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Cryptanalysis and improvement of quantum secure multi-party summation using single photons

Physica Scripta 2024年第3期99卷 035114-035114页

作者： Tsai, Chia-Wei Lin, Jason Yang, Chun-Wei Department of Computer Science and Information Engineering National Taichung University of Science and Technology No.129 section 3 Sanmin Rd North District Taichung404 Taiwan Department of Computer Science and Engineering National Chung Hsing University No. 145 Xingda Rd. South District Taichung40227 Taiwan Program for Digital Health Innovation College of Humanities and Sciences China Medical University No. 100 section 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan

A previous study [Entropy 25.4 (2023): 590] proposed a quantum secure multi-party summation protocol wherein n participants could obtain the modulo-2 summation result using single photons and single-particle operations. Owing to the absence of an entanglement state, this protocol was more practical than other quantum summation protocols that used entanglement properties. Thus, this study investigated the claim that this proposed protocol prevented the participants’ secret inputs from being disclosed. It was found that the previously proposed protocol was vulnerable to a quantum Trojan horse attack owing to the circular qubit transmission mode. Using a security loophole, this study proposed an attack strategy that allowed an outside attacker to steal any participant’s secret input without being detected by a third party and participants. In addition, a simulation experiment was conducted to demonstrate the feasibility of the proposed attack and evaluate the number of quantum Trojan horse probes that the attacker must inject into regular qubit sequences. Finally, a solution was proposed by modifying the protocol to securely prevent quantum Trojan horse attacks. © 2024 IOP Publishing Ltd.

关键词： Photons

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Quantitative Analysis of Colonic Epithelial Cell Aging in a Cell-cycle like Model: Changes in Nucleus and Cytoplasm Along the Crypt Axis

Quantitative Analysis of Colonic Epithelial Cell Aging in a ...

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medical Imaging 2025: Digital and Computational Pathology

作者： Bao, Shunxing Wang, Yaohong Rudravaram, Gaurav Zhang, Rendong Deng, Ruining Yu, Xin Gao, Chenyu Li, Jia Li, Yike Roland, Joseph T. Zuo, Lianrui Liu, Qi Lau, Ken S. Coburn, Lori A. Wilson, Keith T. Landman, Bennett A. Huo, Yuankai Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN United States Department of Anatomical Pathology UT MD Anderson Cancer Center HoustonTX United States Department of Computer Science Vanderbilt University NashvilleTN United States Department of Biostatistics Vanderbilt University Medical Center Nashville United States Department of Otolaryngology-Head and Neck Surgery Vanderbilt University Medical Center NashvilleTN United States Department of Surgery Vanderbilt University Medical Center NashvilleTN United States Department of Cell and Developmental Biology Vanderbilt University School of Medicine NashvilleTN United States Vanderbilt University Medical Center Division of Gastroenterology Hepatology and Nutrition Department of Medicine Nashville United States Vanderbilt University Medical Center Vanderbilt Center for Mucosal Inflammation and Cancer Nashville United States Vanderbilt University School of Medicine Program in Cancer Biology Nashville United States Veterans Affairs Tennessee Valley Healthcare System NashvilleTN United States Vanderbilt University Medical Center Department of Pathology Microbiology and Immunology NashvilleTN United States

ISBN: (纸本)9781510686045

Understanding epithelial cell aging in bowel tissue can provide critical insights into gastrointestinal (GI) health, potentially leading to improved diagnosis, treatment, and prevention strategies for various GI conditions. Despite the significance of cellular aging in the GI tract, previous studies have not quantified epithelial cell maturity development along the base-to-surface axis of colon crypts due to the labor-intensive nature of manual quantification and the lack of a clear definition of cellular age. Moreover, the process faces tremendous challenges when tissue is cut in 2D and examines results solely from one or a few biopsy cuts without reconstructing the full 3D space, as the original cell structure is 3D, leading to variability based on the cut angle. This research addresses these challenges by systematically analyzing the relationship between epithelial cell morphology and their position from the base to the surface in colon crypt tissue. Our approach involves using multiplex immunofluorescence (MxIF) imaging for cell nuclei segmentation, identifying the potential full longitudinal cut, and manually annotating the surface and base of the colon crypts. By analyzing the epithelial cells, we create density maps to investigate the relationship between nucleus size and the surface-to-base distance ratio, defining this ratio as cell age. We also examine the nucleus-to-cytoplasm (N/C) ratio in relation to cell age. For the statistical analysis, we use a robust linear regression model to remove outliers and a random effects model for the final regression. Our results show a decreasing trend in both the N/C ratio and nucleus size as epithelial cells move from the base to the surface. These findings provide a quantitative pipeline for single-cell profiling in a spatial manner, facilitating broader analysis of epithelial cell aging and its implications for GI health. © 2025 SPIE.

关键词： Linear regression

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Identifying Cellular Neighborhood Phenotypes Differentiating Normal and Quiescent Crohn's Disease via MxIF

Identifying Cellular Neighborhood Phenotypes Differentiating...

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medical Imaging 2025: Digital and Computational Pathology

作者： Rudravaram, Gaurav Bao, Shunxing Krishnan, Aravind R. Remedios, Lucas W. Kim, Michael E. Saunders, Adam M. Liu, Qi Lau, Ken S. Roland, Joseph T. Washington, Mary K. Coburn, Lori A. Wilson, Keith T. Huo, Yuankai Landman, Bennett A. Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN United States Department of Computer Science Vanderbilt University NashvilleTN United States Division of Gastroenterology Hepatology and Nutrition Department of Medicine Vanderbilt University Medical Center NashvilleTN United States Vanderbilt Center for Mucosal Inflammation and Cancer Vanderbilt University Medical Center NashvilleTN United States Program in Cancer Biology Vanderbilt University School of Medicine NashvilleTN United States Veterans Affairs Tennessee Valley Healthcare System NashvilleTN United States Department of Pathology Microbiology and Immunology Vanderbilt University Medical Center NashvilleTN United States Center for Quantitative Sciences Vanderbilt University Medical Center NashvilleTN United States Epithelial Biology Center Vanderbilt University Medical Center NashvilleTN United States Department of Cell and Developmental Biology Vanderbilt University School of Medicine NashvilleTN United States Vanderbilt University Department of Biomedical Engineering Nashville United States Department of Biostatistics Vanderbilt University Medical Center Nashville United States

ISBN: (纸本)9781510686045

Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract characterized by alternating periods of activity and remission. This study investigates whether the cellular environments of quiescent (inactive disease) and normal tissues show similarities or differences, exploring potential residual effects from disease and tissue recovery patterns. While active CD can typically be characterized by high neutrophil density, whereas quiescent tissues present less pronounced inflammatory markers. This study leverages multiplexed immunofluorescence (MxIF) data to examine the distributions and patterns of various nuclei subtypes in quiescent versus normal tissues, aiming to determine how similar or different these tissues are in the absence of active inflammation. In our study, we analyze four tissue samples labeled as normal and five as quiescent from CD patients, as determined by a pathologist. We use rigid and deformable registration of MxIF images to analyze these tissues in a unified space and classify the nuclei into 13 subtypes. Using a KD tree, we identify the 10 nearest neighbors for each nucleus, building a combined distance-weighted neighborhood matrix representing both normal and quiescent tissues. We projected these neighborhoods into 2 dimensions using t-distributed stochastic nearest neighbor(t-SNE), clustered them, and calculated the enrichment for each subtype between normal and quiescent states within each of 20 and 40 clusters. In the 20-cluster analysis, we find monocytes enrich in one cluster and leukocytes enrich in two clusters for normal and quiescent tissues respectively. For the 40-cluster analysis, we observe monocytes, macrophages, and leukocytes enrich in one cluster each in normal tissues, and in the quiescent condition, one cluster enriched with enteroendocrine cells, and two clusters enriched with leukocytes. The results were statistically significant as determined by a chi-squared test (p © 2025 SPIE.

关键词： Tissues White blood cells Diseases and disorders Biological samples Matrices Statistical analysis Image segmentation Image registration Critical dimension metrology Inflammation

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Opto2P-FCM: A MEMS Based Miniature Two-Photon Microscope with Patterned Optogenetic Stimulation

Opto2P-FCM: A MEMS Based Miniature Two-Photon Microscope wit...

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Microscopy Histopathology and Analytics, Microscopy 2024 - Part of Optica Biophotonics Congress: Biomedical Optics

作者： Futia, Gregory L. Zohrabi, Mo McCullough, Connor Teel, Alec de Souza, Fabio Simoes Oroke, Ryan Bright, Victor M. Restrepo, Diego Gopinath, Juliet T. Gibson, Emily A. Department of Bioengineering University of Colorado Anschutz Medical Campus AuroraCO80045 United States Department of Cell and Developmental Biology University of Colorado Anschutz Medical Campus AuroraCO80045 United States Department of Electrical Computer and Energy Engineering University of Colorado BoulderCO80309 United States Department of Mechanical Engineering University of Colorado BoulderCO80309 United States Department of Physics University of Colorado BoulderCO80309 United States Materials Science and Engineering Program University of Colorado BoulderCO80309 United States

Miniaturized microscopes for monitoring neural activity are an indispensable tool for neuroscience research. We present a novel MEMS based miniature microscope with patterned optogenetic stimulation capabilities enabl... 详细信息

ISBN: (纸本)9781957171340

关键词： Microscopes

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Using a hybrid neural network architecture for DNA sequence representation: A study on N4-methylcytosine sites

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computers in Biology and Medicine 2024年 178卷 108664-108664页

作者： Nguyen, Van-Nui Ho, Trang-Thi Doan, Thu-Dung Le, Nguyen Quoc Khanh University of Information and Communication Technology Thai Nguyen University Thai Nguyen Viet Nam Department of Computer Science and Information Engineering TamKang University New Taipei251301 Taiwan International Degree Program in Animal Vaccine Technology International College National Pingtung University of Science and Technology Pingtung Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei110 Taiwan AIBioMed Research Group Taipei Medical University Taipei110 Taiwan Translational Imaging Research Center Taipei Medical University Hospital Taipei110 Taiwan

N4-methylcytosine (4mC) is a modified form of cytosine found in DNA, contributing to epigenetic regulation. It exists in various genomes, including the Rosaceae family encompassing significant fruit crops like apples, cherries, and roses. Previous investigations have examined the distribution and functional implications of 4mC sites within the Rosaceae genome, focusing on their potential roles in gene expression regulation, environmental adaptation, and evolution. This research aims to improve the accuracy of predicting 4mC sites within the genome of Fragaria vesca, a Rosaceae plant species. Building upon the original 4mc-w2vec method, which combines word embedding processing and a convolutional neural network (CNN), we have incorporated additional feature encoding techniques and leveraged pre-trained natural language processing (NLP) models with different deep learning architectures including different forms of CNN, recurrent neural networks (RNN) and long short-term memory (LSTM). Our assessments have shown that the best model is derived from a CNN model using fastText encoding. This model demonstrates enhanced performance, achieving a sensitivity of 0.909, specificity of 0.77, and accuracy of 0.879 on an independent dataset. Furthermore, our model surpasses previously published works on the same dataset, thus showcasing its superior predictive capabilities. © 2024 Elsevier Ltd

关键词： Embeddings

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Probabilistic genotype-phenotype maps reveal mutational robustness of RNA folding, spin glasses, and quantum circuits

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Physical Review Research 2025年第1期7卷 013118-013118页

作者： Anna Sappington Vaibhav Mohanty Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Harvard-MIT Program in Health Sciences and Technology Harvard Medical School Boston Massachusetts 02115 USA and Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Harvard/MIT MD-PhD Program Harvard Medical School Boston Massachusetts 02115 USA and Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Department of Chemistry and Chemical Biology Harvard University Cambridge Massachusetts 02138 USA

Recent studies of genotype-phenotype maps have reported universally enhanced phenotypic robustness to genotype mutations, a feature essential to evolution. Virtually all of these studies make a simplifying assumption that each genotype—represented as a sequence—maps deterministically to a single phenotype, such as a discrete structure. Here we introduce probabilistic genotype-phenotype (PrGP) maps, where each genotype maps to a vector of phenotype probabilities, as a more realistic and universal language for investigating robustness in a variety of physical, biological, and computational systems. We study three model systems to show that PrGP maps offer a generalized framework which can handle uncertainty emerging from various physical sources: (1) thermal fluctuation in RNA folding, (2) external field disorder in the spin-glass ground state search problem, and (3) superposition and entanglement in quantum circuits, which are realized experimentally on IBM quantum computers. In all three cases, we observe a biphasic robustness scaling which is enhanced relative to random expectation for more frequent phenotypes and approaches random expectation for less frequent phenotypes. We derive an analytical theory for the behavior of PrGP robustness, and we demonstrate that the theory is highly predictive of empirical robustness.

关键词： Quantum computers

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NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

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ACS Applied Materials and Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien Dhawan, Udesh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CDT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published by American Chemical Society

关键词： Magnetic resonance imaging

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Organizational Intent, Organizational Structures, and Reviewer Mental Models Influence Mortality Review Processes

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Mayo Clinic Proceedings: Innovations, Quality and Outcomes 2023年第6期7卷 515-523页

作者： Khayal, Inas S. Butcher, Rebecca L. McLeish, Colin H. Shentu, Yujia Barnato, Amber E. Dartmouth Institute for Health Policy and Clinical Practice Geisel School of Medicine at Dartmouth Lebanon NH United States Department of Biomedical Data Science Geisel School of Medicine at Dartmouth Lebanon NH United States Center for Program Design and Evaluation Geisel School of Medicine at Dartmouth Lebanon NH United States Department of Computer Science Dartmouth College Hanover NH United States Section of Palliative Care Department of Medicine Dartmouth Hitchcock Medical Center Lebanon NH United States Geisel School of Medicine at Dartmouth Hanover NH United States Tuck School of Business Hanover NH United States Department of Neurosurgery The University of Texas McGovern Medical School Houston

Objective: To identify the factors that influence the mortality review process at health systems, including how mortality review is conducted, cases are adjudicated, and results are used. Methods: We conducted a qualitative analysis of the mortality review processes of 6 US health systems from February 1, 2021 to June 31, 2021. The data sources included individual and small-group semi-structured interviews with mortality review team members and a content analysis of site artifacts (eg, guiding principles, chart abstraction forms, review workflows, and clinical pathways developed from past mortality reviews). We analyzed each site's mortality review process, goals and incentives for mortality review, historical and evolving aspects of mortality review, personnel involved, and post-review use of findings. Results: Across the 6 systems, we interviewed a total of 24 mortality review experts and analyzed 26 site documents. We identified 3 thematic factors that influence mortality review processes: organizational intent, organizational structures for mortality review, and the mental models of individuals involved in the review process. Two subthemes emerged within organizational intent: (1) identifying preventable deaths to lower (clinical or financial) risk and (2) using death cases to guide system improvement. Sites varied in governance and decision rights concerning mortality review and adjudication, with 2 subthemes within organizational structures: (1) centralized-hierarchical and (2) decentralized or multidisciplinary. The analysis of mental models of participating reviewers revealed 2 themes: (1) confirmation of preventability and (2) identification of patterns or “signals.” Conclusion: Understanding the factors that influence mortality review allows health systems to better leverage mortality review for institutional improvement and to develop training that builds shared mental models to enhance the review process. © 2023 The Authors

关键词： AHRQ Agency for Healthcare Research and Quality COREQ COnsolidated criteria for REporting Qualitative research MR mortality review QI quality improvement

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Applications of Artificial Intelligence and Big Data for Strengthening the Role of Intelligence in Human Security

Applications of Artificial Intelligence and Big Data for Str...

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International Conference on Computing, Engineering, and Design (ICCED)

作者： Ahmad Shahrul Mubarok Armi Susandi Teddy Mantoro Medical Intelligence Post-Graduate Program State Intelligence College Bogor Indonesia Departement of Computer Science Media-Tech Lab Sampoerna University Jakarta Indonesia

ISBN: (纸本)9781665453905

The state, through the government, should ensure national security and stability through the policies taken. For this reason, fast and accurate information and data are needed to form the basis for policymaking. Intelligence actors have an essential role in gathering information to identify and prevent threats within and outside the country. Technological advances affect changes in threats and increase the classification of these threats. Covid-19 is a real example of the threat in this era because almost all countries feel its impact. In addition to affecting health, the Covid-19 pandemic also impacts the global economic sector. The economic impact is felt by small and medium industries, goods and services products, and also the tourism sector. The method that is used in this study is a literature review from various national and international journals. AI and Big Data can be used to track viruses in real time, collect adequate public health data, and integrate vaccine use. Also, AI and Big Data can provide local decision and policy-makers with informed, evidence-based predictions. the threat of the Covid-19 pandemic and other infectious diseases that disrupt public health and have a broad impact must be anticipated and addressed in order to achieve the safety and existence of the nation and state. The author wants to emphasize the importance of the role of intelligence in anticipating threats from the visible to the invisible.

关键词： COVID-19 Pandemics Big Data Stability analysis Vaccines Safety Security

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Private Data Protection as Countermeasure Against Misuses of medical Intelligent Technology Data: a Literature Study

Private Data Protection as Countermeasure Against Misuses of...

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International Conference on Computing, Engineering, and Design (ICCED)

作者： Praseptiadi Pratama Dahlian Persadha Armi Susandi Teddy Mantoro Medical Intelligence Post-graduate Program State Intelligence College Bogor Indonesia Department of Computer Science Media-Tech Lab Sampoema University Jakarta Indonesia

ISBN: (纸本)9781665453905

medical Technologies develop along with the development of the Industrial Revolution 4.0 (I.R. 4.0). In I.R. 4.0, a collaborative ecosystem is formed between cyber technology and automation technology to be able to create "intelligent" systems to facilitate various human activities, including activities related to health. The most important thing in the system is data since it is the basis for the development of various key icons technologies in the I.R. 4.0: Cloud Computing, Internet of Things (IoT), Big Data, Artificial Intelligence (Al), Augmented Reality, and Cyber Security. Unfortunately, with the variety of I.R. 4.0 products, the data produced by these products is also scattered everywhere. Misuse of this scattered data—which the owner may not even know where the data are stored—can harm the individual concerned, and even the very existence of the state. Healthcare services now are undergoing Digital Transformation in which these data were needed to build high-quality services. The Health Digital Transformation strategy changes the direction of health services to be simpler and easier to use by the public, increasing efficiency, and thus providing a higher quality health service system so that it can trigger better economic growth. On the regulatory aspect, The Private Data Protection Bill was proposed by the Indonesian government to protect the data of the Indonesian people. Literature studies are used to obtain knowledge between the three: technology development, digital transformation in healthcare, and private data protection. This study seeks how important private data protection regulation is to realize digitally transformed healthcare. The study conducted indicates Private Data Protection Bills have the means to guarantee the rights of the data owner and prevent their data (including medical intelligence data) to be misused.

关键词： Economics Digital transformation Government Ecosystems Data protection Regulation Internet of Things

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