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2008 IEEE Sensors, SENSORS 2008

作者： Liu, Yi-Shao Banada, Padmapriya P. Bhunia, Arun K. Bashir, Rashid Micro and Nanotechnology Laboratory United States Department of Electrical and Computer Engineering Department of Bioengineering University of Illinois at Urbana-Champaign Urbana IL 61801 United States Molecular Microbiology Laboratory and Department of Food Science Purdue University West Lafayette IN 47907 United States Center for infectious diseases Department of Medicine New Jersey Medical school Newark NJ 07130 United States

ISBN: (纸本)9781424425808

In this paper, we present a method for the label-free detection of PCR products using impedance spectroscopy. Instead of using conventional optical detection instruments, our method provides a direct detection of amplified target genes in PCR. As a proof of concept, identification of a target bacterium in a mixture of microorganisms is demonstrated. © 2008 IEEE.

关键词： Polymerase chain reaction

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Web Services based newborn screening system with Support Vector Machines

Web Services based newborn screening system with Support Vec...

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5th International Conference on Information Technology and Applications, ICITA 2008

作者： Hsieh, Sung-Huai Hsieh, Sheau-Ling Weng, Yung-Ching Chien, Yin-Hsiu Wang, Zhenyu Chen, Po-Hao Chang, Hsing-Yu Lai, Feipei Hwu, Wu-Liang Information Systems Office National Taiwan University Hospital Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Network and Computer Centre National Chiao Tung University Hsin Chu Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taiwan Department of Information Management National Taiwan University Taipei Taiwan Department of Medical Genetics National Taiwan University Hospital Taiwan Computing Laboratory Oxford University Oxford United Kingdom

ISBN: (纸本)9780980326727

The clinical symptoms of metabolic disorders during neonatal periods are often not apparent. If not treated earlier, irreversible damages such as mental retardation or even death may occur. Therefore, practicing the newborn screening is essential to prevent newborns from these damages. In the paper, we propose a newborn screening system using Support Vector Machines (SVM) classification techniques to evaluate, interpret, and determine whether a newborn has metabolic disorder diseases. The raw data, i.e., substances concentrations, were collected from the Tandem Mass Spectrometry (MS/MS). In addition, based on the concept of Service-Oriented Architecture (SOA), we design the system under Web Services .NET environment. The system provides features including heterogeneous platforms, protocols, as well as applications. It can be integrated seamlessly into National Taiwan University Hospital Information Systems later.

关键词： Web services

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Jeeva: Enterprise Grid Enabled Web Portal for Protein Secondary Structure Prediction

Jeeva: Enterprise Grid Enabled Web Portal for Protein Second...

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International Conference on Advanced computing and Communications (ADCOM)

作者： Chao Jin Jayavardhana Gubbi Rajkumar Buyya Marimuthu Palaniswami Grid Computing and Distributed Systems (GRIDS) Laboratory Department of Computer Science and Software Engineering University of Melbourne Melbourne VIC Australia Department of Electrical and Electronic Engineering University of Melbourne Melbourne VIC Australia

This paper presents a grid portal for protein secondary structure prediction developed by using services of Aneka, a .NET-based enterprise grid technology. The portal is used by research scientists to discover new prediction structures in a parallel manner. An SVM (support vector machine)-based prediction algorithm is used with 64 sample protein sequences as a case study to demonstrate the potential of enterprise grids.

关键词： Portals Protein engineering Grid computing Prediction algorithms Support vector machines Distributed computing Environmental management Chaos computer science History

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Correlation between optical coherence tomography (OCT) and optical intrinsic signal imaging (OISI) during functional brain activation

Correlation between optical coherence tomography (OCT) and o...

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Biomedical Optics, BIOMED 2008

作者： Chen, Y. Aguirre, A.D. Ruvinskaya, L. Devor, A. Boas, D.A. Fujimoto, J.G. Department of Electrical Engineering Computer Science and Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge MA 02139 United States Harvard-MIT Division of Health Sciences and Technology Cambridge MA United States Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown MA 02129 United States

Simultaneous OCT and OISI were performed on rat somatosensory cortex during forepaw stimulation. The depth-integrated OCT signal correlates well with OISI signal, while OCT resolves layer-specific dynamics in function... 详细信息

关键词： Optical tomography

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MRBAC: Hierarchical Role Management and Security Access Control for Distributed Multimedia Systems

MRBAC: Hierarchical Role Management and Security Access Cont...

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International Symposium on Object-Oriented Real-Time Distributed computing

作者： Na Zhao Min Chen Shu-Ching Chen Mei-Ling Shyu Distributed Multimedia Information System Laboratory School of Computing and Information Sciences Florida International University Miami FL USA Department of Computer Science University of Montana Missoula MT USA Department of Electrical & Computer Engineering University of Miami Coral Gables FL USA

ISBN: (纸本)9780769531328

In this paper, a role-based access control (KBAC) model is applied and extended to a multimedia version called multi-role based access control (MRBAC), which can fully support the comprehensive and multilevel security control requirements of the distributed multimedia applications. The object-oriented concept is adopted in MRBAC to perform the hybrid role hierarchy management and security roles and rules administration. In summary, MRBAC can: 1) support the multi-level security protection for multimedia data; 2) provide access control by checking both the time constrains and IP addresses; and 3) decentralize the administration functions to make the access control management more efficient.

关键词： Access control Multimedia systems Object oriented modeling Data security Information security Multimedia databases Distributed computing Multimedia computing USA Councils Permission

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A kidney segmentation approach from DCE-MRI using level sets

A kidney segmentation approach from DCE-MRI using level sets

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IEEE computer Society Conference on computer Vision and Pattern Recognition Workshops (CVPRW)

作者： H. Abdelmunim Aly A. Farag W. Miller Mohamed AboelGhar Department of Computer Science Computational Biomedicine Laboratory University of Houston Houston TX USA Computer Vision and Image Processing LabDepartment of Electrical and Computer Engineering University of Louisville Louisville KY USA Medical School Mansoura University Mansoura Egypt

Acute rejection is the most common reason of graft failure after kidney transplantation, and early detection is crucial to survive the transplanted kidney function. Automatic classification of normal and acute rejection transplants from dynamic contrast enhanced magnetic resonance imaging (DCEMRI), is of great importance. Kidney segmentation is the first step for such classification. The image intensity inside the kidney is used as an indication of failure/success. Differentiating between different cases cases is implemented by comparing subsequential kidney scans signals. So, this process is mainly dependent on segmentation. This paper introduces a new shape-based segmentation approach based on level sets. Training shapes are collected from different real data sets to represent the shape variations. Signed distance functions are used to represent these shapes. The methodology incorporates image and shape prior information in a variational framework. The shape registration is considered the backbone of the approach where more general transformations can be used to handle the process. We introduce a novel shape dissimilarity measure that enables the use of different (inhomogeneous) scales. The approach gives successful results compared with other techniques restricted to transformations with homogeneous scales. Results for segmenting kidney images will be illustrated and compared with other approaches to show the efficiency of the proposed technique.

关键词： Level set Image segmentation computer vision Magnetic resonance imaging Shape measurement Biopsy Biomedical computing computer science Image processing Biomedical imaging

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Editorial: Dependability and security

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IEEE Transactions on Dependable and Secure computing 2008年第1期5卷 1-3页

作者： Iyer, Ravishankar K. Gligor, Virgil D. Kalbarczyk, Zbigniew T. Kanoun, Karama Katzenbeisser, Stefan Mukherjee, Shubu Shieh, Shiuhpyng Zorian, Yervant Department of Electrical and Computer Engineering Carnegie Mellon University Microsoft's Trusted Computing Academic Advisory Board Center for Reliable and High-Performance Computing Coordinated Science Laboratory University of Illinois Urbana-Champaign United States IEEE IEEE Computer Society LAAS CNRS IFIP Working Group 10.4 on Dependable Computing and Fault Tolerance Special Interest Group on Dependability Benchmarking IFIP Working Group 10.4 French SEE Technical Committee on Trustworthy Computer Systems SEE Working Group Design and Validation for Dependability Technical University Munich Germany Darmstadt University of Technology ACM IACR Intel's SER Tech Council Intel's Architecture Patent Committee Taiwan Information Security Center NCTU IEEE Reliability Society Taipei and Tainan IACR United States Virage Logic Corp. AT and T Bell Laboratories Logic Vision Inc. University of British Columbia IEEE Test Technology Technical Council

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A Newborn Screening System Based on Service-Oriented Architecture Embedded Support Vector Machine

A Newborn Screening System Based on Service-Oriented Archite...

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2008 IEEE International Symposium on Service-Oriented System engineering

作者： Sung-Huai Hsieh Sheau-Ling Hsieh Yin-Hsiu Chien Zhenyu Wang Yung-Ching Weng Feipei Lai Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan Information Systems Office National Taiwan University Hospital Taipei Taiwan Network and Computer Centre National Chiao Tung University Hsinchu Taiwan Department of Medical Genetics National Taiwan University Hospital Taiwan Computing Laboratory Oxford University Oxford UK Department of Electrical Engineering National Taiwan University Taipei Taiwan

The clinical symptoms of metabolic disorders are rarely apparent during the neonatal period, and if they are not treated early, irreversible damage, such as mental retardation, or even death, may occur. Therefore, the practice of newborn screening is important to the prevention of permanent disabilities in *** this paper, we propose a newborn screening system that uses Support Vector Machine (SVM) classification techniques to evaluate raw data on the concentrations of metabolic substances obtained from tandem mass spectrometry (MS/MS) to determine if a newborn has a metabolic disorder. As per the concept of Service-Oriented Architecture (SOA), we designed the system using web services techniques, which are suitable for integrating heterogeneous platforms, protocols, and applications. It can be integrated seamlessly into National Taiwan University Hospital Information Systems (HIS) or other related HIS.

关键词： Pediatrics Service oriented architecture Support vector machines Diseases Hospitals Support vector machine classification Information systems Web services Mass spectroscopy Genetic engineering

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Conducting polymer based active catheter for minimally invasive interventions inside arteries

Conducting polymer based active catheter for minimally invas...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Tina Shoa John D. Madden Niloofar Fekri Nigel R. Munce Victor X.D. Yang Advanced Materials and Process Engineering Laboratory University of British Columbia Vancouver BC Canada Department Electrical and Computer Engineering University of British Columbia Vancouver BC Canada Imaging Research Sunnybrook Health Science Centre and Department of Medical Biophysics University of Toronto Toronto Canada Imaging Research Sunnybrook Health Sciences Centre Canada Department Electrical and Computer Engineering Ryerson University Toronto Canada

An active catheter intended for controllable intravascular maneuvers is presented and initial experimental results are shown. A commercial catheter is coated with polypyrrole and laser micromachined into electrodes, which are electrochemically activated, leading to bending of the catheter. The catheter's electro-chemo-mechanical properties are theoretically modeled to design the first prototype device, and used to predict an optimal polypyrrole thickness for the desired degree of bending within ∼30 seconds. We compared the experimental result of catheter bending to the theoretical model with estimated electrochemical strain, showing reasonable agreement. Finally, we used the model to design an encapsulated catheter with polypyrrole actuation for improved intravascular compatibility and performance.

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Effects of Dielectrophoresis on growth, viability and immuno-reactivity of Listeria monocytogenes

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Journal of Biological engineering 2008年第1期2卷 1-14页

作者： Yang, Liju Banada, Padmapriya P. Bhunia, Arun K. Bashir, Rashid Biomanufacturing Research Institute and Technology Enterprise (BRITE) Department of Pharmaceutical Sciences North Carolina Central University Durham NC 27707 United States Molecular Food Microbiology Laboratory Department of Food Science Purdue University West Lafayette IN 47907 United States Birck Nanotechnology Center Weldon School of Biomedical Engineering Purdue University West Lafayette IN 47907 United States Center for Infectious Diseases Department of Medicine New Jersey Medical School-UMDNJ Newark NJ 07130 185 S. Orange Ave United States Department of Electrical and Computer Engineering Micro and Nanotechnology Laboratories University of Illinois Urbana IL 61801 Urbana-Champaign United States

Dielectrophoresis (DEP) has been regarded as a useful tool for manipulating biological cells prior to the detection of cells. Since DEP uses high AC electrical fields, it is important to examine whether these electrical fields in any way damage cells or affect their characteristics in subsequent analytical procedures. In this study, we investigated the effects of DEP manipulation on the characteristics of Listeria monocytogenes cells, including the immuno-reactivity to several Listeria-specific antibodies, the cell growth profile in liquid medium, and the cell viability on selective agar plates. It was found that a 1-h DEP treatment increased the cell immuno-reactivity to the commercial Listeria species-specific polyclonal antibodies (from KPL) by ∼31.8% and to the C11E9 monoclonal antibodies by ∼82.9%, whereas no significant changes were observed with either anti-InlB or anti-ActA antibodies. A 1-h DEP treatment did not cause any change in the growth profile of Listeria in the low conductive growth medium (LCGM);however, prolonged treatments (4 h or greater) caused significant delays in cell growth. The results of plating methods showed that a 4-h DEP treatment (5 MHz, 20 Vpp) reduced the viable cell numbers by 56.8-89.7 %. These results indicated that DEP manipulation may or may not affect the final detection signal in immuno-based detection depending on the type of antigen-antibody reaction involved. However, prolonged DEP treatment for manipulating bacterial cells could produce negative effects on the cell detection by growth-based methods. Careful selection of DEP operation conditions could avoid or minimize negative effects on subsequent cell detection performance. © 2008 Yang et al;licensee BioMed Central Ltd.

关键词： Listeria Viable Cell Number Interdigitated Microelectrode Listeria Cell electrical Field Exposure

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