotics, ICINCO 2013

作者： She, Jinhua Nakamura, Hitoshi Makino, Koji Ohyama, Yasuhiro Hashimoto, Hiroshi Wu, Min Graduate School of Bionics Computer and Media Sciences Tokyo University of Technology 1404-1 Katakura Hachioji Tokyo 192-0982 Japan Interdisciplinary Graduate School of Medical and Engineering University of Yamanashi 4-3-11 Takeda Kofu 400-8511 Japan Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology Shinagawa Tokyo 140-0011 Japan School of Information Science and Engineering Central South University Changsha 410083 China

ISBN: (纸本)9789898565716

Maximum heart rate (MHR) is commonly used to estimate exercise intensity with the Karvonen formula, and there are several methods of calculating it. In this study, we used pedaling experiments on a cycle ergometer to evaluate methods of determining MHR in order to select the ones most suitable for the Karvonen formula. In the experiments, 43 subjects rode an aerobike. The results show that, for people in their 20s, two methods are suitable for estimating exercise intensity with the Karvonen formula. The main physical parameters affecting exercise intensity were also extracted, based on the experimental results.

关键词： Heart

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