Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone ***,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,ma...
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Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone ***,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,making the structure design of scaffolds for bone repair *** address this issue,we have carefully assessed diverse cell behaviors of bone mesenchymal stem cells(BMSCs)on theβ-tricalcium phosphate(β-TCP)scaffolds with three representative pore morphologies(i.e.,cross column,diamond,and gyroid pore unit,respectively).Among the scaffolds,BMSCs on theβ-TCP scaffold with diamond pore unit(designated as D-scaffold)demonstrated enhanced cytoskeletal forces,elongated nucleus,faster cell mobility,and better osteogenic differentiation potential(for example,the alkaline phosphatase expression level in D-scaffold were 1.5-2 times higher than other groups).RNA-sequencing analysis and signaling pathway intervention revealed that Ras homolog gene family A(RhoA)/Rho-associated kinase-2(ROCK2)has in-depth participated in the pore morphology-mediated BMSCs behaviors,indicating an important role of mechanical signaling transduction in scaffold-cell ***,femoral condyle defect repair results showed that D-scaffold could effectively promote endogenous bone regeneration,of which the osteogenesis rate was 1.2-1.8 times higher than the other ***,this work provides insights into pore morphology-mediated bone regeneration mechanisms for developing novel bioadaptive scaffold designs.
Immunomodulatory properties of orthopedic biomaterials are significant in regulating osteoimmune microenvironment for osteogenesis. The optimized component design of bioceramic is an effective strategy for improving o...
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All-inorganic perovskite solar cells(PSCs) have potential to pass the stability international standard of IEC61215:2016 but cannot deliver high performance and stability due to the poor interface contact. In this pape...
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All-inorganic perovskite solar cells(PSCs) have potential to pass the stability international standard of IEC61215:2016 but cannot deliver high performance and stability due to the poor interface contact. In this paper, Sn-doped TiO_(2)(Ti_(1-x)Sn_(x)O_(2)) ultrathin nanoparticles are prepared for electron transport layer(ETL) by solution process. The ultrathin Ti_(1-x)Sn_(x)O_(2) nanocrystals have greatly improved interface contact due to the facile film formation, good conductivity and high work function. The all-inorganic inverted NiOx/CsPbI_(2)Br/Ti_(1-x)Sn_(x)O_(2)p-i-n device shows a power conversion efficiency(PCE) of 14.0%. We tested the heat stability, light stability and light-heat stability. After stored in 85℃ for 65 days, the inverted PSCs still retains 98% of initial efficiency. Under continuous standard one-sun illumination for 600 h,there is no efficiency decay, and under continuous illumination at 85℃ for 200 h, the device still retains 85% of initial efficiency. The 1.0 cm^(2) device of inverted structure shows a PCE of up to 11.2%. The ultrathin Ti_(1-x)Sn_(x)O_(2)is promising to improve the scalability and stability and thus increase the commercial prospect.
Calcium phosphate bio-ceramics are osteo-conductive,but it remains a challenge to promote the induction of bone augmentation and capillary *** surface micro/nano-topography of materials can be recognized by cells and ...
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Calcium phosphate bio-ceramics are osteo-conductive,but it remains a challenge to promote the induction of bone augmentation and capillary *** surface micro/nano-topography of materials can be recognized by cells and then the cell fate are *** regulation methods of carving surface structures on bio-ceramics employ mineral reagents and organic additives,which might introduce impurity phases and affect the biological *** a previous study,a facile and novel method was utilized with ultrapure water as the unique reagent for hydrothermal treatment,and a uniform hydroxyapatite(HAp)surface layer was constructed on composite ceramics(β-TCP/CaSiO_(3))in *** combined with 3D printing technology,biomimetic hierarchical structure scaffolds were fabricated with interconnected porous composite ceramic scaffolds as the architecture and micro/nano-rod hybrid HAp as the surface *** obtained HAp surface layer favoured cell adhesion,alleviated the cytotoxicity of precursor scaffolds,and upregulated the cellular differentiation of mBMSCs and gene expression of HUVECs in *** vivo studies showed that capillary formation,bone augmentation and new bone matrix formation were upregulated after the HAp surface layer was obtained,and the results confirmed that the fabricated biomimetic hierarchical structure scaffold could be an effective candidate for bone regeneration.
Mechanical metamaterials feature specially designed structures that enhance their mechanical properties. A 3D-printed lattice material (LM) is a typical mechanical metamaterial with high strength, low weight, and cons...
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Sequentially Regulating immune-osteogenesis to orderly transition from the inflammatory phase to bone reconstruction, enhancing bone regeneration while inhibiting osteoclastic resorption, are crucial for treating oste...
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